toxiferine and Postoperative-Complications

Either tacrine (THA) with succinylcholine or alcuronium was used on a randomized basis for laparoscopic procedures in twenty young females. The technique using THA with succinylcholine was found to be more suitable and predictable for this procedure and gave a smoother anaesthetic course, brighter recovery and minimal postoperative complications.

Topics: Adult; Alcuronium; Aminoacridines; Anesthesia Recovery Period; Drug Evaluation; Female; Humans; Laparoscopy; Postoperative Complications; Preanesthetic Medication; Succinylcholine; Tacrine; Toxiferine

Recovery of neuromuscular function and postoperative morbidity were studied in 51 fit female patients who had nonemergency gynaecological laparoscopy as inpatients. They were allocated randomly to one of three groups to receive either atracurium 0.31 mg/kg, alcuronium 0.25 mg/kg, or vecuronium 0.06 mg/kg as part of an otherwise standard anaesthetic technique. There were neither differences in intubation conditions nor in the occurrence of postoperative diplopia whichever muscle relaxant was used. Deficits in grip strength and expiratory force were seen at one hour after reversal with atropine 1.2 mg and neostigmine 2.5 mg in all patients, deficits which persisted for 3 hours in those who received alcuronium. The recovery of inspiratory force was slower and less complete at up to 3 hours in those who received alcuronium and there was a high incidence of minor postoperative morbidity at up to 24 hours in each of the three groups. The only statistical difference in symptomatic morbidity was an increase in muscle weakness in those who received alcuronium compared with atracurium at 3 hours after laparoscopy. Only 25%, 20% and 31% of the patients who received atracurium, alcuronium and vecuronium respectively said that they would have liked to be day stay patients.

Topics: Adult; Alcuronium; Anesthesia Recovery Period; Atracurium; Female; Humans; Laparoscopy; Middle Aged; Neuromuscular Junction; Postoperative Complications; Random Allocation; Respiration; Time Factors; Toxiferine; Vecuronium Bromide

Alcuronium and atracurium were used on a randomised basis as part of the anaesthetic technique for out-patient gynaecological laparoscopy. Conditions for intubation and relaxation were similar but there was a marked decrease in the incidence of minor postoperative sequelae in the atracurium group.

Topics: Alcuronium; Ambulatory Surgical Procedures; Anesthesia, General; Atracurium; Blood Pressure; Female; Heart Rate; Humans; Isoquinolines; Laparoscopy; Neuromuscular Blocking Agents; Postoperative Complications; Random Allocation; Toxiferine

Alcuronium 10 mg was administered to maintain muscle relaxation in two patients before recovery from suxamethonium neuromuscular blockade to facilitate tracheal intubation. This sequence resulted in a markedly prolonged block which could not be antagonised adequately by neostigmine 0.05 mg/kg; initial antagonism was followed rapidly by prolonged recurarisation. Estimation of plasma cholinesterase activity revealed that the two patients were homozygous for the atypical and silent genes. respectively.

Topics: Adult; Alcuronium; Cholinesterases; Female; Humans; Middle Aged; Neostigmine; Postoperative Complications; Pregnancy; Puerperal Disorders; Succinylcholine; Time Factors; Toxiferine

The pharmacokinetic behaviour of alcuronium was studied in three patients undergoing resection of an aortic aneurysm, and in another two patients undergoing total hip replacement (group I). A control group of five elderly patients undergoing relatively minor surgery was included (group II). In group I patients, the values of the pharmacokinetic parameters such as plasma clearance, elimination half-life and the apparent volume of distribution of the drug were found to be comparable to those obtained in normal young patients in previous studies. The group II patients, however, were found to have a prolonged elimination half-life as a result of reduced plasma clearance, possibly an age-related effect. The differences between these two groups of patients may be explained by the differences in the extent of haemorrhage and fluid replacement or changes in blood circulation, or both. However, alcuronium must still be used cautiously in both groups of patients, especially in the light of a recent finding that patients undergoing aortic reconstructive surgery have a high frequency of functional renal failure after operation.

Topics: Aged; Alcuronium; Aortic Aneurysm; Female; Fluid Therapy; Hemorrhage; Hip Prosthesis; Humans; Intraoperative Complications; Kinetics; Male; Middle Aged; Postoperative Complications; Time Factors; Toxiferine

Topics: Anesthesia; Apnea; Decamethonium Compounds; Drug Synergism; Gallamine Triethiodide; Humans; Muscles; Neuromuscular Junction; Postoperative Complications; Respiration; Succinylcholine; Toxiferine; Tubocurarine

Topics: Adult; Anesthesia, Endotracheal; Atropine; Coma; Female; Halothane; Humans; Kidney Transplantation; Male; Nephrectomy; Nitrous Oxide; Postoperative Complications; Respiration, Artificial; Seizures; Succinylcholine; Thiopental; Toxiferine; Transplantation, Homologous