topotecan has been researched along with Cancer of Liver in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 5 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gan, J; Gao, Y; Guo, S; Ning, S; Sun, Y; Wang, P; Wang, X; Xiao, Y; Zhang, Y; Zhi, H; Zhou, H | 1 |
| Fu, W; Kai, GY; Li, L; Liu, XF; Liu, YQ; Peng, LZ; Xu, CR; Zhang, M; Zhang, ZJ; Zhu, LZ | 1 |
| Bai, YP; Li, L; Liu, YQ; Luo, HB; Peng, LZ; Wang, ZP; Xu, CR; Yan, JX; Yang, CJ; Zhang, M; Zhang, ZJ; Zhu, LZ | 1 |
| Chang, J; Li, YN; Liu, ZL; Yao, YM; Zhang, YT; Zhong, XD | 1 |
| Bakhutashvili, I; Banovac, F; Esparza-Trujillo, JA; Henman, A; Karanian, JW; Krishnasamy, VP; Levy, EB; Lewis, AL; Mikhail, AS; Negussie, AH; Pritchard, WF; Tang, Y; Wakim, PG; Willis, SL; Wood, BJ; Woods, DL | 1 |
| Nazha, B; Owonikoko, TK | 1 |
| Baghy, K; Bocsi, J; Dudás, J; Füle, T; Fullár, A; Kovalszky, I; Kudaibergenova, S | 1 |
| Klopfenstein, KJ; Ruymann, FB; Schuller, DE; Scott, S | 1 |
| Cao, Y; Cheng, C; He, CL; Zhang, J; Zhou, YJ | 1 |
| Bowyer, C; Forster, RE; Lewis, AL; Lloyd, AW; Macfarlane, W; Phillips, GJ; Tang, Y | 1 |
| Francia, G; Hackl, C; Kerbel, RS; Man, S; Milsom, C; Xu, P | 1 |
| Bhatt, K; Lane, S; Legenne, P; Spigel, DR; Waterhouse, DM | 1 |
| Pu, SP; Zhang, J; Zhou, YJ | 1 |
| Byun, JH; Choi, DS; Choi, SH; Kim, BS; Kim, HJ; Ko, JY; Lee, GY; Seo, YT; Yang, SH | 1 |
| Han, R; Liu, HY; Pan, XD; Sun, PY; Yang, J; Yuan, KH; Zhu, CG | 1 |
| Dethling, J; Fink, T; Hans, K; Koschel, G; Lorenz, R; Mueller, C; Schade-Brittinger, C; Schroeder, H; Seifart, U; Wolf, M | 1 |
| Chen, Z; Feng, YL; Gu, W; Li, B; Ling, CQ | 1 |
| Ardizzoni, A; Dane, G; Eckardt, JR; Papai, Z; Poulin, R; Preston, AJ; Pujol, JL; Quoix, E; Ross, G; von Pawel, J | 1 |
| Kono, A; Kumazawa, E; Shimazoe, T; Takiguchi, S; Tohgo, A | 1 |
| Benedetti, JK; Macdonald, JS; Natale, RB; O'Rourke, MA; Wall, JG | 1 |
| Burris, H; Fields, S; Gerrits, CJ; Hudson, I; Loos, WJ; Planting, AS; Rodriguez, GI; Schellens, JH; van Beurden, V; van den Burg, ME; Verweij, J; von Hoff, DD | 1 |
| Bally, M; Choice, E; Madden, TD; Masin, D; Redelmeier, T; Tardi, P | 1 |
| Cesano, A; Fields, SZ; Lane, SR; Ross, GA | 1 |
| Fuchs, J; Gratz, KF; Mildenberger, H; von Schweinitz, D; Warmann, SW; Wilkens, L | 1 |
| Alexandre, J; Azoulay, D; Goldwasser, F; Gornet, JM; Gross-Goupil, M; Misset, JL; Romain, D; Tigaud, JM | 1 |
1 review(s) available for topotecan and Cancer of Liver
| Article | Year |
|---|---|
Stabilization of disease as an indicator of clinical benefit associated with chemotherapy in non-small cell lung cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Clinical Trials, Phase II as Topic; Databases, Factual; Disease Progression; Female; Humans; Injections, Intravenous; Karnofsky Performance Status; Life Tables; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Multicenter Studies as Topic; Neoplasm Staging; Proportional Hazards Models; Remission Induction; Retrospective Studies; Risk; Survival Analysis; Topotecan; Treatment Outcome | 2000 |
8 trial(s) available for topotecan and Cancer of Liver
| Article | Year |
|---|---|
Efficacy and safety of oral topotecan and bevacizumab combination as second-line treatment for relapsed small-cell lung cancer: an open-label multicenter single-arm phase II study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Female; Follow-Up Studies; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Salvage Therapy; Small Cell Lung Carcinoma; Survival Rate; Topotecan | 2013 |
