topiramate and Thrombocytopenia

topiramate has been researched along with Thrombocytopenia* in 1 studies

Other Studies

1 other study(ies) available for topiramate and Thrombocytopenia

Article	Year
Topiramate enhances the risk of valproate-associated side effects in three children. Epilepsia, 2002, Volume: 43, Issue:4 We present three children with severe therapy-refractory epilepsy who tolerated valproate (VPA) well in various combinations with other antiepileptic drugs (AEDs) but developed typical VPA side effects in combination with topiramate (TPM).. The clinical symptoms began with apathy in all three children; two of them also had hypothermia. Furthermore all children had elevated blood ammonia levels, one child in combination with increased liver transaminases and one with thrombocytopenia.. All children recovered completely after discontinuation of VPA or TPM.. TPM seems likely to enhance the risk of side effects usually attributed to VPA and not described in TPM monotherapy. Our case reports suggest that possible adverse effects of VPA should be given particular attention when VPA is combined with TPM. Topics: Affective Symptoms; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Hypothermia; Infant; Liver; Liver Diseases; Male; Risk Factors; Thrombocytopenia; Topiramate; Transaminases; Valproic Acid	2002

Article

Year

Topiramate enhances the risk of valproate-associated side effects in three children.

Epilepsia, 2002, Volume: 43, Issue:4

We present three children with severe therapy-refractory epilepsy who tolerated valproate (VPA) well in various combinations with other antiepileptic drugs (AEDs) but developed typical VPA side effects in combination with topiramate (TPM).. The clinical symptoms began with apathy in all three children; two of them also had hypothermia. Furthermore all children had elevated blood ammonia levels, one child in combination with increased liver transaminases and one with thrombocytopenia.. All children recovered completely after discontinuation of VPA or TPM.. TPM seems likely to enhance the risk of side effects usually attributed to VPA and not described in TPM monotherapy. Our case reports suggest that possible adverse effects of VPA should be given particular attention when VPA is combined with TPM.

Topics: Affective Symptoms; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Hypothermia; Infant; Liver; Liver Diseases; Male; Risk Factors; Thrombocytopenia; Topiramate; Transaminases; Valproic Acid

2002