toluene has been researched along with Delayed Effects, Prenatal Exposure in 28 studies
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "They had microcephaly, cerebral palsy, mental retardation, seizures, growth failure and minor craniofacial anomalies, variable growth deficiency including a small midface, narrow bifrontal diameter, low-set ears, thin upper lips and micrognathia." | 5.30 | [Two cases of toluene embryopathy with severe motor and intellectual disabilities syndrome]. ( Aida, N; Arai, H; Hara, M; Iwamoto, H; Miyake, S; Yamada, M; Yamashita, S, 1997) |
| "To determine if maternal toluene abuse produces any structural or developmental disabilities in the developing fetus, a cohort of toluene-exposed infants was ascertained and examined." | 4.79 | Toluene embryopathy: delineation of the phenotype and comparison with fetal alcohol syndrome. ( Hoyme, HE; Pearson, MA; Rimsza, ME; Seaver, LH, 1994) |
| "Volatile organic solvent abuse continues to be a worldwide health problem, including the neurobehavioral teratogenic sequelae of toluene abuse during pregnancy." | 3.85 | Prenatal toluene exposure impairs performance in the Morris Water Maze in adolescent rats. ( Bowen, SE; Callan, SP; Hannigan, JH, 2017) |
| " These studies explored the effects of brief, repeated, prenatal toluene exposures in pregnant female rats on body weight, metabolic rate, body composition, and food intake in their offspring." | 3.74 | Effects of abuse pattern of gestational toluene exposure on metabolism, feeding and body composition. ( Bowen, SE; Coscina, DV; Fata, E; Jarosz, PA; Jen, KL, 2008) |
| "Little is known about the effect of inhalation of methanol and other solvents on the pregnancy and the growth of the fetus." | 3.72 | Intrauterine cerebral infarcts and bilateral frontal cortical leukomalacia following chronic maternal inhalation of carburetor cleaning fluid during pregnancy. ( Bharti, D, 2003) |
| "The present study was undertaken in order to investigate if toluene induced oxidative stress in brains from rats exposed prenatally to 1800 ppm toluene 6 hr/day at days 7-20 during the pregnancy." | 3.71 | Changes in markers of oxidative stress and membrane properties in synaptosomes from rats exposed prenatally to toluene. ( Edelfors, S; Hass, U; Hougaard, KS, 2002) |
| "Pregnant Wistar rats were treated with different concentrations of toluene by inhalation (300, 600, 1000 and 1200 ppm) from day 9 to day 21 of pregnancy for 6 h a day in a whole-body inhalation chamber (controls inhaled fresh air only)." | 3.69 | Postnatal development and behaviour of Wistar rats after prenatal toluene exposure. ( Chahoud, I; Thiel, R, 1997) |
| "Toluene embryopathy is characterised by microcephaly, central nervous system dysfunction, attentional deficits and hyperactivity, developmental delay with greater language deficits, minor craniofacial and limb anomalies, and variable growth deficiency." | 3.67 | Toluene embryopathy: two new cases. ( Hersh, JH, 1989) |
| "Toluene is an organic solvent that is widely used by industry and is ubiquitous in our environment." | 2.46 | Reproductive toxicology and teratology of abused toluene. ( Bowen, SE; Hannigan, JH, 2010) |
| " Thus, the possibility that 4-NT exerted endocrine disrupting effects seems to be very low under the conditions of this study, and when the substance was administered to rats over two generations, doses less than 160 mg/kg/day did not induce any marked adverse effects on the reproductive capacity in the parental animals, with the no observed effect level (NOEL) and the no observed adverse effect (NOAEL) on growth and development in the offspring concluded to be 40 mg/kg/day." | 1.33 | A two-generation reproductive toxicity study of 4-nitrotoluene in rats. ( Aso, S; Ehara, H; Hosyuyama, S; Minobe, Y; Miyata, K; Shiraishi, K; Umano, T, 2005) |
| "They had microcephaly, cerebral palsy, mental retardation, seizures, growth failure and minor craniofacial anomalies, variable growth deficiency including a small midface, narrow bifrontal diameter, low-set ears, thin upper lips and micrognathia." | 1.30 | [Two cases of toluene embryopathy with severe motor and intellectual disabilities syndrome]. ( Aida, N; Arai, H; Hara, M; Iwamoto, H; Miyake, S; Yamada, M; Yamashita, S, 1997) |
