topotecan has been researched along with Brain Neoplasms in 94 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (19.15) | 18.2507 |
| 2000's | 50 (53.19) | 29.6817 |
| 2010's | 26 (27.66) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brabetz, S; Chan, JA; Herold-Mende, C; Kool, M; Korshunov, A; Mack, N; Milde, T; Pfister, SM; Schmidt, C; Schubert, NA; Schwalm, B; Selt, F; Witt, O | 1 |
| Cheon, JE; Choi, JY; Choi, YH; Hong, CR; Hong, KT; Kang, HJ; Kim, IH; Kim, SK; Lee, YJ; Park, JD; Park, KD; Park, SH; Phi, JH; Shin, HY; Wang, KC | 1 |
| Finlay, JL; Gardner, S; Liebes, LF; Tran, HC; Weiner, HL | 1 |
| Cao, B; Chen, XJ; Ge, XH; Li, ZG; Lin, Q; Liu, ML; Liu, YE; Ren, XC; Wang, DY; Wang, YQ | 1 |
| Li, Z; Liu, LB; Liu, XB; Liu, YH; Wang, P; Xue, YX; Zhang, FL | 1 |
| Cao, KI; Kirova, YM | 1 |
| Ausch, C; Bajna, E; Brenner, S; Buxhofer-Ausch, V; Hamilton, G; Jäger, W; Klameth, L; Reiner, A; Riha, J; Schölm, M; Thalhammer, T | 1 |
| Carrasco, R; Cruz, O; de Torres, C; Guillen, A; Lavarino, C; Mañé, S; Mora, J; Parareda, A; Rios, J; Salvador, H; Suñol, M; Vancells, M | 1 |
| Bruce, JN; DeLaPaz, R; Kennedy, BC; Surapaneni, K; Yanagihara, TK | 1 |
| Busse, PM; Ebb, DH; Friedmann, AM; Ladra, MM; Lucas, JT; MacDonald, SM; Marcus, KJ; Tarbell, NJ; Yock, TI | 1 |
| Birg, AV; Broniscer, A; Daryani, VM; Gajjar, AJ; Lin, T; Panetta, JC; Roberts, JK; Robinson, GW; Stewart, CF | 1 |
| Brown, J; Burzawa, JK; Byers, LA; Coleman, RL; Frumovitz, M; Munsell, MF; Ramalingam, P | 1 |
| DeAngulo, G; Heimberger, AB; Hussain, SF; Jordan, J; Koshkina, N; Sun, W; Vasquez, H; Wei, J; Weinberg, J; Wolff, J | 1 |
| Havlioglu, N; Hueser, CN; Nguyen, NC; Osman, M; Patel, AJ | 1 |
| Fietkau, R; Grabenbauer, GG; Hedde, JP; Ko, Y; Kocher, M; Muller, RP; Neuhaus, T; Schueller, H; Stier, S | 1 |
| Hann, CL; Rudin, CM | 1 |
| Bankiewicz, KS; Bringas, JR; Dugich-Djordjevic, M; Eastman, S; Grahn, AY; Hadaczek, P; Johnson, GA; Luz, M | 1 |
| Anver, MR; Bonomi, CA; Borgel, SD; Carter, JP; Gehrs, B; Hollingshead, M; Kinders, RJ; Melillo, G; Parchment, R; Raffeld, M; Rapisarda, A; Shoemaker, RH; Uranchimeg, B | 1 |
| Birkmann, J; Ganslandt, O; Gerber, KD; Grabenbauer, GG; Klautke, G; Meyer, M; Richter, A | 1 |
| Al-Kadhimi, Z; Chow, W; Doroshow, JH; Frankel, P; Leong, L; Lim, D; Mamelak, A; Margolin, K; Morgan, RJ; Shibata, S; Somlo, G; Synold, T; Twardowski, P; Yen, Y | 1 |
| Calabrese, C; Carcaboso, AM; Elmeliegy, MA; Juel, SJ; Shen, J; Stewart, CF; Tracey, L; Waters, CM; Zhang, ZM | 1 |
| Brown, JL; Fang, W; Graham, TC; Omer, C; Pien, C; Thress, K; Zage, PE; Zeng, L; Zweidler-McKay, PA | 1 |
| Allen, JC; Belasco, JB; Fisher, PG; Janss, AJ; Minturn, JE; Patti, R; Phillips, PC | 1 |
| Kumabe, T; Niizuma, H; Osawa, S; Saito, R; Sonoda, Y; Tominaga, T; Watanabe, M | 1 |
| Babyn, P; Chan, HS; Dimaras, H; Doyle, J; Gallie, BL; Halliday, W; Héon, E; Paton, KE; Strahlendorf, C | 1 |
| Assanah, MC; Bruce, JN; Canoll, P; Gil, OD; Kangarlu, A; Linskey, K; Lopez, KA; Tannenbaum, AM; Yun, J | 1 |
| Campone, M; Eierman, W; Greil, R; Kaufman, B; Lane, SR; Lin, NU; Rubin, SD; Steplewski, K; Winer, EP; Zembryki, D | 1 |
| Arias-Mendoza, F; Bagiella, E; Brown, T; Bruce, JN; Bruce, SS; Canoll, P; Dashnaw, S; Mohajed, H; Romanov, A; Sebastian, M; Sonabend, AM; Stuart, RM; Yanagihara, T; Yun, J | 1 |
| Drummond, DC; James, CD; Kirpotin, DB; Michaud, K; Noble, CO; Ozawa, T; Park, JW; Prados, MD; Serwer, LP | 1 |
| Cohn, SL; London, WB; Matthay, KK; Naranjo, A; Park, JR; Santana, VM; Scott, JR; Shaw, PJ; Stewart, CF | 1 |
