topiramate has been researched along with Vascular-Diseases* in 2 studies
2 other study(ies) available for topiramate and Vascular-Diseases
| Article | Year |
|---|---|
Topiramate treatment in Wistar rats during childhood induces sex-specific vascular dysfunction in adulthood.
The present study determined whether treatment during childhood with topiramate (TPM), a new generation antiepileptic drug, results in altered aortic reactivity in adult male and female rats. We also sought to understand the role of endothelium-derived contractile factors in TPM-induced vascular dysfunction. Male and female Wistar rats were treated with TPM (41 mg/kg/day) or water (TPM vehicle) by gavage during childhood (postnatal day, 16-28). In adulthood, thoracic aorta reactivity to phenylephrine (phenyl), as well as aortic thickness and expression of cyclooxygenases (COX-1 and COX-2), NOX2, and p47 Topics: Animals; Anticonvulsants; Aorta; Female; Gene Expression Regulation; Male; NADPH Oxidase 2; NADPH Oxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sex Factors; Topiramate; Vascular Diseases | 2022 |
Efficacy and tolerability of topiramate in vascular generalized chorea.
Topics: Aged; Anticonvulsants; Chorea; Female; Fructose; Humans; Topiramate; Vascular Diseases | 2007 |