| " In conclusion, embryo-fetal toxic effects were apparent in female rats exposed to toluene before and during the early stage of pregnancy." | 1.29 | Reproductive and developmental toxicity studies of toluene. II. Effects of inhalation exposure on fertility in rats. ( Furuya, T; Hirose, A; Inoue, T; Kaneko, T; Kawashima, K; Kurokawa, Y; Matsumoto, K; Naito, K; Ogawa, Y; Ono, A; Saito, M; Sekita, K; Suzuki, S; Tanaka, S; Yasuhara, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (21.43) | 18.7374 |
| 1990's | 7 (25.00) | 18.2507 |
| 2000's | 8 (28.57) | 29.6817 |
| 2010's | 7 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gonzalez-Casanova, I | 1 |
| Stein, AD | 1 |
| Barraza-Villarreal, A | 1 |
| Feregrino, RG | 1 |
| DiGirolamo, A | 1 |
| Hernandez-Cadena, L | 1 |
| Rivera, JA | 1 |
| Romieu, I | 1 |
| Ramakrishnan, U | 1 |
| Vokina, VA | 1 |
| Sosedova, LM | 1 |
| Rukavishnikov, VS | 1 |
| Iakimova, NL | 1 |
| Lizarev, AV | 1 |
| Callan, SP | 1 |
| Hannigan, JH | 3 |
| Bowen, SE | 4 |
| White, KM | 1 |
| Sabatino, JA | 1 |
| He, M | 1 |
| Davis, N | 1 |
| Tang, N | 1 |
| Bearer, CF | 1 |
| Yamamoto, S | 2 |
| Yoshida, Y | 4 |
| Kunugita, N | 4 |
| Arashidani, K | 2 |
| Fujimaki, H | 4 |
| Win-Shwe, TT | 3 |
| Nakajima, D | 2 |
| Tsukahara, S | 1 |
| Bharti, D | 1 |
| Ladefoged, O | 1 |
| Hougaard, KS | 2 |
| Hass, U | 2 |
| Sørensen, IK | 1 |
| Lund, SP | 1 |
| Svendsen, GW | 1 |
| Lam, HR | 1 |
| Aso, S | 1 |
| Miyata, K | 1 |
| Ehara, H | 1 |
| Hosyuyama, S | 1 |
| Shiraishi, K | 1 |
| Umano, T | 1 |
| Minobe, Y | 1 |
| Jarosz, PA | 1 |
| Fata, E | 1 |
| Jen, KL | 1 |
| Coscina, DV | 1 |
| Weiss, B | 1 |
| Pearson, MA | 1 |
| Hoyme, HE | 1 |
| Seaver, LH | 1 |
| Rimsza, ME | 1 |
| Arnold, GL | 1 |
| Kirby, RS | 1 |
| Langendoerfer, S | 1 |
| Wilkins-Haug, L | 1 |
| Taskinen, H | 1 |
| Kyyrönen, P | 1 |
| Hemminki, K | 1 |
| Hoikkala, M | 1 |
| Lajunen, K | 1 |
| Lindbohm, ML | 1 |
| Ono, A | 1 |
| Sekita, K | 1 |
| Ogawa, Y | 1 |
| Hirose, A | 1 |
| Suzuki, S | 1 |
| Saito, M | 1 |
| Naito, K | 1 |
| Kaneko, T | 1 |
| Furuya, T | 1 |
| Kawashima, K | 1 |
| Yasuhara, K | 1 |
| Matsumoto, K | 1 |
| Tanaka, S | 1 |
| Inoue, T | 1 |
| Kurokawa, Y | 1 |
| Thiel, R | 1 |
| Chahoud, I | 1 |
| Arai, H | 1 |
| Yamada, M | 1 |
| Miyake, S | 1 |
| Yamashita, S | 1 |
| Iwamoto, H | 1 |
| Aida, N | 1 |
| Hara, M | 1 |
| Edelfors, S | 1 |
| da-Silva, VA | 1 |
| Malheiros, LR | 1 |
| Bueno, FM | 1 |
| Hersh, JH | 1 |
| Kawata, F | 1 |
| Kudoh, T | 1 |
| Tolstpiatova, GV | 1 |
| Korkach, VI | 1 |
| Bariliak, IR | 1 |
| Samoĭlov, AP | 1 |
| Gudz', OV | 1 |
| Tabacova, S | 1 |
| Shigeta, S | 1 |
| Aikawa, H | 1 |
| Misawa, T | 1 |
| Yoshida, T | 1 |
| Momotani, H | 1 |
| Suzuki, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Prenatal DHA Supplements on Infant Development[NCT00646360] | 1,094 participants (Actual) | Interventional | 2005-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for toluene and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Reproductive toxicology and teratology of abused toluene.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Developmental Disabilities; Female; Humans; Infant, Low | 2010 |
Developmental toxicity of prenatal exposure to toluene.
Topics: Animals; Environmental Exposure; Female; Humans; Incidence; Models, Animal; Pregnancy; Prenatal Expo | 2006 |
Behavioral toxicology and environmental health science. Opportunity and challenge for psychology.
Topics: Air Pollutants; Animals; Behavior; Carbon Disulfide; Child, Preschool; Developmental Disabilities; E | 1983 |
Toluene embryopathy: delineation of the phenotype and comparison with fetal alcohol syndrome.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Developmental Disabilities; Embryo, Mammalian; Ethan | 1994 |
Maternal exposure to environmental chemicals.
Topics: Arsenic; Environmental Exposure; Female; Humans; Hydrocarbons, Chlorinated; Hydrogen Sulfide; Kineti | 1986 |
23 other studies available for toluene and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Prenatal exposure to environmental pollutants and child development trajectories through 7 years.
