topotecan has been researched along with Medulloblastoma in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Erdreich-Epstein, A; Finlay, JL; Hawes, D; Hoang, TQ; Mahdi, MY; Meng, EF; Moats, RA; Shackleford, GM; Tran, HC | 1 |
| Finlay, JL; Gardner, S; Liebes, LF; Tran, HC; Weiner, HL | 1 |
| Kamimura, S; Moritake, H; Nunoi, H; Takeshima, H; Yamada, A; Yamashita, S | 1 |
| Cheepala, S; Fatima, S; Fukuda, Y; Jackson, S; Kawauchi, D; Morfouace, M; Patel, YT; Roussel, MF; Schuetz, JD; Shelat, AA; Sorrentino, BP; Stewart, CF | 1 |
| Ashley, D; Chintagumpala, M; Fouladi, M; Gajjar, A; Houghton, PJ; Iacono, LC; Kellie, SJ; Kirstein, MN; Seele, LG; Stewart, CF; Wallace, D; Zamboni, WC | 1 |
| Díaz, MA; González-Vicent, M; Lassaletta, A; Madero, L; Pérez-Martínez, A; Sevilla, J | 1 |
| Delis, DC; Gajjar, A; Mulhern, RK; Nagel, BJ; Palmer, SL; Reeves, C | 1 |
| Freeman, BB; Gajjar, A; Iacono, LC; Panetta, JC; Stewart, CF | 1 |
| Clayton, J; Grundy, R; Jaspan, T; MacArthur, D; Vloeberghs, M; Walker, D | 1 |
| Beijnen, JH; Gajjar, AJ; Heideman, RL; Houghton, PJ; Rosing, H; Stewart, CF; Zamboni, WC | 1 |
| Cheshire, PJ; Danks, MK; Houghton, PJ; Pawlik, CA; Richmond, LB; Stewart, CF | 1 |
| Danks, MK; Einhaus, SL; Gajjar, AJ; Heideman, RL; Houghton, PJ; Mandrell, TD; Rogers, WP; Stewart, CF; Zamboni, WC | 1 |
| Danks, MK; Pawlik, CA; Whipple, DO; Wolverton, JS | 1 |
| Cheshire, PJ; de Graaf, SS; George, EO; Houghton, PJ; Ma, M; Poquette, CA; Richmond, LB; Stewart, CF; Thompson, J | 1 |
| Ashley, D; Benaim, E; Bowman, L; Gajjar, A; Heideman, R; Jones-Wallace, D; Kellie, SJ; Krance, R; Patel, A; Strother, D; Thompson, S | 1 |
| Bowman, LC; Cunningham, JM; Gajjar, AJ; Houghton, PJ; Houston, JA; Hunt, D; Richardson, SL; Stewart, CF; Yee, GC; Yeoh, EJ | 1 |
4 trial(s) available for topotecan and Medulloblastoma
| Article | Year |
|---|---|
Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor.
Topics: Adolescent; Adult; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; Medulloblastoma; Neuroectodermal Tumors, Primitive; Risk Factors; Topotecan; Treatment Outcome | 2004 |
High-dose chemotherapy with autologous stem cell rescue for children with high risk and recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cerebellar Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Male; Medulloblastoma; Melphalan; Neoplasm Recurrence, Local; Neuroectodermal Tumors, Primitive; Peripheral Blood Stem Cell Transplantation; Radiotherapy, Adjuvant; Supratentorial Neoplasms; Thiotepa; Topotecan; Transplantation, Autologous; Treatment Outcome | 2005 |
Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Area Under Curve; Cerebellar Neoplasms; Child; Child, Preschool; Female; Humans; Male; Medulloblastoma; Models, Biological; Topotecan | 2006 |
Topotecan-filgrastim combination is an effective regimen for mobilizing peripheral blood stem cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Costs and Cost Analysis; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Male; Medulloblastoma; Neuroectodermal Tumors, Primitive; Radiotherapy, Adjuvant; Recombinant Proteins; Retrospective Studies; Therapeutic Equivalency; Topotecan | 2001 |
12 other study(ies) available for topotecan and Medulloblastoma
| Article | Year |
|---|---|
Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma.