| Loos, WJ; Mathijssen, RH; Verweij, J | 1 |
| Babich, JW; Boyd, M; Champion, S; Gaze, MN; Mairs, RJ; McCluskey, AG; Pimlott, SL; Tesson, M | 1 |
| Cardona, AF; Reveiz, L; Rueda, JR | 1 |
| Deppermann, M; Kaubitsch, S; Keppler, U; Korfel, A; Oehm, C; Thiel, E; von Pawel, J | 1 |
| Chiappori, A; Rocha Lima, CM | 1 |
| von Pawel, J | 1 |
| Greco, FA | 1 |
| Carsin, B; Gédouin, D; Guégan, Y; Hamlat, A; Hassel, MB; Lesimple, T; Malhaire, JP; Riffaud, L; Seigneuret, E; Simon, H | 1 |
| Berkenblit, A; Wong, ET | 1 |
| Albani, M; Bucsky, P; Emser, A; Erdlenbruch, B; Gnekow, A; Kühl, J; Längler, A; Peters, O; Völpel, S; Wagner, S; Wolff, JE | 1 |
| Fischer, L; Jahnke, K; Kirchen, H; Klasen, HA; Korfel, A; Thiel, E | 1 |
| Hiraoka, N; Nakayama, M; Ohno, S; Takumi, C; Yamada, R; Yoshikawa, T | 1 |
| Balzarotti, M; Boiardi, A; Calatozzolo, C; Ciusani, E; Croci, D; Salmaggi, A | 1 |
| Ashley, D; Chintagumpala, M; Fouladi, M; Gajjar, A; Houghton, PJ; Iacono, LC; Kellie, SJ; Kirstein, MN; Seele, LG; Stewart, CF; Wallace, D; Zamboni, WC | 1 |
| Bookman, MA; Gallo, JM; Guo, P; Li, S; Ma, J; Orlansky, A; Pulfer, S; Vicini, P; Zhou, F | 1 |
| Eich, HT; Güner, SA; Kocher, M; Müller, RP; Semrau, R | 1 |
| Cromwell, LD; Fadul, CE; Kingman, LS; McDonnell, CE; Meyer, LP; Pipas, JM; Rhodes, CH; Rigas, JR | 1 |
| Altscher, R; Brandtner, M; Chiricuta, IC; Engenhart-Cabillic, R; Gross, MW; Haeusser-Mischlich, H; Siegmann, AD | 1 |
| Barberi-Heyob, M; Chastagner, P; Marchal, C; Merlin, JL; Pinel, S; Taghian, A | 1 |
| Benecke, R; Bombor, I; Fietkau, R; Klautke, G; Piek, J; Schütze, M | 1 |
| Blaney, SM; Burger, P; Chintagumpala, MM; Friedman, HS; Holmes, E; Horowitz, ME; Kepner, J; Kun, LE; McCluggage, C; McLendon, RE; Michalski, J; Modrich, PL; Rutka, J; Stewart, CF; Thompson, S; Woo, S | 1 |
| Bankiewicz, KS; Berger, MS; Drummond, DC; Kirpotin, DB; Krauze, MT; Noble, CO; Park, JW; Saito, R | 1 |
| Bankiewicz, KS; Drummond, DC; Kawaguchi, T; Krauze, MT; Noble, CO; Park, JW; Yamashita, Y | 1 |
| Chianese, M; Cimmino, G; Laus, G; Penitente, R; Pepe, S; Prece, D; Quesada, P | 1 |
| Berthold, F; Hero, B; Klingebiel, T; Längler, A; Simon, T | 1 |
| Grohe, C; Hedde, JP; Kleinschmidt, R; Ko, YD; Lange, O; Losem, C; Metzler, U; Neuhaus, T; Schmidt-Wolf, IG; Schüller, H; Stier, S | 1 |
| Dakhil, S; Dy, GK; Geoffroy, FJ; Jett, JR; Krewer, KD; Krook, J; Kugler, J; Kutteh, L; Mailliard, J; Maurer, M; Rowland, K; Tazelaar, H; Wender, D | 1 |
| Berthold, F; Claviez, A; Frühwald, MC; Harnischmacher, U; Hero, B; Jorch, N; Längler, A; Simon, T | 1 |
| Fels, C; Hau, P; Janssen, G; Liebeskind, AK; Peters, O; Sauerbrey, A; Suttorp, M; Wagner, S; Wolff, JE | 1 |
| McClay, E; Mirmiran, A; Spear, MA | 1 |
| Batchelor, T; Betensky, R; Hochberg, F; Voloschin, AD; Wen, PY | 1 |
| Asadpour, B; Eble, MJ; Gagel, B; Pinkawa, M; Piroth, MD; Stanzel, S | 1 |
| Mazonakis, M; Petinelli, E; Stratakis, J; Varveris, H | 1 |
| Weller, M | 1 |
| Carden, CP; O'Brien, ME | 1 |
| Feun, L; Savaraj, N | 1 |
| Cheshire, PJ; Danks, MK; Friedman, HS; Hallman, JD; Houghton, JA; Houghton, PJ; Lutz, L | 1 |
| Balis, FM; Blaney, SM; Cole, DE; Dedrick, RL; Sung, C | 1 |
| Baker, SD; Crom, WR; Gajjar, A; Heideman, RL; Kuttesch, JF; Stewart, CF | 1 |
| Capranico, G; Caserini, C; Colombo, A; Marchesini, R; Perego, P; Supino, R; Tronconi, M; Zunino, F | 1 |
| Adamson, PC; Allen, JC; Balis, FM; Berg, SL; Blaney, SM; Heideman, RL; Horowitz, ME; Jakacki, RI; Lange, BJ; Packer, RJ; Phillips, PC; Poplack, DG; Reaman, GH; Sallan, SE | 1 |