Topics: Benzene; Child; Child Development; Child, Preschool; Cognition; Environmental Pollutants; Female; Hu | 2018 |
[Neurotoxic effect of toluene on background of prenatal hypoxic brain damage to white rats].
Topics: Animals; Behavior, Animal; Brain; Cognition Disorders; Disease Models, Animal; Electroencephalograph | 2014 |
Prenatal toluene exposure impairs performance in the Morris Water Maze in adolescent rats.
Topics: Animals; Disease Models, Animal; Female; Male; Maze Learning; Pregnancy; Prenatal Exposure Delayed E | 2017 |
Toluene disruption of the functions of L1 cell adhesion molecule at concentrations associated with occupational exposures.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Female; Laminin; Maternal Exposure; Membrane Mi | 2016 |
Children's immunology, what can we learn from animal studies (2): Modulation of systemic Th1/Th2 immune response in infant mice after prenatal exposure to low-level toluene and toll-like receptor (TLR) 2 ligand.
Topics: Animals; Cytokines; Environmental Pollutants; Female; Immunoglobulins; Inhalation Exposure; Ligands; | 2009 |
Suppression of Th1- and Th2-type immune responses in infant mouse spleen after prenatal and postnatal exposure to low-level toluene and peptidoglycan.
Topics: Air Pollutants; Animals; Cytokines; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fem | 2009 |
Differential mRNA expression of neuroimmune markers in the hippocampus of infant mice following toluene exposure during brain developmental period.
Topics: Animals; Animals, Newborn; Cytokines; Female; Gene Expression Regulation, Developmental; Gestational | 2012 |
Developmental stage-specific changes in immunological biomarkers in male C3H/HeN mice after early life toluene exposure.
Topics: Animals; Animals, Newborn; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fo | 2012 |
Intrauterine cerebral infarcts and bilateral frontal cortical leukomalacia following chronic maternal inhalation of carburetor cleaning fluid during pregnancy.
Topics: Acetone; Acidosis; Cerebral Infarction; Drug Combinations; Female; Fetal Diseases; Humans; Infant, N | 2003 |
Effects of combined prenatal stress and toluene exposure on apoptotic neurodegeneration in cerebellum and hippocampus of rats.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Caspase 3; Caspases; Cerebellum; Embryonic and Fetal De | 2004 |
A two-generation reproductive toxicity study of 4-nitrotoluene in rats.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Endocrine Disruptors; Female; Male; | 2005 |
Effects of abuse pattern of gestational toluene exposure on metabolism, feeding and body composition.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Composition; Body Weight; Do | 2008 |
Toluene embryopathy: clinical delineation and developmental follow-up.
Topics: Abnormalities, Drug-Induced; Developmental Disabilities; Embryo, Mammalian; Face; Female; Follow-Up | 1994 |
Laboratory work and pregnancy outcome.
Topics: Abortion, Spontaneous; Adult; Birth Weight; Case-Control Studies; Congenital Abnormalities; Female; | 1994 |
Reproductive and developmental toxicity studies of toluene. II. Effects of inhalation exposure on fertility in rats.
Topics: Administration, Inhalation; Animals; Embryonic and Fetal Development; Female; Fertility; Fetal Death | 1996 |
Postnatal development and behaviour of Wistar rats after prenatal toluene exposure.
Topics: Animals; Animals, Newborn; Discrimination Learning; Female; Fertility; Litter Size; Locomotion; Preg | 1997 |
[Two cases of toluene embryopathy with severe motor and intellectual disabilities syndrome].
Topics: Abnormalities, Drug-Induced; Cerebral Palsy; Child; Craniofacial Abnormalities; Female; Humans; Infa | 1997 |
Changes in markers of oxidative stress and membrane properties in synaptosomes from rats exposed prenatally to toluene.
Topics: Animals; Body Weight; Cell Membrane; Female; Maternal-Fetal Exchange; Oxidative Stress; Pregnancy; P | 2002 |
Effects of toluene exposure during gestation on neurobehavioral development of rats and hamsters.
Topics: Animals; Behavior, Animal; Body Weight; Cricetinae; Female; Litter Size; Male; Mesocricetus; Pregnan | 1990 |
Toluene embryopathy: two new cases.
Topics: Abnormalities, Drug-Induced; Adult; Child, Preschool; Developmental Disabilities; Female; Humans; In | 1989 |
[Effect of toluene inhalation in rats, mice, and mice offsprings].
Topics: Administration, Inhalation; Animals; Animals, Newborn; Brain; Catecholamines; Female; Growth Disorde | 1988 |
[Hygienic standards for 2,4-dichlorotoluene in reservoir water].
Topics: Animals; Blood; Dose-Response Relationship, Drug; Female; Lethal Dose 50; Male; Maximum Allowable Co | 1988 |
Learning impairment in rats following low-level toluene exposure during brain development--a comparative study of high avoidance rats and Wistar rats.
Topics: Animals; Female; Learning Disabilities; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, In | 1986 |