Page last updated: 2024-08-24

topotecan and Carcinoma, Non-Small Cell Lung

topotecan has been researched along with Carcinoma, Non-Small Cell Lung in 91 studies

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	23 (25.27)	18.2507
2000's	54 (59.34)	29.6817
2010's	12 (13.19)	24.3611
2020's	2 (2.20)	2.80

Authors

Authors	Studies
Carenini, N; Dallavalle, S; De Cesare, M; Ferrari, A; Merlini, L; Penco, S; Perego, P; Pratesi, G; Zunino, F	1
Beretta, GL; Dallavalle, S; Gattinoni, S; Mazzini, S; Merlini, L; Scaglioni, L; Tinelli, S; Zunino, F	1
Chen, TC; Chen, YL; Cheng, CM; Hsu, CY; Lu, YJ; Tseng, CH; Tso, HC; Tzeng, CC	1
Weber, JP; Wermke, M	1
Gao, J; Li, X; Liu, Z; Teng, Y; Yin, P; Yu, P	1
Alqahtani, S; Ashby, CR; Bates, SE; Chen, ZS; Deng, T; Gupta, P; Kaddoumi, A; Lei, YX; Wang, YJ; Wurpel, JND; Zhang, GN; Zhang, YK	1
Abonyi-Tóth, Z; Katona, L; Kovács, G; Moldvay, J; Rokszin, G	1
Beitinjaneh, A; Bliss, RL; Dudek, AZ; Kratzke, RA; Leach, J; Powell, SF; Tessema, M	1
Cao, B; Chen, XJ; Ge, XH; Li, ZG; Lin, Q; Liu, ML; Liu, YE; Ren, XC; Wang, DY; Wang, YQ	1
Gjerset, RA; Zhao, M	1
Bi, N; Chen, D; Feng, Q; Hui, Z; Ji, Z; Liang, J; Liu, L; Lyu, J; Wang, J; Wang, L; Wang, X; Xiao, Z; Yin, W; Zhang, H; Zhou, Z	1
Chen, L; Chen, Z; Fu, L; Li, F; Wang, F; Wang, X; Zhang, W	1
Barton, J; Burris, HA; Greco, FA; Infante, J; Jones, S; Patton, J; Shipley, D; Spigel, D; Thompson, D	1
Ross, HJ; Seung, SK	1
Fietkau, R; Grabenbauer, GG; Hedde, JP; Ko, Y; Kocher, M; Muller, RP; Neuhaus, T; Schueller, H; Stier, S	1
Choi, YJ; Jang, WS; Kim, CH; Lee, JC; Lee, SJ; Lee, SS; Rho, JK	1
Ji, W; Lü, JM; Ou, GF; Ren, H; Wang, LH; Wang, XZ; Yin, WB; Zhou, ZM	1
Berros, JP; Blay, P; Coto, PP; Estrada, E; Fernandez, Y; Fra, J; Gonzalez, EE; Izquierdo, M; Jimenez, P; Lacave, AJ; Luque, M; Muñiz, I; Muriel, C; Sanmamed, M; Vieitez, JM; Villanueva, N	1
Arase, H; Fukuoka, M; Ijima, T; Kudoh, S; Masuda, N; Matsui, K; Mukaiyama, A; Nakagawa, K; Negoro, S; Takada, M; Takeda, K; Yoshida, P	1
Carloni, F; Castellani, C; Drudi, F; Lazzari-Agli, L; Sartori, S; Scarpi, E; Tassinari, D; Tombesi, P	1
Belinsky, SA; Bernauer, AM; Dacic, S; Dahlberg, SE; Klinge, DM; Liu, Y; Schiller, JH; Siegfried, JM; Tessema, M; Thomas, CL; Yingling, CM	1
Barnes, BC; Brierre, JE; Buller, EJ; Cole, JL; Felicia Fontenot, M; Lormand, NA; Mills, G; Rainey, JM; Rinaldi, DA; Yadlapati, S	1
Ash-Bernal, R; Browner, I; Erlich, R	1
Biggs, DD; Grubbs, SS; Guarino, MJ; Himelstein, AL; Hogaboom, K; Schneider, CJ; Tilak, S	1
Asmar, L; Garfield, DH; Gregurich, MA; Joppert, MG; Khandelwal, P; Marsland, TA; Nemunaitis, JJ	1
Cantor, R; Dabrow, MB; Francesco, MR; Gilman, PB; Meyer, TJ; Rose, L	1
Dowlati, A; Levitan, N	1
Eckardt, J	1
Treat, J	1
Evans, SS; Harper, SM; Nagourney, RA; Radecki, S; Sommers, BL	1
Pan, XD; Wang, CY	1
Christodoulou, C; Deliyiannis, F; Malamos, NA; Rigatos, SK; Skarlos, DV; Stathopoulos, GP; Stathopoulos, JG	1
Casas, F; Jeremic, B	1
Stewart, DJ	2
Barachini, S; Basolo, F; Danesi, R; Del Tacca, M; Deri, M; Giovannetti, E; Mey, V	1
Fujiwara, K; Harita, S; Hotta, K; Kamei, H; Kiura, K; Okimoto, N; Shibayama, T; Sugimoto, K; Tabata, M; Takigawa, N; Tanimoto, M; Ueoka, H; Umemura, S	1
Brunetti, C; Cassano, G; Colucci, G; Galetta, D; Gebbia, V; Germano, D; Giampaglia, M; Guida, M; Izzi, G; Lorusso, V; Nettis, G; Silvestris, N; Spada, M	1
Fukuda, M; Kitazaki, T; Kohno, S; Nagashima, S; Nakamura, Y; Oka, M; Shiozawa, K; Soda, H; Takemura, M; Tsukamoto, K; Yabuuchi, H	1
Dimitroulis, J; Dimou, E; Karaindros, D; Katis, C; Stathopoulos, GP; Stathopoulos, J; Tsavdaridis, D	1
Davies, AM; Gandara, DR	1
Abratt, RP; Dane, G; Dharan, B; Gervais, R; Grotzinger, KM; Kaukel, E; Krzakowski, M; Ramlau, R; Ross, G; Shepherd, FA; von Pawel, J	1
Fournel, P	1
Chhatriwala, H; Jafri, N; Salgia, R	1
Ajlouni, M; Chapman, R; Kim, JH; Lu, M; Movsas, B; Patel, SH	1
Bo, LD; Bottiroli, G; Casalini, P; Croce, AC; Farina, C; Favini, E; Misiano, P; Petrangolini, G; Pratesi, G; Radaelli, E; Supino, R; Tortoreto, M; Zunino, F	1
Karatapanis, S; Marinopoulos, S; Rasidakis, A; Skorda, L	1
Fields, SZ; Hargis, JB; Lilenbaum, RC; Miller, AA; Rosner, GL; Schilsky, RL	1
Ardizzoni, A	1
Cheson, B; Christian, M; Feigal, EG; Friedman, MA; Grever, M	1
Grant, SC; Kris, MG; Miller, VA; Pisters, KM; Rigas, JR	1
Green, MR	1
Elias, A; Frei, E; Kalish, L; Lynch, TJ; Posner, M; Shulman, LN; Skarin, A; Strauss, G	1
Fossella, FV; Glisson, BS; Hong, WK; Huber, MH; Kane, J; Kemp, BL; Kurie, JM; Lee, JJ; Lee, JS; Lippman, SM; Murphy, WK; Perez-Soler, R; Raber, MN; Robinson, RA; Shin, DM	1
Emami, B; Graham, MV; Harms, W; Matthews, J; Purdy, JA	1
Cooper, JD; Dresler, CM; Emami, B; Graham, MV; Jahanzeb, M; Mortimer, JE	1
Heuser, A; Sauer, R	1
Furuse, K	1
Burris, HA; Eckardt, JR; Raymond, E; Rodriguez, G; Rowinsky, EK; Smith, L; Von Hoff, DD; Weiss, G	1
Hickish, T; Joel, S; Mainwaring, PN; Nicolson, MC; Penson, R; Slevin, M; Smith, IE	1
Perez-Soler, R	1
Bunn, PA; Kelly, K	1
