topotecan has been researched along with Colorectal Cancer in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (50.00) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, C; Jin, W; Li, M; Lou, L; Tang, W; You, T; Zheng, C | 1 |
| Ali, T; Ali, Z; Baseer, A; Batool, S; Din, F; Malik, M; Mukhtiar, M; Mustapha, O; Rehman, M; Shafique, S; Shah, F; Sohail, S; Xing, R; Yousaf, A; Zahid, F; Zaidi, SS; Zeb, A | 1 |
| Barrett, AM; Chen, A; Doroshow, JH; Dull, AB; Hollingshead, MG; Kinders, RJ; Kummar, S; Lawrence, SM; Parchment, RE; Wilsker, DF | 1 |
| Januchowski, R; Nowicki, M; Wojtowicz, K; Zabel, M | 1 |
| Fakhoury, R; Hodroj, MH; Khalife, R; Rizk, S | 1 |
| Fu, Y; Li, Q; Liu, C; Meng, X; Yao, L; Zhao, X; Zu, B; Zu, Y | 1 |
| Deckert, PM; Hütter, G; Keilholz, U; Szélenyi, H; Thiel, E | 1 |
| Bucior, J; Kempiński, M; Knopik, J; Sosada, K; Tomczyk, A; Ziółko, E | 1 |
| Brown, JM; Cao, H; Choi, CY; Faix, JD; Giaccia, AJ; Koong, AC; Le, QT; Nelson, DW; Sunar-Reeder, B; Zhu, Y | 1 |
| Batey, MA; Calabrese, CR; Canan, S; Curtin, NJ; Hostomsky, Z; Kyle, S; Maegley, KA; Newell, DR; Skalitzky, D; Thomas, HD; Wang, LZ; Webber, SE | 1 |
| Fields, SZ; Hargis, JB; Lilenbaum, RC; Miller, AA; Rosner, GL; Schilsky, RL | 1 |
| Creemers, GJ; Dirix, LY; Gamucci, T; Hudson, I; Schöffski, P; Vallentin, S; Verweij, J; Wanders, J | 1 |
| Beijnen, JH; Creemers, GJ; Davies, BE; de Boer-Dennert, M; Maes, RA; Rodenhuis, S; Rosing, H; Schellens, JH; ten Bokkel Huinink, WW; van Warmerdam, LJ; Verweij, J | 1 |
| Creemers, GJ; de Boer-Dennert, M; Gerrits, CJ; Harteveld, M; Hudson, I; Loos, W; Planting, AS; Schellens, JH; Stoter, G; van Beurden, VM; van der Burg, ME; Verweij, J | 1 |
| Anderson, S; Beidler, D; Belliveau, D; Burtness, BA; Cheng, YC; Fedele, J; Flynn, SD; Murren, JR; Pizzorno, G; Tocino, I; Zelterman, D | 1 |
| Creemers, GJ | 1 |
| Astoul, C; Ollitrault, N; Salvat, D | 1 |
| Alberts, DS; Benedetti, JK; Macdonald, JS; Modiano, M | 1 |
| Baker, SD; Burks, K; Donehower, RC; Grochow, LB; O'Reilly, S; Rowinsky, EK | 1 |
| Punt, CJ | 1 |
| Burris, H; Fields, S; Gerrits, CJ; Hudson, I; Loos, WJ; Planting, AS; Rodriguez, GI; Schellens, JH; van Beurden, V; van den Burg, ME; Verweij, J; von Hoff, DD | 1 |
| Blanke, CD; Rothenberg, ML | 1 |
| Boisdron-Celle, M; Boulanger, N; Gamelin, E | 1 |
| Brodziak, A; Bucior, J; Danikiewicz, A; Foltyn, W; Jastrzebska-Okoń, K; Knopik, J; Nowakowska-Zajdel, E; Ziółko, E | 1 |
| Bianco, AR; Catalano, G; Ciardiello, F; Damiano, V; De Laurentiis, M; De Placido, S; Matano, E; Pensabene, M; Pepe, S; Tortora, G | 1 |
| Abbruzzese, JL; Anzai, H; Frost, P | 1 |
4 review(s) available for topotecan and Colorectal Cancer
| Article | Year |
|---|---|
Topotecan in advanced colorectal cancer.
Topics: Animals; Antineoplastic Agents; Camptothecin; Clinical Trials as Topic; Colorectal Neoplasms; Humans; Neoplasm Metastasis; Neoplasm Staging; Topoisomerase I Inhibitors; Topotecan | 1997 |
New drugs in the treatment of colorectal carcinoma.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Topotecan; Trimetrexate; Uracil | 1998 |
Topoisomerase I inhibitors in the treatment of colorectal cancer.
Topics: Animals; Antineoplastic Agents; Camptothecin; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Humans; Irinotecan; Topoisomerase I Inhibitors; Topotecan | 1999 |
[Pharmacokinetic monitoring].
Topics: Antineoplastic Agents; Body Mass Index; Camptothecin; Colorectal Neoplasms; Drug Interactions; Drug Monitoring; Etoposide; Fluorouracil; Humans; Irinotecan; Liver; Paclitaxel; Topotecan | 2000 |
11 trial(s) available for topotecan and Colorectal Cancer
| Article | Year |
|---|---|
Phase I/II trial of topotecan given as continuous infusion in combination with oxaliplatin in 5-FU-pretreated patients with colorectal cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Drug Resistance; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Topotecan | 2004 |
[Effect of palliative chemotherapy with topoisomerase inhibitor on the quality of life and survival of patients with advanced colorectal carcinoma].
