topotecan has been researched along with Rhabdomyosarcoma in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (29.63) | 18.2507 |
| 2000's | 14 (51.85) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Ebinger, M; Fuchs, J; Heinz, AT; Klingebiel, T; Koscielniak, E; Kratz, CP; Ljungman, G; Münter, MW; Pajtler, KW; Rößler, J; Schönstein, A; Seitz, G; Sparber-Sauer, M; Stegmaier, S; Timmermann, B; Vokuhl, C; von Kalle, T | 1 |
| Beilken, A; Bochennek, K; Claviez, A; Dantonello, T; Dirksen, U; Klingebiel, T; Koscielniak, E; Sauerbrey, A | 1 |
| Baruchel, S; Kumar, S; Marrano, P; Thorner, P; Wu, B; Zhang, L | 1 |
| Biassoni, V; Casanova, M; Catania, S; Favini, F; Ferrari, A; Luksch, R; Meazza, C; Morosi, C; Podda, M; Zaffignani, E | 1 |
| Anderson, JR; Arndt, CA; Breneman, JC; Donaldson, SS; Hawkins, DS; Hayes-Jordan, AA; Meyer, WH; Paidas, CN; Parham, DM; Rodeberg, DA; Stoner, JA; Teot, LA; Wharam, MD | 1 |
| Kumabe, T; Niizuma, H; Osawa, S; Saito, R; Sonoda, Y; Tominaga, T; Watanabe, M | 1 |
| Baruchel, S; Kerbel, RS; Kumar, S; Man, S; Mokhtari, RB; Oliveira, ID; Sheikh, R; Wu, B; Xu, P; Yeger, H; Zhang, L | 1 |
| Breitfeld, PP; Lyden, ER; Meyer, WH; Qualman, SJ; Walterhouse, DO; Wharam, MD | 1 |
| Anderson, BD; Smith, MA | 1 |
| Anderson, JR; Breitfeld, PP; Lager, JJ; Lyden, ER; Meyer, WH; Pappo, AS | 1 |
| Gupta, AA; Pappo, AS | 1 |
| Berardi, AC; Dominici, C; McDowell, HP; Meco, D; Raschellà, G; Riccardi, A; Riccardi, R; Tanno, B | 1 |
| Cheshire, PJ; Danks, MK; Friedman, HS; Hallman, JD; Houghton, JA; Houghton, PJ; Lutz, L | 1 |
| Ali-Osman, F; Bigner, DD; Colvin, OM; Dolan, ME; Friedman, HS; Griffith, OW; Kaufmann, SH; Moschel, RC; Schold, SC | 1 |
| Bissery, MC; Cheshire, PJ; Hallman, JC; Houghton, JA; Houghton, PJ; Mathieu-Boué, A | 1 |
| Adamson, PC; Balis, FM; Berg, SL; Blaney, SM; Bleyer, WA; Gillespie, A; Krailo, MD; Needle, MN; Poplack, DG; Reaman, GH; Sato, JK | 1 |
| Cheshire, PJ; Houghton, JA; Houghton, PJ; Luo, X; Poquette, C; Richmond, LB; Santana, VM; Stewart, CF; Thompson, J; Zamboni, WC | 1 |
| Cheshire, PJ; Danks, MK; Houghton, PJ; Pawlik, CA; Richmond, LB; Stewart, CF | 1 |
| Cheshire, PJ; de Graaf, SS; George, EO; Houghton, PJ; Ma, M; Poquette, CA; Richmond, LB; Stewart, CF; Thompson, J | 1 |
| Barberi-Heyob, M; Chastagner, P; Duprez, A; Hoffstetter, S; Marchal, C; Merlin, JL; Vassal, G | 1 |
| Breneman, J; Crist, W; Lyden, E; Meza, J; Pappo, AS; Teot, L; Vietti, T; Wiener, E | 1 |
| Bernstein, ML; Harris, MB; Hayashi, R; Kepner, JL; Saylors, RL; Stine, KC; Sullivan, J; Vietti , TJ; Wall, DA | 1 |
| Anderson, JR; Breneman, JC; Crist, WM; Donaldson, SS; Grier, HE; Link, MP; Maurer, HM; Paidas, CN; Pappo, AS; Qualman, SJ; Raney, RB; Smith, LM; Teot, LA; Wiener, ES | 1 |
| Anderson, JR; Barr, FG; Crist, WM; Donaldson, SS; Maurer, HM; Pappo, AS; Qualman, SJ; Raney, RB; Wiener, ES | 1 |
| Houghton, PJ; Santana, VM | 1 |
| Ames, MM; Krailo, MD; Mares, WL; Mosher, R; Reaman, GH; Reid, JM; Seibel, NL; Wells, RJ; Wiersma, SR | 1 |
| Cheshire, PJ; Houghton, JA; Houghton, PJ; Myers, L; Stewart, CF; Synold, TW | 1 |
3 review(s) available for topotecan and Rhabdomyosarcoma
| Article | Year |
|---|---|
Pooled analysis of phase II window studies in children with contemporary high-risk metastatic rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Child; Child, Preschool; Clinical Trials, Phase II as Topic; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Enzyme Inhibitors; Etoposide; Female; Humans; Ifosfamide; Irinotecan; Lymphatic Metastasis; Male; Rhabdomyosarcoma; Survival Analysis; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan; Treatment Outcome | 2006 |
New drugs for the treatment of metastatic or refractory soft tissue sarcomas in children.
