toluene has been researched along with Abnormalities, Drug-Induced in 29 studies
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "They had microcephaly, cerebral palsy, mental retardation, seizures, growth failure and minor craniofacial anomalies, variable growth deficiency including a small midface, narrow bifrontal diameter, low-set ears, thin upper lips and micrognathia." | 5.30 | [Two cases of toluene embryopathy with severe motor and intellectual disabilities syndrome]. ( Aida, N; Arai, H; Hara, M; Iwamoto, H; Miyake, S; Yamada, M; Yamashita, S, 1997) |
| " How these Internet resources can be utilized to obtain information on and evaluate the developmental risk associated with exposures during pregnancy will be illustrated using toluene." | 4.81 | Developmental toxicity: web resources for evaluating risk in humans. ( Faustman, EM; Polifka, JE, 2002) |
| "To determine if maternal toluene abuse produces any structural or developmental disabilities in the developing fetus, a cohort of toluene-exposed infants was ascertained and examined." | 4.79 | Toluene embryopathy: delineation of the phenotype and comparison with fetal alcohol syndrome. ( Hoyme, HE; Pearson, MA; Rimsza, ME; Seaver, LH, 1994) |
| "A rat model was developed to study toluene-abuse embryopathy, a clinical syndrome which occurs in offspring of women who abuse toluene during pregnancy." | 3.69 | Development of a rat model of toluene-abuse embryopathy. ( Gospe, SM; Saeed, DB; Zeman, FJ; Zhou, SS, 1996) |
| "Toluene embryopathy is characterised by microcephaly, central nervous system dysfunction, attentional deficits and hyperactivity, developmental delay with greater language deficits, minor craniofacial and limb anomalies, and variable growth deficiency." | 3.67 | Toluene embryopathy: two new cases. ( Hersh, JH, 1989) |
| "Three children with microcephaly, central nervous system dysfunction, minor craniofacial and limb anomalies, and variable growth deficiency were born to women who inhaled large quantities of pure toluene throughout pregnancy." | 3.67 | Toluene embryopathy. ( Hersh, JH; Podruch, PE; Rogers, G; Weisskopf, B, 1985) |
| "Toluene is an organic solvent that is widely used by industry and is ubiquitous in our environment." | 2.46 | Reproductive toxicology and teratology of abused toluene. ( Bowen, SE; Hannigan, JH, 2010) |
| "Also, spontaneous abortion has generally not been observed as a major problem among highly exposed women who abuse toluene during pregnancy." | 2.41 | Review of the epidemiological evidence relating toluene to reproductive outcomes. ( Bukowski, JA, 2001) |
| "Chronic toluene abuse produces a renal tubular acidosis with maternal hypokalemia and profoundly lowered serum pH." | 2.40 | Teratogen update: toluene. ( Wilkins-Haug, L, 1997) |
| "Toluene is a widely used industrial solvent, and humans may also have high exposures to toluene from the deliberate inhalation ("sniffing") of paint reducer, paint thinner, or paint for their narcotic effects." | 2.38 | Reproductive and developmental toxicity of toluene: a review. ( Donald, JM; Hooper, K; Hopenhayn-Rich, C, 1991) |
| "Toluene is a commonly abused organic solvent." | 1.35 | Alterations in rat fetal morphology following abuse patterns of toluene exposure. ( Bowen, SE; Hannigan, JH; Irtenkauf, S; Stefanski, AL, 2009) |
| " At Caesarean section on GD20, no adverse effects on implantation, number and viability of fetuses, or fetal sex distribution were observed." | 1.34 | Developmental and reproductive toxicity evaluation of toluene vapor in the rat II. Developmental toxicity. ( Nicolich, MJ; Roberts, LG; Schreiner, CA, 2007) |
| "Hexachlorobenzene- and TCDD-treated embryos tested positively for expression of cytochrome P450 1A indicating that the cytochrome metabolic pathways were already functional in these early embryos, and suggested that a product of the cytochrome system may be involved in HCB and TCDD pollution associated cardiovascular defects." | 1.30 | The aquatic vertebrate embryo as a sentinel for toxins: zebrafish embryo dechorionation and perivitelline space microinjection. ( Mizell, M; Romig, ES, 1997) |
