toluene has been researched along with Seizures in 22 studies
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " By day 1, and extending through 4 days following kainic acid-induced seizures, brains from DNA-PKcs null mice showed widespread neurodegeneration that encompassed the entire hippocampal CA1-CA3 pyramidal cell layer, entorhinal cortex, and lateral septum, with relative sparing of the dentate gyrus granule cell layer and hilus, as judged by toluidine blue, Fluoro-Jade B, and terminal dUTP nick end labeling staining." | 7.73 | DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. ( Chechlacz, M; Gilliams-Francis, K; Lamonica, K; Lin, SL; Liu, J; Naegele, JR; Navarro-Quiroga, I; Neema, M, 2005) |
| " The effects of toluene and 1,1,1-trichloroethane (TCE) on NMDA-induced seizures in mice were studied using three experimental protocols: (a) animals injected i." | 7.72 | Effects of inhaled toluene and 1,1,1-trichloroethane on seizures and death produced by N-methyl-D-aspartic acid in mice. ( Balster, RL; Camacho-Muñoz, C; Cruz, SL; Gauthereau, MY; López-Rubalcava, C, 2003) |
| "The effect of toluene on seizures induced by chemoconvulsants acting on these receptors was compared." | 5.33 | Effects of toluene on seizures induced by convulsants acting at distinct ligand-gated ion channels. ( Chan, MH; Chen, HH; Lee, CC, 2006) |
| " By day 1, and extending through 4 days following kainic acid-induced seizures, brains from DNA-PKcs null mice showed widespread neurodegeneration that encompassed the entire hippocampal CA1-CA3 pyramidal cell layer, entorhinal cortex, and lateral septum, with relative sparing of the dentate gyrus granule cell layer and hilus, as judged by toluidine blue, Fluoro-Jade B, and terminal dUTP nick end labeling staining." | 3.73 | DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. ( Chechlacz, M; Gilliams-Francis, K; Lamonica, K; Lin, SL; Liu, J; Naegele, JR; Navarro-Quiroga, I; Neema, M, 2005) |
| " The effects of toluene and 1,1,1-trichloroethane (TCE) on NMDA-induced seizures in mice were studied using three experimental protocols: (a) animals injected i." | 3.72 | Effects of inhaled toluene and 1,1,1-trichloroethane on seizures and death produced by N-methyl-D-aspartic acid in mice. ( Balster, RL; Camacho-Muñoz, C; Cruz, SL; Gauthereau, MY; López-Rubalcava, C, 2003) |
| "The effects of toluene on the sensitivity to seizures induced by aminophylline were investigated." | 3.72 | Toluene exposure increases aminophylline-induced seizure susceptibility in mice. ( Chan, MH; Chen, HH, 2003) |
| "Solvent blood concentrations and subnarcotic effects (inhibition of electrically evoked seizures) were measured in rats exposed to constant or fluctuating air concentrations of toluene or acetone." | 3.69 | Pattern of inhalation exposure: blood levels and acute subnarcotic effects of toluene and acetone in rats. ( Frantík, E; Hornychová, M; Nosek, M; Vodicková, L, 1996) |
| "Rats were subjected to seizures induced by kainic acid, and the resulting changes in CNS zinc staining were studied with the toluene sulfonamide quinoline fluorescence method." | 3.67 | Translocation of zinc may contribute to seizure-induced death of neurons. ( Frederickson, CJ; Hernandez, MD; McGinty, JF, 1989) |
| "There are reports of patients whose epileptic seizures are prevented by means of olfactory stimulation." | 1.48 | Intense olfactory stimulation blocks seizures in an experimental model of epilepsy. ( Bertti-Dutra, P; de Lima Umeoka, EH; de Oliveira, JAC; Del Vecchio, F; Delfino-Pereira, P; Fernandes, A; Garcia-Cairasco, N; Marroni, SS; Santos, VR, 2018) |
