topiramate and Neuromyelitis-Optica

topiramate has been researched along with Neuromyelitis-Optica* in 1 studies

Other Studies

1 other study(ies) available for topiramate and Neuromyelitis-Optica

Article	Year
Successful treatment of paroxysmal tonic spasms with topiramate in a patient with neuromyelitis optica. Multiple sclerosis and related disorders, 2015, Volume: 4, Issue:5 A 49-year-old woman with neuromyelitis optica (NMO) developed severe quadriplegia and frequent paroxysmal tonic spasms (PTS). Carbamazepine, although initially effective against PTS, caused drug eruption and she was unable to continue. PTS re-emerged after discontinuation of carbamazepine and hindered rehabilitation. Then topiramate was started, and PTS promptly disappeared. The patient became able to resume rehabilitation and her activity of daily life improved significantly. Carbamazepine and topiramate have a common pharmacological action to block voltage-gated sodium channels. The action may have contributed to inhibition of ephaptic transmission in the demyelinating lesions by NMO and eventually improved PTS. Topics: Anticonvulsants; Carbamazepine; Drug Eruptions; Dystonia; Female; Fructose; Humans; Middle Aged; Neuromyelitis Optica; Sodium Channel Blockers; Topiramate; Treatment Outcome	2015

Article

Year

Successful treatment of paroxysmal tonic spasms with topiramate in a patient with neuromyelitis optica.

Multiple sclerosis and related disorders, 2015, Volume: 4, Issue:5

A 49-year-old woman with neuromyelitis optica (NMO) developed severe quadriplegia and frequent paroxysmal tonic spasms (PTS). Carbamazepine, although initially effective against PTS, caused drug eruption and she was unable to continue. PTS re-emerged after discontinuation of carbamazepine and hindered rehabilitation. Then topiramate was started, and PTS promptly disappeared. The patient became able to resume rehabilitation and her activity of daily life improved significantly. Carbamazepine and topiramate have a common pharmacological action to block voltage-gated sodium channels. The action may have contributed to inhibition of ephaptic transmission in the demyelinating lesions by NMO and eventually improved PTS.

Topics: Anticonvulsants; Carbamazepine; Drug Eruptions; Dystonia; Female; Fructose; Humans; Middle Aged; Neuromyelitis Optica; Sodium Channel Blockers; Topiramate; Treatment Outcome

2015