| "They had microcephaly, cerebral palsy, mental retardation, seizures, growth failure and minor craniofacial anomalies, variable growth deficiency including a small midface, narrow bifrontal diameter, low-set ears, thin upper lips and micrognathia." | 1.30 | [Two cases of toluene embryopathy with severe motor and intellectual disabilities syndrome]. ( Aida, N; Arai, H; Hara, M; Iwamoto, H; Miyake, S; Yamada, M; Yamashita, S, 1997) |
| "Toluene is a widely used solvent in industry which is the subject of abuse among the younger generation." | 1.29 | Reproductive and developmental toxicity studies of toluene. I. Teratogenicity study of inhalation exposure in pregnant rats. ( Furuya, T; Hirose, A; Kaneko, T; Matsumoto, K; Naito, K; Ogawa, Y; Ohno, K; Ono, A; Saito, M; Sekita, K, 1995) |
| " This study was performed in an endeavour to fulfil two requirements for proof of teratogenicity of a substance, namely development of an animal model and demonstration of a dose-response relationship of teratogenicity." | 1.28 | Embryotoxicity of xylene and toluene: an in vitro study. ( Brown-Woodman, PD; Picker, K; Ritchie, HE; Webster, WS, 1991) |
| "Toluene was found to potentiate the toxic effect of ASA and to increase both maternal and embryonic toxicity." | 1.27 | Combined embryotoxic action of toluene, a widely used industrial chemical, and acetylsalicylic acid (aspirin). ( Barcza, G; Lõrincz, M; Tátrai, E; Ungváry, G, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (48.28) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bowen, SE | 2 |
| Irtenkauf, S | 1 |
| Hannigan, JH | 2 |
| Stefanski, AL | 1 |
| Roberts, LG | 1 |
| Nicolich, MJ | 1 |
| Schreiner, CA | 1 |
| Ungváry, G | 3 |
| Tátrai, E | 2 |
| Lõrincz, M | 1 |
| Barcza, G | 1 |
| Shigeta, S | 1 |
| Aikawa, H | 1 |
| Misawa, T | 1 |
| Rodics, K | 1 |
| Ono, A | 1 |
| Sekita, K | 1 |
| Ohno, K | 1 |
| Hirose, A | 1 |
| Ogawa, Y | 1 |
| Saito, M | 1 |
| Naito, K | 1 |
| Kaneko, T | 1 |
| Furuya, T | 1 |
| Matsumoto, K | 1 |
| Pearson, MA | 1 |
| Hoyme, HE | 1 |
| Seaver, LH | 1 |
| Rimsza, ME | 1 |
| Arnold, GL | 1 |
| Kirby, RS | 1 |
| Langendoerfer, S | 1 |
| Wilkins-Haug, L | 2 |
| Gospe, SM | 1 |
| Zhou, SS | 1 |
| Saeed, DB | 1 |
| Zeman, FJ | 1 |
| Mizell, M | 1 |
| Romig, ES | 1 |
| Arai, H | 1 |
| Yamada, M | 1 |
| Miyake, S | 1 |
| Yamashita, S | 1 |
| Iwamoto, H | 1 |
| Aida, N | 1 |
| Hara, M | 1 |
| Bukowski, JA | 1 |
| Dalgaard, M | 1 |
| Hossaini, A | 1 |
| Hougaard, KS | 1 |
| Hass, U | 1 |
| Ladefoged, O | 1 |
| Polifka, JE | 1 |
| Faustman, EM | 1 |
| Elovaara, E | 1 |
| Hemminki, K | 1 |
| Vainio, H | 1 |
| Inouye, M | 1 |
| Murakami, U | 1 |
| Brown-Woodman, PD | 1 |
| Webster, WS | 1 |
| Picker, K | 1 |
| Ritchie, HE | 1 |
| Donald, JM | 1 |
| Hooper, K | 1 |
| Hopenhayn-Rich, C | 1 |
| Hersh, JH | 2 |
| Kurosaki, T | 1 |
| Kawashima, K | 1 |
| Nakaura, S | 1 |
| Tanaka, S | 1 |
| Djajalaksana, S | 1 |
| Takanaka, A | 1 |
| McDonald, JC | 1 |
| Lavoie, J | 1 |
| Côté, R | 1 |
| McDonald, AD | 1 |
| Courtney, KD | 1 |
| Andrews, JE | 1 |
| Springer, J | 1 |
| Ménache, M | 1 |
| Williams, T | 1 |
| Dalley, L | 1 |
| Graham, JA | 1 |
| Podruch, PE | 1 |
| Rogers, G | 1 |
| Weisskopf, B | 1 |
| Krotov, IuA | 1 |
| Chebotar', NA | 1 |
| Euler, HH | 1 |
7 reviews available for toluene and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Reproductive toxicology and teratology of abused toluene.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Developmental Disabilities; Female; Humans; Infant, Low | 2010 |
Toluene embryopathy: delineation of the phenotype and comparison with fetal alcohol syndrome.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Developmental Disabilities; Embryo, Mammalian; Ethan | 1994 |
Teratogen update: toluene.
Topics: Abnormalities, Drug-Induced; Acidosis, Renal Tubular; Administration, Inhalation; Administration, Or | 1997 |
Review of the epidemiological evidence relating toluene to reproductive outcomes.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Bias; Confounding Factors, Epidemiologic; Epidem | 2001 |
Developmental toxicity: web resources for evaluating risk in humans.
