toluene 2,4-diisocyanate and Disease Models, Animal

Topics: Air Pollutants, Occupational; Animals; Asthma; Bronchial Hyperreactivity; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; Humans; Immunoglobulin E; Mice; Occupational Diseases; Occupational Exposure; T-Lymphocytes; Toluene 2,4-Diisocyanate

Topics: Allergens; Animals; Asthma; Cyanates; Disease Models, Animal; Isocyanates; Mice; Models, Biological; Models, Chemical; Toluene 2,4-Diisocyanate

Topics: Administration, Inhalation; Administration, Oral; Air Pollutants, Occupational; Animals; Carcinogens; Disease Models, Animal; Female; Guinea Pigs; Humans; Irritants; Lethal Dose 50; Male; Mice; Rats; Rats, Inbred F344; Toluene 2,4-Diisocyanate

Topics: Administration, Inhalation; Animals; Disease Models, Animal; Guinea Pigs; Humans; Maximum Allowable Concentration; Meta-Analysis as Topic; Mice; Occupational Exposure; Respiration Disorders; Toluene 2,4-Diisocyanate

Topics: Animals; Bronchi; Disease Models, Animal; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Lung; Lung Diseases; Occupational Diseases; Skin Tests; Subtilisins; Time Factors; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Benzamides; Cell Line; Cytokines; Depsipeptides; Disease Models, Animal; Histone Deacetylase 1; Humans; Inflammation; Male; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Receptor for Advanced Glycation End Products; Signal Transduction; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Dexamethasone; Disease Models, Animal; Extracellular Traps; Humans; Inflammation; Interleukin-8; Mice; Steroids; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchi; Cell Line; Cytokines; Disease Models, Animal; Epithelial Cells; Humans; Inflammasomes; Inflammation; Male; Mice; Mice, Inbred BALB C; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate

Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Immunity, Innate; Lymphocytes; Mice; Mice, Inbred C57BL; MicroRNAs; Toluene 2,4-Diisocyanate

Topics: Acetylcysteine; Allergens; Animals; Anti-Asthmatic Agents; Antioxidants; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Glutathione; Immunoglobulin E; Interleukin-4; Interleukin-5; Leukocyte Count; Lung; Male; Mice, Inbred BALB C; Neutrophils; Superoxide Dismutase; Toluene 2,4-Diisocyanate

Topics: A549 Cells; Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Chemotaxis, Leukocyte; Disease Models, Animal; Eosinophils; Female; Humans; Interleukin-33; Interleukin-8; Lung; Mice, Inbred BALB C; Pneumonia; Receptors, Aryl Hydrocarbon; Signal Transduction; Toluene 2,4-Diisocyanate; Up-Regulation

Topics: Administration, Oral; Animals; Cytokines; Dendritic Cells; Dermatitis, Allergic Contact; Disease Models, Animal; Female; Humans; Inflammation Mediators; Keratinocytes; Mice, Inbred BALB C; Pruritus; Skin; Th2 Cells; THP-1 Cells; Toluene 2,4-Diisocyanate; Trichothecenes

Topics: Airway Remodeling; Animals; Anti-Inflammatory Agents; Asthma; Cytokines; Dexamethasone; Disease Models, Animal; Heterocyclic Compounds, 3-Ring; Immunoglobulin E; Inflammation; Male; Mice; Mice, Inbred BALB C; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Toluene 2,4-Diisocyanate; Treatment Outcome

Topics: Adult; Aged; Animals; Anti-Asthmatic Agents; Asthma; beta Catenin; Bronchoconstriction; Case-Control Studies; Cell Line; Disease Models, Animal; Female; Humans; JNK Mitogen-Activated Protein Kinases; Lung; Male; Mice, Inbred C57BL; Middle Aged; Phosphorylation; Pneumonia; Protein Kinase Inhibitors; Receptor for Advanced Glycation End Products; Serum Albumin, Human; Signal Transduction; Toluene 2,4-Diisocyanate

