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topotecan and Sensitivity and Specificity

topotecan has been researched along with Sensitivity and Specificity in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.79)18.2507
2000's12 (63.16)29.6817
2010's4 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bai, F; Fraga, CH; Hubbard, KE; Miller, L; Panetta, JC; Schaiquevich, P; Stewart, CF1
Arellano, C; Bettuing, L; Chatelut, E; Gandia, P; Woodley, J1
Aucélio, RQ; da Cunha, AL; Marques, FF1
Chang, QY; Li, M; Li, XG; Li, YF; Liu, J; Song, PP; Tian, HM; Wang, XB; Wu, LY; Zhang, W; Zhao, D1
Ingebrandt, S; Koppenhöfer, D; Susloparova, A; Vu, XT; Weil, M1
Nyormoi, O; Satoh, TH; Surmacz, TA; Whitacre, CM1
Lane, SR; Ross, GA; ten Bokkel Huinink, W1
Daw, NC; Furman, WL; Gajjar, AJ; Hawkins, DR; Houghton, PJ; Iacono, LC; Panetta, JC; Santana, VM; Stewart, CF1
Balthasar, JP; Chen, J1
Dadashzadeh, S; Shafaghi, B; Vali, AM1
Beijnen, JH; Buckle, T; de Vries, NA; Ouwehand, M; van Tellingen, O1
Bansal, T; Jaggi, M; Khar, RK; Mishra, G; Mukherjee, R; Singh, M; Talegaonkar, S1
Kim, K1
Loos, WJ; Schellens, JH; Stoter, G; Verweij, J1
Ardizzoni, A; de Cupis, A; Favoni, RE; Grossi, F; Loprevite, M; Merlo, F; Pirani, P1
Huang, J; Kandel, JJ; Kim, E; Manley, C; Middlesworth, W; Moore, JT; O'Toole, K; Soffer, SZ; Stolar, C; Yamashiro, DJ; Yokoi, A1
Apan, A; Bayar, N; Böke, B; Koç, MC1
Bakr, M; Bauer, J; Bodmer, A; Duvoisin, B; Ketterer, N; Leyvraz, S; Perey, L; Stupp, R1
Gelderblom, H; Loos, WJ; Nooter, K; Sparreboom, A; Stoter, G; van Zomeren, DM; Verweij, J1

Trials

3 trial(s) available for topotecan and Sensitivity and Specificity

ArticleYear
Long-term survival in a phase III, randomised study of topotecan versus paclitaxel in advanced epithelial ovarian carcinoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Disease Progression; Drug Administration Schedule; Female; Humans; Incidence; Infusions, Intravenous; Neoplasm Recurrence, Local; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Paclitaxel; Quality of Life; Sensitivity and Specificity; Survival Analysis; Topotecan

2004
Phase I and pharmacokinetic study of topotecan administered orally once daily for 5 days for 2 consecutive weeks to pediatric patients with refractory solid tumors.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Mar-01, Volume: 22, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Maximum Tolerated Dose; Neoplasms; Salvage Therapy; Sampling Studies; Sensitivity and Specificity; Topotecan; Treatment Outcome

2004
Is cisplatin required for the treatment of non-small-cell lung cancer? Experience and preliminary results of a phase I/II trial with topotecan and vinorelbine.
    Oncology, 2001, Volume: 61 Suppl 1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Sensitivity and Specificity; Survival Rate; Topotecan; Treatment Outcome; Vinblastine; Vinorelbine

2001

Other Studies

16 other study(ies) available for topotecan and Sensitivity and Specificity

ArticleYear
Application of a highly specific and sensitive fluorescent HPLC method for topotecan lactone in whole blood.
    Biomedical chromatography : BMC, 2009, Volume: 23, Issue:7

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Linear Models; Methanol; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Spectrometry, Fluorescence; Topotecan

2009
Quantification of topotecan by liquid chromatography-mass spectrometry (LC-MS). Application to intestinal transport using rat everted gut sacs.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Mar-01, Volume: 878, Issue:7-8

    Topics: Animals; Antiemetics; Antineoplastic Agents; Chromatography, Liquid; Drug Interactions; Duodenum; Hydrogen-Ion Concentration; Least-Squares Analysis; Male; Mass Spectrometry; Models, Biological; Ondansetron; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Topotecan

2010
Laser induced fluorescence and photochemical derivatization for trace determination of camptothecin.
    Talanta, 2010, Nov-15, Volume: 83, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Fluorescence; Irinotecan; Lasers; Pharmaceutical Preparations; Photochemistry; Sensitivity and Specificity; Spectrometry, Fluorescence; Topotecan

2010
[Application of ATP-tumor chemosensitivity assay in recurrent epithelial ovarian cancer].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2010, Volume: 32, Issue:11

    Topics: Adenosine Triphosphate; Antineoplastic Combined Chemotherapy Protocols; CA-125 Antigen; Carcinoma, Endometrioid; Cystadenocarcinoma, Serous; Deoxycytidine; Disease-Free Survival; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Female; Follow-Up Studies; Gemcitabine; Humans; Luminescent Measurements; Neoplasm Recurrence, Local; Ovarian Neoplasms; Paclitaxel; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity; Survival Rate; Topotecan

