Page last updated: 2024-08-24

topotecan and Cancer of the Retina

topotecan has been researched along with Cancer of the Retina in 94 studies

Research

Studies (94)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (7.45)	29.6817
2010's	70 (74.47)	24.3611
2020's	17 (18.09)	2.80

Authors

Authors	Studies
Abramson, DH; Francis, JH; Gobin, YP	1
Abramson, DH; Cancela, B; Chantada, G; Clausse, M; Del Río, M; Del Sole, MJ; Francis, JH; Lamas, G; Lubieniecki, F; Nejamkin, P; Schaiquevich, P	1
Abramson, DH; Antal, Z; Dunkel, IJ; Francis, JH; Friedman, DN; Gobin, YP; Marathe, PH	1
Abramson, DH; Asprea, M; Chantada, G; Fandiño, A; Francis, JH; Lagomarsino, E; Opezzo, J; Requejo, F; Sampor, C; Schaiquevich, P; Vater, A	1
Jabbour, P; Leahey, AM; Selzer, EB; Shields, CL; Welch, RJ	1
Akyüz, C; Kiratli, H; Koç, I; Öztürk, E; Varan, A	1
Ancona-Lezama, D; Baldassari, MP; Dalvin, LA; Das, S; Hammoud, B; Jabbour, P; Lim, LS; Ramesh, S; Shields, CL; Shivashankar, K; Sweid, A; Texakalidis, P; Tjoumakaris, S; Weinberg, JH; Xu, V	1
Abramson, DH; Brodie, SE; Francis, JH; Muca, E; Nadelmann, J	1
Goyal, P; Kochhar, S; Narang, S; Pandey, AK; Sindhu, M	1
Li, X; Lu, S; Ma, J; Tanumiharjo, S; Xing, Y; Yu, X	1
Daniels, AB; Friedman, DL; Froehler, MT; Zheng, Y	1
Borri, M; De Francesco, S; Hadjistilianou, T; Stacey, AW	1
Aghajanpour, L; Amoli, FA; Atyabi, F; Delrish, E; Dinarvand, R; Ghassemi, F; Jabbarvand, M; Lashay, A; Soleimani, M	1
Brennan, RC; King, BA; Sahr, N; Sykes, A; Wilson, MW	1
Acosta, G; Fiani, B; Haynes, M; Nikolaidis, D; Rose, A; Runnels, J; Wong, A	1
Abramson, DH; Bogan, CM; Boyd, KL; Bridges, TM; Calcutt, MW; Chen, SC; Daniels, AB; Francis, JH; Friedman, DL; Hsieh, T; Kaczmarek, JV; Liao, A; Lindsley, CW; Nadelmann, JB; Pierce, JM; Richmond, A	1
Kıratlı, H; Koç, İ; Lotfisadigh, S; Taylan Şekeroğlu, H	1
Cocarta, AI; Dunovska, K; Feriancikova, B; Hobzova, R; Hrabeta, J; Kodetova, M; Pochop, P; Sirc, J; Svojgr, K; Uhlik, J	1
Aggarwal, V; Dhami, A; Maitray, A; Munusamy, S; Ramamurthy, S; Ravikumar, R; Rishi, P; Sharma, M; Sharma, T	1
Abramson, DH; Brodie, SE; Francis, JH; Gobin, YP; Iyer, S	1
Bramuglia, GF; Carcaboso, AM; Castillo-Ecija, H; Chantada, GL; Cuadrado-Vilanova, M; Mora, J; Olaciregui, NG; Opezzo, JAW; Paco, S; Pascual-Pasto, G; Restrepo-Perdomo, CA; Rivero, EM; Schaiquevich, P; Suñol, M; Torrebadell, M; Vila-Ubach, M	1
Bagheri, N; Corrales-Medina, FF; Harbour, JW; Paez-Escamilla, M; Teira, LE	1
Abramson, DH; Berry, JL; Cassoux, N; Francis, JH; Frenkel, S; Hadjistilianou, D; Ji, X; Munier, FL; Schefler, AC; Shields, CL; Teixeira, LF	1
Beck-Popovic, M; Gaillard, MC; Hadjistilianou, D; Maeder, P; Munier, FL; Puccinelli, F; Stathopoulos, C	1
Harbour, JW; Paez-Escamilla, M	1
Gaillard, MC; Munier, FL; Stathopoulos, C	1
Ceciliano, A; Chantada, GL; Fandiño, A; Funes, S; Lagomarsino, E; Manzitti, J; Neira, P; Peralta, L; Sampor, C; Schaiquevich, P; Sgroi, M; Villasante, F	1
Abramson, DH; Brodie, SE; Dunkel, IJ; Francis, JH; Gobin, YP; Levin, A; Mauguen, A; Mondesire-Crump, I; Rowlands, MA	1
Honavar, SG; Mulay, K; Rao, R; Reddy, VAP	1
Ancona-Lezama, D; Dalvin, LA; Jabbour, P; Lucio-Alvarez, JA; Masoomian, B; Shields, CL	1
Meng, B; Qu, W; Wang, S; Yu, Y	1
Bosaleh, A; Chantada, G; Deu, A; Fandiño, A; Requejo, F; Rodriguez, A; Sampor, C; Schaiquevich, P; Sgroi, M; Zugbi, S	1
Ancona-Lezama, D; Dalvin, LA; Jabbour, P; Lucio-Alvarez, JA; Shields, CL	1
Beck-Popovic, M; Gaillard, MC; Moulin, A; Munier, FL; Puccinelli, F; Stathopoulos, C	1
Guo, L; Han, M; Li, J; Song, D; Wang, C; Wang, L; Wang, Z; Wu, C; Yang, Y; Zhao, J	1
Aroonroch, R; Boontawon, T; Chaitankar, V; Chittavanich, P; Hongeng, S; Jinawath, N; Kaewkhaw, R; Rojanaporn, D; Saengwimol, D; Thammachote, W	1
Khetan, V; Sharma, M	1
Honavar, SG; Rao, R; Sthapit, PR	1
Abramson, DH; Brodie, S; Francis, JH; Gobin, YP; Levin, AM; McFadden, M	1
Blair, M; Kotlyar, B; Shapiro, M	1
Camp, DA; Lally, SE; Shields, CL	1
Kapoor, S	1
Chan, HS; Dimaras, H; Gallie, BL; Halliday, W; Héon, E; Yousef, YA	1
Buitrago, E; Ceciliano, A; Chantada, GL; Fandino, A; Lucena, E; Romero, L; Sampor, C; Schaiquevich, P; Taich, P; Villasante, F	1