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Palliative Care; Quality of Life; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome | 2004 |
Phase I study of topotecan and cisplatin in patients with advanced solid tumors: a cancer and leukemia group B study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Neoplasms, Unknown Primary; Neutropenia; Recombinant Proteins; Salivary Gland Neoplasms; Stomach Neoplasms; Topotecan | 1994 |
Topotecan in colorectal cancer: a phase II study of the EORTC early clinical trials group.
Topics: Adult; Aged; Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Topotecan | 1995 |
Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedure.
Topics: Aged; Agranulocytosis; Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Feasibility Studies; Female; Humans; Infusion Pumps; Infusions, Intravenous; Male; Middle Aged; Ovarian Neoplasms; Thrombocytopenia; Topoisomerase I Inhibitors; Topotecan | 1996 |
Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Female; Humans; Infusion Pumps; Male; Middle Aged; Topotecan | 1996 |
Phase II evaluation of topotecan in patients with advanced colorectal cancer. A Southwest Oncology Group trial (SWOG 9241).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Disease Progression; Female; Humans; Injections, Intravenous; Male; Middle Aged; Survival Analysis; Topotecan | 1997 |
High-dose topotecan with granulocyte-colony stimulating factor in fluoropyrimidine-refractory colorectal cancer: a phase II and pharmacodynamic study.
Topics: Adult; Aged; Colorectal Neoplasms; Drug Administration Schedule; Female; Granulocyte Colony-Stimulating Factor; Humans; Leukocyte Count; Male; Middle Aged; Neutrophils; Pyrimidines; Topotecan; Treatment Failure | 1998 |
Five days of oral topotecan (Hycamtin), a phase I and pharmacological study in adult patients with solid tumours.
Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colorectal Neoplasms; Fatigue; Female; Hematologic Diseases; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Ovarian Neoplasms; Topotecan; Treatment Outcome | 1998 |
[Evaluation of quality of life in patients with advanced colorectal cancer treated with topotecan].
Topics: Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Humans; Injections, Intravenous; Male; Middle Aged; Quality of Life; Topoisomerase I Inhibitors; Topotecan | 2001 |
Preclinical and phase I study of oxaliplatin and topotecan in combination in human cancer.
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Middle Aged; Organoplatinum Compounds; Ovarian Neoplasms; Oxaliplatin; Topotecan; Tumor Cells, Cultured | 2002 |
11 other study(ies) available for topotecan and Colorectal Cancer
| Article | Year |
|---|---|
7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Colorectal Neoplasms; Drug Design; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Hydrolysis; Inhibitory Concentration 50; Irinotecan; Models, Chemical; Rhodamines; Structure-Activity Relationship; Topotecan | 2009 |
Development, Characterization, and Evaluation of SLN-Loaded Thermoresponsive Hydrogel System of Topotecan as Biological Macromolecule for Colorectal Delivery.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Colorectal Neoplasms; Drug Delivery Systems; Female; Humans; Hydrogels; Lipids; Macromolecular Substances; Male; Mice, Nude; Mucous Membrane; Nanoparticles; Particle Size; Rats, Sprague-Dawley; Rectum; Temperature; Topotecan | 2021 |
Evaluation of Pharmacodynamic Responses to Cancer Therapeutic Agents Using DNA Damage Markers.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Cycle Proteins; Clofarabine; Colorectal Neoplasms; Deoxycytidine; DNA Damage; DNA Repair; Gemcitabine; HCT116 Cells; Histones; HT29 Cells; Humans; Mice; Mice, Nude; Nuclear Proteins; Rad51 Recombinase; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Colorectal Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Glycosylation; Humans; Ovarian Neoplasms; Paclitaxel; Phenotype; Topotecan; Tunicamycin | 2015 |
Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro.
Topics: Antineoplastic Agents; Apoptosis; Benzoquinones; Cell Proliferation; Colorectal Neoplasms; Drug Synergism; HT29 Cells; Humans; Nigella sativa; Seeds; Topoisomerase I Inhibitors; Topotecan | 2016 |
In vitro and in vivo evaluation of camptothecin nanosuspension: a novel formulation with high antitumor efficacy and low toxicity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Chromatography, Supercritical Fluid; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Compounding; Humans; Mice; Mice, Inbred BALB C; Nanotechnology; Solvents; Technology, Pharmaceutical; Topoisomerase I Inhibitors; Topotecan; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Chorionic Gonadotropin, beta Subunit, Human; Colorectal Neoplasms; DNA-Binding Proteins; Flavonoids; Genes, Reporter; Genetic Vectors; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred BALB C; Mice, Inbred SENCAR; Neoplasm Transplantation; Nuclear Proteins; Piperidines; Topotecan; Transcription Factors; Transfection; Transplantation, Heterologous | 2005 |
Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.
Topics: Animals; Antineoplastic Agents; Benzodiazepines; Cell Line, Tumor; Colorectal Neoplasms; Dacarbazine; DNA Repair; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Gamma Rays; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Maximum Tolerated Dose; Mice; Mice, Nude; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Structure-Activity Relationship; Temozolomide; Topoisomerase I Inhibitors; Topotecan | 2007 |
Dose-escalation and pharmacodynamic study of topotecan in combination with cyclophosphamide in patients with refractory cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Cyclophosphamide; DNA Fragmentation; DNA, Neoplasm; Drug Administration Schedule; Female; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Topotecan | 1997 |
[Derivatives of camptothecin. A new class of antineoplastic agents].
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Female; Humans; Irinotecan; Ovarian Neoplasms; Topotecan | 1997 |
Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azacitidine; Camptothecin; Colorectal Neoplasms; Decitabine; DNA Topoisomerases, Type I; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Female; Lethal Dose 50; Methylation; Mice; Mice, Inbred BALB C; Topotecan; Tumor Cells, Cultured | 1992 |