Page last updated: 2024-08-24

topotecan and Experimental Neoplasms

topotecan has been researched along with Experimental Neoplasms in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (14.29)	18.2507
2000's	11 (39.29)	29.6817
2010's	12 (42.86)	24.3611
2020's	1 (3.57)	2.80

Authors

Authors	Studies
LaVoie, EJ; Li, TK; Liu, A; Liu, LF; Ray, A; Ruchelman, AL; Singh, SK; Wu, X; Yang, JM	1
Chen, G; Han, S; Jiang, X; Li, H; Li, Y; Lu, X; Ping, G; Wang, L; Wang, S; Wu, C; Yang, J	1
Chen, YL; Chen, YR; Chiu, CC; Chou, CK; Liu, W; Tseng, CH; Tzeng, CC	1
Chepanova, AA; Kaledin, VI; Lavrik, OI; Leung, E; Leung, IKH; Luzina, OA; Nikolin, VP; Patel, J; Popova, NA; Reynisson, J; Salakhutdinov, NF; Sokolov, DN; Volcho, KP; Zafar, A; Zakharenko, AL; Zakharova, OD	1
Deng, J; Lei, F; Li, J; Liang, Z; Shi, T; Wang, Y; Wang, Z; Yang, X; Zhang, H	1
Adams, DJ; Balmus, G; Barros, AC; Beli, P; Bradley, A; Chen, E; Coates, J; Demir, M; Durant, ST; Forment, JV; Fu, B; Galanty, Y; Herzog, M; Jackson, SP; Martinez, FM; Metzakopian, E; Ostermaier, M; Pilger, D; Ponstingl, H; Sczaniecka-Clift, M; Stankovic, T; Woods, M; Yang, F; Yusa, K	1
Banerjee, R; Prasad, C	1
Bloomfield, A; Dorton, R; Guan, J; Leamon, CP; Nelson, M; Reddy, JA; Vetzel, M	1
Chen, LK; Chen, WQ; Chen, ZS; Fu, LW; Huang, ZC; Talele, TT; Tang, SJ; To, KK; Wang, F; Wang, XK; Zhang, YK	1
Fu, LW; Huang, LY; Huang, ZC; To, KK; Wang, F; Wang, XK; Xu, JH; Yang, K; Ye, S	1
Benz, CC; Connolly-Ingram, C; Drummond, DC; Gabriel, BS; Guo, Z; Hann, B; Hayes, ME; Hong, K; Kirpotin, DB; Liu, B; Marks, JD; Noble, CO; Park, JW	1
Armeanu-Ebinger, S; Bonin, M; Fuchs, J; Poths, S; Ruck, P; Seitz, G; Warmann, SW	1
Anders Kolb, E; Billups, CA; Carol, H; Gorlick, R; Houghton, PJ; Kang, MH; Keir, ST; Lock, R; Madden, SL; Maris, JM; Morton, CL; Reynolds, CP; Smith, MA; Teicher, BA; Zhang, MX	1
Ingebrandt, S; Koppenhöfer, D; Susloparova, A; Vu, XT; Weil, M	1
Carenini, N; Carminati, P; Cucco, C; De Cesare, M; Merlini, L; Penco, S; Perego, P; Pisano, C; Pratesi, G; Righetti, SC; Vesci, L; Zunino, F	1
Inciūra, A; Juozaityte, E	1
Blazar, BR; Krieg, AM; Rodeberg, DA; Weigel, BJ	1
Chen, Y; Deng, YJ; Hao, AJ; Hao, YL; Wang, KZ; Zhang, Y	1
Belfiore, P; Croce, AC; Dal Bo, L; Farina, C; Misiano, P; Petrangolini, G; Pratesi, G; Supino, R; Tortoreto, M; Zunino, F	1
Kondo, S; Kondo, Y	1
Cheshire, PJ; Danks, MK; Friedman, HS; Hallman, JD; Houghton, JA; Houghton, PJ; Lutz, L	1
Johnson, RK; McCabe, FL	1
Danks, MK; Houghton, JA; Houghton, PJ; Luo, X; Stewart, CF; Thompson, J; Zamboni, WC	1
Bianco, AR; Bianco, R; Ciardiello, F; Damiano, V; De Lorenzo, S; De Placido, S; Fan, Z; Mendelsohn, J; Pepe, S; Tortora, G	1
Bianco, AR; Bianco, R; Caputo, R; Ciardiello, F; Damiano, V; De Placido, S; Pomatico, G; Tortora, G	1
Harada, M; Murata, J; Okuno, S; Sakakibara, H; Sakamura, Y; Suzuki, T	1
Fuchs, J; Gratz, KF; Mildenberger, H; von Schweinitz, D; Warmann, SW; Wilkens, L	1
Huang, J; Kandel, JJ; Kim, ES; Manley, CA; McCrudden, KW; Middlesworth, W; Soffer, SZ; Yamashiro, DJ; Yokoi, A	1