Abramson, DH; Brodie, SE; Dunkel, IJ; Francis, JH; Gobin, YP; Marr, BP; Riedel, ER	1
Arepalli, SA; Caywood, EH; Jabbour, P; Lally, SE; Manjandavida, FP; Pieretti, G; Shields, CL; Shields, JA	1
Ghadimi, H; Ghassemi, F; Khodabandeh, A; Roohipoor, R; Shields, CL	1
Maidana, DE; Pellegrini, M; Shields, CL; Shields, JA	1
Bramuglia, G; Buitrago, E; Carcaboso, AM; Chantada, GL; Opezzo, J; Schaiquevich, P; Taich, P	1
Palanivelu, MS; Ramanjulu, R	1
Ghassemi, F; Khodabande, A; Shields, CL	1
Brennan, R; Kaste, SC; Orr, B; Tse, BC; Wilson, MW	1
Belmar, Á; Ossandón, D; Pérez, V; Shields, CL; Varas, M; Zanolli, M; Zúñiga, P	1
Lawson, BM; Saktanasate, J; Say, EA; Shields, CL	1
Astudillo, PP; Chan, HS; Durairaj, P; Gallie, BL; Héon, E	1
Dolz-Marco, R; Ferenczy, SR; Hasanreisoglu, M; Shields, CL; Shields, JA	1
Abramson, DH; Francis, JH; Kellick, MG; Marr, BP; Schaiquevich, P	1
Cao, C; Jabbour, PM; Pointdujour-Lim, R; Say, EA; Shields, CL; Shields, JA	1
Bansal, N; Koundanya, V; Ramamurthy, S; Ravikumar, R; Rishi, P; Saravanan, M; Sharma, T	1
Bertelli, E; Bracco, S; Cioni, S; De Francesco, S; Galluzzi, P; Gennari, P; Guglielmucci, D; Hadjistilianou, T; Leonini, S; Romano, DG; Tarantino, F; Vallone, IM; Venturi, C	1
Bracco, S; De Francesco, S; Galluzzi, P; Hadjistilianou, T; Menicacci, F; Motolese, E	1
Abruzzo, TA; Augsburger, JJ; Corrêa, ZM; Geller, JI; Lane, A; Michaels, ST	1
Beggache, M; Douglass, AM; Say, EA; Shields, CL; Shields, JA	1
Deebajah, R; Hajja, Y; Jaradat, I; Mehyar, M; Nawaiseh, I; Sultan, I; Yousef, YA	1
Abramson, DH; Brodie, SE; Dunkel, IJ; Fabius, AW; Francis, JH; Gobin, YP; Marr, BP; Mondesire-Crump, I	1
Hasanreisoglu, M; Iyer, PG; Jabbour, P; Lally, SE; Say, EA; Shields, CL; Shields, JA	1
Alset, AE; Caywood, E; Jabbour, P; Say, EA; Shields, CL; Shields, JA	1
Fuller, DG; Jabbour, PM; Khoo, CT; Magan, T; Shields, CL	1
Abramson, DH; Chantada, GL; Fabius, AW; Francis, JH; Schaiquevich, P	1
Abramson, DH; Brodie, SE; Francis, JH; Marr, B; Mondesire-Crump, I; Zabor, EC	1
Abramson, DH; Francis, JH; Iyer, S; Karl, MD; Marr, B	1
Beck-Popovic, M; Fabian, ID; Gaillard, MC; Munier, FL; Puccinelli, F	1
Chan, H; Gallie, BL; Halliday, W; Hèon, E; Shaikh, F; Soliman, SE	1
Budning, A; Chan, HS; Dai, S; Dimaras, H; Doyle, J; Drake, J; Gallie, BL; Halliday, W; Héon, E	1
Abramson, DH; Bramuglia, GF; Carcaboso, AM; Chantada, GL; de Davila, MT; Fandino, AC; Guitter, MR; Lagomarsino, E; Manzitti, J; Rose, AB	1
Dalgard, CL; deNiro, JE; Gonzalez, M; O'Brien, JM	1
Abramson, DH; Brodie, SE; Dunkel, IJ; Gobin, YP; Marr, B	2
Abramson, DH; Bramuglia, GF; Buitrago, E; Chantada, G; Fandiño, A; Höcht, C; Navo, E; Schaiquevich, P	1
Carcaboso, AM; Dyer, MA; Egorin, M; Federico, S; Nemeth, KM; Schaiquevich, P; Shen, Y; Stewart, C; Zhang, J	1
Babyn, P; Chan, HS; Dimaras, H; Doyle, J; Gallie, BL; Halliday, W; Héon, E; Paton, KE; Strahlendorf, C	1
Chan, HS; Dimaras, H; Gallie, BL; Héon, E; Mallipatna, AC	1
Abramson, DH; Brodie, SE; Dunkel, IJ; Gobin, YP; Hung, C; Marr, BP	1
Billups, CA; Brennan, R; Free, TM; Given, V; Haik, BG; Helton, K; McCarville, MB; Merchant, TE; Qaddoumi, I; Rodriguez-Galindo, C; Stewart, CF; Tagen, M; Wilson, MW; Wu, J	1
Abramson, DH; Brodie, SE; Dunkel, I; Gobin, YP; Marr, BP; Palioura, S	1
Darsova, D; Klapkova, E; Kodetova, D; Lestak, J; Malis, J; Pochop, P; Tesfaye, H; Uhlik, J; Vajner, L	1
Abramson, DH; Brodie, SE; Dunkel, IJ; Gobin, YP; Marr, BP	1
Ceciliano, A; Chantada, GL; Dominguez, J; Fandino, AC; Millan, N; Schaiquevich, P; Taich, P; Villasante, F	1
Liu, W; Shan, BE; Yuan, NF; Zhang, M	1
Asprea, M; Bramuglia, GF; Buitrago, E; Chantada, GL; Croxatto, JO; Del Sole, MJ; Fandino, A; Schaiquevich, P; Torbidoni, A	1
Casak, SJ; Chantada, GL; Fandiño, AC; Manzitti, J; Mato, G; Schvartzman, E	1
Dyer, MA; Egorin, M; Gray, JK; Laurie, NA; Leggas, M; Relling, M; Stewart, C; Zhang, J	1
Abramson, DH; Bramuglia, GF; Carcaboso, AM; Chantada, GL; Chiappetta, DA; de Davila, MT; Fandiño, AC; Rubio, MC	1
Dalgard, C; Edelhauser, HF; Grossniklaus, HE; Lee, L; O'Brien, JM; Tsui, JY; Van Quill, KR	1