Topics: Adaptor Proteins, Signal Transducing; Animals; Antibodies; Asthma; Calcium-Binding Proteins; Disease Models, Animal; Female; Immunoglobulin E; Lung; Mice, Inbred BALB C; Spleen; Th17 Cells; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Class I Phosphatidylinositol 3-Kinases; Class Ib Phosphatidylinositol 3-Kinase; Disease Models, Animal; Eosinophils; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Neutrophils; Toluene 2,4-Diisocyanate

Topics: Animals; Antibodies, Monoclonal, Humanized; Asthma; Disease Models, Animal; Drug Resistance; Humans; Interleukin-6; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Signal Transduction; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Cell Line; Cytokines; Disease Models, Animal; Gene Expression; Glycation End Products, Advanced; HMGB1 Protein; Humans; Male; Mice, Inbred BALB C; Peptides; Phosphorylation; Protein Conformation; Receptor for Advanced Glycation End Products; STAT5 Transcription Factor; Thymic Stromal Lymphopoietin; Toluene 2,4-Diisocyanate

Topics: Animals; Antibodies; Asthma; Disease Models, Animal; Immunoglobulin E; Interleukin-13; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Toluene 2,4-Diisocyanate

Topics: Allergens; Animals; Dermatitis, Atopic; Detergents; Dinitrochlorobenzene; Disease Models, Animal; Female; Formaldehyde; Immunoglobulin E; Interferon-gamma; Interleukin-4; Isocyanates; Mast Cells; Mice, Inbred BALB C; Phthalic Anhydrides; Pyroglyphidae; Skin; Th2 Cells; Toluene; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; beta Catenin; Bronchoalveolar Lavage Fluid; Cell Count; Cell Line; Disease Models, Animal; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Low Density Lipoprotein Receptor-Related Protein-6; Lung; Male; Mice, Inbred BALB C; Phosphorylation; Receptor for Advanced Glycation End Products; Toluene 2,4-Diisocyanate

Topics: Administration, Oral; Animals; Benzhydryl Compounds; Cell Line; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Disease Progression; Environmental Pollutants; Epithelial Cells; Female; Humans; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Phenols; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate

Topics: Animals; Anti-Asthmatic Agents; Asthma, Occupational; Bronchoalveolar Lavage Fluid; Cadherins; Collagen; Disease Models, Animal; Diterpenes; Female; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; beta Catenin; Caveolin 1; Disease Models, Animal; Male; Mice, Inbred BALB C; Protein Stability; Receptor for Advanced Glycation End Products; Signal Transduction; src-Family Kinases; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchodilator Agents; Disease Models, Animal; Drug Resistance; Fluticasone; Glucocorticoids; Interleukin-17; Mice; Mice, Inbred BALB C; Prednisone; Toluene 2,4-Diisocyanate

Topics: Airway Remodeling; Animals; Asthma; Caspase 1; Disease Models, Animal; Furans; Heterocyclic Compounds, 4 or More Rings; Indenes; Interleukin-18; Male; Mice; Mice, Inbred C57BL; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein; Respiratory Hypersensitivity; Serpins; Sulfonamides; Sulfones; Th17 Cells; Th2 Cells; Toluene 2,4-Diisocyanate; Viral Proteins

Topics: Administration, Cutaneous; Administration, Intranasal; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Dendritic Cells; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Leukocytes; Lung; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Toluene 2,4-Diisocyanate

Topics: Allergens; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Cadherins; Cells, Cultured; Dexamethasone; Disease Models, Animal; Drug Antagonism; Epithelial Cells; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Neutrophils; Toluene 2,4-Diisocyanate

Topics: Acute Lung Injury; Animals; Asthma; Biomarkers; Breath Tests; Carbon Dioxide; Chlorine; Disease Models, Animal; Equipment Design; Exhalation; Inhalation Exposure; Lipopolysaccharides; Male; Nitric Oxide; Phosgene; Plethysmography, Impedance; Rats; Rats, Inbred BN; Rats, Wistar; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; B-Lymphocyte Subsets; B7-1 Antigen; B7-2 Antigen; Bronchoconstrictor Agents; CD40 Antigens; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, SCID; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Cell Count; Cell Movement; Cells, Cultured; Chemokine CXCL2; Disease Models, Animal; HMGB1 Protein; Lung; Male; Mice; Neutrophils; Pyruvates; Receptors, Interleukin-8B; Toluene 2,4-Diisocyanate; Tumor Necrosis Factor-alpha

