trachelogenin and Colonic-Neoplasms

trachelogenin has been researched along with Colonic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for trachelogenin and Colonic-Neoplasms

Article	Year
In vitro antitumor effect of a lignan isolated from Combretum fruticosum, trachelogenin, in HCT-116 human colon cancer cells. Toxicology in vitro : an international journal published in association with BIBRA, 2018, Volume: 47 The use of natural products in therapeutics has been growing over the years. Lignans are compounds with large pharmaceutical use, which has aroused interest in the search for new drugs to treat diseases. The present study evaluated the cytotoxicity of (-)-trachelogenin, a dibenzylbutyrolactone type lignan isolated from Combretum fruticosum, against several tumor and non-tumor cell lines using the MTT assay and its possible mechanism of action. (-)-Trachelogenin showed IC Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Autophagosomes; Autophagy; Beclin-1; Brazil; Cell Line; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Combretum; Drug Discovery; Ethnopharmacology; HCT116 Cells; Humans; Inhibitory Concentration 50; Medicine, Traditional; Microtubule-Associated Proteins; Molecular Structure; Neoplasm Proteins; Plant Stems; Vacuoles	2018
Endogenous enzyme-hydrolyzed fruit of Cirsium brachycephalum: optimal source of the antiproliferative lignan trachelogenin regulating the Wnt/β-catenin signaling pathway in the SW480 colon adenocarcinoma cell line. Fitoterapia, 2015, Volume: 100 The molecular constituents of Cirsium brachycephalum fruits were identified, quantified and isolated for the first time. The lignan glycoside tracheloside was the main compound, which was transformed quantitatively into its aglycone trachelogenin by endogenous enzymatic treatment of the fruit. Following this transformation by high performance liquid chromatography (HPLC) hyphenated with UV and mass spectrometry (MS) detections on a quantitative basis, the enzyme-hydrolyzed fruit was found to be the richest raw material containing trachelogenin (17.2mg/g) reported to date. Thus, the enzyme-hydrolyzed fruit was used to isolate trachelogenin using preparative HPLC in order to (1) unambiguously confirm its identity by gas chromatography-MS, nuclear magnetic resonance spectroscopy and optical rotation, and (2) investigate its in vitro antiproliferative activities against the SW480 colon adenocarcinoma cell line. Trachelogenin significantly affected the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway in a concentration-dependent manner. These changes account for the antiproliferative effects of trachelogenin. Topics: 4-Butyrolactone; Adenocarcinoma; Antineoplastic Agents, Phytogenic; beta Catenin; Cell Line, Tumor; Cirsium; Colonic Neoplasms; Fruit; Glycogen Synthase Kinase 3; Humans; Lignans; Molecular Structure; Proto-Oncogene Proteins c-myc; Wnt Signaling Pathway	2015

Article

Year

In vitro antitumor effect of a lignan isolated from Combretum fruticosum, trachelogenin, in HCT-116 human colon cancer cells.

Toxicology in vitro : an international journal published in association with BIBRA, 2018, Volume: 47

The use of natural products in therapeutics has been growing over the years. Lignans are compounds with large pharmaceutical use, which has aroused interest in the search for new drugs to treat diseases. The present study evaluated the cytotoxicity of (-)-trachelogenin, a dibenzylbutyrolactone type lignan isolated from Combretum fruticosum, against several tumor and non-tumor cell lines using the MTT assay and its possible mechanism of action. (-)-Trachelogenin showed IC

Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Autophagosomes; Autophagy; Beclin-1; Brazil; Cell Line; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Combretum; Drug Discovery; Ethnopharmacology; HCT116 Cells; Humans; Inhibitory Concentration 50; Medicine, Traditional; Microtubule-Associated Proteins; Molecular Structure; Neoplasm Proteins; Plant Stems; Vacuoles

2018

Endogenous enzyme-hydrolyzed fruit of Cirsium brachycephalum: optimal source of the antiproliferative lignan trachelogenin regulating the Wnt/β-catenin signaling pathway in the SW480 colon adenocarcinoma cell line.

Fitoterapia, 2015, Volume: 100

The molecular constituents of Cirsium brachycephalum fruits were identified, quantified and isolated for the first time. The lignan glycoside tracheloside was the main compound, which was transformed quantitatively into its aglycone trachelogenin by endogenous enzymatic treatment of the fruit. Following this transformation by high performance liquid chromatography (HPLC) hyphenated with UV and mass spectrometry (MS) detections on a quantitative basis, the enzyme-hydrolyzed fruit was found to be the richest raw material containing trachelogenin (17.2mg/g) reported to date. Thus, the enzyme-hydrolyzed fruit was used to isolate trachelogenin using preparative HPLC in order to (1) unambiguously confirm its identity by gas chromatography-MS, nuclear magnetic resonance spectroscopy and optical rotation, and (2) investigate its in vitro antiproliferative activities against the SW480 colon adenocarcinoma cell line. Trachelogenin significantly affected the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway in a concentration-dependent manner. These changes account for the antiproliferative effects of trachelogenin.

Topics: 4-Butyrolactone; Adenocarcinoma; Antineoplastic Agents, Phytogenic; beta Catenin; Cell Line, Tumor; Cirsium; Colonic Neoplasms; Fruit; Glycogen Synthase Kinase 3; Humans; Lignans; Molecular Structure; Proto-Oncogene Proteins c-myc; Wnt Signaling Pathway

2015