toremifene and Salivary-Gland-Neoplasms

Adenoid cystic carcinoma of the salivary gland (ACC-SG) is a slow-growing tumor that is refractory to most chemotherapeutic agents. Estrogen receptor (ER) antagonists provide a novel approach for recurrent disease.. We report two cases of ACC-SC in which Tamoxifen/Toremifene were used.. Both patients obtained long-term stability of disease with no associated toxicity.. Given the relatively unsuccessful treatments for ACC-SC and the low toxicity of ER antagonists, such therapy should be considered in these patients for its potential disease-stabilizing effects.

Topics: Adult; Antineoplastic Agents, Hormonal; Carcinoma, Adenoid Cystic; Combined Modality Therapy; Female; Humans; Lung Neoplasms; Neoplasm Recurrence, Local; Salivary Gland Neoplasms; Tamoxifen; Toremifene