topiroxostat has been researched along with Acute-Kidney-Injury* in 1 studies
1 other study(ies) available for topiroxostat and Acute-Kidney-Injury
| Article | Year |
|---|---|
Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity
Hereditary renal hypouricemia type 1 (RHUC1) is caused by URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced AKI (EIAKI). However, because there is no useful experimental RHUC1 animal model, the precise pathophysiologic mechanisms underlying EIAKI have yet to be elucidated. We established a high HPRT activity. The novel Topics: Acute Kidney Injury; Allopurinol; Animals; Disease Models, Animal; Enzyme Inhibitors; Hypoxanthine Phosphoribosyltransferase; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitriles; NLR Family, Pyrin Domain-Containing 3 Protein; Organic Anion Transporters; Physical Exertion; Pyridines; Renal Tubular Transport, Inborn Errors; Sodium-Potassium-Exchanging ATPase; Urate Oxidase; Urinary Calculi; Xanthine Dehydrogenase | 2022 |