Carney, DN	1
Grant, SC; Kindler, HL; Krebs, JB; Kris, MG; Miller, VA; Ross, GA; Slevin, ML; Smith, IE	1
Apicella, A; Cartení, G; Comella, G; Comella, P; Frasci, G; Gravina, A; Guida, T; Lapenta, L; Lombardi, R; Natale, M; Nicolella, GP; Pacilio, C; Panza, N	1
Ardizzoni, A; de Cupis, A; Favoni, RE; Grossi, F; Loprevite, M; Merlo, F; Pirani, P	1
Ferreira, CG; Giaccone, G; Peters, GJ; Pinedo, HM; Tolis, C	1
Chakravarthy, A; Choy, H; Johnson, D	1
Ferreira, CG; Giaccone, G; Kummer, AJ; Peters, GJ; Pinedo, HM; Span, SW; Tolis, C; van Lopik, T	1
Atassi, G; Guilbaud, N; Jan, M; Kraus-Berthier, L; Naze, M; Pierré, A	1
Bate, WW; Grill, JP; Hatfield, AK; Jett, JR; Knost, JA; Marschke, RF; Schaefer, PL; Sloan, JA; Weitz, JJ; Zenk, DW	1
Anderson, H; Carrington, B; Cheeseman, S; Hearn, S; Ranson, M; Ross, G; Thatcher, N; White, SC	1
Cesano, A; Fields, SZ; Lane, SR; Ross, GA	1
Ferreira, CG; Giaccone, G; Kruyt, FA; Peters, GJ; Span, SW	1
De Cesare, M; Pratesi, G; Zunino, F	1
Berger, NA; Berger, SJ; Dowlati, A; Gordon, NH; Gosky, DM; Hoppel, CL; Ingalls, ST; Levitan, N; Remick, SC	1
Dingemans, AC; Giaccone, G; Postmus, PE; Scagliotti, GV; Span, S; van Ark-Otte, J; van der Valk, P	1
Baguley, BC; Baker, M; Bootle, D; Charlton, PA; Dangerfield, W; Denny, WA; Kofler, B; Mistry, P; Okiji, S; Stewart, AJ	1
Barnes, B; Brierre, J; Buller, E; Cole, J; Fontenot, F; Lormand, N; Rainey, J; Rinaldi, D	1
Schiller, JH	2
Huang, CH; Treat, J	1
Eckardt, JR	1
Bakr, M; Bauer, J; Bodmer, A; Duvoisin, B; Ketterer, N; Leyvraz, S; Perey, L; Stupp, R	1
Fields, SZ; Hearn, S; Martoni, A; Pujol, JL; Ross, G; Tumolo, S; von Pawel, J	1
Agelaki, S; Androulakis, N; Georgoulias, V; Kakolyris, S; Kalbakis, K; Kouroussis, C; Mavroudis, D; Souglakos, J; Vamvakas, L; Vardakis, N	1
Boccieri, MG; Bruschi, G; Lo Re, G; Saracchini, S; Toffoli, G; Tumolo, S	1
Giaccone, G; Huisman, C; Postmus, PE; Smit, EF	1
Kato, Y; Saijo, N	1
Ettinger, DS; Forastiere, AA; Grochow, LB; Hendricks, CB; Hurowitz, LA; Kaufmann, SH; Lubejko, BG; McGuire, WP; Rowinsky, EK; Sartorius, SE	1
Ariyoshi, Y; Sugiura, T	1

Reviews

23 review(s) available for topotecan and Carcinoma, Non-Small Cell Lung

Article	Year
[Small cell lung cancer-Established standards and new approaches]. Innere Medizin (Heidelberg, Germany), 2022, Volume: 63, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Small Cell Lung Carcinoma; Topotecan	2022
Noninferiority trials in second-line treatments of nonsmall cell lung cancer: a systematic review of literature with meta-analysis of phase III randomized clinical trials. American journal of clinical oncology, 2012, Volume: 35, Issue:6 Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; Docetaxel; Gefitinib; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Quinazolines; Randomized Controlled Trials as Topic; Taxoids; Topotecan	2012
Single-agent chemotherapy for non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2003, Volume: 41 Suppl 4 Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Humans; Lung Neoplasms; Topotecan	2003
[Current status of camptothecin derivatives as natural antitumor agents]. Yao xue xue bao = Acta pharmaceutica Sinica, 2003, Volume: 38, Issue:9 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Structure-Activity Relationship; Topotecan; Tumor Cells, Cultured	2003
Update on the role of topotecan in the treatment of non-small cell lung cancer. The oncologist, 2004, Volume: 9 Suppl 6 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Topotecan	2004
A review of topoisomerase inhibition in lung cancer. Cancer biology & therapy, 2006, Volume: 5, Issue:12 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Lung Neoplasms; Topoisomerase Inhibitors; Topotecan	2006
Camptothecin analogues in the treatment of non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 1995, Volume: 12 Suppl 1 Topics: Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Drug Evaluation, Preclinical; Humans; Lung Neoplasms; Topotecan	1995
New chemotherapeutic agents in non-small-cell lung cancer. Seminars in oncology, 1993, Volume: 20, Issue:2 Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Design; Humans; Interferons; Irinotecan; Lung Neoplasms; Paclitaxel; Topotecan; Vinblastine; Vinorelbine	1993
New chemotherapeutic agents for non-small cell lung cancer. Chest, 1995, Volume: 107, Issue:6 Suppl Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Quinoxalines; Sulfanilamides; Taxoids; Topotecan; Vinblastine; Vinorelbine	1995
New directions for chemotherapy in non-small-cell lung cancer. Chest, 1993, Volume: 103, Issue:4 Suppl Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Non-Small-Cell Lung; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Topotecan; Vinblastine; Vinorelbine	1993