Topics: Animals; Camptothecin; Child; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Humans; Irinotecan; Rhabdomyosarcoma; Sarcoma; Survival Rate; Topoisomerase I Inhibitors; Topotecan | 2006 |
Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: a selective review of intergroup rhabdomyosarcoma study group experience and rationale for Intergroup Rhabdomyosarcoma Study V.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Infant; Male; Melphalan; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Neoplasm Staging; Pilot Projects; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Retrospective Studies; Rhabdomyosarcoma; Salvage Therapy; Sarcoma; Soft Tissue Neoplasms; Survival Rate; Topotecan; Treatment Outcome; Vincristine | 2001 |
7 trial(s) available for topotecan and Rhabdomyosarcoma
| Article | Year |
|---|---|
Response of children with stage IV soft tissue sarcoma to topotecan and carboplatin: a phase II window trial of the cooperative soft tissue sarcoma group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Neoadjuvant Therapy; Neoplasm Staging; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Sarcoma, Synovial; Soft Tissue Neoplasms; Survival Rate; Topotecan; Treatment Outcome | 2013 |
Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Neoplasm Staging; Rhabdomyosarcoma; Topotecan; Vincristine | 2009 |
Efficacy of topotecan and cyclophosphamide given in a phase II window trial in children with newly diagnosed metastatic rhabdomyosarcoma: a Children's Oncology Group study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Female; Humans; Male; Neoplasm Metastasis; Rhabdomyosarcoma; Survival Analysis; Topotecan; Vincristine | 2004 |
Phase II trial of topotecan administered as 72-hour continuous infusion in children with refractory solid tumors: a collaborative Pediatric Branch, National Cancer Institute, and Children's Cancer Group Study.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant; Infusions, Intravenous; Male; Neoplasms; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Rhabdomyosarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Topotecan | 1998 |
Up-front window trial of topotecan in previously untreated children and adolescents with metastatic rhabdomyosarcoma: an intergroup rhabdomyosarcoma study.
Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Agents; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Male; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Survival Rate; Topotecan | 2001 |
Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a Pediatric Oncology Group phase II study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Infusions, Intravenous; Male; Neoplasm Recurrence, Local; Neoplasms; Neuroblastoma; Osteosarcoma; Rhabdomyosarcoma; Sarcoma, Ewing; Topotecan | 2001 |
Phase I trial of cisplatin and topotecan in children with recurrent solid tumors: Children's Cancer Group Study 0942.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Cisplatin; Female; Granulocyte Colony-Stimulating Factor; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Neoplasm Recurrence, Local; Neoplasms; Neutropenia; Rhabdomyosarcoma; Salvage Therapy; Topotecan; Treatment Outcome | 2002 |
17 other study(ies) available for topotecan and Rhabdomyosarcoma
| Article | Year |
|---|---|
Second-line treatment of pediatric patients with relapsed rhabdomyosarcoma adapted to initial risk stratification: Data of the European Soft Tissue Sarcoma Registry (SoTiSaR).
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Chronic Disease; Cyclophosphamide; Etoposide; Humans; Polyketides; Recurrence; Retrospective Studies; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Topotecan | 2023 |
Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models.
