topiramate and Panuveitis

A 36-year-old female presented with the complaints of pain, photophobia, redness, and sudden diminution of vision in both the eyes following topiramate for migraine treatment. On examination, there was panuveitis with angle-closure glaucoma in both the eyes with fibrinous exudate with pigments in the anterior chamber of the left eye. B scan revealed increased choroidal thickness in both the eyes. Serial anterior segment optical coherence tomography scans were done in the left eye to demonstrate the gradual resolution of the fibrin material from the anterior chamber. There was complete resolution of inflammation in both eyes following discontinuation of topiramate and treatment with systemic and topical steroids. There was an improvement in visual acuity in the left eye following complicated cataract surgery.

Topics: Administration, Oral; Adult; Anterior Eye Segment; Anti-Obesity Agents; Female; Fructose; Glaucoma, Angle-Closure; Gonioscopy; Humans; Intraocular Pressure; Microscopy, Acoustic; Panuveitis; Severity of Illness Index; Tomography, Optical Coherence; Topiramate; Visual Acuity

A 54-year-old male patient presented to our clinic with acute angle-closure glaucoma and panuveitis in both eyes after being treated with topiramate for binge eating and obesity. This case report emphasises the hazardous side effects of treatment with topiramate with unusual indication and the precaution a caretaker must take when treating a patient.

Topics: Acute Disease; Anti-Obesity Agents; Fructose; Glaucoma, Angle-Closure; Humans; Male; Middle Aged; Panuveitis; Topiramate