Page last updated: 2024-08-24

topotecan and Melanoma

topotecan has been researched along with Melanoma in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (41.67)18.2507
2000's4 (33.33)29.6817
2010's3 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Amaria, R; Ashkin, E; Bernatchez, C; Chen, Y; Davis, RE; Devi, S; Forget, MA; Haymaker, C; Heffernan, T; Hu, J; Huang, L; Hwu, P; Kalra, A; Liu, C; Malu, S; Mbofung, RM; McKenzie, JA; Muller, F; Peng, W; Pradeep, S; Roszik, J; Satani, N; Sood, A; Tieu, T; Williams, L; Xu, C; Zhang, M; Zorro Manrique, S1
Animati, F; Bellarosa, D; Bigioni, M; Binaschi, M; Bressan, A; Bugianesi, R; Crea, A; Maggi, CA; Manzini, S; Parlani, M; Rivoltini, L1
de Lange, J; Jager, MJ; Jochemsen, AG; Lodder, K; Ly, LV; Teunisse, AF; Verlaan-de Vries, M1
Ju, RJ; Li, N; Li, RJ; Lu, WL; Wang, XX; Wang, ZH; Yao, HJ; Yu, Y; Zhang, L; Zhang, Y; Zhou, J1
Binda, M; Citti, L; Daidone, MG; De Cesare, M; Folini, M; Pennati, M; Pratesi, G; Zaffaroni, N; Zunino, F1
Kraut, E; Muller, MT; Staubus, A; Subramanian, D; Young, DC1
Caserini, C; Orlandi, L; Silvestrini, R; Supino, R; Vaglini, M; Zaffaroni, N; Zunino, F1
Boothman, DA; Kinsella, TJ; Lamond, JP; Wang, M1
Balcerzak, SP; Gochnour, D; Kraut, EH; Staubus, A; Walker, MJ1
Conlon, KC; Curti, BD; Gause, BL; Janik, JE; Korn, EL; Longo, DL; Miller, LL; Sharfman, W; Smith, JW; Stevens, D; Sznol, M; Urba, WJ1
Agelaki, S; Androulakis, N; Georgoulias, V; Kakolyris, S; Kalbakis, K; Kouroussis, C; Mavroudis, D; Souglakos, J; Vamvakas, L; Vardakis, N1
Slichenmyer, WJ; Von Hoff, DD1

Reviews

1 review(s) available for topotecan and Melanoma

ArticleYear
New natural products in cancer chemotherapy.
    Journal of clinical pharmacology, 1990, Volume: 30, Issue:9

    Topics: Adenocarcinoma; Alkaloids; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Drugs, Investigational; Harringtonines; Homoharringtonine; Humans; Infusions, Intravenous; Irinotecan; Melanoma; Paclitaxel; Phytotherapy; Plant Extracts; Plants, Medicinal; Topotecan

1990

Trials

4 trial(s) available for topotecan and Melanoma

ArticleYear
Analysis of topoisomerase I/DNA complexes in patients administered topotecan.
    Cancer research, 1995, May-15, Volume: 55, Issue:10

    Topics: Antineoplastic Agents; Camptothecin; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; HeLa Cells; Humans; Lymphoma, Non-Hodgkin; Melanoma; Topotecan

1995
Phase II trial of topotecan in malignant melanoma.
    Cancer investigation, 1997, Volume: 15, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Camptothecin; Enzyme Inhibitors; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Topotecan

1997
A prospective randomized phase II trial of GM-CSF priming to prevent topotecan-induced neutropenia in chemotherapy-naive patients with malignant melanoma or renal cell carcinoma.
    Blood, 2001, Apr-01, Volume: 97, Issue:7

    Topics: Anemia; Antineoplastic Agents; Carcinoma, Renal Cell; Diabetes Mellitus, Type 1; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hypotension; Kidney Neoplasms; Melanoma; Neutropenia; Premedication; Prospective Studies; Remission Induction; Severity of Illness Index; Skin Neoplasms; Stroke; Thrombocytopenia; Topotecan; Treatment Outcome

2001
A phase I clinical trial of topotecan given every 2 weeks in patients with refractory solid tumors.
    Oncology, 2001, Volume: 61, Issue:4

    Topics: Adult; Aged; Anemia; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Melanoma; Middle Aged; Neoplasms; Neutropenia; Ovarian Neoplasms; Thrombocytopenia; Topotecan; Uterine Cervical Neoplasms

2001

Other Studies

7 other study(ies) available for topotecan and Melanoma

ArticleYear
The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy.
    Journal of the National Cancer Institute, 2018, 07-01, Volume: 110, Issue:7

    Topics: Animals; Cell Line, Tumor; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Humans; Immunotherapy, Adoptive; Irinotecan; Lymphocytes, Tumor-Infiltrating; Melanoma; Mice; Mice, Inbred C57BL; T-Lymphocytes, Cytotoxic; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Tumor Microenvironment; Xenograft Model Antitumor Assays

2018
Antitumor activity of delimotecan against human metastatic melanoma: pharmacokinetics and molecular determinants.
    International journal of cancer, 2009, Nov-15, Volume: 125, Issue:10

    Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dextrans; Female; Humans; Leukemia, Myeloid; Macrophages; Melanoma; Mice; Mice, Nude; Ovarian Neoplasms; Tissue Distribution; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2009
Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma.
    Oncogene, 2012, Mar-01, Volume: 31, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Drug Synergism; Furans; Humans; Hypoxia; Imidazoles; Melanoma; Melanoma, Experimental; Mice; Phosphorylation; Piperazines; Protein Serine-Threonine Kinases; Topotecan; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Uveal Neoplasms

2012
Mitochondrial targeting topotecan-loaded liposomes for treating drug-resistant breast cancer and inhibiting invasive metastases of melanoma.
    Biomaterials, 2012, Volume: 33, Issue:6

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Liposomes; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Skin Neoplasms; Topotecan

2012
Ribozyme-mediated down-regulation of survivin expression sensitizes human melanoma cells to topotecan in vitro and in vivo.
    Carcinogenesis, 2004, Volume: 25, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 9; Caspases; Down-Regulation; Humans; In Vitro Techniques; Inhibitor of Apoptosis Proteins; Melanoma; Mice; Microtubule-Associated Proteins; Neoplasm Proteins; RNA, Catalytic; Survivin; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous

2004
Modulation of melphalan cytotoxic activity in human melanoma cell lines.
    Anti-cancer drugs, 1996, Volume: 7, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Blotting, Northern; Camptothecin; Drug Interactions; Enzyme Inhibitors; Ethacrynic Acid; Humans; Melanoma; Melphalan; Temperature; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

1996
Concentration and timing dependence of lethality enhancement between topotecan, a topoisomerase I inhibitor, and ionizing radiation.
    International journal of radiation oncology, biology, physics, 1996, Sep-01, Volume: 36, Issue:2

    Topics: Antineoplastic Agents; Camptothecin; Cell Survival; Combined Modality Therapy; Fibroblasts; Humans; Melanoma; Neoplasms; Radiation Dosage; Radiation Tolerance; Time Factors; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

1996