Phase II study to topotecan and cisplatin in advanced hepatocellular carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Humans; Liver Neoplasms; Male; Middle Aged; Topotecan; Treatment Outcome | 2003 |
Randomised phase II study comparing topotecan/carboplatin administration for 5 versus 3 days in the treatment of extensive-stage small-cell lung cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carcinoma, Small Cell; Central Nervous System Neoplasms; Cisplatin; Female; Humans; Infusions, Intravenous; Liver Neoplasms; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Survival Rate; Time Factors; Topotecan; Treatment Outcome | 2007 |
[Ginsenosides and dexamethasone in managing the liver injury and renal function after transcatheter arterial chemoembolization for hepatic carcinoma patient].
Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Blood Urea Nitrogen; Chemoembolization, Therapeutic; Creatinine; Dexamethasone; Drug Therapy, Combination; Epirubicin; Female; Fluorouracil; Ginsenosides; Glucocorticoids; Humans; Iodized Oil; Kidney; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Topotecan | 2006 |
Phase III study of oral compared with intravenous topotecan as second-line therapy in small-cell lung cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Small Cell; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Salvage Therapy; Survival Rate; Topotecan | 2007 |
Phase II trial to topotecan in hepatocellular carcinoma: a Southwest Oncology Group study.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Antineoplastic Agents; Carcinoma, Hepatocellular; Enzyme Inhibitors; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neutropenia; Thrombocytopenia; Topoisomerase I Inhibitors; Topotecan | 1997 |
Five days of oral topotecan (Hycamtin), a phase I and pharmacological study in adult patients with solid tumours.
Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colorectal Neoplasms; Fatigue; Female; Hematologic Diseases; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Ovarian Neoplasms; Topotecan; Treatment Outcome | 1998 |
Combination of topotecan and oxaliplatin in inoperable hepatocellular cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Topotecan | 2002 |
16 other study(ies) available for topotecan and Cancer of Liver
| Article | Year |
|---|---|
PD-L1-Mediated Immunosuppression in Hepatocellular Carcinoma: Relationship with Macrophages Infiltration and Inflammatory Response Activity.
Topics: B7-H1 Antigen; Carcinoma, Hepatocellular; Cytokines; Dasatinib; Humans; Immunosuppression Therapy; Inflammation; Liver Neoplasms; Macrophages; Programmed Cell Death 1 Receptor; Topotecan; Tumor Microenvironment; Vemurafenib | 2022 |
Anti-tumor effects and mechanism of a novel camptothecin derivative YCJ100.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Topoisomerases, Type I; Female; Humans; Liver Neoplasms; Mice; Molecular Docking Simulation; Pancreatic Neoplasms; Topoisomerase I Inhibitors; Topotecan; Xenograft Model Antitumor Assays | 2022 |
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; DNA Topoisomerases, Type I; Humans; Liver Neoplasms; Mice; Topoisomerase I Inhibitors; Topotecan | 2023 |
Novel treatment of refractory / recurrent pulmonary hepatoblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Disease-Free Survival; Female; Hepatoblastoma; Humans; Liver Neoplasms; Lung Neoplasms; Male; Neoplasm Recurrence, Local; Oxaliplatin; Radiofrequency Ablation; Retrospective Studies; Survival Rate; Topotecan; Treatment Outcome; Vincristine | 2020 |
Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model.