Topics: Administration, Inhalation; Airway Resistance; Animals; Asthma; Carrier Proteins; Caspase 1; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; HMGB1 Protein; Inflammasomes; Lung; Male; Mice, Inbred BALB C; Neutrophil Infiltration; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Transport; Random Allocation; Respiratory Mucosa; Signal Transduction; Specific Pathogen-Free Organisms; Toluene 2,4-Diisocyanate

Topics: Animals; Anti-Asthmatic Agents; Antioxidants; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Nyctaginaceae; Plant Extracts; Rats; Rats, Sprague-Dawley; Toluene 2,4-Diisocyanate

Topics: Administration, Oral; Aggression; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Behavior, Animal; Brain; Dermatitis, Atopic; Disease Models, Animal; Female; Janus Kinases; Male; Mice, Inbred BALB C; Piperidines; Protein Kinase Inhibitors; Pruritus; Pyrimidines; Pyrroles; Stress, Psychological; Sulfonamides; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Chickens; Disease Models, Animal; HMGB1 Protein; Immunoglobulins; Interleukin-4; Male; Mice; Mice, Inbred BALB C; Neutrophils; Toluene 2,4-Diisocyanate

Topics: Air Pollutants, Occupational; Animals; Asthma; Cross Reactions; Disease Models, Animal; Immunoglobulin E; Isocyanates; Male; Mice, Inbred C57BL; Th1-Th2 Balance; Toluene 2,4-Diisocyanate

Topics: Animals; Anti-Allergic Agents; Benzofurans; Cytokines; Disease Models, Animal; Gene Expression Regulation; HeLa Cells; Histamine; Humans; Male; Protein Kinase C-delta; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Rhinitis, Allergic; Tephrosia; Th2 Cells; Toluene 2,4-Diisocyanate

Topics: Animals; Antigens, CD; Cell Proliferation; Cells, Cultured; CTLA-4 Antigen; Dermatitis, Allergic Contact; Disease Models, Animal; Female; Inducible T-Cell Co-Stimulator Protein; Integrin alpha Chains; Kinetics; Lymphocyte Activation; Mice, Inbred BALB C; Neuropilin-1; Phenotype; Receptors, CCR6; Skin; T-Lymphocytes, Regulatory; Toluene 2,4-Diisocyanate

Topics: Animals; Chemokine CCL17; Chemotaxis; Coculture Techniques; Dendritic Cells; Dermatitis, Atopic; Disease Models, Animal; Female; Histamine; Humans; Indoles; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Piperazines; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Skin; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; beta Catenin; Disease Models, Animal; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Male; Mice; Mice, Inbred BALB C; Receptor for Advanced Glycation End Products; Structure-Activity Relationship; Toluene 2,4-Diisocyanate

Topics: Airway Remodeling; Animals; Anti-Asthmatic Agents; Asthma; beta Catenin; Biomarkers; Bridged Bicyclo Compounds, Heterocyclic; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Immunoglobulin E; Immunohistochemistry; Lymphocytes; Male; Mice; Molecular Targeted Therapy; Pyrimidinones; Signal Transduction; Toluene 2,4-Diisocyanate

Topics: Animals; Anti-Allergic Agents; Calcimycin; Cell Degranulation; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drugs, Chinese Herbal; Guinea Pigs; Histamine; Humans; Immunoglobulin E; Interleukin-6; Janus Kinase 2; Leukotriene D4; Male; Mast Cells; Phosphorylation; Rhinitis, Allergic; Signal Transduction; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Tetradecanoylphorbol Acetate; Toluene 2,4-Diisocyanate; Tumor Necrosis Factor-alpha

Topics: Administration, Cutaneous; Administration, Oral; Animals; Cell Line; Dendritic Cells; Dermatitis, Allergic Contact; Disease Models, Animal; Ear; Female; Humans; Infant, Newborn; Inflammation; Interleukin-1beta; Interleukin-4; Keratinocytes; Metalloporphyrins; Mice; Mice, Inbred BALB C; p-Methoxy-N-methylphenethylamine; Pruritus; Skin; Skin Cream; Superoxide Dismutase; Toluene 2,4-Diisocyanate

