toluene and Aging
toluene has been researched along with Aging in 25 studies
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver were investigated in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content using monoclonal antibodies." | 7.68 | Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content. ( Elovaara, E; Gelboin, HV; Katakura, Y; Kishi, R; Nakajima, T; Park, SS; Vainio, H; Wang, RS, 1992) |
| " Three approaches were used: (1) pharmacokinetic (PK), (2) cardiac biomarkers, and (3) whole-animal physiology to assess whether aging increases susceptibility to toluene in the Brown Norway (BN) rat." | 5.36 | Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approach. ( Devito, M; Gordon, CJ; Gottipolu, RR; Kenyon, EM; Kodavanti, UP; Mack, CM; MacPhail, RC; Nyska, A; Richards, JE; Schladweiler, MC; Shannahan, JH; Thomas, R; Wallenborn, JG, 2010) |
| " Individual measurements of age, ventilation rate, blood/air partition coefficient, body weight, and adipose tissue fraction were made on 26 male subjects exposed to 50 ppm 2H8-toluene and 50 ppm toluene for 2 hr at rest, with collection of venous blood samples for 120 hr postexposure." | 3.69 | Interindividual differences in 2H8-toluene toxicokinetics assessed by semiempirical physiologically based model. ( Dills, RL; Kalman, DA; Morgan, MS; Nothstein, GL; Pierce, CH; Shen, DD, 1996) |
| "Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver were investigated in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content using monoclonal antibodies." | 3.68 | Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content. ( Elovaara, E; Gelboin, HV; Katakura, Y; Kishi, R; Nakajima, T; Park, SS; Vainio, H; Wang, RS, 1992) |
| "Toluene-induced CPP was associated with increased excitability of IL5/6 mPFC neurons projecting to the core of the NAc and reduced excitability of those projecting to the NAc shell." | 1.48 | Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference. ( Wayman, WN; Woodward, JJ, 2018) |
| "Inhalant abuse is prevalent in adolescent populations, with chronic use resulting in neurobiological and cognitive abnormalities in adulthood." | 1.40 | Specific impairments in instrumental learning following chronic intermittent toluene inhalation in adolescent rats. ( Axelsson, M; Dick, AL; Duncan, JR; Lawrence, AJ, 2014) |
| "Toluene has been shown to inhibit the nicotinic acetylcholine receptors." | 1.35 | Toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome. ( Chan, MH; Chen, HH; Chien, TH; Tang, YC, 2008) |
| "Toluene induction was already well developed in the youngest age group of both sexes; in most cases the induced enzyme levels in young rats were as high or higher than in adults." | 1.27 | Age-and sex-related differences in rat liver microsomal enzymes and their inducibility by toluene. ( Pyykkö, K, 1983) |
Research
Studies (25)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wayman, WN | 1 |
| Woodward, JJ | 1 |
| Fu, W | 1 |
| Liu, Y | 2 |
| Sun, C | 1 |
| Yin, H | 1 |
| Duncan, JR | 2 |
| Gibbs, SJ | 1 |
| Lawrence, AJ | 2 |
| Dick, AL | 1 |
| Axelsson, M | 1 |
| Lee, JS | 1 |
| Ward, WO | 1 |
| Wolf, DC | 1 |
| Allen, JW | 1 |
| Mills, C | 1 |
| DeVito, MJ | 1 |
| Corton, JC | 1 |
| Murase, D | 1 |
| Hachiya, A | 1 |
| Amano, Y | 1 |
| Ohuchi, A | 1 |
| Kitahara, T | 1 |
| Takema, Y | 1 |
| Gordon, CJ | 1 |
| Gottipolu, RR | 1 |
| Kenyon, EM | 1 |
| Thomas, R | 1 |
| Schladweiler, MC | 1 |
| Mack, CM | 1 |
| Shannahan, JH | 1 |
| Wallenborn, JG | 1 |
| Nyska, A | 1 |
| MacPhail, RC | 3 |
| Richards, JE | 1 |
| Devito, M | 1 |
| Kodavanti, UP | 1 |
| Pascual, R | 1 |
| Aedo, L | 1 |
| Meneses, JC | 1 |
| Vergara, D | 1 |
| Reyes, A | 1 |
| Bustamante, C | 1 |
| Chen, HH | 2 |
| Lin, YR | 1 |
| Chan, MH | 2 |
| Royland, JE | 1 |
| Kodavanti, PR | 1 |
| Schmid, JE | 1 |
| Farmer, JD | 1 |
| Jarema, KA | 1 |
| Huerta-Rivas, A | 1 |
| López-Rubalcava, C | 1 |
| Sánchez-Serrano, SL | 1 |
| Valdez-Tapia, M | 1 |
| Lamas, M | 1 |
| Cruz, SL | 1 |
| Macdonald, WA | 1 |
| Pedersen, TH | 1 |
| Clausen, T | 1 |
| Nielsen, OB | 1 |
| Tang, YC | 1 |
| Chien, TH | 1 |
| Grasso, P | 1 |
| Sharratt, M | 1 |
| Davies, DM | 1 |
| Irvine, D | 1 |
| Pyykkö, K | 1 |
| Devlin, EW | 1 |
| Brammer, JD | 1 |
| Puyear, RL | 1 |
| Hillefors-Berglund, M | 1 |
| von Euler, G | 1 |
| Pierce, CH | 1 |
| Dills, RL | 1 |
| Morgan, MS | 1 |
| Nothstein, GL | 1 |
| Shen, DD | 1 |
| Kalman, DA | 1 |
| Shimamoto, A | 1 |
| Tanaka, E | 1 |
| Mizuno, D | 1 |
| Misawa, S | 1 |
| Nakajima, T | 1 |
| Wang, RS | 1 |
| Katakura, Y | 1 |
| Kishi, R | 1 |
| Elovaara, E | 1 |
| Park, SS | 1 |
| Gelboin, HV | 1 |
| Vainio, H | 1 |
| Ghosh, TK | 1 |
| Copeland, RL | 1 |
| Pradhan, SN | 1 |
| Harman, D | 1 |
| Kormendy, CG | 1 |
| Bender, AD | 1 |
| Kohn, RR | 1 |
Reviews
2 reviews available for toluene and Aging
| Article | Year |
|---|---|
Prolongation of life: role of free radical reactions in aging.