[Topoisomerase I inhibitor with potential radiosensitizing effect]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1997, Volume: 173, Issue:3 Topics: Antineoplastic Agents; Brain Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Child; Clinical Trials as Topic; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Neoplasms; Ovarian Neoplasms; Radiation-Sensitizing Agents; Radiotherapy Dosage; Topoisomerase I Inhibitors; Topotecan	1997
[Lung cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:13 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase II as Topic; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Taxoids; Topotecan; Vinblastine; Vinorelbine	1997
Topotecan in the treatment of non-small cell lung cancer. Seminars in oncology, 1997, Volume: 24, Issue:6 Suppl 20 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Humans; Lung Neoplasms; Neoplasm Staging; Topoisomerase I Inhibitors; Topotecan	1997
New chemotherapeutic agents prolong survival and improve quality of life in non-small cell lung cancer: a review of the literature and future directions. Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:5 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Neoplasm Staging; Paclitaxel; Quality of Life; Randomized Controlled Trials as Topic; Taxoids; Topotecan; Vinblastine; Vinorelbine	1998
New agents in the management of advanced non-small cell lung cancer. Seminars in oncology, 1998, Volume: 25, Issue:4 Suppl 9 Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Lung Neoplasms; Paclitaxel; Taxoids; Topotecan; Vinblastine; Vinorelbine	1998
The role of radiation, with or without chemotherapy, in the management of NSCLC. Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:10 Suppl 5 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Drug Synergism; Gemcitabine; Humans; Lung Neoplasms; Paclitaxel; Radiation-Sensitizing Agents; Topotecan; Vinblastine; Vinorelbine	1999
Stabilization of disease as an indicator of clinical benefit associated with chemotherapy in non-small cell lung cancer patients. International journal of oncology, 2000, Volume: 17, Issue:3 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Clinical Trials, Phase II as Topic; Databases, Factual; Disease Progression; Female; Humans; Injections, Intravenous; Karnofsky Performance Status; Life Tables; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Multicenter Studies as Topic; Neoplasm Staging; Proportional Hazards Models; Remission Induction; Retrospective Studies; Risk; Survival Analysis; Topotecan; Treatment Outcome	2000
New advances in lung cancer chemotherapy: topotecan and the role of topoisomerase I inhibitors. Oncology, 2001, Volume: 61 Suppl 1 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; DNA Topoisomerases, Type I; Enzyme Inhibitors; Female; Humans; Lung Neoplasms; Male; Prognosis; Survival Analysis; Topotecan; Treatment Outcome	2001
Preliminary results of combined therapy with topotecan and carboplatin in advanced non-small-cell lung cancer. Oncology, 2001, Volume: 61 Suppl 1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; Survival Analysis; Topotecan; Treatment Outcome	2001
Future role of topotecan in the treatment of lung cancer. Oncology, 2001, Volume: 61 Suppl 1 Topics: Administration, Oral; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Forecasting; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Neoplasm Staging; Prognosis; Survival Analysis; Topotecan; Treatment Outcome	2001
Topoisomerase I inhibitors combination chemotherapy in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2001, Volume: 34 Suppl 4 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Docetaxel; Doxorubicin; Enzyme Inhibitors; Etoposide; Gemcitabine; Humans; Ifosfamide; Irinotecan; Lung Neoplasms; Paclitaxel; Taxoids; Topoisomerase I Inhibitors; Topotecan; Vinblastine; Vinorelbine	2001
[Developed new agents for lung cancer]. Nihon Geka Gakkai zasshi, 2002, Volume: 103, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Docetaxel; Enzyme Inhibitors; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Taxoids; Topoisomerase I Inhibitors; Topotecan; Vinblastine; Vinorelbine	2002
[DNA topoisomerase inhibitor]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13 Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Drug Administration Schedule; Female; Humans; Irinotecan; Lung Neoplasms; Male; Mice; Phenazines; Topoisomerase I Inhibitors; Topotecan	1992

Trials

35 trial(s) available for topotecan and Carcinoma, Non-Small Cell Lung

Article	Year
Phase II study of topotecan and bevacizumab in advanced, refractory non--small-cell lung cancer. Clinical lung cancer, 2013, Volume: 14, Issue:5 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Cohort Studies; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; Salvage Therapy; Survival Rate; Topotecan	2013
Phase II clinical trial of whole-brain irradiation plus three-dimensional conformal boost with concurrent topotecan for brain metastases from lung cancer. Radiation oncology (London, England), 2013, Oct-14, Volume: 8 Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Cranial Irradiation; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Radiotherapy, Conformal; Small Cell Lung Carcinoma; Topotecan	2013