2010
Impedance spectroscopy with field-effect transistor arrays for the analysis of anti-cancer drug action on individual cells.
    Biosensors & bioelectronics, 2013, Feb-15, Volume: 40, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Biosensing Techniques; Cell Line, Tumor; Cell Separation; Cell Survival; Dielectric Spectroscopy; Drug Evaluation, Preclinical; Equipment Design; Equipment Failure Analysis; Flow Cytometry; Humans; Neoplasms, Experimental; Reproducibility of Results; Sensitivity and Specificity; Topotecan; Transistors, Electronic; Treatment Outcome

2013
Inhibition of focal adhesion kinase by antisense oligonucleotides enhances the sensitivity of breast cancer cells to camptothecins.
    Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al, 2003, Volume: 27, Issue:1

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Camptothecin; Caspase 3; Caspase 9; Caspases; Cell Adhesion; Enzyme Activation; Enzyme Precursors; Female; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Humans; Oligonucleotides, Antisense; Poly(ADP-ribose) Polymerases; Protein-Tyrosine Kinases; Sensitivity and Specificity; Topotecan; Tumor Cells, Cultured; Tumor Protein, Translationally-Controlled 1

2003
High-performance liquid chromatographic assay for the determination of total and free topotecan in the presence and absence of anti-topotecan antibodies in mouse plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Feb-25, Volume: 816, Issue:1-2

    Topics: Animals; Antibodies; Antineoplastic Agents; Chromatography, High Pressure Liquid; Mice; Mice, Inbred BALB C; Reproducibility of Results; Sensitivity and Specificity; Topotecan

2005
Simple and sensitive high performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of topotecan in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Apr-25, Volume: 818, Issue:2

    Topics: Carboxylic Acids; Chromatography, High Pressure Liquid; Drug Stability; Humans; Lactones; Reproducibility of Results; Sensitivity and Specificity; Topotecan

2005
Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography.
    Biomedical chromatography : BMC, 2007, Volume: 21, Issue:11

    Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Stability; Feasibility Studies; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Molecular Structure; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Spectrometry, Fluorescence; Tissue Distribution; Topotecan

2007
Concurrent determination of topotecan and model permeability markers (atenolol, antipyrine, propranolol and furosemide) by reversed phase liquid chromatography: utility in Caco-2 intestinal absorption studies.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Nov-15, Volume: 859, Issue:2

    Topics: Antipyrine; Atenolol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chromatography, High Pressure Liquid; Drug Stability; Furosemide; Humans; Intestinal Absorption; Permeability; Propranolol; Reproducibility of Results; Sensitivity and Specificity; Topotecan

2007
SEQPWR and SEQOPR: computer programs for design of maximum information trials based on group sequential logrank tests.
    Computer methods and programs in biomedicine, 1995, Volume: 46, Issue:2

    Topics: Algorithms; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Small Cell; Cisplatin; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Data Interpretation, Statistical; Etoposide; Feasibility Studies; Follow-Up Studies; Humans; Linear Models; Lung Neoplasms; Programming Languages; Research Design; Sensitivity and Specificity; Software; Survival Rate; Topotecan

1995
Sensitive high-performance liquid chromatographic fluorescence assay for the quantitation of topotecan (SKF 104864-A) and its lactone ring-opened product (hydroxy acid) in human plasma and urine.
    Journal of chromatography. B, Biomedical applications, 1996, Apr-12, Volume: 678, Issue:2

    Topics: Camptothecin; Chromatography, High Pressure Liquid; Drug Stability; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Hydrolysis; Hydroxy Acids; Kinetics; Regression Analysis; Sensitivity and Specificity; Topoisomerase I Inhibitors; Topotecan

1996
Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity.
    International journal of oncology, 1999, Volume: 15, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cisplatin; Deoxycytidine; Docetaxel; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Inhibitory Concentration 50; Irinotecan; Lung Neoplasms; Paclitaxel; Sensitivity and Specificity; Taxoids; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

1999
Combination antiangiogenic therapy: increased efficacy in a murine model of Wilms tumor.
    Journal of pediatric surgery, 2001, Volume: 36, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Disease Models, Animal; Endothelial Growth Factors; In Situ Nick-End Labeling; Injections, Intraperitoneal; Kidney Neoplasms; Lymphokines; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Reference Values; Sensitivity and Specificity; Survival Rate; Topotecan; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wilms Tumor

2001
Efficacy of topotecan treatment on an experimental model of transient evoked otoacoustic emissions.
    International journal of pediatric otorhinolaryngology, 2001, Nov-01, Volume: 61, Issue:2

    Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intravenous; Male; Models, Animal; Otoacoustic Emissions, Spontaneous; Probability; Rabbits; Sensitivity and Specificity; Statistics, Nonparametric; Topotecan

2001
Determination of topotecan in human whole blood and unwashed erythrocytes by high-performance liquid chromatography.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Jan-05, Volume: 766, Issue:1

    Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Topotecan

2002