Other Studies

28 other study(ies) available for topotecan and Experimental Neoplasms

Article	Year
Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435. Bioorganic & medicinal chemistry letters, 2002, Nov-18, Volume: 12, Issue:22 Topics: Animals; Antineoplastic Agents; Aza Compounds; Cell Division; Chrysenes; DNA; Enzyme Inhibitors; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Topoisomerase I Inhibitors; Transplantation, Heterologous; Treatment Outcome; Tumor Cells, Cultured	2002
Novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitor: synthesis, anti-invasive and anti-angiogenic properties. European journal of medicinal chemistry, 2015, Jan-07, Volume: 89 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Movement; Cell Proliferation; Chalcone; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Tumor Cells, Cultured	2015
Discovery of indeno[1,2-b]quinoxaline derivatives as potential anticancer agents. European journal of medicinal chemistry, 2016, Jan-27, Volume: 108 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Indenes; Molecular Structure; Neoplasms, Experimental; Quinoxalines; Structure-Activity Relationship; Zebrafish	2016
Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models. European journal of medicinal chemistry, 2019, Jan-01, Volume: 161 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Phosphoric Diester Hydrolases; Quantum Theory; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topotecan	2019
Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer. European journal of medicinal chemistry, 2022, Jan-15, Volume: 228 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Quinazolines; Stomach Neoplasms; Structure-Activity Relationship	2022
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. Nature communications, 2019, 01-08, Volume: 10, Issue:1 Topics: Animals; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Cell Line, Tumor; Cell Survival; CRISPR-Cas Systems; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Ligase ATP; DNA Replication; Drug Resistance, Neoplasm; Female; Humans; Mice; Mice, Inbred NOD; Mice, Knockout; Mouse Embryonic Stem Cells; Mutation; Neoplasms, Experimental; Phthalazines; Piperazines; Topotecan	2019
Ultrasound-Triggered Spatiotemporal Delivery of Topotecan and Curcumin as Combination Therapy for Cancer. The Journal of pharmacology and experimental therapeutics, 2019, Volume: 370, Issue:3 Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Curcumin; Drug Delivery Systems; Female; Humans; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanostructures; Neoplasms, Experimental; Topotecan; Ultrasonics	2019
Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Apr-15, Volume: 20, Issue:8 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboplatin; Cell Line, Tumor; Cell Proliferation; Cisplatin; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Folic Acid; HeLa Cells; Humans; Irinotecan; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Neoplasms; Neoplasms, Experimental; Paclitaxel; Taxoids; Topotecan; Treatment Outcome; Vinca Alkaloids; Xenograft Model Antitumor Assays	2014
CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function. Biochemical pharmacology, 2014, Sep-15, Volume: 91, Issue:2 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Heterografts; Humans; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Pyridines; Real-Time Polymerase Chain Reaction; Rhodamine 123; Topotecan; Triazoles	2014
Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo. Oncotarget, 2014, Dec-15, Volume: 5, Issue:23 Topics: Afatinib; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flow Cytometry; Humans; Immunohistochemistry; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Neoplasms, Experimental; Quinazolines; Real-Time Polymerase Chain Reaction; Topotecan; Xenograft Model Antitumor Assays	2014
Development of a highly stable and targetable nanoliposomal formulation of topotecan. Journal of controlled release : official journal of the Controlled Release Society, 2010, Jan-04, Volume: 141, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Stability; ErbB Receptors; Female; Humans; Liposomes; Mice; Mice, Nude; Molecular Structure; Nanostructures; Neoplasms, Experimental; Receptor, ErbB-2; Time Factors; Topotecan; Xenograft Model Antitumor Assays	2010
Inhibition of glutathione-S-transferase as a treatment strategy for multidrug resistance in childhood rhabdomyosarcoma. International journal of oncology, 2010, Volume: 36, Issue:2 Topics: Animals; Antineoplastic Agents; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression; Gene Expression Profiling; Glutathione Transferase; Humans; Mice; Mice, Nude; Neoplasms, Experimental; Oligonucleotide Array Sequence Analysis; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Topotecan; Vincristine; Xenograft Model Antitumor Assays	2010
Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatric blood & cancer, 2012, Volume: 58, Issue:2 Topics: Animals; Cell Proliferation; Child; Disease-Free Survival; DNA Topoisomerases, Type I; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Naphthyridines; Neoplasms, Experimental; Survival Rate; Topoisomerase I Inhibitors; Topotecan; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2012