Reviews

4 review(s) available for topotecan and Cancer of the Retina

Article	Year
The role for intra-arterial chemotherapy for refractory retinoblastoma: a systematic review. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021, Volume: 23, Issue:10 Topics: Antineoplastic Agents; Bronchial Spasm; Carboplatin; Drug Resistance, Neoplasm; Edema; Eyelashes; Febrile Neutropenia; Humans; Infusions, Intra-Arterial; Melphalan; Methotrexate; Nausea; Retinal Neoplasms; Retinoblastoma; Salvage Therapy; Topotecan; Vitreous Hemorrhage; Vomiting	2021
Ocular pharmacology of topotecan and its activity in retinoblastoma. Retina (Philadelphia, Pa.), 2014, Volume: 34, Issue:9 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Routes; Humans; Intravitreal Injections; Retinal Neoplasms; Retinoblastoma; Tissue Distribution; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured; Vitreous Body	2014
Properties and clinical utility of topotecan fluorescence: uses for retinoblastoma. The British journal of ophthalmology, 2015, Volume: 99, Issue:10 Topics: Fluorescein Angiography; Fundus Oculi; Humans; Intravitreal Injections; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan; Vitreous Body	2015
OCULAR PHARMACOLOGY OF CHEMOTHERAPY FOR RETINOBLASTOMA. Retina (Philadelphia, Pa.), 2017, Volume: 37, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Infusions, Intra-Arterial; Injections, Intraocular; Melphalan; Retinal Neoplasms; Retinoblastoma; Topotecan	2017

Trials

4 trial(s) available for topotecan and Cancer of the Retina

Article	Year
Chemoreduction with topotecan and vincristine: Quantifying tumor response in bilateral retinoblastoma patients. Pediatric blood & cancer, 2021, Volume: 68, Issue:4 Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Female; Humans; Infant; Male; Retinal Neoplasms; Retinoblastoma; Topotecan; Treatment Outcome; Tumor Burden; Vincristine	2021
A phase I study of periocular topotecan in children with intraocular retinoblastoma. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:4 Topics: Antineoplastic Agents; Area Under Curve; Child, Preschool; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Eye Enucleation; Humans; Magnetic Resonance Imaging; Maximum Tolerated Dose; Retinal Neoplasms; Retinoblastoma; Tomography, X-Ray Computed; Topotecan	2009
Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery). Ophthalmology, 2010, Volume: 117, Issue:8 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Electroretinography; Female; Fluorescein Angiography; Follow-Up Studies; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Ophthalmic Artery; Prospective Studies; Retinal Neoplasms; Retinoblastoma; Topotecan; Treatment Outcome; Visual Acuity	2010
Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity. Cancer, 2012, Nov-15, Volume: 118, Issue:22 Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Female; Granulocyte Colony-Stimulating Factor; Humans; Infant; Male; Neutropenia; Retinal Neoplasms; Retinoblastoma; Survival Rate; Thrombocytopenia; Topoisomerase I Inhibitors; Topotecan; Vincristine	2012