| Cairncross, G; Eisenhauer, E; Forsyth, P; Macdonald, D; Sawka, C; Stewart, D; Wainman, N | 1 |
| Friedman, HS; Houghton, PJ | 1 |
| Heuser, A; Sauer, R | 1 |
| Ardizzoni, A; Dombernowsky, P; Gamucci, T; Giaccone, G; Hansen, H; Kaplan, S; Postmus, P; Schaefer, B; Verweij, J; Wanders, J | 1 |
| Cnaan, A; Janss, AJ; Levow, C; Phillips, PC; Shpilsky, A; Sutton, L; Zhao, H | 1 |
| Danks, MK; Pawlik, CA; Whipple, DO; Wolverton, JS | 1 |
| Barone, TA; Ciesielski, MJ; Fenstermaker, RA; Greenberg, SJ; Lis, A; Plunkett, RJ; Pollina, J | 1 |
| Arbuck, S; Cokgor, I; Fields, S; Friedman, AH; Friedman, HS; Graden, D; Houghton, PJ; Kerby, T; McLendon, RE; Zilisch, JE | 1 |
| Loos, WJ; Schellens, JH; Straathof, CS; van den Bent, MJ; Vecht, CJ | 1 |
| Kaubitzsch, S; Lan, J; Manegold, C; Schäfer, B; Schütte, W; Staab, HJ; von Pawel, JV | 1 |
| Buchfelder, M; Fahlbusch, R; Grabenbauer, GG; Sauer, R; Schrell, U; Staab, HJ | 1 |
| Bartussek, C; Naumann, U; Weller, M | 1 |
| Cheshire, PJ; de Graaf, SS; George, EO; Houghton, PJ; Ma, M; Poquette, CA; Richmond, LB; Stewart, CF; Thompson, J | 1 |
| Dichgans, J; Esser, P; Meyermann, R; Rieger, J; Rieger, L; Streffer, J; Weller, M; Winter, S | 1 |
| Prados, MD | 1 |
| Bruce, JN; Chakrabarti, I; Chi, JH; Hall, JS; Hurley, PT; Kaiser, MG; Parsa, AT | 1 |
| Bruce, JN; Chakrabarti, I; Fine, RL; Hall, JS; Kaiser, MG; Parsa, AT | 1 |
| Ashley, D; Benaim, E; Bowman, L; Gajjar, A; Heideman, R; Jones-Wallace, D; Kellie, SJ; Krance, R; Patel, A; Strother, D; Thompson, S | 1 |
| Deertz, H; Hilfrich, J; Kieback, DG; Mesrogli, M; Oberhoff, C; Schindler, AE; Sehouli, J; Staab, HJ; van Soest, C; von Minckwitz, G; Würstlein, R | 1 |
| Boulad, F; Calleja, E; Cheung, NK; Dunkel, IJ; Kramer, K; Kushner, BH | 1 |
| Altscher, R; Brandtner, M; Engenhart-Cabillic, R; Gross, MW; Häusser-Mischlich, H; Kiricuta, IC; Siegmann, AD | 1 |
| Fietkau, R; Grüschow, K; Klautke, G | 1 |
| Bando, H; Sano, T; Ueda, H | 1 |
9 review(s) available for topotecan and Brain Neoplasms
| Article | Year |
|---|---|
[Radiotherapy plus concomitant systemic therapies for patients with brain metastases from breast cancer].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials, Phase II as Topic; Dacarbazine; Deoxycytidine; Female; Fluorouracil; Humans; Lapatinib; Protein Kinase Inhibitors; Quinazolines; Radiotherapy, Adjuvant; Receptor, ErbB-2; Temozolomide; Thalidomide; Topoisomerase I Inhibitors; Topotecan; Trastuzumab; Vinblastine; Vinorelbine | 2014 |
Management of small-cell lung cancer: incremental changes but hope for the future.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials, Phase II as Topic; Cranial Irradiation; Dose Fractionation, Radiation; Etoposide; Humans; Lung Neoplasms; Neoplasm Staging; Practice Guidelines as Topic; Prognosis; Radiotherapy, Adjuvant; Radiotherapy, High-Energy; Randomized Controlled Trials as Topic; Small Cell Lung Carcinoma; Survival Analysis; Topotecan; Treatment Outcome | 2008 |
Chemotherapy for brain metastases from small cell lung cancer.
Topics: Antineoplastic Agents; Brain Neoplasms; Cisplatin; Cranial Irradiation; Humans; Lung Neoplasms; Randomized Controlled Trials as Topic; Small Cell Lung Carcinoma; Teniposide; Topotecan | 2012 |
Treatment of relapsed small-cell lung cancer--a focus on the evolving role of topotecan.
Topics: Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Carcinoma, Small Cell; Humans; Lung Neoplasms; Neoplasm Recurrence, Local; Prognosis; Quality of Life; Survival Analysis; Topotecan | 2003 |
The role of topotecan in the treatment of brain metastases.
