topiramate and Influenza--Human

topiramate has been researched along with Influenza--Human* in 1 studies

Other Studies

1 other study(ies) available for topiramate and Influenza--Human

Article	Year
Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? Seizure, 2008, Volume: 17, Issue:1 We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity. The time-interval between fever, administration of acetaminophen, epileptic status and liver enzyme disturbances in our four cases suggests that accumulation of toxic acetaminophen-metabolites is possibly responsible for liver toxicity. If acetaminophen and its metabolites cause those liver problems in children treated with the combination of VPA and TPM, the advice to use acetaminophen for treating fever in children using this combination, should be changed. Only future clinical observations and research can solve this clinical dilemma. Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Chemical and Drug Induced Liver Injury; Developmental Disabilities; Drug Therapy, Combination; Enzymes; Female; Fructose; Humans; Infant; Influenza, Human; Liver Function Tests; Male; Myoclonic Epilepsy, Juvenile; NAV1.1 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Sodium Channels; Syndrome; Topiramate; Valproic Acid	2008

Article

Year

Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen?

Seizure, 2008, Volume: 17, Issue:1

We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity. The time-interval between fever, administration of acetaminophen, epileptic status and liver enzyme disturbances in our four cases suggests that accumulation of toxic acetaminophen-metabolites is possibly responsible for liver toxicity. If acetaminophen and its metabolites cause those liver problems in children treated with the combination of VPA and TPM, the advice to use acetaminophen for treating fever in children using this combination, should be changed. Only future clinical observations and research can solve this clinical dilemma.

Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Chemical and Drug Induced Liver Injury; Developmental Disabilities; Drug Therapy, Combination; Enzymes; Female; Fructose; Humans; Infant; Influenza, Human; Liver Function Tests; Male; Myoclonic Epilepsy, Juvenile; NAV1.1 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Sodium Channels; Syndrome; Topiramate; Valproic Acid

2008