A randomized phase II trial of oral topotecan versus docetaxel in the second-line treatment of non-small-cell lung cancer. Clinical lung cancer, 2008, Volume: 9, Issue:3 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Disease Progression; Docetaxel; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Survival Rate; Taxoids; Topotecan; Treatment Outcome	2008
Phase II trial of combined modality therapy with concurrent topotecan plus radiotherapy followed by consolidation chemotherapy for unresectable stage III and selected stage IV non-small-lung cancer. International journal of radiation oncology, biology, physics, 2009, Mar-01, Volume: 73, Issue:3 Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Docetaxel; Etoposide; Female; Follow-Up Studies; Hematologic Diseases; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pilot Projects; Taxoids; Topotecan	2009
A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer. British journal of cancer, 2009, Jan-27, Volume: 100, Issue:2 Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; Prospective Studies; Quality of Life; Small Cell Lung Carcinoma; Survival Rate; Topotecan; Treatment Outcome	2009
Activity of topotecan given intravenously for 5 days every three weeks in patients with advanced non-small cell lung cancer pretreated with platinum and taxanes: a phase II study. Investigational new drugs, 2011, Volume: 29, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Platinum Compounds; Prospective Studies; Survival; Taxoids; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome	2011
Phase I and pharmacologic study of weekly bolus topotecan for advanced non-small-cell lung cancer. Clinical lung cancer, 2010, Jul-01, Volume: 11, Issue:4 Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Salvage Therapy; Survival Rate; Tissue Distribution; Topotecan; Treatment Outcome	2010
A Phase II trial of topotecan and gemcitabine in patients with previously treated, advanced nonsmall cell lung carcinoma. Cancer, 2002, Sep-15, Volume: 95, Issue:6 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Female; Gemcitabine; Humans; Lung Neoplasms; Male; Middle Aged; Survival Rate; Topotecan	2002
A dose-escalation study of weekly topotecan, cisplatin, and gemcitabine front-line therapy in patients with inoperable non-small cell lung cancer. The oncologist, 2002, Volume: 7, Issue:6 Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Disease Progression; Drug Administration Schedule; Female; Gemcitabine; Humans; Lung Neoplasms; Male; Middle Aged; Prospective Studies; Survival Analysis; Thrombocytopenia; Topotecan; Treatment Outcome	2002
A phase II multicenter study of combined topotecan and gemcitabine as first line chemotherapy for advanced non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2003, Volume: 39, Issue:2 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Deoxycytidine; Female; Gemcitabine; Humans; Lung Neoplasms; Male; Middle Aged; Survival Rate; Topotecan; Treatment Outcome	2003
Combined therapy with topotecan and gemcitabine in patients with inoperable or metastatic non-small cell lung cancer. Cancer investigation, 2003, Volume: 21, Issue:4 Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Survival Analysis; Topotecan; Treatment Outcome	2003
Weekly administration of topotecan and paclitaxel in pretreated advanced cancer patients: a phase I/II study. Cancer chemotherapy and pharmacology, 2004, Volume: 54, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Ovarian Neoplasms; Paclitaxel; Topotecan	2004
A phase I study of 3-day topotecan and cisplatin in elderly patients with small-cell lung cancer. Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:6 Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Female; Humans; Male; Maximum Tolerated Dose; Topotecan	2006
Topotecan plus ifosfamide in patients with platinum refractory advanced/metastatic non-small cell lung cancer: a phase II trial. Oncology reports, 2005, Volume: 14, Issue:6 Topics: Adult; Aged; Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Drug Resistance, Neoplasm; Female; Humans; Ifosfamide; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neutropenia; Platinum; Thrombocytopenia; Topotecan; Treatment Outcome	2005
Front-line paclitaxel and topotecan chemotherapy in advanced or metastatic non-small-cell lung cancer: a phase II trial. Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:4 Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Paclitaxel; Survival Analysis; Topotecan	2006
Phase III study comparing oral topotecan to intravenous docetaxel in patients with pretreated advanced non-small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jun-20, Volume: 24, Issue:18 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Docetaxel; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Taxoids; Topotecan	2006
