toremifene has been researched along with Marburg-Virus-Disease* in 1 studies
1 other study(ies) available for toremifene and Marburg-Virus-Disease
| Article | Year |
|---|---|
Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections.
The recent Ebola epidemics in West Africa underscore the great need for effective and practical therapies for future Ebola virus outbreaks. We have discovered a new series of remarkably potent small molecule inhibitors of Ebola virus entry. These 4-(aminomethyl)benzamide-based inhibitors are also effective against Marburg virus. Synthetic routes to these compounds allowed for the preparation of a wide variety of structures, including a conformationally restrained subset of indolines (compounds Topics: A549 Cells; Animals; Antiviral Agents; Benzamides; Chlorocebus aethiops; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Hemorrhagic Fever, Ebola; Humans; Marburg Virus Disease; Microsomes, Liver; Molecular Docking Simulation; Structure-Activity Relationship; Toremifene; Vero Cells; Viral Envelope Proteins; Virus Internalization | 2020 |