Topics: Animals; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Humans; Irinotecan; Liver Neoplasms; Liver Neoplasms, Experimental; Microspheres; Rabbits; Topoisomerase I Inhibitors; Topotecan | 2020 |
The clinical conundrum of managing relapsed small cell lung cancer.
Topics: Anthracyclines; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepinones; Carboplatin; Clinical Decision-Making; Disease Progression; Etoposide; Humans; Immunoconjugates; Irinotecan; Liver Neoplasms; Lung Neoplasms; Molecular Targeted Therapy; Neoplasm Recurrence, Local; Nivolumab; Paclitaxel; Piperazines; Pyrimidines; Salvage Therapy; Small Cell Lung Carcinoma; Temozolomide; Thiourea; Topotecan | 2019 |
Heparin and liver heparan sulfate can rescue hepatoma cells from topotecan action.
Topics: Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; DNA Topoisomerases, Type I; DNA, Neoplasm; Hep G2 Cells; Heparin; Heparitin Sulfate; Humans; Liver; Liver Neoplasms; Topotecan | 2014 |
Prolonged survival with continuous infusion topotecan: a report of 2 cases.
Topics: Adolescent; Antineoplastic Agents; Carcinoma, Hepatocellular; Child; Child, Preschool; Female; Head and Neck Neoplasms; Histiocytoma, Malignant Fibrous; Humans; Infusions, Intravenous; Liver Neoplasms; Neoplasms, Second Primary; Palliative Care; Survival; Topotecan | 2008 |
The expression of Bcl-XL, Bcl-XS and p27Kip1 in topotecan-induced apoptosis in hepatoblastoma HepG2 cell line.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Cell Cycle; Cell Line; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p27; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Hepatoblastoma; Humans; Immunohistochemistry; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Microscopy, Electron, Transmission; RNA Interference; Signal Transduction; Time Factors; Topoisomerase I Inhibitors; Topotecan; Transfection | 2008 |
Development of a combination drug-eluting bead: towards enhanced efficacy for locoregional tumour therapies.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Doxorubicin; Humans; Irinotecan; Liver Neoplasms; Mice; Mice, Nude; Pancreatic Neoplasms; Prostheses and Implants; Sirolimus; Topotecan; Xenograft Model Antitumor Assays | 2012 |
Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models.
Topics: Administration, Metronomic; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease Models, Animal; Female; Fluorouracil; HT29 Cells; Humans; Immunohistochemistry; Injections; Leucovorin; Liver Neoplasms; Mice; Mice, SCID; Organoplatinum Compounds; Survival Rate; Topotecan | 2013 |
[Preliminary study of apoptosis of human hepatocarcinoma cell line HepG2 induced by topotecan].
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Topotecan; Tumor Cells, Cultured | 2002 |
[Synthesis and antitumor activity of 20-O-linked camptothecin ester derivatives].
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Esters; Female; Humans; Inhibitory Concentration 50; Liver Neoplasms; Mice; Mice, Inbred ICR; Molecular Structure; Neoplasm Transplantation; Topotecan; Tumor Burden; Xenograft Model Antitumor Assays | 2004 |
Antitumor effect of DX-8951, a novel camptothecin analog, on human pancreatic tumor cells and their CPT-11-resistant variants cultured in vitro and xenografted into nude mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; DNA Fragmentation; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Irinotecan; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasm Proteins; Neoplasm Transplantation; Pancreatic Neoplasms; Prodrugs; Splenic Neoplasms; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured | 1997 |
Liposomal encapsulation of topotecan enhances anticancer efficacy in murine and human xenograft models.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Drug Carriers; Female; Humans; Leukemia L1210; Liposomes; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, SCID; Survival Rate; Topotecan; Transplantation, Heterologous | 2000 |
Successful therapy of subcutaneously growing human hepatoblastoma xenografts with topotecan.
Topics: alpha-Fetoproteins; Animals; Antineoplastic Agents; Cell Division; Hepatoblastoma; Humans; Immunohistochemistry; Infant, Newborn; Infusions, Parenteral; Liver Neoplasms; Mice; Mice, Nude; Necrosis; Neoplasms, Experimental; Topotecan; Transplantation, Heterologous | 2001 |