| "Because seizures activate p53, and p53-deficient mice are reportedly resistant to damage caused by prolonged seizures, we investigated the role of miR-34a in seizure-induced neuronal death in vivo." | 1.38 | MicroRNA-34a upregulation during seizure-induced neuronal death. ( Henshall, DC; Jimenez-Mateos, EM; Matsushima, S; Reynolds, JP; Sano, T; Taki, W, 2012) |
| "Toluene has been shown to inhibit the nicotinic acetylcholine receptors." | 1.35 | Toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome. ( Chan, MH; Chen, HH; Chien, TH; Tang, YC, 2008) |
| "Toluene is a commonly abused inhalant." | 1.34 | Effects of toluene exposure during brain growth spurt on GABA(A) receptor-mediated functions in juvenile rats. ( Chan, MH; Chen, HH; Lin, YR; Liu, CL, 2007) |
| "The effect of toluene on seizures induced by chemoconvulsants acting on these receptors was compared." | 1.33 | Effects of toluene on seizures induced by convulsants acting at distinct ligand-gated ion channels. ( Chan, MH; Chen, HH; Lee, CC, 2006) |
| "Toluene is an abused solvent widely used in several commercial products." | 1.31 | Neonatal toluene exposure selectively alters sensitivity to different chemoconvulsant drugs in juvenile rats. ( Chen, HH; Lee, YF, 2002) |
| "Seizures in human temporal lobe epilepsy are characterized by paroxysmal activity in the limbic system." | 1.31 | Strong olfactory stimulation reduces seizure susceptibility in amygdala-kindled rats. ( Ebert, U; Löscher, W, 2000) |
| "Ethyl acetate produced generalized clonic seizures and deaths at high doses and was ineffective to prevent electroshock- and PTZ-induced seizures at low doses." | 1.28 | Anticonvulsant and convulsant effects of organic solvents. ( Pires, ML; Shiotsuki, N; Silva-Filho, AR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (31.82) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, DC | 1 |
| Lee, KY | 1 |
| Lizarazo, S | 1 |
| Cook, JK | 1 |
| Tsai, NP | 1 |
| Delfino-Pereira, P | 1 |
| Bertti-Dutra, P | 1 |
| de Lima Umeoka, EH | 1 |
| de Oliveira, JAC | 1 |
| Santos, VR | 1 |
| Fernandes, A | 1 |
| Marroni, SS | 1 |
| Del Vecchio, F | 1 |
| Garcia-Cairasco, N | 1 |
| Sano, T | 1 |
| Reynolds, JP | 1 |
| Jimenez-Mateos, EM | 1 |
| Matsushima, S | 1 |
| Taki, W | 1 |
| Henshall, DC | 1 |
| Chen, HH | 5 |
| Lee, YF | 1 |
| Cruz, SL | 1 |
| Gauthereau, MY | 1 |
| Camacho-Muñoz, C | 1 |
| López-Rubalcava, C | 1 |
| Balster, RL | 2 |
| Wiley, JL | 1 |
| Bale, AS | 1 |
| Chan, MH | 4 |
| Lee, CC | 1 |
| Neema, M | 1 |
| Navarro-Quiroga, I | 1 |
| Chechlacz, M | 1 |
| Gilliams-Francis, K | 1 |
| Liu, J | 1 |
| Lamonica, K | 1 |
| Lin, SL | 1 |
| Naegele, JR | 1 |
| Liu, CL | 1 |
| Lin, YR | 1 |
| Tang, YC | 1 |
| Chien, TH | 1 |
| Wood, RW | 1 |
| Coleman, JB | 1 |
| Schuler, R | 1 |
| Cox, C | 1 |
| Frantík, E | 1 |
| Vodicková, L | 1 |
| Hornychová, M | 1 |
| Nosek, M | 1 |
| Ebert, U | 1 |
| Löscher, W | 1 |
| Culmsee, C | 1 |
| Zhu, X | 1 |
| Yu, QS | 1 |
| Chan, SL | 1 |
| Camandola, S | 1 |
| Guo, Z | 1 |
| Greig, NH | 1 |
| Mattson, MP | 1 |
| Contreras, CM | 1 |
| González-Estrada, T | 1 |
| Zarabozo, D | 1 |
| Fernández-Guardiola, A | 1 |
| Georgiev, VP | 1 |
| Petkova, BP | 1 |
| Helliwell, M | 1 |
| Murphy, M | 1 |
| Silva-Filho, AR | 1 |
| Pires, ML | 1 |
| Shiotsuki, N | 1 |
| Frederickson, CJ | 1 |
| Hernandez, MD | 1 |
| McGinty, JF | 1 |
| Ollstein, RN | 1 |
| Symonds, FC | 1 |
| Crikelair, GF | 1 |
| Pelle, L | 1 |
| De Ropp, RS | 1 |
| Kastl, L | 1 |
| Furst, A | 1 |
22 other studies available for toluene and Seizures
| Article | Year |
|---|---|
ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model.