Topics: Aged; Aging; Amyloidosis; Animals; Arteriosclerosis; Chemistry, Organic; Chickens; Diet; Dietary Fat | 1969 |
Chemical interference with aging.
Topics: Adrenal Cortex Hormones; Aging; Animals; Antioxidants; Appetite Depressants; Autoimmune Diseases; Br | 1971 |
Other Studies
23 other studies available for toluene and Aging
| Article | Year |
|---|---|
Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference.
Topics: Administration, Inhalation; Aging; Animals; Cerebral Cortex; Conditioning, Operant; Drug-Seeking Beh | 2018 |
Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy.
Topics: Adipocytes, Beige; Adiponectin; Adipose Tissue, White; Adiposity; Aging; Animals; Benzothiazoles; Ce | 2019 |
Chronic intermittent toluene inhalation in adolescent rats alters behavioural responses to amphetamine and MK801.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Dizocilpine Maleate; Excitatory Amin | 2014 |
Specific impairments in instrumental learning following chronic intermittent toluene inhalation in adolescent rats.
Topics: Administration, Inhalation; Aging; Animals; Body Weight; Conditioning, Operant; Cues; Dietary Sucros | 2014 |
Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats.
Topics: Age Factors; Aging; Animals; Biotransformation; Cluster Analysis; Enzymes; Female; Gene Expression P | 2008 |
The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling.
Topics: Aging; Animals; Benzothiazoles; Cytokines; Epidermal Cells; Epidermis; Female; Gene Expression Regul | 2009 |
Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approach.
Topics: Aging; Animals; Biomarkers; Brain; Dose-Response Relationship, Drug; Gene Expression Regulation; Glu | 2010 |
Solvent inhalation (toluene and n-hexane) during the brain growth spurt impairs the maturation of frontal, parietal and occipital cerebrocortical neurons in rats.
Topics: Administration, Inhalation; Aging; Animals; Cerebral Cortex; Drug Combinations; Female; Hexanes; Mal | 2010 |
Toluene exposure during brain growth spurt and adolescence produces differential effects on N-methyl-D-aspartate receptor-mediated currents in rat hippocampus.
Topics: Aging; Animals; CA1 Region, Hippocampal; Electric Stimulation; Excitatory Amino Acid Agonists; Excit | 2011 |
Toluene effects on gene expression in the hippocampus of young adult, middle-age, and senescent Brown Norway Rats.
Topics: Administration, Oral; Aging; Animals; Biomarkers; Dose-Response Relationship, Drug; Gene Expression | 2012 |
Toluene effects on the motor activity of adolescent, young-adult, middle-age and senescent male Brown Norway rats.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Male; Motor Activity; Rats; Rats, Inbred BN; Solv | 2012 |
Toluene impairs learning and memory, has antinociceptive effects, and modifies histone acetylation in the dentate gyrus of adolescent and adult rats.
Topics: Aging; Analgesics; Animals; Avoidance Learning; Dentate Gyrus; Histone Acetyltransferases; Inhalatio | 2012 |
N-Benzyl-p-toluene sulphonamide allows the recording of trains of intracellular action potentials from nerve-stimulated intact fast-twitch skeletal muscle of the rat.
Topics: Action Potentials; Aging; Animals; Electrophysiology; Muscle Contraction; Muscle Fibers, Fast-Twitch | 2005 |
Toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome.
Topics: Aging; Animals; Behavior, Animal; Blotting, Western; Body Temperature; Brain; Disease Models, Animal | 2008 |
Neurophysiological and psychological disorders and occupational exposure to organic solvents.
Topics: Aging; Alcoholic Intoxication; Animals; Behavior, Animal; Carbon Disulfide; Chloroform; Electroencep | 1984 |
Age-and sex-related differences in rat liver microsomal enzymes and their inducibility by toluene.
Topics: Aging; Animals; Body Weight; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male; | 1983 |
Acute toxicity of toluene to three age groups of fathead minnows (Pimephales promelas).
Topics: Aging; Animals; Fishes; Lethal Dose 50; Toluene | 1982 |
Persistent, specific and dose-dependent effects of toluene exposure on dopamine D2 agonist binding in the rat caudate-putamen.
Topics: Aging; Analysis of Variance; Animals; Binding, Competitive; Body Weight; Caudate Nucleus; Dopamine A | 1995 |
Interindividual differences in 2H8-toluene toxicokinetics assessed by semiempirical physiologically based model.
Topics: Absorption; Adipose Tissue; Adult; Aging; Blood-Air Barrier; Body Weight; Computer Simulation; Envir | 1996 |
Age- and sex-related changes in toluene metabolism by rat hepatic microsomes in vitro.
Topics: Aging; Animals; Benzyl Alcohol; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Female; In | 1999 |
Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content.
Topics: Aging; Analgesics; Animals; Antibodies, Monoclonal; Benzyl Alcohol; Benzyl Alcohols; Chloral Hydrate | 1992 |
Sensitivity of EEG in young rats to toluene exposure.
Topics: Aging; Animals; Electrodes, Implanted; Electroencephalography; Electromyography; Male; Rats; Rats, I | 1990 |
Effect of antioxidants on life-span of C57BL mice.
Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Body Weight; Environment; | 1971 |