Topics: Aged; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Radiotherapy, Adjuvant; Topoisomerase I Inhibitors; Topotecan | 2004 |
[A case of brain metastasis of small cell lung cancer improved with nogitecan hydrochloride (topotecan) after prophylactic irradiation].
Topics: Antineoplastic Agents; Brain; Brain Neoplasms; Carcinoma, Small Cell; Combined Modality Therapy; Cranial Irradiation; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Middle Aged; Tomography, X-Ray Computed; Topotecan | 2004 |
Topoisomerase I inhibitors for the treatment of brain tumors.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Glioblastoma; Humans; Irinotecan; Neoplasm Recurrence, Local; Survival Analysis; Topoisomerase I Inhibitors; Topotecan | 2008 |
[Topoisomerase I inhibitor with potential radiosensitizing effect].
Topics: Antineoplastic Agents; Brain Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Child; Clinical Trials as Topic; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Neoplasms; Ovarian Neoplasms; Radiation-Sensitizing Agents; Radiotherapy Dosage; Topoisomerase I Inhibitors; Topotecan | 1997 |
Future directions in the treatment of malignant gliomas with temozolomide.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Bone Marrow Transplantation; Brain Neoplasms; Carmustine; Cisplatin; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; Genetic Therapy; Glioblastoma; Humans; Temozolomide; Topotecan | 2000 |
35 trial(s) available for topotecan and Brain Neoplasms
| Article | Year |
|---|---|
Phase II clinical trial of whole-brain irradiation plus three-dimensional conformal boost with concurrent topotecan for brain metastases from lung cancer.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Cranial Irradiation; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Radiotherapy, Conformal; Small Cell Lung Carcinoma; Topotecan | 2013 |
Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant.
Topics: Administration, Oral; Age Factors; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Child, Preschool; Female; Gastrointestinal Absorption; Gene Frequency; Genotype; Humans; Infant; Male; Models, Biological; Neoplasm Proteins; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Polymorphism, Single Nucleotide; Topoisomerase I Inhibitors; Topotecan | 2016 |
A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; Prospective Studies; Quality of Life; Small Cell Lung Carcinoma; Survival Rate; Topotecan; Treatment Outcome | 2009 |
Effects of concurrent topotecan and radiation on 6-month progression-free survival in the primary treatment of glioblastoma multiforme.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Prospective Studies; Quality of Life; Radiotherapy Dosage; Topotecan; Young Adult | 2009 |
Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Spinal Cord Neoplasms; Tamoxifen; Topotecan; Young Adult | 2010 |
A phase II study of metronomic oral topotecan for recurrent childhood brain tumors.
Topics: Brain Neoplasms; Brain Stem Neoplasms; Child; Disease-Free Survival; Ependymoma; Female; Glioma; Humans; Male; Neuroectodermal Tumors, Primitive; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome | 2011 |
Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Lapatinib; Middle Aged; Neoplasm Staging; Quinazolines; Receptor, ErbB-2; Topotecan | 2011 |
Pilot induction regimen incorporating pharmacokinetically guided topotecan for treatment of newly diagnosed high-risk neuroblastoma: a Children's Oncology Group study.
Topics: Adult; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Induction Chemotherapy; Infant; Male; Neuroblastoma; Pilot Projects; Topoisomerase I Inhibitors; Topotecan | 2011 |
Response to topotecan of symptomatic brain metastases of small-cell lung cancer also after whole-brain irradiation. a multicentre phase II study.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma, Small Cell; Cranial Irradiation; Disease Progression; Hematologic Diseases; Humans; Infusions, Intravenous; Lung Neoplasms; Middle Aged; Prospective Studies; Survival Analysis; Topotecan | 2002 |
Phase I study of topotecan in combination with concurrent radiotherapy in adults with glioblastoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Female; Glioblastoma; Humans; Infusion Pumps; Male; Maximum Tolerated Dose; Middle Aged; Survival Rate; Topotecan | 2003 |
Oral topotecan in children with recurrent or progressive high-grade glioma: a Phase I/II study by the German Society for Pediatric Oncology and Hematology.
Topics: Administration, Oral; Adolescent; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Female; Glioma; Humans; Male; Topotecan; Treatment Outcome | 2004 |
Response of relapsed or refractory primary central nervous system lymphoma (PCNSL) to topotecan.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Enzyme Inhibitors; Female; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Neoplasm Proteins; Prospective Studies; Remission Induction; Salvage Therapy; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome | 2004 |
Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor.
Topics: Adolescent; Adult; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; Medulloblastoma; Neuroectodermal Tumors, Primitive; Risk Factors; Topotecan; Treatment Outcome | 2004 |
Phase I/II trial of simultaneous whole-brain irradiation and dose-escalating topotecan for brain metastases.
Topics: Adult; Aged; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Cranial Irradiation; DNA Topoisomerases, Type I; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Pilot Projects; Radiotherapy; Radiotherapy Dosage; Remission Induction; Time Factors; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome | 2005 |
A Phase II trial of paclitaxel and topotecan with filgrastim in patients with recurrent or refractory glioblastoma multiforme or anaplastic astrocytoma.
Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Filgrastim; Glioblastoma; Granulocyte Colony-Stimulating Factor; Humans; Leukopenia; Male; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Recombinant Proteins; Thrombocytopenia; Topotecan; Treatment Outcome | 2005 |
Open-label simultaneous radio-chemotherapy of glioblastoma multiforme with topotecan in adults.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Disease-Free Survival; Feasibility Studies; Female; Glioblastoma; Humans; Male; Middle Aged; Pilot Projects; Prospective Studies; Quality of Life; Survival Rate; Topotecan | 2005 |
Concurrent chemoradiotherapy and adjuvant chemotherapy with Topotecan for patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Glioblastoma; Humans; Male; Middle Aged; Survival Analysis; Topotecan; Treatment Outcome | 2006 |
A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Alkyl and Aryl Transferases; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carrier Proteins; Child; Child, Preschool; Disease-Free Survival; Female; Glioma; Humans; Immunohistochemistry; Male; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm, Residual; Nuclear Proteins; Procarbazine; Survival Analysis; Topotecan | 2006 |
Topotecan and etoposide in the treatment of relapsed high-risk neuroblastoma: results of a phase 2 trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Etoposide; Female; Humans; Infant; Male; Neoplasm Recurrence, Local; Neuroblastoma; Topotecan; Treatment Outcome | 2007 |
A phase I/II trial of topotecan and radiation therapy for brain metastases in patients with solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Dose-Response Relationship, Radiation; Feasibility Studies; Female; Humans; Lung Neoplasms; Male; Middle Aged; Radiation-Sensitizing Agents; Radiotherapy Dosage; Radiotherapy, Adjuvant; Topotecan; Treatment Outcome | 2007 |
Topotecan and paclitaxel in previously treated patients with relapsed small cell lung cancer: phase II trial of the North Central Cancer Treatment Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Small Cell; Disease Progression; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Paclitaxel; Survival Rate; Topotecan | 2006 |
Topotecan, cyclophosphamide, and etoposide (TCE) in the treatment of high-risk neuroblastoma. Results of a phase-II trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Disease-Free Survival; Etoposide; Female; Humans; Infant; Infant, Newborn; Male; Neoplasm Recurrence, Local; Neuroblastoma; Topotecan; Treatment Outcome | 2007 |
Pegylated-liposomal doxorubicin and oral topotecan in eight children with relapsed high-grade malignant brain tumors.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma; Child; Child, Preschool; Choroid Plexus Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Drug Eruptions; Glioblastoma; Hematologic Diseases; Humans; Neoplasm Recurrence, Local; Polyethylene Glycols; Recurrence; Retrospective Studies; Stomatitis; Topotecan; Treatment Outcome | 2008 |
Phase I/II study of IV topotecan in combination with whole brain radiation for the treatment of brain metastases.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Radiotherapy Dosage; Topotecan; Treatment Outcome | 2007 |
Topotecan as salvage therapy for relapsed or refractory primary central nervous system lymphoma.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Disease-Free Survival; Enzyme Inhibitors; Female; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Salvage Therapy; Topotecan; Treatment Outcome | 2008 |
Phase I study of weekly topotecan combined to concurrent external cranial irradiation in adults with glioblastoma multiforme of the brain.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Middle Aged; Topotecan; Treatment Outcome | 2008 |
Phase II evaluation of topotecan for pediatric central nervous system tumors.
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Brain Stem; Camptothecin; Child; Child, Preschool; Drug Administration Schedule; Female; Glioblastoma; Glioma; Humans; Infant; Infusions, Intravenous; Male; Topotecan | 1996 |
Phase II study of topotecan in patients with recurrent malignant glioma. National Clinical Institute of Canada Clinical Trials Group.
Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Camptothecin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glioblastoma; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Topotecan; Treatment Outcome | 1996 |
Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and New Dr
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Camptothecin; Carcinoma, Small Cell; Humans; Lung Neoplasms; Remission Induction; Survival Analysis; Topotecan | 1997 |
Topotecan treatment of adults with primary malignant glioma. The Brain Tumor Center at Duke.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm, Residual; Topotecan; Treatment Outcome | 1999 |
Topotecan as a 21-day continuous infusion with accelerated 3D-conformal radiation therapy for patients with glioblastoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Glioblastoma; Humans; Infusions, Intravenous; Middle Aged; Radiotherapy, Conformal; Topotecan | 1999 |
Topotecan chemotherapy in patients with breast cancer and brain metastases: results of a pilot study.
Topics: Adult; Aged; Brain Neoplasms; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Middle Aged; Survival Rate; Topotecan; Treatment Outcome | 2001 |
Topotecan combined with myeloablative doses of thiotepa and carboplatin for neuroblastoma, brain tumors, and other poor-risk solid tumors in children and young adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child; Child, Preschool; Combined Modality Therapy; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Male; Neuroblastoma; Radiotherapy, Adjuvant; Remission Induction; Thiotepa; Topotecan; Treatment Outcome | 2001 |
Acute toxicity and changes in quality of life during a combined radio-chemotherapy of glioblastomas with topotecan (Hycamtin).
