tosylphenylalanyl-chloromethyl-ketone and Intracranial-Hemorrhages

tosylphenylalanyl-chloromethyl-ketone has been researched along with Intracranial-Hemorrhages* in 1 studies

Other Studies

1 other study(ies) available for tosylphenylalanyl-chloromethyl-ketone and Intracranial-Hemorrhages

ArticleYear
Inhibitor of nuclear factor-Kappa B activation attenuates venular constriction, leukocyte rolling-adhesion and microvessel rupture induced by ethanol in intact rat brain microcirculation: relation to ethanol-induced brain injury.
    Neuroscience letters, 2002, Dec-06, Volume: 334, Issue:1

    The present study was designed to test the hypothesis that acute, local administration of a specific inhibitor of nuclear factor-Kappa B activation (which prevents rapid proteolysis of IKB-alpha) will attenuate cerebral (cortical) venular constrictions, leukocyte-endothelial wall interactions and postcapillary damage induced by medium to high concentrations of ethanol in the intact rat brain. Perivascular or i.p. administration of ethanol (100, 250 mg/dl) to the intact rat brain resulted in concentration-dependent venular vasospasm, rolling and adherence of leukocytes to venular walls and rupture of postcapillary venules with focal hemorrhages. Superfusion of the in-situ brain with N(alpha)-L-tosyl-L-phenylalanine chloromethyl ketone (TPCK), a specific inhibitor of IKB-alpha proteolysis, attenuated greatly the spasmogenic, leukocyte rolling-endothelial cell adhesion and postcapillary hemorrhages induced by ethanol. These new data suggest that inhibition of alcohol-inducible degradation of IKB-alpha by TPKC can prevent much of the adverse microvascular actions of ethanol in the intact rat brain. Moreover, these new in-situ results suggest that activation of nuclear factor-Kappa B seems to play a major modulatory role in the adverse cerebral vascular actions of concentrations of alcohol found in the blood of alcohol-intoxicated subjects and human stroke victims.

    Topics: Animals; Cerebral Cortex; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Ethanol; Intracranial Hemorrhages; Leukocyte Rolling; Male; Microcirculation; NF-kappa B; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Tosylphenylalanyl Chloromethyl Ketone; Vasoconstriction; Venules

2002