toluene has been researched along with Optic Atrophy, Hereditary, Leber in 1 studies
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.
Optic Atrophy, Hereditary, Leber: A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))
| Excerpt | Relevance | Reference |
|---|---|---|
| " The toxic effect of this compound was similar in control cells irrespective of the mtDNA background." | 1.35 | The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity. ( Achilli, A; Barbieri, A; Carelli, V; Ghelli, A; Iommarini, L; Mattioli, S; Pala, M; Porcelli, AM; Rugolo, M; Torroni, A; Vidoni, S; Zanna, C, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghelli, A | 1 |
| Porcelli, AM | 1 |
| Zanna, C | 1 |
| Vidoni, S | 1 |
| Mattioli, S | 1 |
| Barbieri, A | 1 |
| Iommarini, L | 1 |
| Pala, M | 1 |
| Achilli, A | 1 |
| Torroni, A | 1 |
| Rugolo, M | 1 |
| Carelli, V | 1 |
1 other study available for toluene and Optic Atrophy, Hereditary, Leber
| Article | Year |
|---|---|
The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity.
Topics: Adenosine Triphosphate; Cell Survival; DNA, Mitochondrial; Fibroblasts; Haplotypes; Hexanones; Human | 2009 |