topiramate and Eye-Diseases

Treatments used for several neurological conditions may adversely affect the eye. Vigabatrin-related retinal toxicity leads to a visual field defect. Optic neuropathy may result from ethambutol and isoniazid, and from radiation therapy. Posterior subcapsular cataract is associated with systemic corticosteroids. Transient refractive error changes may follow treatment with acetazolamide or topiramate, and corneal deposits and keratitis with amandatine. Intraocular pressure can be elevated in susceptible individuals by anticholinergic drugs, including oxybutynin, tolterodine, benzhexol, propantheline, atropine and amitriptyline, and also by systemic corticosteroids and by topiramate. Nystagmus, diplopia and extraocular muscle palsies can occur with antiepileptic drugs, particularly phenytoin and carbamazepine. Ocular neuromyotonia can follow parasellar radiation. Congenital ocular malformations can result from in utero exposure to maternally prescribed sodium valproate, phenytoin and carbamazepine. Neurologists must be aware of potential ocular toxicity of these drugs, and appropriately monitor for potential adverse events.

Topics: Acetazolamide; Adrenal Cortex Hormones; Amantadine; Anticonvulsants; Antitubercular Agents; Cholinergic Antagonists; Dopamine Agents; Ethambutol; Eye Diseases; Female; Fructose; Humans; Isoniazid; Male; Radiotherapy; Topiramate; Vigabatrin

Topics: Anticonvulsants; Child; Eye Diseases; Humans; Topiramate; Zonisamide

To report recent ocular adverse drug reactions identified by the National Registry of Drug-Induced Ocular Side Effects.. Case reports from the National Registry and the World Health Organization were collected and adverse drug reactions categorized as follows: certain, probable/likely, possible, unlikely, and conditional/unclassifiable.. Bisphosphonates are associated with ocular inflammation, including the first reports of drug-related scleritis. Topiramate is shown to cause angle-closure glaucoma. Cetirizine can cause an oculogyric crisis, and there is strong evidence retinoids cause intracranial hypertension.. Recent reports to the National Registry have led to identification of new ocular adverse drug reactions.

Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Cetirizine; Child; Child, Preschool; Diphosphonates; Drug-Related Side Effects and Adverse Reactions; Eye; Eye Diseases; Female; Fructose; Humans; Infant; Male; Middle Aged; Ophthalmic Solutions; Registries; Retinoids; Topiramate; United States; United States Food and Drug Administration; World Health Organization