Other Studies

86 other study(ies) available for topotecan and Cancer of the Retina

Article	Year
Orbital Retinoblastoma Treated with Intra-arterial Chemotherapy. Ophthalmology, 2021, Volume: 128, Issue:10 Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carboplatin; Child, Preschool; Drug Therapy, Combination; Humans; Infusions, Intra-Arterial; Magnetic Resonance Imaging; Male; Melphalan; Ophthalmic Artery; Orbital Neoplasms; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan	2021
Ocular and systemic toxicity of high-dose intravitreal topotecan in rabbits: Implications for retinoblastoma treatment. Experimental eye research, 2022, Volume: 218 Topics: Animals; Intravitreal Injections; Rabbits; Retinal Neoplasms; Retinoblastoma; Topotecan; Vitreous Body	2022
Biochemical measures of ovarian function in female survivors of retinoblastoma treated with intra-arterial melphalan: an initial report. Ophthalmic genetics, 2022, Volume: 43, Issue:6 Topics: Carboplatin; Child; Electroretinography; Female; Humans; Infant; Infusions, Intra-Arterial; Melphalan; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Survivors; Topotecan; Treatment Outcome	2022
Pharmacokinetics of Orbital Topotecan After Ophthalmic Artery Chemosurgery and Intravenous Infusion in the Swine Model. Investigative ophthalmology & visual science, 2023, 09-01, Volume: 64, Issue:12 Topics: Animals; Infusions, Intravenous; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Swine; Topotecan	2023
Management of retinoblastoma in older children (>5 years) using intra-arterial chemotherapy: Comparison of outcomes to prechemotherapy and intravenous chemotherapy eras. Indian journal of ophthalmology, 2019, Volume: 67, Issue:12 Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carboplatin; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Intravitreal Injections; Male; Melphalan; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Young Adult	2019
Comparison of intravitreal melphalan with and without topotecan in the management of vitreous disease in retinoblastoma. Japanese journal of ophthalmology, 2020, Volume: 64, Issue:4 Topics: Antineoplastic Agents, Alkylating; Child, Preschool; Drug Therapy, Combination; Eye Diseases; Eye Enucleation; Female; Follow-Up Studies; Humans; Infant; Intravitreal Injections; Kaplan-Meier Estimate; Male; Melphalan; Neoplasm Seeding; Proportional Hazards Models; Retinal Diseases; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Vitreous Body	2020
Intra-Arterial Chemotherapy for Retinoblastoma in Infants ≤10 kg: 74 Treated Eyes with 222 IAC Sessions. AJNR. American journal of neuroradiology, 2020, Volume: 41, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Treatment Outcome	2020
Is intravitreal topotecan toxic to retinal function? The British journal of ophthalmology, 2021, Volume: 105, Issue:7 Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Electroretinography; Female; Follow-Up Studies; Humans; Infant; Intravitreal Injections; Male; Melphalan; Retina; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topoisomerase I Inhibitors; Topotecan	2021
Adverse drug reaction after intravitreal injection of topotecan. Indian journal of ophthalmology, 2020, Volume: 68, Issue:8 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and Adverse Reactions; Humans; Intravitreal Injections; Retinal Neoplasms; Retinoblastoma; Topotecan	2020
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma. BMC cancer, 2020, Aug-26, Volume: 20, Issue:1 Topics: Chemotherapy, Adjuvant; Child; Child, Preschool; Follow-Up Studies; Humans; Infant; Intravitreal Injections; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Salvage Therapy; Topotecan; Treatment Outcome; Visual Acuity; Vitrectomy; Vitreous Body	2020
Intra-arterial Chemotherapy as Primary Treatment for Cavitary Retinoblastoma: Excellent Response in Eight Tumors. Ophthalmology. Retina, 2021, Volume: 5, Issue:5 Topics: Antineoplastic Agents; Carboplatin; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Time Factors; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Ultrasonography	2021
The Addition of Topotecan to Melphalan in the Treatment of Retinoblastoma with Intra-arterial Chemotherapy. Ophthalmology. Retina, 2021, Volume: 5, Issue:8 Topics: Antineoplastic Agents, Alkylating; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Humans; Infant; Injections, Intra-Arterial; Male; Melphalan; Prospective Studies; Retina; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome	2021
Efficacy of topotecan nanoparticles for intravitreal chemotherapy of retinoblastoma. Experimental eye research, 2021, Volume: 204 Topics: Animals; Antineoplastic Agents; Calorimetry, Differential Scanning; Chitosan; Drug Carriers; Flow Cytometry; Humans; Intravitreal Injections; Male; Nanoparticles; Neoplasm Transplantation; Particle Size; Rats; Rats, Wistar; Retinal Neoplasms; Retinoblastoma; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Treatment Outcome; Tumor Cells, Cultured; X-Ray Diffraction	2021
Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study. The British journal of ophthalmology, 2022, Volume: 106, Issue:2 Topics: Animals; Antineoplastic Agents, Alkylating; Humans; Intravitreal Injections; Melphalan; Neoplasm Seeding; Rabbits; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Vitreous Body	2022
Management of cataracts secondary to intravitreal chemotherapy injections for retinoblastoma seeding. European journal of ophthalmology, 2022, Volume: 32, Issue:3 Topics: Antineoplastic Agents, Alkylating; Cataract; Child; Child, Preschool; Humans; Infant; Intravitreal Injections; Melphalan; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Vitreous Body	2022
Hydrogel implants for transscleral diffusion delivery of topotecan: In vivo proof of concept in a rabbit eye model. International journal of pharmaceutics, 2021, Sep-05, Volume: 606 Topics: Animals; Hydrogels; Rabbits; Retinal Neoplasms; Retinoblastoma; Topotecan; Vitreous Body	2021
Intra-arterial chemotherapy for retinoblastoma: Two-year results from tertiary eye-care center in India. Indian journal of ophthalmology, 2017, Volume: 65, Issue:4 Topics: Antineoplastic Agents, Alkylating; Child, Preschool; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Incidence; India; Infant; Injections, Intra-Arterial; Male; Melphalan; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Time Factors; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Ultrasonography	2017
Retinoblastoma Vitreous Seed Clouds (Class 3): A Comparison of Treatment with Ophthalmic Artery Chemosurgery with or without Intravitreous and Periocular Chemotherapy. Ophthalmology, 2017, Volume: 124, Issue:10 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child, Preschool; Cohort Studies; Disease-Free Survival; Electroretinography; Female; Humans; Infusions, Intra-Arterial; Intravitreal Injections; Kaplan-Meier Estimate; Male; Melphalan; Neoplasm Seeding; Ophthalmic Artery; Retina; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Vitreous Body	2017
Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier. Journal of controlled release : official journal of the Controlled Release Society, 2017, Oct-28, Volume: 264 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Retinal Barrier; Humans; Mice, Nude; Pantoprazole; Rabbits; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan; Vitreous Body; Xenograft Model Antitumor Assays	2017
Intracameral Topotecan Hydrochloride for Anterior Chamber Seeding of Retinoblastoma. JAMA ophthalmology, 2017, 12-01, Volume: 135, Issue:12 Topics: Anterior Chamber; Female; Humans; Infant; Injections, Intraocular; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan; Ultrasonography	2017
Risk of Extraocular Extension in Eyes With Retinoblastoma Receiving Intravitreous Chemotherapy. JAMA ophthalmology, 2017, 12-01, Volume: 135, Issue:12 Topics: Antineoplastic Agents; Child, Preschool; Cryotherapy; Female; Humans; Infant; Intravitreal Injections; Male; Melphalan; Methotrexate; Microscopy, Acoustic; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Risk Factors; Topotecan	2017
Successful conservative treatment of massive choroidal relapse in 2 retinoblastoma patients monitored by ultrasound biomicroscopy and/or spectral domain optic coherence tomography. Ophthalmic genetics, 2018, Volume: 39, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Choroid Neoplasms; Conservative Treatment; Fatal Outcome; Female; Fluorescein Angiography; Humans; Infant; Infusions, Intra-Arterial; Magnetic Resonance Imaging; Melphalan; Microscopy, Acoustic; Neoplasm Recurrence, Local; Retinal Neoplasms; Retinoblastoma; Tomography, Optical Coherence; Topotecan	2018
Anterior Chamber Chemotherapy in Retinoblastoma-Necessary But Not Sufficient for Aqueous Seeding Control-Reply. JAMA ophthalmology, 2018, 05-01, Volume: 136, Issue:5 Topics: Anterior Chamber; Humans; Retinal Neoplasms; Retinoblastoma; Topotecan	2018
Anterior Chamber Chemotherapy in Retinoblastoma-Necessary but Not Sufficient for Aqueous Seeding Control. JAMA ophthalmology, 2018, 05-01, Volume: 136, Issue:5 Topics: Anterior Chamber; Humans; Retinal Neoplasms; Retinoblastoma; Topotecan	2018
Feasibility and results of an intraarterial chemotherapy program for the conservative treatment of retinoblastoma in Argentina. Pediatric blood & cancer, 2018, Volume: 65, Issue:8 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Argentina; Carboplatin; Child; Child, Preschool; Conservative Treatment; Disease-Free Survival; Feasibility Studies; Female; Humans; Infusions, Intra-Arterial; Male; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Young Adult	2018
Total retinal detachments due to retinoblastoma: Outcomes following intra-arterial chemotherapy/ophthalmic artery chemosurgery. PloS one, 2018, Volume: 13, Issue:4 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child, Preschool; Electroretinography; Female; Follow-Up Studies; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Ophthalmic Artery; Retina; Retinal Detachment; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Survival Analysis; Topotecan; Treatment Outcome	2018
Eye salvage in diffuse anterior retinoblastoma using systemic chemotherapy with periocular and intravitreal topotecan. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2018, Volume: 22, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Carboplatin; Etoposide; Gonioscopy; Humans; Infant; Infusions, Intravenous; Intravitreal Injections; Male; Microscopy, Acoustic; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Salvage Therapy; Topoisomerase I Inhibitors; Topotecan; Vincristine	2018
Ophthalmic Vascular Events after Primary Unilateral Intra-arterial Chemotherapy for Retinoblastoma in Early and Recent Eras. Ophthalmology, 2018, Volume: 125, Issue:11 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Female; Fluorescein Angiography; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Ophthalmoscopy; Retinal Diseases; Retinal Neoplasms; Retinal Vessels; Retinoblastoma; Retrospective Studies; Risk Factors; Topotecan; Ultrasonography; Young Adult	2018
Folic acid-conjugated mesoporous silica nanoparticles for enhanced therapeutic efficacy of topotecan in retina cancers. International journal of nanomedicine, 2018, Volume: 13 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Shape; Endocytosis; Folic Acid; Humans; Nanoparticles; Porosity; Retinal Neoplasms; Silicon Dioxide; Topotecan; Treatment Outcome	2018
Combined high-dose intra-arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma. Pediatric blood & cancer, 2018, Volume: 65, Issue:12 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nervous System Neoplasms; Child, Preschool; Humans; Infusions, Intra-Arterial; Injections, Spinal; Male; Melphalan; Retinal Neoplasms; Retinoblastoma; Topotecan	2018
OPHTHALMIC VASCULAR EVENTS AFTER INTRA-ARTERIAL CHEMOTHERAPY FOR RETINOBLASTOMA: Real-World Comparison Between Primary and Secondary Treatments. Retina (Philadelphia, Pa.), 2019, Volume: 39, Issue:12 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Choroid; Female; Fluorescein Angiography; Humans; Infant; Infant, Newborn; Infusions, Intra-Arterial; Male; Melphalan; Ophthalmic Artery; Retinal Diseases; Retinal Neoplasms; Retinal Vessels; Retinoblastoma; Retrospective Studies; Topotecan; Young Adult	2019
INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR FOR THE MANAGEMENT OF NEOVASCULARIZATION IN RETINOBLASTOMA AFTER INTRAVENOUS AND/OR INTRAARTERIAL CHEMOTHERAPY: Long-Term Outcomes in a Series of 35 Eyes. Retina (Philadelphia, Pa.), 2019, Volume: 39, Issue:12 Topics: Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Fluorescein Angiography; Humans; Infant; Infusions, Intra-Arterial; Infusions, Intravenous; Intravitreal Injections; Male; Melphalan; Microscopy, Acoustic; Ranibizumab; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Retinal Neoplasms; Retinal Neovascularization; Retinoblastoma; Retrospective Studies; Topotecan; Vascular Endothelial Growth Factor A	2019
Intra-arterial chemotherapy for unilateral advanced intraocular retinoblastoma: Results and short-term complications. Medicine, 2018, Volume: 97, Issue:42 Topics: Antineoplastic Agents; Child, Preschool; Eye; Female; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Meningeal Arteries; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Treatment Outcome	2018
A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma. Scientific reports, 2018, 10-23, Volume: 8, Issue:1 Topics: Antineoplastic Agents; Carcinogenesis; Child, Preschool; DNA Copy Number Variations; Gene Expression Regulation, Neoplastic; Humans; Infant; Melphalan; Models, Biological; Neoplasm Staging; Organoids; Retinal Neoplasms; Retinoblastoma; Topotecan	2018
