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toluene and Aging

toluene has been researched along with Aging in 25 studies

methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver were investigated in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content using monoclonal antibodies."7.68Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content. ( Elovaara, E; Gelboin, HV; Katakura, Y; Kishi, R; Nakajima, T; Park, SS; Vainio, H; Wang, RS, 1992)
" Three approaches were used: (1) pharmacokinetic (PK), (2) cardiac biomarkers, and (3) whole-animal physiology to assess whether aging increases susceptibility to toluene in the Brown Norway (BN) rat."5.36Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approach. ( Devito, M; Gordon, CJ; Gottipolu, RR; Kenyon, EM; Kodavanti, UP; Mack, CM; MacPhail, RC; Nyska, A; Richards, JE; Schladweiler, MC; Shannahan, JH; Thomas, R; Wallenborn, JG, 2010)
" Individual measurements of age, ventilation rate, blood/air partition coefficient, body weight, and adipose tissue fraction were made on 26 male subjects exposed to 50 ppm 2H8-toluene and 50 ppm toluene for 2 hr at rest, with collection of venous blood samples for 120 hr postexposure."3.69Interindividual differences in 2H8-toluene toxicokinetics assessed by semiempirical physiologically based model. ( Dills, RL; Kalman, DA; Morgan, MS; Nothstein, GL; Pierce, CH; Shen, DD, 1996)
"Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver were investigated in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content using monoclonal antibodies."3.68Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content. ( Elovaara, E; Gelboin, HV; Katakura, Y; Kishi, R; Nakajima, T; Park, SS; Vainio, H; Wang, RS, 1992)
"Toluene-induced CPP was associated with increased excitability of IL5/6 mPFC neurons projecting to the core of the NAc and reduced excitability of those projecting to the NAc shell."1.48Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference. ( Wayman, WN; Woodward, JJ, 2018)
"Inhalant abuse is prevalent in adolescent populations, with chronic use resulting in neurobiological and cognitive abnormalities in adulthood."1.40Specific impairments in instrumental learning following chronic intermittent toluene inhalation in adolescent rats. ( Axelsson, M; Dick, AL; Duncan, JR; Lawrence, AJ, 2014)
"Toluene has been shown to inhibit the nicotinic acetylcholine receptors."1.35Toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome. ( Chan, MH; Chen, HH; Chien, TH; Tang, YC, 2008)
"Toluene induction was already well developed in the youngest age group of both sexes; in most cases the induced enzyme levels in young rats were as high or higher than in adults."1.27Age-and sex-related differences in rat liver microsomal enzymes and their inducibility by toluene. ( Pyykkö, K, 1983)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19906 (24.00)18.7374
1990's5 (20.00)18.2507
2000's4 (16.00)29.6817
2010's10 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wayman, WN1
Woodward, JJ1
Fu, W1
Liu, Y2
Sun, C1
Yin, H1
Duncan, JR2
Gibbs, SJ1
Lawrence, AJ2
Dick, AL1
Axelsson, M1
Lee, JS1
Ward, WO1
Wolf, DC1
Allen, JW1
Mills, C1
DeVito, MJ1
Corton, JC1
Murase, D1
Hachiya, A1
Amano, Y1
Ohuchi, A1
Kitahara, T1
Takema, Y1
Gordon, CJ1
Gottipolu, RR1
Kenyon, EM1
Thomas, R1
Schladweiler, MC1
Mack, CM1
Shannahan, JH1
Wallenborn, JG1
Nyska, A1
MacPhail, RC3
Richards, JE1
Devito, M1
Kodavanti, UP1
Pascual, R1
Aedo, L1
Meneses, JC1
Vergara, D1
Reyes, A1
Bustamante, C1
Chen, HH2
Lin, YR1
Chan, MH2
Royland, JE1
Kodavanti, PR1
Schmid, JE1
Farmer, JD1
Jarema, KA1
Huerta-Rivas, A1
López-Rubalcava, C1
Sánchez-Serrano, SL1
Valdez-Tapia, M1
Lamas, M1
Cruz, SL1
Macdonald, WA1
Pedersen, TH1
Clausen, T1
Nielsen, OB1
Tang, YC1
Chien, TH1
Grasso, P1
Sharratt, M1
Davies, DM1
Irvine, D1
Pyykkö, K1
Devlin, EW1
Brammer, JD1
Puyear, RL1
Hillefors-Berglund, M1
von Euler, G1
Pierce, CH1
Dills, RL1
Morgan, MS1
Nothstein, GL1
Shen, DD1
Kalman, DA1
Shimamoto, A1
Tanaka, E1
Mizuno, D1
Misawa, S1
Nakajima, T1
Wang, RS1
Katakura, Y1
Kishi, R1
Elovaara, E1
Park, SS1
Gelboin, HV1
Vainio, H1
Ghosh, TK1
Copeland, RL1
Pradhan, SN1
Harman, D1
Kormendy, CG1
Bender, AD1
Kohn, RR1

Reviews

2 reviews available for toluene and Aging

ArticleYear
Prolongation of life: role of free radical reactions in aging.
    Journal of the American Geriatrics Society, 1969, Volume: 17, Issue:8

    Topics: Aged; Aging; Amyloidosis; Animals; Arteriosclerosis; Chemistry, Organic; Chickens; Diet; Dietary Fat

1969
Chemical interference with aging.
    Gerontologia, 1971, Volume: 17, Issue:1

    Topics: Adrenal Cortex Hormones; Aging; Animals; Antioxidants; Appetite Depressants; Autoimmune Diseases; Br

1971

Other Studies

23 other studies available for toluene and Aging

ArticleYear
Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 02-07, Volume: 38, Issue:6