Topics: Allergens; Animals; B-Lymphocytes; Cytokines; Dinitrochlorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Immunization; Immunoglobulin E; Local Lymph Node Assay; Lymph Nodes; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred BALB C; Multiple Chemical Sensitivity; Phthalic Anhydrides; Toluene 2,4-Diisocyanate

Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Disease Models, Animal; Dose-Response Relationship, Immunologic; Environmental Pollutants; Female; Immunoglobulin E; Lung; Mice; Mice, Inbred BALB C; Phthalic Anhydrides; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate; Trachea

Topics: Allergens; Animals; Bronchial Provocation Tests; Cytokines; Dinitrochlorobenzene; Disease Models, Animal; Inflammation; Interferon-gamma; Interleukin-4; Irritants; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Phthalic Anhydrides; Respiratory Hypersensitivity; RNA, Messenger; Toluene 2,4-Diisocyanate

Topics: Animals; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Histamine; Histidine Decarboxylase; Hypersensitivity; Male; Medicine, Kampo; Nasal Mucosa; Rats; Rats, Inbred BN; Receptors, Histamine H1; RNA, Messenger; Signal Transduction; Toluene 2,4-Diisocyanate

Topics: Animals; Antigens, CD; Asthma; Cells, Cultured; Cross Reactions; Cytokines; Disease Models, Animal; Immunoglobulins; Local Lymph Node Assay; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phenylenediamines; Statistics, Nonparametric; Toluene 2,4-Diisocyanate

Topics: Administration, Intranasal; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Respiratory Aspiration; Toluene 2,4-Diisocyanate; Up-Regulation

Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Dibenzoxepins; Disease Models, Animal; Drug Administration Schedule; Histamine H1 Antagonists, Non-Sedating; Male; Nerve Growth Factor; Olopatadine Hydrochloride; Rats; Rats, Inbred BN; Rhinitis, Allergic, Seasonal; Terfenadine; Toluene 2,4-Diisocyanate; Vascular Endothelial Growth Factor A

Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Disease Models, Animal; Ear; Female; Hypersensitivity; Immunologic Factors; Inflammation; Interleukins; Membrane Microdomains; Mice; Phosphorylcholine; Pruritus; Skin; T-Lymphocytes; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Gold; Immunoglobulin E; Lung; Macrophages; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Neutrophils; Pulmonary Edema; Titanium; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Mass Spectrometry; Methacholine Chloride; Mice; Neutrophils; Oxidative Stress; Proteome; Toluene 2,4-Diisocyanate

Topics: Adoptive Transfer; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Immunoglobulin E; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Time Factors; Toluene 2,4-Diisocyanate

Topics: Animals; Disease Models, Animal; Down-Regulation; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity; Male; Microarray Analysis; Nasal Mucosa; Phytotherapy; Plant Extracts; Rats; Rats, Inbred Strains; Signal Transduction; Sophora; Toluene 2,4-Diisocyanate; Ubiquitins

Topics: Albizzia; Animals; Disease Models, Animal; HeLa Cells; Histamine; Histamine H1 Antagonists; Histidine Decarboxylase; Humans; Male; Plant Bark; Plant Extracts; Rats; Rats, Inbred BN; Real-Time Polymerase Chain Reaction; Receptors, Histamine H1; Rhinitis, Allergic, Perennial; Signal Transduction; Toluene 2,4-Diisocyanate; Transcription, Genetic

Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Asthma; Basic Helix-Loop-Helix Transcription Factors; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cytokines; Disease Models, Animal; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred BALB C; Pneumonia; Reactive Oxygen Species; Ribonucleotides; Signal Transduction; Toluene 2,4-Diisocyanate; Vascular Endothelial Growth Factor A

Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Female; Inhalation Exposure; Leukocytes; Macrophages; Mice; Toluene 2,4-Diisocyanate

Topics: Animals; Cytosol; Dermatitis, Contact; Disease Models, Animal; Golgi Apparatus; HeLa Cells; Histamine; Histamine H1 Antagonists; Humans; Male; Phorbol Esters; Poly(ADP-ribose) Polymerases; Protein Kinase C-delta; Protein Transport; Quercetin; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Signal Transduction; Toluene 2,4-Diisocyanate; Up-Regulation