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Data Interpretation, Statistical; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Prospective Studies; Quality of Life; Radiotherapy; Radiotherapy Dosage; Radiotherapy, Conformal; Survival Analysis; Time Factors; Topoisomerase I Inhibitors; Topotecan | 2001 |
Phase I/II clinical trial of concurrent radiochemotherapy in combination with topotecan for the treatment of brain metastases.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Tomography, X-Ray Computed; Topotecan; Treatment Outcome | 2002 |
50 other study(ies) available for topotecan and Brain Neoplasms
| Article | Year |
|---|---|
Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Proliferation; Child, Preschool; Dactinomycin; Female; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Germ Cell and Embryonal; Neuroectodermal Tumors, Primitive; Pteridines; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
Tandem high-dose chemotherapy with topotecan-thiotepa-carboplatin and melphalan-etoposide-carboplatin regimens for pediatric high-risk brain tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child; Child, Preschool; Etoposide; Female; Humans; Infant; Male; Melphalan; Retrospective Studies; Stem Cell Transplantation; Survival Rate; Thiotepa; Topotecan; Transplantation, Autologous; Treatment Outcome | 2019 |
Pilot study assessing a seven-day continuous intrathecal topotecan infusion for recurrent or progressive leptomeningeal metastatic cancer.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Cerebellar Neoplasms; Ependymoma; Humans; Injections, Spinal; Male; Medulloblastoma; Meningeal Neoplasms; Neoplasm Recurrence, Local; Pilot Projects; Topotecan; Treatment Outcome; Young Adult | 2014 |
Topoisomerase I inhibitors, shikonin and topotecan, inhibit growth and induce apoptosis of glioma cells and glioma stem cells.
Topics: Apoptosis; Brain Neoplasms; Caspase 3; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Glioma; Humans; Naphthoquinones; Neoplastic Stem Cells; Proto-Oncogene Proteins c-bcl-2; Topoisomerase I Inhibitors; Topotecan | 2013 |
Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Chromogranins; Cisplatin; Drug Resistance, Neoplasm; Etoposide; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Lung; Lung Neoplasms; Organic Anion Transporters; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Small Cell Lung Carcinoma; Synaptophysin; Topotecan; Tumor Cells, Cultured | 2015 |
Results of induction chemotherapy in children older than 18 months with stage-4 neuroblastoma treated with an adaptive-to-response modified N7 protocol (mN7).
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Brain Neoplasms; Carboplatin; Child; Child, Preschool; Cisplatin; Cohort Studies; Consolidation Chemotherapy; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Immunotherapy; Induction Chemotherapy; Infant; Isotretinoin; Male; Neoadjuvant Therapy; Neoplasm Staging; Neuroblastoma; Neurosurgical Procedures; Pilot Projects; Prospective Studies; Radiotherapy; Thiotepa; Topotecan; Treatment Outcome; Vincristine | 2015 |
Early Cerebral Blood Volume Changes Predict Progression After Convection-Enhanced Delivery of Topotecan for Recurrent Malignant Glioma.
Topics: Adult; Aged; Antineoplastic Agents; Blood Volume; Brain Neoplasms; Cerebrovascular Circulation; Convection; Disease Progression; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Predictive Value of Tests; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Tumor Burden | 2015 |
Proton therapy for pediatric and adolescent esthesioneuroblastoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Esthesioneuroblastoma, Olfactory; Etoposide; Female; Humans; Kaplan-Meier Estimate; Male; Meningeal Neoplasms; Nasal Cavity; Nose Neoplasms; Proton Therapy; Radiation Injuries; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Adjuvant; Retrospective Studies; Topotecan; Treatment Outcome; Vincristine; Young Adult | 2015 |
Combination therapy with topotecan, paclitaxel, and bevacizumab improves progression-free survival in recurrent small cell neuroendocrine carcinoma of the cervix.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Carcinoma, Neuroendocrine; Disease Progression; Disease-Free Survival; Female; Humans; Neoplasm Recurrence, Local; Paclitaxel; Platinum; Retrospective Studies; Survival Rate; Topotecan; Uterine Cervical Neoplasms; Young Adult | 2017 |
Topotecan enhances immune clearance of gliomas.
Topics: Antibody-Dependent Cell Cytotoxicity; Brain Neoplasms; CD3 Complex; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Flow Cytometry; Glioblastoma; Humans; Immunotherapy; Interferon-gamma; Signal Transduction; T-Lymphocytes; Topotecan; Up-Regulation | 2009 |
Extrapulmonary small cell carcinoma: involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans.
Topics: Antineoplastic Agents; Brain Neoplasms; Carcinoma, Small Cell; Combined Modality Therapy; Craniotomy; Female; Fluorodeoxyglucose F18; Humans; Middle Aged; Neoplasm Recurrence, Local; Positron-Emission Tomography; Radiopharmaceuticals; Tomography, X-Ray Computed; Topotecan | 2008 |
Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Survival; Contrast Media; Convection; Drug Delivery Systems; Gadolinium DTPA; Glioblastoma; Humans; Liposomes; Male; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Survival Rate; Tissue Distribution; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2009 |
Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bevacizumab; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Cell Proliferation; DNA Damage; Drug Synergism; Female; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoenzyme Techniques; Luciferases; Mice; Mice, Nude; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2009 |
Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas.
Topics: Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Drug Synergism; Gefitinib; Glioma; Humans; Mice; Mice, Nude; Neovascularization, Pathologic; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Topotecan; Xenograft Model Antitumor Assays | 2010 |
The selective Trk inhibitor AZ623 inhibits brain-derived neurotrophic factor-mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Neuroblastoma; Protein Kinase Inhibitors; Receptor, trkB; Signal Transduction; Substrate Specificity; Topotecan; Xenograft Model Antitumor Assays | 2011 |
Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Carboplatin; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Dactinomycin; Doxorubicin; Etoposide; Humans; Ifosfamide; Infant; Infratentorial Neoplasms; Irinotecan; Melphalan; Neoplasm Metastasis; Neuroblastoma; Rhabdomyosarcoma; Thiotepa; Topotecan; Vincristine | 2011 |
Multifaceted chemotherapy for trilateral retinoblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Cyclosporine; Cytarabine; Etoposide; Fatal Outcome; Female; Humans; Infant; Magnetic Resonance Imaging; Male; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Pineal Gland; Retinal Neoplasms; Retinoblastoma; Tomography, X-Ray Computed; Topotecan; Vincristine | 2011 |
Convection-enhanced delivery of topotecan into a PDGF-driven model of glioblastoma prolongs survival and ablates both tumor-initiating cells and recruited glial progenitors.