A prospective phase II study of induction carboplatin and vinorelbine followed by concomitant topotecan and accelerated radiotherapy (ART) in locally advanced non-small cell lung cancer (NSCLC). Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2007, Volume: 2, Issue:9 Topics: Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Intravenous; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Prospective Studies; Radiation-Sensitizing Agents; Topotecan; Treatment Outcome; Vinblastine; Vinorelbine	2007
Phase I study of topotecan and cisplatin in patients with advanced solid tumors: a cancer and leukemia group B study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:12 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Neoplasms, Unknown Primary; Neutropenia; Recombinant Proteins; Salivary Gland Neoplasms; Stomach Neoplasms; Topotecan	1994
Phase II study of topotecan in metastatic non-small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:2 Topics: Aged; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Middle Aged; Topotecan; Treatment Outcome	1994
Phase II study of topotecan in patients with advanced non-small-cell lung cancer previously untreated with chemotherapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:2 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Camptothecin; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Female; Humans; Leukopenia; Lung Neoplasms; Male; Middle Aged; Survival Rate; Thrombocytopenia; Topotecan; Treatment Outcome	1996
3-D conformal radiotherapy for lung cancer. The Washington University experience. Frontiers of radiation therapy and oncology, 1996, Volume: 29 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Feasibility Studies; Humans; Lung Neoplasms; Lymph Nodes; Missouri; Radiation Injuries; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Thorax; Topotecan	1996
Results of a trial with topotecan dose escalation and concurrent thoracic radiation therapy for locally advanced, inoperable nonsmall cell lung cancer. International journal of radiation oncology, biology, physics, 1996, Dec-01, Volume: 36, Issue:5 Topics: Aged; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Female; Humans; Lung Neoplasms; Male; Middle Aged; Prospective Studies; Thorax; Topotecan	1996
Phase I study of daily times five topotecan and single injection of cisplatin in patients with previously untreated non-small-cell lung carcinoma. Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:10 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Lung Neoplasms; Male; Middle Aged; Neutropenia; Thrombocytopenia; Topotecan	1997
Continuous infusional topotecan in advanced breast and non-small-cell lung cancer: no evidence of increased efficacy. British journal of cancer, 1997, Volume: 76, Issue:12 Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Topotecan	1997
Phase II trial of topotecan administered as a 21-day continuous infusion in previously untreated patients with stage IIIB and IV non-small-cell lung cancer. American journal of clinical oncology, 1998, Volume: 21, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Infusion Pumps; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Survival Analysis; Topoisomerase I Inhibitors; Topotecan	1998
Cisplatin-topotecan-paclitaxel weekly administration with G-CSF support for ovarian and small-cell lung cancer patients: a dose-finding study. Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:3 Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Male; Middle Aged; Ovarian Neoplasms; Paclitaxel; Prognosis; Topotecan; Treatment Outcome	1999
A randomized phase II trial of two schedules of topotecan for the treatment of advanced stage non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2000, Volume: 28, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Survival Analysis; Thrombocytopenia; Topotecan; Treatment Outcome	2000
Phase II study of oral topotecan in advanced non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:3 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Alopecia; Anemia; Antineoplastic Agents; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasm Staging; Neutropenia; Thrombocytopenia; Topotecan; Treatment Outcome; Vomiting	2000
Phase II and pharmacokinetic/pharmacodynamic trial of sequential topoisomerase I and II inhibition with topotecan and etoposide in advanced non-small-cell lung cancer. Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:2 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Etoposide; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Lung Neoplasms; Male; Middle Aged; Mutation; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan	2001
A phase I-II trial of topotecan and gemcitabine in patients with previously treated, advanced non-small cell lung cancer (LOA-3). Cancer investigation, 2001, Volume: 19, Issue:5 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neutropenia; Thrombocytopenia; Topotecan; Treatment Outcome	2001