Topics: Aerosols; Air Pollutants, Occupational; Animals; Chemical Industry; Disease Models, Animal; Environmental Monitoring; Female; Guinea Pigs; Hot Temperature; Isocyanates; Lung; Male; Perfusion; Polyurethanes; Probability; Risk Assessment; Toluene 2,4-Diisocyanate

Topics: Administration, Intranasal; Animals; Capsaicin; Disease Models, Animal; Female; Immunohistochemistry; Male; Nasal Mucosa; Rabbits; Rhinitis, Allergic, Perennial; Toluene 2,4-Diisocyanate

Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Guinea Pigs; Larynx; Male; Pulmonary Eosinophilia; Toluene 2,4-Diisocyanate; Trachea

Topics: Administration, Intranasal; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dermatitis, Allergic Contact; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Occupational Exposure; Plethysmography, Whole Body; Respiratory Mechanics; Toluene 2,4-Diisocyanate

Topics: Animals; Anti-Bacterial Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Doxycycline; Female; Inflammation; Lung; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Ovalbumin; Protease Inhibitors; RNA, Messenger; Toluene 2,4-Diisocyanate

Topics: Airway Resistance; Animals; Bronchial Provocation Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate

Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Glucocorticoids; Male; Nasal Mucosa; Random Allocation; Rats; Receptors, Histamine H1; Reverse Transcriptase Polymerase Chain Reaction; Toluene 2,4-Diisocyanate; Up-Regulation

Topics: Airway Resistance; Albumins; Albuterol; Allergens; Animals; Asthma; Chromones; Dexamethasone; Disease Models, Animal; Fucose; Guinea Pigs; Hypersensitivity, Delayed; Immunoglobulin E; Immunoglobulin G; Male; Time Factors; Toluene 2,4-Diisocyanate; Trachea

Topics: Administration, Inhalation; Allergens; Animals; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophils; Female; Inhalation Exposure; Rats; Rats, Wistar; Toluene 2,4-Diisocyanate

Topics: Animals; Antibody Formation; Antibody Specificity; Asthma; Disease Models, Animal; Female; Inflammation; Interleukin-1; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interleukin-1; Respiratory Hypersensitivity; Signal Transduction; Toluene 2,4-Diisocyanate; Up-Regulation

Topics: Administration, Topical; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Inhalation Exposure; Injections, Subcutaneous; Lung; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Th2 Cells; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Catechin; Disease Models, Animal; Gene Expression Regulation; Inflammation; Interleukin-5; Matrix Metalloproteinase 9; Mice; Reactive Oxygen Species; Respiratory System; Toluene 2,4-Diisocyanate; Tumor Necrosis Factor-alpha

Topics: Animals; Chlorpheniramine; Dibenzazepines; Disease Models, Animal; Histamine; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Nasal Mucosa; Plethysmography, Whole Body; Rats; Rats, Inbred BN; Rhinitis; Toluene 2,4-Diisocyanate

Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulins; In Vitro Techniques; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, SCID; Skin; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Cell Adhesion Molecules; Cytokines; Disease Models, Animal; Inflammation; Mice; NF-kappa B; PPAR gamma; Respiratory System; Th2 Cells; Toluene 2,4-Diisocyanate; Transforming Growth Factor beta1

Topics: Alum Compounds; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Inflammation; Interleukin-4; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Th2 Cells; Toluene 2,4-Diisocyanate

Topics: Administration, Inhalation; Aerosols; Animals; Antibody Specificity; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Immunoglobulin G; Mice; Mice, Inbred C57BL; Nasal Mucosa; Occupational Diseases; Random Allocation; Rhinitis, Allergic, Perennial; Th1 Cells; Th2 Cells; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Disease Models, Animal; Disease Susceptibility; Female; Gene Expression Regulation; Interleukin-4; Irritants; Lung; Male; Maternal Exposure; Mice; Mice, Inbred BALB C; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Th1 Cells; Th2 Cells; Toluene 2,4-Diisocyanate