Topics: Animals; Brain Neoplasms; Cell Survival; Disease Models, Animal; Glioblastoma; Immunohistochemistry; Neoplastic Stem Cells; Neuroglia; Platelet-Derived Growth Factor; Rats; Topotecan; Xenograft Model Antitumor Assays | 2011 |
Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump.
Topics: Animals; Brain Neoplasms; Contrast Media; Convection; Drug Delivery Systems; Gadolinium DTPA; Glioma; Humans; Image Processing, Computer-Assisted; Infusion Pumps, Implantable; Infusions, Subcutaneous; Liposomes; Magnetic Resonance Imaging; Male; Swine; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured | 2011 |
Investigation of intravenous delivery of nanoliposomal topotecan for activity against orthotopic glioblastoma xenografts.
Topics: Animals; Brain Neoplasms; Drug Delivery Systems; Female; Glioblastoma; Humans; Immunoenzyme Techniques; Liposomes; Luminescent Measurements; Mice; Mice, Nude; Nanotechnology; Survival Rate; Tissue Distribution; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2011 |
Determining the best dose for the individual patient.
Topics: Brain Neoplasms; Female; Humans; Induction Chemotherapy; Male; Neuroblastoma; Topoisomerase I Inhibitors; Topotecan | 2011 |
Inhibition of poly(ADP-Ribose) polymerase enhances the toxicity of 131I-metaiodobenzylguanidine/topotecan combination therapy to cells and xenografts that express the noradrenaline transporter.
Topics: 3-Iodobenzylguanidine; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Combined Modality Therapy; DNA Breaks; Female; Flow Cytometry; Histones; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neuroblastoma; Norepinephrine Plasma Membrane Transport Proteins; Phosphorylation; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Radiopharmaceuticals; Topotecan; Tumor Stem Cell Assay | 2012 |
The role of topotecan in treating small cell lung cancer: second-line treatment.
Topics: Administration, Oral; Antineoplastic Agents; Brain Neoplasms; Carcinoma, Small Cell; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Lung Neoplasms; Topoisomerase I Inhibitors; Topotecan | 2003 |
Topotecan as first-line therapy for small cell lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Carcinoma, Small Cell; Cisplatin; Etoposide; Forecasting; Humans; Lung Neoplasms; Paclitaxel; Platinum; Topotecan | 2003 |
Effect of association of temozolomide with other chemotherapic agents on cell growth inhibition in glioma cell lines.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Proliferation; Cisplatin; Dacarbazine; Doxorubicin; Drug Interactions; Glioma; Humans; Temozolomide; Topotecan; Tumor Cells, Cultured | 2004 |
Pharmacokinetic model-predicted anticancer drug concentrations in human tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Computer Simulation; Cyclohexanes; Dacarbazine; Female; Humans; Male; Models, Biological; O-(Chloroacetylcarbamoyl)fumagillol; Ovarian Neoplasms; Predictive Value of Tests; Rats; Rats, Inbred F344; Rats, Nude; Sesquiterpenes; Temozolomide; Topotecan; Transplantation, Heterologous; Vascular Endothelial Growth Factor A | 2004 |
Topotecan can compensate for protracted radiation treatment time effects in high grade glioma xenografts.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Disease Progression; Dose-Response Relationship, Radiation; Drug Administration Schedule; Female; Glioma; Humans; Mice; Mice, Nude; Topotecan; Transplantation, Heterologous | 2006 |
Convection-enhanced delivery of Ls-TPT enables an effective, continuous, low-dose chemotherapy against malignant glioma xenograft model.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Convection; Dose-Response Relationship, Drug; Drug Delivery Systems; Glioma; Humans; Liposomes; Male; Rats; Rats, Nude; Topotecan; Xenograft Model Antitumor Assays | 2006 |
Convection-enhanced delivery of a topoisomerase I inhibitor (nanoliposomal topotecan) and a topoisomerase II inhibitor (pegylated liposomal doxorubicin) in intracranial brain tumor xenografts.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Delivery Systems; Glioblastoma; Humans; Male; Polyethylene Glycols; Rats; Rats, Nude; Rats, Sprague-Dawley; Survival Rate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan; Xenograft Model Antitumor Assays | 2007 |
Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54(p53wt) and U251(p53mut) glioblastoma cell lines.
Topics: Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Densitometry; DNA Damage; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Glioblastoma; Humans; In Situ Nick-End Labeling; Indicators and Reagents; Mutation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Quinazolines; Signal Transduction; Topotecan; Tumor Suppressor Protein p53 | 2007 |
Postoperative radiotherapy of glioblastoma multiforme: analysis and critical assessment of different treatment strategies and predictive factors.
Topics: Adult; Aged, 80 and over; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Craniotomy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Infusions, Intravenous; Male; Middle Aged; Prognosis; Radiation Injuries; Radiotherapy, Adjuvant; Retrospective Studies; Salvage Therapy; Temozolomide; Topotecan | 2007 |
[Chemotherapy for brain tumors in adult patients].
