topiramate and Disruptive--Impulse-Control--and-Conduct-Disorders

To review the scientific evidence examining the comorbidity among eating disorders and bipolar disorder (BD).. We reviewed all published English-language studies addressing the comorbidity of anorexia nervosa, bulimia, bulimia nervosa, and binge eating disorder in patients with BD and studies of comorbidity of BD in patients with eating disorders. In addition, we discuss the pharmacologic treatment implications from reviewed studies of agents used in BD and eating disorders.. Community and clinical population studies of the lifetime prevalence rates of eating disorders in patients with BD, and of BD in patients with eating disorders, particularly when subthreshold and spectrum manifestations of these disorders are included, indicate high rates of comorbidity among these illnesses.. Pharmacologic treatment approaches to patients with BD and a co-occurring eating disorder require examination of the possible adverse effects of the treatment of each syndrome on the other and attempts to manage both syndromes with agents that might be beneficial to both.

Topics: Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Comorbidity; Disruptive, Impulse Control, and Conduct Disorders; Feeding and Eating Disorders; Fructose; Humans; Isoxazoles; Topiramate; Zonisamide

Repetitive skin picking that culminates in skin lesions and excoriations has a fairly common prevalence and causes clinically significant distress. Myriads of agents have been used to treat the condition with no convincing results.. Ten patients (8 women and 2 men) with skin-picking disorder (per DSM-5 criteria) were enrolled in the study. The study was conducted from December 1, 2013, to December 29, 2014. The patients were treated with 12-week open-label topiramate in a titrating-upward dose (25-200 mg/d). Different measures to evaluate the efficacy of topiramate included subjective and objective assessment, photographs, the Skin Picking Scale modified after the Yale-Brown Obsessive-Compulsive Scale (SPS-Y-BOCS), the Skin Picking Impact Scale, the Clinical Global Impressions-Improvement (CGI-I) and CGI-Severity scales, and the Beck Anxiety Inventory and Beck Depression Inventory.. Topiramate improved time spent skin picking from 85 minutes to 30 minutes per day. Seven patients (70%) were very much improved (n = 4) and much improved (n = 30) on the CGI-I. The scores on the Skin Picking Impact Scale and SPS-Y-BOCS also improved. The mean time to respond to topiramate was about 8 to 10 weeks. Anxiety and depression symptoms improved after reduction in skin-picking symptoms (the Beck Anxiety Inventory score improved from a mean of 38.8 to 13.8 and the Beck Depression Inventory score from 28.9 to 10.1).. Topiramate appears to be a promising agent in the treatment of skin-picking symptoms. Double-blind controlled trials are needed to further evaluate the safety and efficacy of topiramate in larger population samples.. ISRCTN registry identifier: ISRCTN15791118.

Topics: Adolescent; Adult; Anxiety; Depression; Disruptive, Impulse Control, and Conduct Disorders; Female; Fructose; Humans; Male; Pilot Projects; Psychiatric Status Rating Scales; Psychotropic Drugs; Severity of Illness Index; Skin; Socioeconomic Factors; Time Factors; Topiramate; Treatment Outcome; Young Adult

Topics: Anticonvulsants; Antiparkinson Agents; Disruptive, Impulse Control, and Conduct Disorders; Female; Fructose; Humans; Male; Middle Aged; Parkinson Disease; Severity of Illness Index; Topiramate

Topics: Adolescent; Adult; Anticonvulsants; Attention Deficit and Disruptive Behavior Disorders; Bipolar Disorder; Child; Disruptive, Impulse Control, and Conduct Disorders; Fructose; Humans; Receptors, Glutamate; Research Design; Topiramate; Treatment Outcome

Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Carbonic Anhydrase Inhibitors; Disruptive, Impulse Control, and Conduct Disorders; Drinking Behavior; Fructose; Humans; Hypernatremia; Male; Sodium Channel Blockers; Topiramate

Kleptomania, defined in the American Psychiatric Association's Diagnostic and Statistical Manua of Mental Disorders, Text Revision: DSM-IV-TR, as the inability to resist the impulse to steal objects that are not needed for personal use or for their monetary value, may reflect a form of obsessive-compulsive spectrum disorder and/or affective spectrum disorder. We report on a patient who developed kleptomania and left temporal lobe epilepsy around the same time; both disorders were completely resolved in this patient with topiramate.

Topics: Adult; Anticonvulsants; Disruptive, Impulse Control, and Conduct Disorders; Epilepsy, Temporal Lobe; Female; Fructose; Humans; Topiramate