    Topics: Administration, Inhalation; Aging; Animals; Cerebral Cortex; Conditioning, Operant; Drug-Seeking Beh

2018
Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:1

    Topics: Adipocytes, Beige; Adiponectin; Adipose Tissue, White; Adiposity; Aging; Animals; Benzothiazoles; Ce

2019
Chronic intermittent toluene inhalation in adolescent rats alters behavioural responses to amphetamine and MK801.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:3

    Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Dizocilpine Maleate; Excitatory Amin

2014
Specific impairments in instrumental learning following chronic intermittent toluene inhalation in adolescent rats.
    Psychopharmacology, 2014, Volume: 231, Issue:8

    Topics: Administration, Inhalation; Aging; Animals; Body Weight; Conditioning, Operant; Cues; Dietary Sucros

2014
Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 106, Issue:1

    Topics: Age Factors; Aging; Animals; Biotransformation; Cluster Analysis; Enzymes; Female; Gene Expression P

2008
The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling.
    The Journal of biological chemistry, 2009, Feb-13, Volume: 284, Issue:7

    Topics: Aging; Animals; Benzothiazoles; Cytokines; Epidermal Cells; Epidermis; Female; Gene Expression Regul

2009
Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approach.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:4

    Topics: Aging; Animals; Biomarkers; Brain; Dose-Response Relationship, Drug; Gene Expression Regulation; Glu

2010
Solvent inhalation (toluene and n-hexane) during the brain growth spurt impairs the maturation of frontal, parietal and occipital cerebrocortical neurons in rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2010, Volume: 28, Issue:6

    Topics: Administration, Inhalation; Aging; Animals; Cerebral Cortex; Drug Combinations; Female; Hexanes; Mal

2010
Toluene exposure during brain growth spurt and adolescence produces differential effects on N-methyl-D-aspartate receptor-mediated currents in rat hippocampus.
    Toxicology letters, 2011, Sep-10, Volume: 205, Issue:3

    Topics: Aging; Animals; CA1 Region, Hippocampal; Electric Stimulation; Excitatory Amino Acid Agonists; Excit

2011
Toluene effects on gene expression in the hippocampus of young adult, middle-age, and senescent Brown Norway Rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 126, Issue:1

    Topics: Administration, Oral; Aging; Animals; Biomarkers; Dose-Response Relationship, Drug; Gene Expression

2012
Toluene effects on the motor activity of adolescent, young-adult, middle-age and senescent male Brown Norway rats.
    Neurotoxicology, 2012, Volume: 33, Issue:1

    Topics: Age Factors; Aging; Analysis of Variance; Animals; Male; Motor Activity; Rats; Rats, Inbred BN; Solv

2012
Toluene impairs learning and memory, has antinociceptive effects, and modifies histone acetylation in the dentate gyrus of adolescent and adult rats.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 102, Issue:1

    Topics: Aging; Analgesics; Animals; Avoidance Learning; Dentate Gyrus; Histone Acetyltransferases; Inhalatio

2012
N-Benzyl-p-toluene sulphonamide allows the recording of trains of intracellular action potentials from nerve-stimulated intact fast-twitch skeletal muscle of the rat.
    Experimental physiology, 2005, Volume: 90, Issue:6

    Topics: Action Potentials; Aging; Animals; Electrophysiology; Muscle Contraction; Muscle Fibers, Fast-Twitch

2005
Toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 101, Issue:2

    Topics: Aging; Animals; Behavior, Animal; Blotting, Western; Body Temperature; Brain; Disease Models, Animal

2008
Neurophysiological and psychological disorders and occupational exposure to organic solvents.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1984, Volume: 22, Issue:10

    Topics: Aging; Alcoholic Intoxication; Animals; Behavior, Animal; Carbon Disulfide; Chloroform; Electroencep

1984
Age-and sex-related differences in rat liver microsomal enzymes and their inducibility by toluene.
    Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:5

    Topics: Aging; Animals; Body Weight; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male;

1983
Acute toxicity of toluene to three age groups of fathead minnows (Pimephales promelas).
    Bulletin of environmental contamination and toxicology, 1982, Volume: 29, Issue:1

    Topics: Aging; Animals; Fishes; Lethal Dose 50; Toluene

1982
Persistent, specific and dose-dependent effects of toluene exposure on dopamine D2 agonist binding in the rat caudate-putamen.
    Toxicology, 1995, Jun-26, Volume: 100, Issue:1-3

    Topics: Aging; Analysis of Variance; Animals; Binding, Competitive; Body Weight; Caudate Nucleus; Dopamine A

1995
Interindividual differences in 2H8-toluene toxicokinetics assessed by semiempirical physiologically based model.
    Toxicology and applied pharmacology, 1996, Volume: 139, Issue:1

    Topics: Absorption; Adipose Tissue; Adult; Aging; Blood-Air Barrier; Body Weight; Computer Simulation; Envir

1996
Age- and sex-related changes in toluene metabolism by rat hepatic microsomes in vitro.
    Research communications in molecular pathology and pharmacology, 1999, Volume: 104, Issue:3

    Topics: Aging; Animals; Benzyl Alcohol; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Female; In

1999
Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Aging; Analgesics; Animals; Antibodies, Monoclonal; Benzyl Alcohol; Benzyl Alcohols; Chloral Hydrate

1992
Sensitivity of EEG in young rats to toluene exposure.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4

    Topics: Aging; Animals; Electrodes, Implanted; Electroencephalography; Electromyography; Male; Rats; Rats, I

1990
Effect of antioxidants on life-span of C57BL mice.
    Journal of gerontology, 1971, Volume: 26, Issue:3

    Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Body Weight; Environment;

1971