Commentary: Periocular topotecan for retinoblastoma. Indian journal of ophthalmology, 2018, Volume: 66, Issue:12 Topics: Humans; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan	2018
Periocular topotecan for vitreous seeds in retinoblastoma. Indian journal of ophthalmology, 2018, Volume: 66, Issue:12 Topics: Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Injections, Intraocular; Male; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Visual Acuity; Vitreous Body	2018
Association of electroretinography with visual outcomes after ophthalmic artery chemosurgery for retinoblastoma in ICRb D and E eyes. PloS one, 2019, Volume: 14, Issue:1 Topics: Carboplatin; Case-Control Studies; Child; Child, Preschool; Electroretinography; Female; Humans; Infant; Infant, Newborn; Male; Melphalan; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Visual Acuity	2019
Exudative Retinal Detachment Following Intravitreal Chemotherapeutic Treatment for Retinoblastoma. Ophthalmic surgery, lasers & imaging retina, 2019, 04-01, Volume: 50, Issue:4 Topics: Antineoplastic Agents, Alkylating; Child, Preschool; Drug Therapy, Combination; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Humans; Injections, Intraocular; Intravitreal Injections; Macula Lutea; Male; Melphalan; Retinal Detachment; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan; Triamcinolone Acetonide; Ultrasonography	2019
Heterochromia following intravitreal chemotherapy in two cases. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2019, Volume: 23, Issue:4 Topics: Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Infant; Intravitreal Injections; Iris Diseases; Melphalan; Pigmentation Disorders; Retinal Neoplasms; Retinoblastoma; Tomography, Optical Coherence; Topotecan	2019
Beyond retinocytomas: clinical benefit of topotecan in the management of other intra-cranial tumors especially glioblastomas. Chinese medical journal, 2013, Volume: 126, Issue:9 Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Female; Humans; Inhibitor of Apoptosis Proteins; Male; Neoplasm Proteins; PTEN Phosphohydrolase; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan	2013
No ocular motility complications after subtenon topotecan with fibrin sealant for retinoblastoma. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2013, Volume: 48, Issue:6 Topics: Child, Preschool; Combined Modality Therapy; Cross-Sectional Studies; Eye Enucleation; Eye Movement Measurements; Eye Movements; Fibrin Tissue Adhesive; Follow-Up Studies; Humans; Infant; Infant, Newborn; Injections; Ocular Motility Disorders; Postoperative Complications; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Tenon Capsule; Tissue Adhesives; Topoisomerase I Inhibitors; Topotecan; Treatment Failure	2013
Clinical pharmacokinetics of intra-arterial melphalan and topotecan combination in patients with retinoblastoma. Ophthalmology, 2014, Volume: 121, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Ophthalmic Artery; Prospective Studies; Retinal Neoplasms; Retinoblastoma; Topotecan	2014
Electroretinogram monitoring of dose-dependent toxicity after ophthalmic artery chemosurgery in retinoblastoma eyes: six year review. PloS one, 2014, Volume: 9, Issue:1 Topics: Carboplatin; Electroretinography; Humans; Melphalan; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Topotecan; Treatment Outcome	2014
Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma. Ophthalmology, 2014, Volume: 121, Issue:7 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Female; Fluorescein Angiography; Follow-Up Studies; Humans; Infant; Infusions, Intra-Arterial; International Classification of Diseases; Male; Melphalan; Microscopy, Acoustic; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Treatment Outcome; Young Adult	2014
Combined intravitreal melphalan and topotecan for refractory or recurrent vitreous seeding from retinoblastoma. JAMA ophthalmology, 2014, Volume: 132, Issue:8 Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Female; Humans; Infant; Intravitreal Injections; Male; Melphalan; Neoplasm Seeding; Recurrence; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Vitreous Body	2014
Choroidal thickness after intraarterial chemotherapy for retinoblastoma. Retina (Philadelphia, Pa.), 2014, Volume: 34, Issue:10 Topics: Antineoplastic Combined Chemotherapy Protocols; Atrophy; Case-Control Studies; Child; Child, Preschool; Choroid; Female; Fluorescein Angiography; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Organ Size; Retinal Neoplasms; Retinoblastoma; Tomography, Optical Coherence; Topotecan	2014
Is combination therapy for resistant vitreous seeds really essential? JAMA ophthalmology, 2015, Volume: 133, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Melphalan; Neoplasm Seeding; Retinal Neoplasms; Topotecan; Vitreous Body	2015
Is combination therapy for resistant vitreous seeds really essential? - reply. JAMA ophthalmology, 2015, Volume: 133, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Melphalan; Neoplasm Seeding; Retinal Neoplasms; Topotecan; Vitreous Body	2015
Enophthalmos and choroidal atrophy after intraophthalmic artery chemotherapy for retinoblastoma. Ophthalmology, 2015, Volume: 122, Issue:2 Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Atrophy; Chemotherapy, Cancer, Regional Perfusion; Choroid; Choroid Diseases; Combined Modality Therapy; Diseases in Twins; Enophthalmos; Female; Fluorescein Angiography; Humans; Infant; Laser Coagulation; Magnetic Resonance Imaging; Melphalan; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Scleritis; Topoisomerase I Inhibitors; Topotecan; Twins, Monozygotic	2015
Using cost-effective intra-arterial chemotherapy to treat retinoblastoma in Chile. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2014, Volume: 18, Issue:6 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chile; Cost-Benefit Analysis; Developing Countries; Drug Costs; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Retinal Neoplasms; Retinoblastoma; Topotecan	2014
Intravitreal chemotherapy provides control for massive vitreous seeding from retinoblastoma. Journal of pediatric ophthalmology and strabismus, 2014, Dec-12, Volume: 51 Online Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Eye Neoplasms; Female; Humans; Intravitreal Injections; Melphalan; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Topotecan; Vitreous Body	2014
Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2015, Volume: 19, Issue:1 Topics: Anti-Allergic Agents; Antineoplastic Agents; Child, Preschool; Conjunctival Diseases; Diphenhydramine; Drug Carriers; Drug Hypersensitivity; Edema; Eye Enucleation; Eyelid Diseases; Female; Fibrin Tissue Adhesive; Humans; Male; Retinal Neoplasms; Retinoblastoma; Tenon Capsule; Topoisomerase I Inhibitors; Topotecan; Urticaria	2015