Topics: Abnormalities, Drug-Induced; Databases as Topic; Embryonic and Fetal Development; Female; Humans; In | 2002 |
Reproductive and developmental toxicity of toluene: a review.
Topics: Abnormalities, Drug-Induced; Animals; Embryonic and Fetal Development; Female; Growth; Humans; Infan | 1991 |
Mafenide acetate cream: a review.
Topics: Abnormalities, Drug-Induced; Anti-Infective Agents, Local; Burns; Drug Resistance, Microbial; Infect | 1971 |
22 other studies available for toluene and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Alterations in rat fetal morphology following abuse patterns of toluene exposure.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Crown-Rump Length; Dose-Response Relationship, | 2009 |
Developmental and reproductive toxicity evaluation of toluene vapor in the rat II. Developmental toxicity.
Topics: Abnormalities, Drug-Induced; Air Pollutants; Animals; Body Weight; Bone and Bones; Dose-Response Rel | 2007 |
Combined embryotoxic action of toluene, a widely used industrial chemical, and acetylsalicylic acid (aspirin).
Topics: Abnormalities, Drug-Induced; Amniotic Fluid; Animals; Aspirin; Drug Interactions; Embryo, Mammalian; | 1983 |
Effects of maternal exposure to toluene during pregnancy on mouse embryos and fetuses.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Embryo Implantation; Embryo, Mammalian; Female | 1982 |
Embryotoxic effects of simultaneously applied exposure of benzene and toluene.
Topics: Abnormalities, Drug-Induced; Animals; Benzene; Body Weight; Female; Fetal Growth Retardation; Fetus; | 1980 |
Reproductive and developmental toxicity studies of toluene. I. Teratogenicity study of inhalation exposure in pregnant rats.
Topics: Abnormalities, Drug-Induced; Administration, Inhalation; Animals; Animals, Newborn; Embryonic and Fe | 1995 |
Toluene embryopathy: clinical delineation and developmental follow-up.
Topics: Abnormalities, Drug-Induced; Developmental Disabilities; Embryo, Mammalian; Face; Female; Follow-Up | 1994 |
Development of a rat model of toluene-abuse embryopathy.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Brain; Disease Models, Animal; Eating; F | 1996 |
The aquatic vertebrate embryo as a sentinel for toxins: zebrafish embryo dechorionation and perivitelline space microinjection.
Topics: Abnormalities, Drug-Induced; Animals; Benzene; Cardiovascular System; Chorion; Embryo, Nonmammalian; | 1997 |
[Two cases of toluene embryopathy with severe motor and intellectual disabilities syndrome].
Topics: Abnormalities, Drug-Induced; Cerebral Palsy; Child; Craniofacial Abnormalities; Female; Humans; Infa | 1997 |
Developmental toxicity of toluene in male rats: effects on semen quality, testis morphology, and apoptotic neurodegeneration.
Topics: Abnormalities, Drug-Induced; Administration, Inhalation; Animals; Animals, Newborn; Apoptosis; Body | 2001 |
Effects of methylene chloride, trichloroethane, trichloroethylene, tetrachloroethylene and toluene on the development of chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Hydrocarbons, Chlorinated; Methylene Chloride; T | 1979 |
Teratogenicity of 2,5-diaminotoluene, a hair-dye constituent, in mice.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Coloring Agents; Cosmetics; Female; Fetal Deat | 1977 |
Embryotoxicity of xylene and toluene: an in vitro study.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Embryo, Mammalian; In Vitro | 1991 |
Toluene embryopathy: two new cases.
Topics: Abnormalities, Drug-Induced; Adult; Child, Preschool; Developmental Disabilities; Female; Humans; In | 1989 |
[Effects of dibenzyltoluene on fetal developments of rats].
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Dose-Response Relationship, Drug; | 1988 |
Chemical exposures at work in early pregnancy and congenital defect: a case-referent study.
Topics: Abnormalities, Drug-Induced; Air Pollutants, Occupational; Digestive System Abnormalities; Female; H | 1987 |
A perinatal study of toluene in CD-1 mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Isoenzymes; L-Lactate Dehydrogenase; Mice; Preg | 1986 |
The possible contribution of industrial chemicals (organic solvents) to the incidence of congenital defects caused by teratogenic drugs and consumer goods--an experimental study.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Benzene; Drug Synergism; Ethanol; Female; Fetus; Preg | 1985 |
Toluene embryopathy.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Environmental Pollution; Female; Growth Disorders; Hu | 1985 |
[Study of the embryotoxic and teratogenic effect of several industrial substances formed during the production of dimethylterephthalate].
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Occupational Medicine; Phthalic Aci | 1972 |
[Animal experimental studies of an industrial noxa].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Animals; Female; Humans; Infant, Newbor | 1967 |