Feasibility of oral topotecan plus intravenous paclitaxel in advanced non-small-cell lung cancer. Oncology, 2001, Volume: 61 Suppl 1 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Feasibility Studies; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Paclitaxel; Survival Rate; Topotecan; Treatment Outcome	2001
Is cisplatin required for the treatment of non-small-cell lung cancer? Experience and preliminary results of a phase I/II trial with topotecan and vinorelbine. Oncology, 2001, Volume: 61 Suppl 1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Sensitivity and Specificity; Survival Rate; Topotecan; Treatment Outcome; Vinblastine; Vinorelbine	2001
A phase I clinical trial of topotecan given every 2 weeks in patients with refractory solid tumors. Oncology, 2001, Volume: 61, Issue:4 Topics: Adult; Aged; Anemia; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Melanoma; Middle Aged; Neoplasms; Neutropenia; Ovarian Neoplasms; Thrombocytopenia; Topotecan; Uterine Cervical Neoplasms	2001
A phase I study of sequential intravenous topotecan and etoposide in lung cancer patients. Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neutropenia; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan; Treatment Outcome	2001
Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:4 Topics: Adult; Aged; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neutropenia; Ovarian Neoplasms; Topotecan	1992

Other Studies

33 other study(ies) available for topotecan and Carcinoma, Non-Small Cell Lung

Article	Year
Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin. Bioorganic & medicinal chemistry letters, 2001, Feb-12, Volume: 11, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Division; Combinatorial Chemistry Techniques; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Structure-Activity Relationship; Survival Rate; Tumor Cells, Cultured	2001
Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors. Bioorganic & medicinal chemistry letters, 2008, Feb-15, Volume: 18, Issue:4 Topics: Anthraquinones; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Lung Neoplasms; Pyrones; Structure-Activity Relationship; Topoisomerase I Inhibitors	2008
Synthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers. European journal of medicinal chemistry, 2013, Volume: 59 Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chalcone; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Quinolines	2013
The therapeutic inhibition of topoisomerase inhibitor and crizotinib combination in EGFR wild and mutant lung cancer cells. Biochemical pharmacology, 2022, Volume: 205 Topics: Animals; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Crizotinib; Drug Resistance, Neoplasm; ErbB Receptors; Lung Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Reactive Oxygen Species; Topoisomerase Inhibitors; Topotecan	2022
Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo. Cancer letters, 2018, 06-28, Volume: 424 Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Mice; Neoplasm Proteins; Quinazolines; Topotecan; Up-Regulation; Xenograft Model Antitumor Assays	2018
[Analysis of drug therapy of lung cancer in Hungary]. Magyar onkologia, 2013, Volume: 57, Issue:1 Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carboplatin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Chemotherapy, Adjuvant; Cisplatin; Databases, Factual; Deoxycytidine; Docetaxel; Drug Administration Schedule; Erlotinib Hydrochloride; Etoposide; Gemcitabine; Glutamates; Guanine; Humans; Hungary; Inpatients; Insurance, Health; Lung Neoplasms; Paclitaxel; Pemetrexed; Prescription Drugs; Quinazolines; Retrospective Studies; Taxoids; Topotecan	2013
Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. PloS one, 2015, Volume: 10, Issue:8 Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Colonic Neoplasms; DNA Topoisomerases, Type I; Female; Gene Expression; Humans; Irinotecan; Lung; Lung Neoplasms; Molecular Sequence Data; Neoplasms; Ovarian Neoplasms; Phosphorylation; Serine; Topotecan	2015
[Outcome of concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer patients]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2015, Volume: 37, Issue:11 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Cisplatin; Cyclophosphamide; Esophagitis; Humans; Lung Neoplasms; Neoplasm Staging; Radiation Pneumonitis; Radiotherapy, Conformal; Retrospective Studies; Topotecan	2015
ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics. Scientific reports, 2017, 01-06, Volume: 7 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Disease Models, Animal; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Heterografts; Lapatinib; Mice, Nude; Mitoxantrone; Neoplasm Proteins; Neoplasm Transplantation; Quinazolines; Topotecan	2017
