toxin-nt-2 and Lymphoma

toxin-nt-2 has been researched along with Lymphoma* in 1 studies

Other Studies

1 other study(ies) available for toxin-nt-2 and Lymphoma

ArticleYear
Structure-activity studies of trichothecenes: cytotoxicity of analogues and reaction products derived from T-2 toxin and neosolaniol.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:3

    Forty-two analogues and reaction products derived from T-2 toxin or neosolaniol were assayed for their cytotoxicity to cultured mouse lymphoma cells. Structure-activity relationships confirmed the stereospecific nature of the cytotoxic action of T-2. Cytotoxicity was particularly susceptible to changes at C3, C4, C9, and C10 but was relatively unaffected by changes at C8, which appears to represent a region of steric tolerance in the interaction of T-2 with a cellular constituent. The most potent compounds were T-2, diacetoxyscirpenol, and a series of C8 ester analogues 11 and 31-35.

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Drug Screening Assays, Antitumor; Lymphoma; Mice; Sesquiterpenes; Structure-Activity Relationship; T-2 Toxin; Trichothecenes; Tumor Cells, Cultured

1989