Topics: Adenoviridae; Animals; Asthma; Disease Models, Animal; Down-Regulation; Female; Inflammation; Inhalation Exposure; Interleukin-17; Mice; Mice, Inbred BALB C; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase; Sulfones; Toluene 2,4-Diisocyanate

Topics: Animals; Dexamethasone; Disease Models, Animal; Gene Expression Regulation; HeLa Cells; Histamine; Histidine Decarboxylase; Humans; Hypersensitivity; Male; Mast Cells; Nasal Mucosa; Rats; Rats, Inbred BN; Receptors, Histamine H1; Signal Transduction; Toluene 2,4-Diisocyanate; Up-Regulation

Topics: Animals; Anti-Allergic Agents; Dibenzoxepins; Disease Models, Animal; Histamine; Histamine H1 Antagonists, Non-Sedating; Male; Nasal Lavage Fluid; Nerve Growth Factor; Olopatadine Hydrochloride; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Perennial; Toluene 2,4-Diisocyanate; Vascular Endothelial Growth Factor A

Topics: Animals; Asthma; Cyanates; Disease Models, Animal; Guinea Pigs; Histamine Release; Rhinitis, Allergic, Perennial; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Cross Reactions; Cyanates; Disease Models, Animal; Female; Guinea Pigs; Humans; Immunization; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin E; Immunoglobulin G; Isocyanates; Occupational Diseases; Passive Cutaneous Anaphylaxis; Serum Albumin; Toluene 2,4-Diisocyanate; Transferrin

Topics: Animals; Asthma; Cyanates; Disease Models, Animal; Female; Guinea Pigs; Immune Sera; Immunoglobulin E; Isocyanates; Occupational Diseases; Respiratory Function Tests; Toluene 2,4-Diisocyanate; Transferrin

Topics: Animals; Asthma; Cyanates; Disease Models, Animal; Guinea Pigs; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Cyanates; Disease Models, Animal; Female; Guinea Pigs; Lung; Male; Occupational Diseases; Toluene 2,4-Diisocyanate

Topics: Administration, Intranasal; Administration, Topical; Allergens; Analysis of Variance; Animals; Cytokines; Dinitrochlorobenzene; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Haptens; Immunoglobulin E; Immunoglobulin G; Luminescent Measurements; Lung; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Skin; Toluene 2,4-Diisocyanate

Topics: Administration, Intranasal; Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Female; Guinea Pigs; Nasal Mucosa; Olfactory Bulb; Rhinitis, Allergic, Perennial; Substance P; Toluene 2,4-Diisocyanate; Tyrosine 3-Monooxygenase

Topics: Administration, Intranasal; Animals; Asthma; Disease Models, Animal; Guinea Pigs; Histamine Release; Immunoglobulin E; Immunoglobulin G; Lung; Male; Passive Cutaneous Anaphylaxis; Respiration; Toluene 2,4-Diisocyanate

Topics: Administration, Inhalation; Animals; Antibody Specificity; Disease Models, Animal; Female; Guinea Pigs; Histamine Release; Immunoglobulin G; Lung; Mast Cells; Prostaglandins E; Respiratory Hypersensitivity; Serum Albumin; Toluene 2,4-Diisocyanate

Topics: Administration, Inhalation; Allergens; Animals; Antibody Specificity; Antigen-Antibody Complex; Dinitrochlorobenzene; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Guinea Pigs; Haptens; Injections, Intradermal; Isocyanates; Male; Molecular Weight; Phthalic Anhydrides; Respiration; Respiratory Hypersensitivity; Serum Albumin; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Guinea Pigs; Hypersensitivity, Delayed; Inflammation; Male; Respiratory System; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Disease Models, Animal; Guinea Pigs; Hypersensitivity, Delayed; Immunoglobulin E; Immunoglobulin G; Male; Passive Cutaneous Anaphylaxis; Toluene 2,4-Diisocyanate

Topics: Animals; Disease Models, Animal; Guinea Pigs; Hypersensitivity, Immediate; Nasal Mucosa; Rhinitis, Allergic, Perennial; Toluene 2,4-Diisocyanate