HIF-1alpha modulation by topoisomerase inhibitors in non-small cell lung cancer cell lines. Journal of cancer research and clinical oncology, 2009, Volume: 135, Issue:8 Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Enzyme Inhibitors; Etoposide; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Proto-Oncogene Proteins c-akt; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan	2009
[Effect of different chemotherapy regimens for concurrent chemoradiotherapy on locally advanced non-small cell lung cancer]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2009, Volume: 31, Issue:2 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Combined Modality Therapy; Etoposide; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Paclitaxel; Proportional Hazards Models; Radiation Pneumonitis; Radiotherapy, Conformal; Retrospective Studies; Survival Rate; Topotecan	2009
SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15. Oncogene, 2012, Sep-13, Volume: 31, Issue:37 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Cytokines; DNA Methylation; DNA Topoisomerases, Type I; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Prognosis; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; Sulfatases; Sulfotransferases; Topoisomerase I Inhibitors; Topotecan; Ubiquitins	2012
Early detection and successful treatment of drug-induced pneumonitis with corticosteroids. Cancer investigation, 2002, Volume: 20, Issue:7-8 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Gemcitabine; Glucocorticoids; Humans; Lung Neoplasms; Male; Paclitaxel; Pneumonia; Prednisone; Radiography, Thoracic; Tomography, X-Ray Computed; Topotecan; Treatment Outcome; Vinblastine; Vinorelbine	2002
Combination chemotherapy with topotecan for non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2003, Volume: 41 Suppl 4 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Gemcitabine; Humans; Lung Neoplasms; Paclitaxel; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan; Vinblastine; Vinorelbine	2003
Weekly topotecan in the management of lung cancer. Lung cancer (Amsterdam, Netherlands), 2003, Volume: 41 Suppl 4 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Drug Administration Schedule; Humans; Lung Neoplasms; Topotecan	2003
Ex vivo analysis of topotecan: advancing the application of laboratory-based clinical therapeutics. British journal of cancer, 2003, Nov-03, Volume: 89, Issue:9 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; In Vitro Techniques; Irinotecan; Lethal Dose 50; Lung Neoplasms; Male; Neoplasms; Prostatic Neoplasms; Topotecan; Tumor Cells, Cultured	2003
In regard to Bogart et al.: 70 Gy thoracic radiotherapy is feasible concurrent with chemotherapy for limited-stage non-small-cell lung cancer: Analysis of cancer and leukemia group B study 39808 (Int J Radiat Oncol Biol Phys 2004;59:460-468). International journal of radiation oncology, biology, physics, 2004, Dec-01, Volume: 60, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Paclitaxel; Radiotherapy Dosage; Recurrence; Topotecan	2004
Foreword--new directions for topotecan in lung cancer treatment. The oncologist, 2004, Volume: 9 Suppl 6 Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Humans; Lung Neoplasms; Quality of Life; Topotecan	2004
Interaction between gemcitabine and topotecan in human non-small-cell lung cancer cells: effects on cell survival, cell cycle and pharmacogenetic profile. British journal of cancer, 2005, Feb-28, Volume: 92, Issue:4 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 3; Caspases; Cell Cycle; Cell Line, Tumor; Deoxycytidine; Deoxycytidine Kinase; DNA Fragmentation; Drug Synergism; Enzyme Inhibitors; Gemcitabine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Phosphorylation; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Topoisomerase I Inhibitors; Topotecan	2005
BCRP/ABCG2 levels account for the resistance to topoisomerase I inhibitors and reversal effects by gefitinib in non-small cell lung cancer. Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:5 Topics: Adenosine Triphosphatases; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Flow Cytometry; Gefitinib; Gene Expression; Humans; Irinotecan; Lung Neoplasms; Neoplasm Proteins; Protein Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Fluorescence; Topoisomerase I Inhibitors; Topotecan	2006
Oral second-line chemotherapy for advanced non-small-cell lung cancer: the bottom line. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jun-20, Volume: 24, Issue:18 Topics: Administration, Oral; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Neoplasm Recurrence, Local; Randomized Controlled Trials as Topic; Topotecan	2006
[From ASCO and WCLC 2005 to clinical practice: "conventional" treatments]. Revue de pneumologie clinique, 2006, Volume: 62 Spec no 1 Topics: Administration, Oral; Age Factors; Aged; Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials, Phase III as Topic; Deoxycytidine; Docetaxel; Etoposide; Follow-Up Studies; Gemcitabine; Humans; Irinotecan; Lung; Lung Neoplasms; Mediastinoscopy; Meta-Analysis as Topic; Middle Aged; Neoplasm Staging; Palliative Care; Pneumonectomy; Radiotherapy Dosage; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Taxoids; Time Factors; Topotecan	2006
