toxin-nt-2 has been researched along with Lymphoma* in 1 studies
1 other study(ies) available for toxin-nt-2 and Lymphoma
Article | Year |
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Structure-activity studies of trichothecenes: cytotoxicity of analogues and reaction products derived from T-2 toxin and neosolaniol.
Forty-two analogues and reaction products derived from T-2 toxin or neosolaniol were assayed for their cytotoxicity to cultured mouse lymphoma cells. Structure-activity relationships confirmed the stereospecific nature of the cytotoxic action of T-2. Cytotoxicity was particularly susceptible to changes at C3, C4, C9, and C10 but was relatively unaffected by changes at C8, which appears to represent a region of steric tolerance in the interaction of T-2 with a cellular constituent. The most potent compounds were T-2, diacetoxyscirpenol, and a series of C8 ester analogues 11 and 31-35. Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Drug Screening Assays, Antitumor; Lymphoma; Mice; Sesquiterpenes; Structure-Activity Relationship; T-2 Toxin; Trichothecenes; Tumor Cells, Cultured | 1989 |