Page last updated: 2024-09-04

torcetrapib and Coronary Disease

torcetrapib has been researched along with Coronary Disease in 16 studies

*Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. [MeSH]

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (43.75)29.6817
2010's7 (43.75)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Adam, LP; Chang, M; Chen, AY; Chen, XQ; Cooper, CB; Finlay, HJ; Galella, MA; Harikrishnan, LS; Huang, CS; Jiang, J; Kamau, MG; Lawrence, RM; Li, J; Miller, AV; Nirschl, DS; Poss, MA; Qiao, JX; Salvati, ME; Sitkoff, DF; Sleph, PG; Taylor, DS; Van Kirk, K; Wang, TC; Wexler, RR; Yang, RZ; Yin, X1
Amin, RP; Bao, J; Blaustein, RO; Campeau, LC; Chen, Q; Chen, YH; Cote, J; Duffy, JL; Hartmann, G; Johns, DG; Katipally, R; Leung, D; Lipardi, C; Liu, G; Liu, J; Lu, Z; Metzger, D; Mitra, K; Murphy, BA; Ondeyka, D; Shao, PP; Sinclair, PJ; Sun, W; Tan, L; Tyagarajan, S; Vachal, P; Wang, SP; Wollenberg, GK; Xu, Y; Ye, F; Zhao, K1
Bis, JC; Charoen, P; Chaturvedi, N; Drenos, F; Finan, C; Franceschini, N; Gaunt, TR; Giambartolomei, C; Gordillo-Marañón, M; Hingorani, AD; Hughes, AD; Hunt, NB; Kivimaki, M; Lawlor, DA; Mook-Kanamori, DO; O'Donnell, CJ; Papacosta, O; Price, JF; Schmidt, AF; Sofat, R; Wannamethee, G; Wong, A; Zwierzyna, M1
Schaefer, EJ1
deGoma, EM; Rader, DJ1
Francis, DP; Keene, D; Price, C; Shun-Shin, MJ1
Tomlinson, B1
Mombelli, G; Sirtori, CR1
Toth, PP1
Bays, H; Davidson, M; McKenney, J1
Chapman, MJ1
Asztalos, BF; Schaefer, EJ1
Einecke, D1
Hoekstra, JA; McKenney, JM1
Barter, PJ; Brewer, B; Buhr, KA; Caulfield, M; Eriksson, M; Fisher, MR; Grundy, SM; Kastelein, JJ; Komajda, M; Lopez-Sendon, J; Mosca, L; Revkin, JH; Shear, CL; Tall, AR; Tardif, JC; Waters, DD1
Ewart, RM1

Reviews

9 review(s) available for torcetrapib and Coronary Disease

ArticleYear
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.
    Nature communications, 2021, 09-24, Volume: 12, Issue:1

    Topics: Amides; Anticholesteremic Agents; Benzodiazepines; Cardiovascular Diseases; Cholesterol Ester Transfer Proteins; Coronary Disease; Esters; Humans; Mendelian Randomization Analysis; Oxazolidinones; Quinolines; Sulfhydryl Compounds

2021
Effects of cholesteryl ester transfer protein inhibitors on human lipoprotein metabolism: why have they failed in lowering coronary heart disease risk?
    Current opinion in lipidology, 2013, Volume: 24, Issue:3

    Topics: Amides; Anticholesteremic Agents; Apolipoproteins; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Esters; Humans; Lipid Metabolism; Protein Binding; Quinolines; Sulfhydryl Compounds; Treatment Failure; Triglycerides

2013
Future of cholesteryl ester transfer protein inhibitors.
    Annual review of medicine, 2014, Volume: 65

    Topics: Amides; Anticholesteremic Agents; Atherosclerosis; Benzodiazepines; Cholesterol; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Esters; Humans; Oxazolidinones; Quinolines; Sulfhydryl Compounds

2014
Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients.
    BMJ (Clinical research ed.), 2014, Jul-18, Volume: 349

    Topics: Amides; Anticholesteremic Agents; Cholesterol Ester Transfer Proteins; Coronary Disease; Esters; Fibric Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, HDL; Myocardial Infarction; Niacin; Oxazolidinones; Quinolines; Randomized Controlled Trials as Topic; Stroke; Sulfhydryl Compounds

