topiramate and Frontotemporal-Lobar-Degeneration

Abnormal eating behaviours are specific to frontotemporal lobar degeneration and increase caregiver burden. Topiramate, an anticonvulsant, suppresses cravings for alcohol and other substances and is a potential treatment for binge eating. However, there are few reports on topiramate efficacy for abnormal eating behaviours in frontotemporal lobar degeneration patients. We present three Japanese frontotemporal lobar degeneration patients with abnormal eating behaviours. Topiramate was effective, especially for compulsive eating, in cases with distinct lobar atrophy, but not for all abnormal eating behaviours.

Topics: Aged; Anticonvulsants; Bulimia; Feeding Behavior; Female; Frontotemporal Lobar Degeneration; Fructose; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Topiramate; Treatment Outcome