Impedance spectroscopy with field-effect transistor arrays for the analysis of anti-cancer drug action on individual cells. Biosensors & bioelectronics, 2013, Feb-15, Volume: 40, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Biosensing Techniques; Cell Line, Tumor; Cell Separation; Cell Survival; Dielectric Spectroscopy; Drug Evaluation, Preclinical; Equipment Design; Equipment Failure Analysis; Flow Cytometry; Humans; Neoplasms, Experimental; Reproducibility of Results; Sensitivity and Specificity; Topotecan; Transistors, Electronic; Treatment Outcome	2013
Pattern of antitumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:12 Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Mice; Mice, Nude; Neoplasms, Experimental; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2002
[Preclinical studies of concomitant chemoradiation]. Medicina (Kaunas, Lithuania), 2003, Volume: 39, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Child; Combined Modality Therapy; Deoxycytidine; Female; Gemcitabine; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Paclitaxel; Radiation Tolerance; Time Factors; Topotecan; Transplantation, Heterologous	2003
CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Aug-01, Volume: 9, Issue:8 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; CpG Islands; Cyclophosphamide; Disease Models, Animal; Drug Synergism; Female; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Oligonucleotides; Rhabdomyosarcoma, Embryonal; T-Lymphocytes; Time Factors; Topotecan	2003
In-vitro cytotoxicity, in-vivo biodistribution and anti-tumour effect of PEGylated liposomal topotecan. The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:10 Topics: Animals; Antineoplastic Agents; Area Under Curve; Biological Availability; Bone Marrow; Cell Line, Tumor; Cell Survival; Drug Compounding; Drug Stability; Female; Humans; Inhibitory Concentration 50; Liposomes; Liver; Lung; Male; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Polyethylene Glycols; Spleen; Tissue Distribution; Topotecan; Xenograft Model Antitumor Assays	2005
Effect of a novel vacuolar-H+-ATPase inhibitor on cell and tumor response to camptothecins. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Camptothecin; Enzyme Inhibitors; Female; HT29 Cells; Humans; Indoles; Irinotecan; Mice; Neoplasm Proteins; Neoplasms, Experimental; Staining and Labeling; Topotecan; Vacuolar Proton-Translocating ATPases	2006
American Association for Cancer Research--97th annual meeting. IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:6 Topics: Adenine; Animals; Antineoplastic Agents; Benzoquinones; Glioblastoma; HSP90 Heat-Shock Proteins; Humans; Indoles; Janus Kinase 2; Lactams, Macrocyclic; Neoplasms, Experimental; Organophosphonates; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Topotecan; Tyrphostins	2006
Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:5 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Mice; Mice, Inbred CBA; Neoplasms, Experimental; Random Allocation; Rhabdomyosarcoma; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured	1995
Comparative activity of oral and parenteral topotecan in murine tumor models: efficacy of oral topotecan. Cancer investigation, 1994, Volume: 12, Issue:3 Topics: Administration, Oral; Animals; Camptothecin; Female; Infusions, Parenteral; Mice; Neoplasms, Experimental; Topotecan	1994
Schedule-dependent efficacy of camptothecins in models of human cancer. Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Irinotecan; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured	1996
Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:4 Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; ErbB Receptors; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Topotecan; Tumor Cells, Cultured; Tumor Stem Cell Assay	1999
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Carboplatin; Cell Division; Cisplatin; Docetaxel; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Survival Rate; Taxoids; Thiophenes; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured	2000
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats. Journal of controlled release : official journal of the Controlled Release Society, 2001, Mar-12, Volume: 71, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Carbohydrate Sequence; Cell Line; Chromatography; Dextrans; Female; Half-Life; Macrophages; Molecular Sequence Data; Neoplasms, Experimental; Prodrugs; Rats; Rats, Wistar; Tissue Distribution; Topotecan	2001
Successful therapy of subcutaneously growing human hepatoblastoma xenografts with topotecan. Medical and pediatric oncology, 2001, Volume: 37, Issue:5 Topics: alpha-Fetoproteins; Animals; Antineoplastic Agents; Cell Division; Hepatoblastoma; Humans; Immunohistochemistry; Infant, Newborn; Infusions, Parenteral; Liver Neoplasms; Mice; Mice, Nude; Necrosis; Neoplasms, Experimental; Topotecan; Transplantation, Heterologous	2001
Distinct response of experimental neuroblastoma to combination antiangiogenic strategies. Journal of pediatric surgery, 2002, Volume: 37, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Endothelial Growth Factors; Enzyme Inhibitors; Female; Lymphokines; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Neuroblastoma; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2002