Topics: Animals; Benzothiazoles; Endoplasmic Reticulum Stress; Fragile X Mental Retardation Protein; Fragile | 2021 |
Intense olfactory stimulation blocks seizures in an experimental model of epilepsy.
Topics: Acoustic Stimulation; Amygdala; Animals; Brain Stem; Disease Models, Animal; Epilepsy, Reflex; Kindl | 2018 |
MicroRNA-34a upregulation during seizure-induced neuronal death.
Topics: Animals; Apoptosis; Argonaute Proteins; Benzothiazoles; Hippocampus; Immunoprecipitation; Kainic Aci | 2012 |
Neonatal toluene exposure selectively alters sensitivity to different chemoconvulsant drugs in juvenile rats.
Topics: Age Factors; Animals; Animals, Newborn; Convulsants; Drug Synergism; Excitatory Amino Acid Agonists; | 2002 |
Effects of inhaled toluene and 1,1,1-trichloroethane on seizures and death produced by N-methyl-D-aspartic acid in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; | 2003 |
Evaluation of toluene dependence and cross-sensitization to diazepam.
Topics: Animals; Convulsants; Diazepam; Excitatory Amino Acid Agonists; Inhalation Exposure; Male; Mice; Mot | 2003 |
Toluene exposure increases aminophylline-induced seizure susceptibility in mice.
Topics: Aminophylline; Animals; Benzaldehydes; Bronchodilator Agents; Caffeine; Disease Models, Animal; Drug | 2003 |
Effects of toluene on seizures induced by convulsants acting at distinct ligand-gated ion channels.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Ion Channel Gating; Male; Mice; Mice, Inbred | 2006 |
DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures.
Topics: Animals; Benzothiazoles; Cell Death; Cells, Cultured; DNA Damage; DNA Repair; DNA-Activated Protein | 2005 |
Effects of toluene exposure during brain growth spurt on GABA(A) receptor-mediated functions in juvenile rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Diazepam; Electric Stimulation; GABA Agonists; G | 2007 |
Toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome.
Topics: Aging; Animals; Behavior, Animal; Blotting, Western; Body Temperature; Brain; Disease Models, Animal | 2008 |
Anticonvulsant and antipunishment effects of toluene.
Topics: Animals; Benzodiazepinones; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug | 1984 |
Pattern of inhalation exposure: blood levels and acute subnarcotic effects of toluene and acetone in rats.
Topics: Acetone; Administration, Inhalation; Animals; Body Burden; Dose-Response Relationship, Drug; Male; M | 1996 |
Strong olfactory stimulation reduces seizure susceptibility in amygdala-kindled rats.
Topics: Ammonia; Amygdala; Animals; Epilepsy, Temporal Lobe; Female; Kindling, Neurologic; Odorants; Olfacto | 2000 |
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Ca | 2001 |
Petit mal and grand mal seizures produced by toluene or benzene intoxication in the cat.
Topics: Amygdala; Animals; Benzene; Cats; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy | 1979 |
Effect of p-chlorophenylalanine on the central nervous excitability threshold and on the activity of some central depressants.
Topics: Animals; Central Nervous System; Depression, Chemical; Fenclonine; Hypnotics and Sedatives; Injectio | 1975 |
Drug-induced neurological disease.
Topics: Adolescent; Child; Humans; Male; Seizures; Substance-Related Disorders; Toluene | 1979 |
Anticonvulsant and convulsant effects of organic solvents.
Topics: Acetates; Animals; Anticonvulsants; Convulsants; Electroshock; Epilepsy, Tonic-Clonic; Hexanes; Leth | 1992 |
Translocation of zinc may contribute to seizure-induced death of neurons.
Topics: Amygdala; Animals; Cell Survival; Cerebellum; Hippocampus; In Vitro Techniques; Kainic Acid; Nerve D | 1989 |
Alternate case study of topical sulfamylon and silver sulfadiazine in burns.
Topics: Acidosis; Adolescent; Adult; Anemia; Burns; Child; Child, Preschool; Female; Humans; Male; Pseudomon | 1971 |
Biochemical and behavioral effects of some substituted catechols.
Topics: Aldehydes; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Brain; Carbon Is | 1969 |