Spectral Domain Optical Coherence Tomography Reveals Hidden Fovea Beneath Extensive Vitreous Seeding From Retinoblastoma. Retina (Philadelphia, Pa.), 2015, Volume: 35, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Eye Neoplasms; Female; Fovea Centralis; Humans; Infusions, Intra-Arterial; Intravitreal Injections; Melphalan; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Tomography, Optical Coherence; Topotecan; Vitreous Body	2015
Rescue intra-arterial chemotherapy following retinoblastoma recurrence after initial intra-arterial chemotherapy. Journal francais d'ophtalmologie, 2015, Volume: 38, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child, Preschool; Eye Enucleation; Female; Follow-Up Studies; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Neoplasm Recurrence, Local; Retinal Neoplasms; Retinoblastoma; Retinoscopy; Retreatment; Salvage Therapy; Topotecan; Treatment Failure; Treatment Outcome	2015
Intra-arterial chemotherapy for retinoblastoma: First Indian report. Indian journal of ophthalmology, 2015, Volume: 63, Issue:4 Topics: Antineoplastic Agents; Carboplatin; Child, Preschool; Dose-Response Relationship, Drug; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Humans; Incidence; India; Infant; Injections, Intra-Arterial; Male; Melphalan; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Time Factors; Topoisomerase I Inhibitors; Topotecan	2015
Identification of Intraorbital Arteries in Pediatric Age by High Resolution Superselective Angiography. Orbit (Amsterdam, Netherlands), 2015, Volume: 34, Issue:5 Topics: Angiography, Digital Subtraction; Antineoplastic Combined Chemotherapy Protocols; Carotid Artery, Internal; Child, Preschool; Humans; Infusions, Intra-Arterial; Melphalan; Ophthalmic Artery; Orbit; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan	2015
Alternated intra-arterial and intravitreal chemotherapy for advanced intraocular retinoblastoma: preliminary successful results without systemic chemotherapy. International ophthalmology, 2015, Volume: 35, Issue:6 Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Female; Humans; Infant; Injections, Intra-Arterial; Intravitreal Injections; Male; Melphalan; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan	2015
Selective Ophthalmic Artery Infusion Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience. Journal of pediatric hematology/oncology, 2016, Volume: 38, Issue:1 Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan	2016
INTRAVITREOUS CHEMOTHERAPY FOR ACTIVE VITREOUS SEEDING FROM RETINOBLASTOMA: Outcomes After 192 Consecutive Injections. The 2015 Howard Naquin Lecture. Retina (Philadelphia, Pa.), 2016, Volume: 36, Issue:6 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Eye Neoplasms; Female; Follow-Up Studies; Humans; Infant; Intravitreal Injections; Male; Melphalan; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Vitreous Body	2016
Chemoreduction of Progressive Intraocular Retinoblastoma by Systemic Topotecan. Ophthalmic genetics, 2016, Volume: 37, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Child, Preschool; Eye Enucleation; Female; Follow-Up Studies; Humans; Infant; Male; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Salvage Therapy; Topoisomerase I Inhibitors; Topotecan	2016
Simultaneous Bilateral Ophthalmic Artery Chemosurgery for Bilateral Retinoblastoma (Tandem Therapy). PloS one, 2016, Volume: 11, Issue:6 Topics: Carboplatin; Child; Child, Preschool; Electroretinography; Female; Humans; Kaplan-Meier Estimate; Male; Melphalan; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan	2016
Secondary and tertiary intra-arterial chemotherapy for massive persistent or recurrent subretinal retinoblastoma seeds following previous chemotherapy exposure: long-term tumor control and globe salvage in 30 eyes. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2016, Volume: 20, Issue:4 Topics: Antineoplastic Agents; Carboplatin; Child, Preschool; Female; Humans; Infant; Male; Melphalan; Neoplasm Recurrence, Local; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan	2016
Retinoblastoma Control With Primary Intra-arterial Chemotherapy: Outcomes Before and During the Intravitreal Chemotherapy Era. Journal of pediatric ophthalmology and strabismus, 2016, Sep-01, Volume: 53, Issue:5 Topics: Antineoplastic Agents, Alkylating; Child; Child, Preschool; Eye Enucleation; Female; Humans; Infant; Infusions, Intra-Arterial; Intravitreal Injections; Male; Melphalan; Neoplasm Seeding; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topoisomerase I Inhibitors; Topotecan	2016
Intra-arterial Chemotherapy for Adult Onset Retinoblastoma in a 32-Year-Old Man. Journal of pediatric ophthalmology and strabismus, 2016, Jul-30, Volume: 53 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Combined Modality Therapy; Humans; Infusions, Intra-Arterial; Male; Melphalan; Neoplasm Recurrence, Local; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Topotecan; Ultrasonography; Visual Acuity; Vitreous Body	2016
Efficacy and Toxicity of Intravitreous Chemotherapy for Retinoblastoma: Four-Year Experience. Ophthalmology, 2017, Volume: 124, Issue:4 Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cohort Studies; Disease-Free Survival; Electroretinography; Female; Humans; Infant; Injections, Intraocular; Intravitreal Injections; Male; Melphalan; Neoplasm Seeding; Ophthalmic Artery; Ophthalmoscopy; Retina; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Vitreous Body	2017
Intraocular Pressure Changes Following Intravitreal Melphalan and Topotecan for the Treatment of Retinoblastoma With Vitreous Seeding. Journal of pediatric ophthalmology and strabismus, 2017, May-01, Volume: 54, Issue:3 Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Intraocular Pressure; Intravitreal Injections; Male; Melphalan; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Vitreous Body; Young Adult	2017
Diagnosis and management of secondary epipapillary retinoblastoma. The British journal of ophthalmology, 2017, Volume: 101, Issue:10 Topics: Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Carboplatin; Child, Preschool; Cryotherapy; Female; Humans; Hyperthermia, Induced; Infant; Infusions, Intra-Arterial; Male; Melphalan; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Tomography, Optical Coherence; Topotecan	2017
White orbital mass after enucleation for retinoblastoma: The power of illusion. Ophthalmic genetics, 2017, Volume: 38, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Catgut; Eye Enucleation; Fluorescein Angiography; Foreign-Body Reaction; Granuloma, Foreign-Body; Humans; Infant; Intravitreal Injections; Magnetic Resonance Imaging; Male; Melphalan; Neoplasm Staging; Orbital Diseases; Orbital Implants; Retinal Neoplasms; Retinoblastoma; Suture Techniques; Topotecan	2017
Trilateral retinoblastoma with pituitary-hypothalamic dysfunction. Ophthalmic genetics, 2008, Volume: 29, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cytarabine; Etoposide; Fatal Outcome; Female; Gestational Age; Humans; Hypothalamic Diseases; Infant; Infusions, Parenteral; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Pituitary Neoplasms; Retinal Neoplasms; Retinoblastoma; Retinoblastoma Protein; Tomography, X-Ray Computed; Topotecan; Vincristine	2008