Topics: Activation, Metabolic; Administration, Metronomic; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Inhibitory Concentration 50; Mice, Inbred NOD; Mice, SCID; Neuroblastoma; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Rhabdomyosarcoma; Topotecan; Xenograft Model Antitumor Assays | 2016 |
Efficacy of topotecan plus vincristine and doxorubicin in children with recurrent/refractory rhabdomyosarcoma.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Doxorubicin; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Neoplasm Recurrence, Local; Rhabdomyosarcoma; Topotecan; Treatment Outcome; Vincristine | 2009 |
Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Carboplatin; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Dactinomycin; Doxorubicin; Etoposide; Humans; Ifosfamide; Infant; Infratentorial Neoplasms; Irinotecan; Melphalan; Neoplasm Metastasis; Neuroblastoma; Rhabdomyosarcoma; Thiotepa; Topotecan; Vincristine | 2011 |
Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor.
Topics: Administration, Metronomic; Administration, Oral; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell Line, Tumor; Endothelial Cells; Humans; Indazoles; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels; Neoplasms; Neoplastic Cells, Circulating; Neovascularization, Pathologic; Neuroblastoma; Osteosarcoma; Pyrimidines; Random Allocation; Rhabdomyosarcoma; Stem Cells; Sulfonamides; Topoisomerase I Inhibitors; Topotecan; Xenograft Model Antitumor Assays | 2011 |
A window on reality?
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Ethics, Medical; Humans; Rhabdomyosarcoma; Topotecan; Treatment Outcome | 2004 |
Imatinib mesylate potentiates topotecan antitumor activity in rhabdomyosarcoma preclinical models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Cell Line, Tumor; Drug Evaluation, Preclinical; Humans; Imatinib Mesylate; Mice; Mice, Nude; Neoplasm Proteins; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Rhabdomyosarcoma; RNA, Messenger; Topotecan; Xenograft Model Antitumor Assays | 2007 |
Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Mice; Mice, Inbred CBA; Neoplasms, Experimental; Random Allocation; Rhabdomyosarcoma; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured | 1995 |
Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Camptothecin; Carmustine; DNA Polymerase I; DNA Polymerase II; DNA Topoisomerases, Type II; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Male; Melphalan; Mice; Mice, Inbred BALB C; Mice, Nude; Rhabdomyosarcoma; Topotecan; Transferases; Transplantation, Heterologous | 1994 |
Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor
Topics: Adolescent; Adult; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Child; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Irinotecan; Male; Melphalan; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Rhabdomyosarcoma; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured; Vincristine | 1993 |
Relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Bone Marrow Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Mice; Mice, Inbred CBA; Neuroblastoma; Retroperitoneal Space; Rhabdomyosarcoma; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous | 1998 |
Effective schedules of exposure of medulloblastoma and rhabdomyosarcoma xenografts to topotecan correlate with in vitro assays.
Topics: Animals; Antineoplastic Agents; Cell Division; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Administration Schedule; Drug Screening Assays, Antitumor; Humans; Medulloblastoma; Mice; Rhabdomyosarcoma; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
Synergy of topotecan in combination with vincristine for treatment of pediatric solid tumor xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Child; Drug Resistance, Neoplasm; Female; Humans; Medulloblastoma; Mice; Mice, Inbred CBA; Neuroblastoma; Rhabdomyosarcoma; Thymectomy; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured; Vincristine; Whole-Body Irradiation | 1999 |
In vivo potentiation of radiation response by topotecan in human rhabdomyosarcoma xenografted into nude mice.
Topics: Adolescent; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Combined Modality Therapy; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Synergism; Female; Humans; Mice; Mice, Nude; Radiation-Sensitizing Agents; Rhabdomyosarcoma; Topotecan; Xenograft Model Antitumor Assays | 2000 |
Which patients with microscopic disease and rhabdomyosarcoma experience relapse after therapy? A report from the soft tissue sarcoma committee of the children's oncology group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Follow-Up Studies; Humans; Infant; Multivariate Analysis; Neoplasm Recurrence, Local; Prognosis; Rhabdomyosarcoma; Soft Tissue Neoplasms; Survival Rate; Topotecan; Treatment Failure; Vincristine | 2001 |
Clinical trials using irinotecan.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Child; Chromosome Breakage; Clinical Trials as Topic; DNA Damage; DNA Replication; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Administration Schedule; Enzyme Inhibitors; Humans; Irinotecan; Mice; Multicenter Studies as Topic; Neoplasm Proteins; Neuroblastoma; Rhabdomyosarcoma; Topoisomerase I Inhibitors; Topotecan; Xenograft Model Antitumor Assays | 2002 |
Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors.
Topics: Adenocarcinoma; Adult; Animals; Antineoplastic Agents; Camptothecin; Child; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Osteosarcoma; Remission Induction; Rhabdomyosarcoma; Time Factors; Topotecan; Tumor Cells, Cultured | 1992 |