Antimetastatic effect of a small-molecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1 Topics: Animals; Antineoplastic Agents; Benzamides; Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Line, Tumor; Cell Movement; Female; Humans; Indoles; Integrin alphaVbeta3; Lung Neoplasms; Mice; Mice, Nude; Topotecan; Vacuolar Proton-Translocating ATPases; Wound Healing; Xenograft Model Antitumor Assays	2008
Multiple myeloma emerging after chemotherapy for non-small-cell lung cancer. Medical oncology (Northwood, London, England), 2008, Volume: 25, Issue:4 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Docetaxel; Humans; Lung Neoplasms; Male; Multiple Myeloma; Neoplasms, Second Primary; Taxoids; Topotecan; Vinblastine; Vinorelbine	2008
Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity. International journal of oncology, 1999, Volume: 15, Issue:4 Topics: Adenocarcinoma; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cisplatin; Deoxycytidine; Docetaxel; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Inhibitory Concentration 50; Irinotecan; Lung Neoplasms; Paclitaxel; Sensitivity and Specificity; Taxoids; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured	1999
Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines. European journal of cancer (Oxford, England : 1990), 1999, Volume: 35, Issue:5 Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flow Cytometry; Gemcitabine; Genes, p53; Humans; Immunohistochemistry; Lung Neoplasms; Topotecan; Tumor Cells, Cultured	1999
Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Caspase 8; Caspase 9; Caspases; Cisplatin; Deoxycytidine; Fas Ligand Protein; fas Receptor; Flow Cytometry; Gemcitabine; Genes, p53; Humans; Lung Neoplasms; Membrane Glycoproteins; Paclitaxel; Recombinant Proteins; Signal Transduction; Topotecan; Transfection; Tumor Cells, Cultured	2000
Histology and sensitivity to anticancer drugs of two human non-small cell lung carcinomas implanted in the pleural cavity of nude mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:1 Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Doxorubicin; Ellipticines; Etoposide; Female; Gemcitabine; Humans; Lung Neoplasms; Lymphatic Metastasis; Mice; Mice, Nude; Neoplasm Metastasis; Paclitaxel; Pleural Neoplasms; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured; Vinblastine; Vinorelbine	2000
Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer research, 2000, Dec-15, Volume: 60, Issue:24 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Chloromethyl Ketones; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; bcl-X Protein; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cisplatin; Cytochrome c Group; Cytosol; Deoxycytidine; DNA, Complementary; Fas-Associated Death Domain Protein; Gemcitabine; Genes, Dominant; Humans; Inhibitory Concentration 50; Jurkat Cells; Lung Neoplasms; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Spectrometry, Fluorescence; Topotecan; Transfection; Tumor Cells, Cultured	2000
Improvement of therapeutic index of low-dose topotecan delivered per os. Annals of the New York Academy of Sciences, 2000, Volume: 922 Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Humans; Injections, Intravenous; Lung Neoplasms; Mice; Mice, Nude; Topotecan; Xenograft Model Antitumor Assays	2000
Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2001, Volume: 32, Issue:2 Topics: Amino Acid Substitution; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; ATP-Binding Cassette Transporters; Biomarkers; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cyclophosphamide; DNA Mutational Analysis; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Neoplasm; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Ifosfamide; Isoenzymes; Ki-67 Antigen; Life Tables; Lung Neoplasms; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Mutation, Missense; Neoplasm Proteins; Paclitaxel; Point Mutation; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Teniposide; Topotecan; Treatment Outcome; Vault Ribonucleoprotein Particles	2001
Antitumor activity of XR5944, a novel and potent topoisomerase poison. Anti-cancer drugs, 2001, Volume: 12, Issue:4 Topics: Aminoquinolines; Animals; Antigens, Neoplasm; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Indenes; Inhibitory Concentration 50; Injections, Intraperitoneal; Injections, Intravenous; Isoenzymes; Lung Neoplasms; Mice; Mice, Nude; Phenazines; Remission Induction; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2001
Novel therapies in lung cancer management. An update on the role of topotecan. Oncology, 2001, Volume: 61 Suppl 1 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Combined Modality Therapy; Female; Humans; Lung Neoplasms; Male; Prognosis; Topotecan; Treatment Outcome	2001