Differential microRNA-34a expression and tumor suppressor function in retinoblastoma cells. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:10 Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspases; Cell Survival; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; MicroRNAs; Piperazines; Retinal Neoplasms; Retinoblastoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Topotecan; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2009
Bilateral superselective ophthalmic artery chemotherapy for bilateral retinoblastoma: tandem therapy. Archives of ophthalmology (Chicago, Ill. : 1960), 2010, Volume: 128, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Catheters, Indwelling; Electroretinography; Evoked Potentials, Visual; Female; Follow-Up Studies; Functional Laterality; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Ophthalmic Artery; Retina; Retinal Neoplasms; Retinoblastoma; Topotecan; Treatment Outcome	2010
Pharmacokinetic analysis of topotecan after intra-vitreal injection. Implications for retinoblastoma treatment. Experimental eye research, 2010, Volume: 91, Issue:1 Topics: Animals; Antineoplastic Agents; Aqueous Humor; Biological Availability; Chromatography, High Pressure Liquid; Injections; Rabbits; Retinal Neoplasms; Retinoblastoma; Topotecan; Vitreous Body	2010
Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma. Cancer, 2011, Jan-15, Volume: 117, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cell Line, Tumor; Conjunctiva; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Rats; Retinal Neoplasms; Retinoblastoma; Topotecan; Visual Acuity; Xenograft Model Antitumor Assays	2011
Multifaceted chemotherapy for trilateral retinoblastoma. Archives of ophthalmology (Chicago, Ill. : 1960), 2011, Volume: 129, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Cyclosporine; Cytarabine; Etoposide; Fatal Outcome; Female; Humans; Infant; Magnetic Resonance Imaging; Male; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Pineal Gland; Retinal Neoplasms; Retinoblastoma; Tomography, X-Ray Computed; Topotecan; Vincristine	2011
Periocular topotecan for intraocular retinoblastoma. Archives of ophthalmology (Chicago, Ill. : 1960), 2011, Volume: 129, Issue:6 Topics: Child, Preschool; Follow-Up Studies; Humans; Infant; Infant, Newborn; Injections; Orbit; Retina; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome	2011
Success of intra-arterial chemotherapy (chemosurgery) for retinoblastoma: effect of orbitovascular anatomy. Archives of ophthalmology (Chicago, Ill. : 1960), 2012, Volume: 130, Issue:2 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Blood Flow Velocity; Carboplatin; Child; Child, Preschool; Female; Fluorescein Angiography; Humans; Infant; Infusions, Intra-Arterial; Male; Melphalan; Ophthalmic Artery; Orbit; Regional Blood Flow; Retinal Neoplasms; Retinoblastoma; Topotecan; Young Adult	2012
Ophthalmic artery chemosurgery for less advanced intraocular retinoblastoma: five year review. PloS one, 2012, Volume: 7, Issue:4 Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Disease-Free Survival; Eye; Follow-Up Studies; Humans; Infant; Melphalan; Ophthalmic Artery; Ophthalmologic Surgical Procedures; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topotecan; Young Adult	2012
Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: alternative retinoblastoma treatment. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2012, Volume: 156, Issue:4 Topics: Animals; Rabbits; Retina; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan; Vitreous Body	2012
Three-drug intra-arterial chemotherapy using simultaneous carboplatin, topotecan and melphalan for intraocular retinoblastoma: preliminary results. The British journal of ophthalmology, 2012, Volume: 96, Issue:10 Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Infusions, Intra-Arterial; Male; Melphalan; Middle Aged; Pilot Projects; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Young Adult	2012
Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for relapsed retinoblastoma. Pediatric blood & cancer, 2013, Volume: 60, Issue:5 Topics: Administration, Intravenous; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Humans; Injections, Intra-Arterial; Injections, Intraocular; Male; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Ophthalmic Artery; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Salvage Therapy; Topotecan; Treatment Outcome; Vincristine; Young Adult	2013
Effect of topotecan on retinocytoma cell apoptosis and expression of Livin and PTEN. Chinese medical journal, 2013, Volume: 126, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Cell Line, Tumor; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Inhibitor of Apoptosis Proteins; Male; Neoplasm Proteins; PTEN Phosphohydrolase; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan	2013
Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma. Experimental eye research, 2013, Volume: 108 Topics: Animals; Drug Administration Schedule; Electroretinography; Intravitreal Injections; Models, Biological; Nonlinear Dynamics; Ophthalmoscopy; Rabbits; Retina; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan; Vitreous Body	2013
Activity of topotecan in retinoblastoma. Ophthalmic genetics, 2004, Volume: 25, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Retinal Neoplasms; Retinoblastoma; Tomography, X-Ray Computed; Topoisomerase I Inhibitors; Topotecan	2004
Topotecan combination chemotherapy in two new rodent models of retinoblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Oct-15, Volume: 11, Issue:20 Topics: Animals; Animals, Newborn; Antineoplastic Agents; Apoptosis; Carboplatin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Etoposide; Eye; Humans; Mice; Mice, Knockout; Rats; Retinal Neoplasms; Retinoblastoma; Time Factors; Topotecan; Vincristine; Xenograft Model Antitumor Assays	2005
Topotecan vitreous levels after periocular or intravenous delivery in rabbits: an alternative for retinoblastoma chemotherapy. Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:8 Topics: Animals; Antineoplastic Agents; Blood-Retinal Barrier; Infusions, Intravenous; Injections; Models, Biological; Rabbits; Retinal Neoplasms; Retinoblastoma; Topotecan; Vitreous Body	2007
Subconjunctival topotecan in fibrin sealant in the treatment of transgenic murine retinoblastoma. Investigative ophthalmology & visual science, 2008, Volume: 49, Issue:2 Topics: Animals; Antigens, Polyomavirus Transforming; Antineoplastic Agents; Apoptosis; Cell Cycle; Conjunctiva; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Enzyme Inhibitors; Fibrin Tissue Adhesive; Injections; Luteinizing Hormone; Mice; Mice, Transgenic; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured	2008