Topics: Animals; Cell Line, Tumor; Female; Humans; Infusions, Intraventricular; Injections, Intraventricular; Medulloblastoma; Meningeal Neoplasms; Meninges; Mice; Mice, Transgenic; Survival Analysis; Time Factors; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Xenograft Model Antitumor Assays | 2019 |
Pilot study assessing a seven-day continuous intrathecal topotecan infusion for recurrent or progressive leptomeningeal metastatic cancer.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Cerebellar Neoplasms; Ependymoma; Humans; Injections, Spinal; Male; Medulloblastoma; Meningeal Neoplasms; Neoplasm Recurrence, Local; Pilot Projects; Topotecan; Treatment Outcome; Young Adult | 2014 |
Proposed strategy for the use of high-dose chemotherapy with stem cell rescue and intrathecal topotecan without whole-brain irradiation for infantile classic medulloblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Female; Humans; Infant; Injections, Spinal; Medulloblastoma; Melphalan; Neoplasm Recurrence, Local; Prognosis; Stem Cell Transplantation; Topotecan; Transplantation, Autologous | 2014 |
ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport, Active; Cell Division; Cell Line, Tumor; Cell Membrane; Cerebellar Neoplasms; Drug Resistance, Neoplasm; High-Throughput Screening Assays; Humans; Medulloblastoma; Mice; Mice, Knockout; Neoplasm Proteins; Propionates; Protoporphyrins; Quinolines; Topoisomerase I Inhibitors; Topotecan | 2015 |
Early patterns of verbal memory impairment in children treated for medulloblastoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Radiation; Female; Hippocampus; Humans; Infant; Intelligence; Male; Medulloblastoma; Mental Recall; Neoadjuvant Therapy; Neuropsychological Tests; Radiation Injuries; Reference Values; Topotecan; Verbal Learning; Vocabulary; Wechsler Scales | 2006 |
Intrathecal chemotherapy delivered by a lumbar-thecal catheter in metastatic medulloblastoma: a case illustration.
Topics: Antineoplastic Agents; Arachnoid; Catheterization; Cerebellar Neoplasms; Cerebral Ventricle Neoplasms; Child; Female; Humans; Injections, Spinal; Lumbosacral Region; Magnetic Resonance Imaging; Medulloblastoma; Neoplasm Invasiveness; Pia Mater; Radiography, Thoracic; Topotecan | 2008 |
Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma.
Topics: Anticonvulsants; Antineoplastic Agents; Cerebellar Neoplasms; Child, Preschool; Drug Interactions; Humans; Lactones; Male; Medulloblastoma; Metabolic Clearance Rate; Models, Biological; Phenytoin; Topotecan | 1998 |
Effective schedules of exposure of medulloblastoma and rhabdomyosarcoma xenografts to topotecan correlate with in vitro assays.
Topics: Animals; Antineoplastic Agents; Cell Division; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Administration Schedule; Drug Screening Assays, Antitumor; Humans; Medulloblastoma; Mice; Rhabdomyosarcoma; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
A four-hour topotecan infusion achieves cytotoxic exposure throughout the neuraxis in the nonhuman primate model: implications for treatment of children with metastatic medulloblastoma.
Topics: Animals; Antineoplastic Agents; Cerebral Ventricles; Child; Humans; Infusions, Intravenous; Lumbosacral Region; Macaca mulatta; Male; Medulloblastoma; Topotecan; Tumor Cells, Cultured | 1998 |
Intermittent exposure of medulloblastoma cells to topotecan produces growth inhibition equivalent to continuous exposure.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Division; Child; Culture Media; DNA, Neoplasm; Drug Administration Schedule; Drug Stability; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Humans; Image Processing, Computer-Assisted; Medulloblastoma; Mice; Microscopy, Fluorescence; Neoplasm Proteins; Neoplasm Transplantation; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured | 1997 |
Synergy of topotecan in combination with vincristine for treatment of pediatric solid tumor xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Child; Drug Resistance, Neoplasm; Female; Humans; Medulloblastoma; Mice; Mice, Inbred CBA; Neuroblastoma; Rhabdomyosarcoma; Thymectomy; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured; Vincristine; Whole-Body Irradiation | 1999 |
Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Brain Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Feasibility Studies; Female; Humans; Male; Medulloblastoma; Neuroectodermal Tumors, Primitive; Stem Cells; Topotecan; Vincristine | 2001 |