2014
CETP Inhibition: does the future look promising?
    Current cardiology reports, 2011, Volume: 13, Issue:6

    Topics: Anticholesteremic Agents; Atherosclerosis; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Female; Humans; Incidence; Male; Quinolines; Risk Factors

2011
Torcetrapib/atorvastatin combination therapy.
    Expert review of cardiovascular therapy, 2005, Volume: 3, Issue:5

    Topics: Animals; Atorvastatin; Clinical Trials as Topic; Coronary Disease; Drug Therapy, Combination; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Quinolines

2005
Therapeutic elevation of HDL-cholesterol to prevent atherosclerosis and coronary heart disease.
    Pharmacology & therapeutics, 2006, Volume: 111, Issue:3

    Topics: Amides; Animals; Atherosclerosis; Biological Transport; Cholesterol; Cholesterol, HDL; Coronary Disease; Esters; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Oxidative Stress; PPAR alpha; PPAR delta; PPAR gamma; Quinolines; Sulfhydryl Compounds

2006
Cholesteryl ester transfer protein inhibition, high-density lipoprotein metabolism and heart disease risk reduction.
    Current opinion in lipidology, 2006, Volume: 17, Issue:4

    Topics: Amides; Animals; Carrier Proteins; Cholesterol Ester Transfer Proteins; Coronary Disease; Esters; Glycoproteins; Humans; Lipid Metabolism; Lipoproteins, HDL; Quinolines; Risk; Sulfhydryl Compounds

2006
Will torcetrapib be the next big thing in coronary heart disease risk reduction?
    Current atherosclerosis reports, 2007, Volume: 9, Issue:1

    Topics: Anticholesteremic Agents; Coronary Disease; Forecasting; Humans; Quinolines; Risk

2007

Trials

1 trial(s) available for torcetrapib and Coronary Disease

ArticleYear
Effects of torcetrapib in patients at high risk for coronary events.
    The New England journal of medicine, 2007, Nov-22, Volume: 357, Issue:21

    Topics: Aged; Anticholesteremic Agents; Atorvastatin; Cardiovascular Diseases; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Male; Middle Aged; Mortality; Pyrroles; Quinolines

2007

Other Studies

6 other study(ies) available for torcetrapib and Coronary Disease

ArticleYear
Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Anticholesteremic Agents; Apolipoprotein B-100; Blood Pressure; Cholesterol Ester Transfer Proteins; Coronary Disease; Cricetinae; Drug Discovery; Heart Rate; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Transgenic; Molecular Structure; Pyridines; Rats; Stilbenes

2012
Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.
    Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18

    Topics: Animals; Anticholesteremic Agents; Cholesterol Ester Transfer Proteins; Coronary Disease; Dogs; Humans; Macaca mulatta; Mice, Inbred C57BL; Molecular Structure; Oxazolidinones; Rats, Wistar; Structure-Activity Relationship

2021
Raising high-density lipoprotein: for better or worse?
    Heart (British Cardiac Society), 2010, Volume: 96, Issue:17

    Topics: Anticholesteremic Agents; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Coronary Disease; Humans; Quinolines

2010
Cholesteryl ester transfer protein antagonism by drugs--a poor choice.
    Clinical chemistry, 2010, Volume: 56, Issue:10

    Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Atorvastatin; Cholesterol Ester Transfer Proteins; Clinical Trials as Topic; Coronary Disease; Drug Therapy, Combination; Genetic Predisposition to Disease; Heptanoic Acids; Humans; Polymorphism, Genetic; Pyrroles; Quinolines; Risk

2010
[High lowering of lipids can melt coronary plaques -- is coronary disease reversible?].
    MMW Fortschritte der Medizin, 2006, Jun-15, Volume: 148, Issue:24

    Topics: Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Controlled Clinical Trials as Topic; Coronary Disease; Coronary Vessels; Drug Therapy, Combination; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Longitudinal Studies; Placebos; Pravastatin; Pyrimidines; Pyrroles; Quinolines; Rosuvastatin Calcium; Sulfonamides; Time Factors; Treatment Outcome; Ultrasonography, Interventional

2006
Lessons from torcetrapib: putting patient-oriented evidence first.
    American family physician, 2008, Mar-01, Volume: 77, Issue:5

    Topics: Anticholesteremic Agents; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Coronary Disease; Humans; Hyperhomocysteinemia; Prognosis; Quinolines

2008