Topics: Acetylcholine; Airway Resistance; Animals; Blood Pressure; Bronchial Hyperreactivity; Bronchial Provocation Tests; Disease Models, Animal; Elasticity; Lung Diseases; Maximum Allowable Concentration; Occupational Diseases; Rabbits; Reproducibility of Results; Toluene 2,4-Diisocyanate

Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Animals; Bronchi; Bronchoconstriction; Capsaicin; Disease Models, Animal; Lung Diseases; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Occupational Diseases; Rabbits; Receptors, Neurokinin-2; Substance P; Toluene 2,4-Diisocyanate; Trachea

Topics: Administration, Inhalation; Allergens; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypersensitivity, Delayed; Injections, Intradermal; Mathematics; Reproducibility of Results; Respiration; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate

Topics: Animals; Bronchial Provocation Tests; Calcitonin Gene-Related Peptide; Cell Count; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization; Immunoglobulin G; Immunohistochemistry; Inflammation; Male; Nerve Fibers; Respiratory System; Substance P; Tachykinins; Toluene 2,4-Diisocyanate

Topics: Acetylcholine; Animals; Culture Techniques; Cyanates; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Guinea Pigs; Isocyanates; Lung Diseases; Muscle Contraction; Muscle, Smooth; Reference Values; Toluene 2,4-Diisocyanate; Trachea

Topics: Allergens; Animals; Cytokines; Dietary Supplements; Disease Models, Animal; Drug Hypersensitivity; Female; Immunoglobulin E; Interferon-gamma; Interleukins; Lymphocyte Count; Mice; Mice, Inbred BALB C; Random Allocation; Spleen; Toluene 2,4-Diisocyanate; Vitamin E

Topics: Administration, Topical; Animals; Benzamides; Cyclosporine; Dermatitis, Allergic Contact; Dinitrobenzenes; Disease Models, Animal; Female; Interleukin-4; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Pyridines; Toluene 2,4-Diisocyanate

Topics: Animals; Antibodies; Blotting, Western; Disease Models, Animal; Electrophoresis, Gel, Pulsed-Field; Enzyme-Linked Immunosorbent Assay; Guinea Pigs; Hypersensitivity, Immediate; Immunoproteins; Injections, Intradermal; Male; Sensitivity and Specificity; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Disease Models, Animal; Female; Inflammation Mediators; Mice; Mice, Inbred C57BL; Mice, Nude; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Protease Inhibitors; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Interleukin-4; Interleukin-6; Lung; Lymphocyte Subsets; Lymphocytes; Male; Occupational Diseases; Rats; Rats, Wistar; Spleen; Statistics, Nonparametric; Toluene 2,4-Diisocyanate

Topics: Administration, Inhalation; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Migration Inhibition; Cell Movement; Disease Models, Animal; Endothelial Growth Factors; Extravasation of Diagnostic and Therapeutic Materials; Female; Indoles; Inflammation; Leukocyte Count; Lymphokines; Mice; Mice, Inbred BALB C; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Toluene 2,4-Diisocyanate; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Allergens; Animals; Antigen-Antibody Reactions; Atmosphere Exposure Chambers; Cyanates; Disease Models, Animal; Equipment Design; Guinea Pigs; Lung Diseases; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Disease Models, Animal; Guinea Pigs; Immunoglobulin E; Occupational Diseases; Passive Cutaneous Anaphylaxis; Toluene 2,4-Diisocyanate

Topics: Administration, Cutaneous; Animals; Cross Reactions; Cyanates; Dermatitis, Contact; Disease Models, Animal; Hypersensitivity, Delayed; Immunization, Passive; Isocyanates; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes; Toluene 2,4-Diisocyanate

Topics: Administration, Intranasal; Animals; Cyanates; Disease Models, Animal; Guinea Pigs; Histamine; Male; Mucus; Nasal Mucosa; Passive Cutaneous Anaphylaxis; Rhinitis, Allergic, Perennial; Toluene 2,4-Diisocyanate

Topics: Animals; Cyanates; Dermatitis, Contact; Disease Models, Animal; Female; Fluocinolone Acetonide; Mice; Toluene 2,4-Diisocyanate

Topics: Animals; Asthma; Cyanates; Disease Models, Animal; Guinea Pigs; Lung; Male; Nasal Mucosa; Toluene 2,4-Diisocyanate