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Genetic Markers; Glioma; Humans; Lymphoma; Prognosis; Promoter Regions, Genetic; Temozolomide; Topotecan; Tumor Suppressor Proteins | 2008 |
Small-cell lung cancer, getting smaller but still difficult to treat.
Topics: Antineoplastic Agents; Brain Neoplasms; Carcinoma, Small Cell; Cranial Irradiation; Humans; Lung Neoplasms; Radiotherapy, Adjuvant; Recurrence; Topotecan | 2008 |
Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Mice; Mice, Inbred CBA; Neoplasms, Experimental; Random Allocation; Rhabdomyosarcoma; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured | 1995 |
A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Camptothecin; Haplorhini; Metabolic Clearance Rate; Models, Biological; Topotecan | 1994 |
Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors.
Topics: Adolescent; Antineoplastic Agents; Bayes Theorem; Brain Neoplasms; Camptothecin; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Male; Statistics, Nonparametric; Topotecan | 1996 |
Interaction of ionizing radiation with topotecan in two human tumor cell lines.
Topics: Antineoplastic Agents; Blotting, Northern; Brain Neoplasms; Camptothecin; Cell Line; Cell Survival; DNA Topoisomerases, Type I; Dose-Response Relationship, Radiation; Gene Expression; Glioblastoma; Humans; Lung Neoplasms; Radiation, Ionizing; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured | 1996 |
Treatment of central nervous system xenografts with camptothecins.
Topics: Adult; Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Child; Drug Screening Assays, Antitumor; Humans; Irinotecan; Mice; Mice, Nude; Neoplasm Transplantation; Topotecan; Transplantation, Heterologous | 1996 |
Synergistic cytotoxicity of topoisomerase I inhibitors with alkylating agents and etoposide in human brain tumor cell lines.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Etoposide; Humans; In Vitro Techniques; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured | 1998 |
Intermittent exposure of medulloblastoma cells to topotecan produces growth inhibition equivalent to continuous exposure.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Division; Child; Culture Media; DNA, Neoplasm; Drug Administration Schedule; Drug Stability; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Humans; Image Processing, Computer-Assisted; Medulloblastoma; Mice; Microscopy, Fluorescence; Neoplasm Proteins; Neoplasm Transplantation; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured | 1997 |
Intratumoral infusion of topotecan prolongs survival in the nude rat intracranial U87 human glioma model.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Survival; Enzyme Inhibitors; Glioma; Humans; Infusions, Parenteral; Rats; Rats, Nude; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured | 1998 |
The accumulation of topotecan in 9L glioma and in brain parenchyma with and without dexamethasone administration.
Topics: Animals; Brain; Brain Neoplasms; Dexamethasone; Female; Glioma; Rats; Rats, Inbred F344; Reference Values; Tissue Distribution; Topotecan | 1999 |
Topotecan--a new treatment option in the therapy of brain metastases of lung cancer.
Topics: Adult; Aged; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Lung Neoplasms; Male; Middle Aged; Retrospective Studies; Topotecan | 1999 |
Accumulation of mutant p53(V143A) modulates the growth, clonogenicity, and radiochemosensitivity of malignant glioma cells independent of endogenous p53 status.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Carmustine; Cell Death; Cell Division; Cisplatin; Clone Cells; Combined Modality Therapy; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Gene Expression Regulation, Neoplastic; Genes, Dominant; Glioma; Humans; In Vitro Techniques; Paclitaxel; Point Mutation; Radiotherapy; Teniposide; Topotecan; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vincristine | 1999 |
Synergy of topotecan in combination with vincristine for treatment of pediatric solid tumor xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Child; Drug Resistance, Neoplasm; Female; Humans; Medulloblastoma; Mice; Mice, Inbred CBA; Neuroblastoma; Rhabdomyosarcoma; Thymectomy; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured; Vincristine; Whole-Body Irradiation | 1999 |
Evidence for a constitutive, verapamil-sensitive, non-P-glycoprotein multidrug resistance phenotype in malignant glioma that is unaltered by radiochemotherapy in vivo.
Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Neoplasms; Calcium Channel Blockers; Carmustine; Combined Modality Therapy; DNA, Neoplasm; Doxorubicin; Drug Resistance, Neoplasm; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; In Vitro Techniques; Male; Middle Aged; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Teniposide; Topotecan; Tumor Cells, Cultured; Verapamil; Vincristine | 2000 |
Limitations of the C6/Wistar rat intracerebral glioma model: implications for evaluating immunotherapy.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Brain Neoplasms; Cell Division; Glioma; Immunity, Cellular; Immunotherapy; Male; Neoplasm Transplantation; Rats; Rats, Inbred F344; Rats, Wistar; Survival Analysis; Topotecan; Tumor Cells, Cultured | 2000 |
Tissue distribution and antitumor activity of topotecan delivered by intracerebral clysis in a rat glioma model.
Topics: Animals; Brain Neoplasms; Drug Delivery Systems; Glioma; Injections, Intraperitoneal; Neoplasm Transplantation; Rats; Rats, Wistar; Tissue Distribution; Topotecan; Tumor Cells, Cultured | 2000 |
Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Brain Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Feasibility Studies; Female; Humans; Male; Medulloblastoma; Neuroectodermal Tumors, Primitive; Stem Cells; Topotecan; Vincristine | 2001 |
[A case of recurrent small cell lung cancer with symptoms improved by nogitecan hydrochloride].
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma, Small Cell; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Lung Neoplasms; Topotecan | 2002 |