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toluene 2,4-diisocyanate and Airway Hyper-Responsiveness

toluene 2,4-diisocyanate has been researched along with Airway Hyper-Responsiveness in 68 studies

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (42.65)	18.7374
1990's	19 (27.94)	18.2507
2000's	10 (14.71)	29.6817
2010's	8 (11.76)	24.3611
2020's	2 (2.94)	2.80

Authors

Authors	Studies
Cui, H; He, J; He, Y; Luo, G; Sun, E; Yang, F; Zhai, Z; Zhao, H; Zhao, W; Zhuang, J; Zhuang, L	1
Chen, R; Chen, S; Chen, Z; Deng, Y; Li, D; Liang, Z; Liu, S; Yang, K; Yu, L; Zha, S	1
Fukuyama, T; Ishimota, M; Makino, E; Tajiki-Nishino, R; Tajima, H; Watanabe, Y	1
Ishihara, Y; Isse, T; Kakiuchi, N; Kawamoto, T; Koriyama, C; Ohta, M; Tanaka, M; Tanaka, R; Tsuchiya, T; Tsuji, M; Yamamoto, M; Yu, HS	1
Lim, JCW; Mohtarrudin, N; Stanslas, J; Sulaiman, I; Tan, K	1
Chen, R; Chen, S; Guan, H; He, Q; Huang, P; Luo, Y; Peng, G; Tao, A; Wei, S; Yan, J; Yao, L; Zhang, Q; Zou, Z	1
Borak, J; Calter, MA; Dworak, JJ; Fields, CA; Roberts, DW	1
Pauluhn, J	2
Fukuyama, T; Harada, T; Hayashi, K; Kosaka, T; Saito, TR; Shuto, Y; Tajima, Y; Ueda, H	1
Jabłońska, E; Kur, B; Polakowska, E; Tarkowski, M	1
Hong, CS; Hur, GY; Jang, AS; Kim, CW; Kim, SH; Park, CS; Park, HS; Park, SM; Ye, YM	1
Aranda, A; Blanca, M; Campo, P; Canto, G; Díaz-Perales, A; Doñia, I; Lisbona, FJ; Pineda, F; Rondon, C	1
Ahonen, N; Järvelä, M; Järventaus, H; Korpi, A; Lindberg, HK; Norppa, H; Pasanen, AL; Rosenberg, C; Säkkinen, K; Santonen, T; Tornaeus, J	1
Bloksma, N; Henricks, PA; Nijkamp, FP; Schijf, MA; Valstar, DL	1
Hwang, CS; Im, GJ; Jung, HH	1
Johnson, VJ; Luster, MI; Yucesoy, B	1
Ban, M; Binet, S; Huguet, N; Langonné, I; Morel, G; Pépin, E	1
De Vooght, V; Hoet, PH; Nawrot, TS; Nemery, B; Vanhooren, HM; Vanoirbeek, JA	1
Ayres, JG; Dick, FD; Shakeri, MS	1
Alarie, Y; Karol, MH	1
Alarie, Y; Brady, M; Dixon, C; Karol, MH	1
Butcher, BT	1
Baur, X; Diller, W; Dorsch, W; Fruhmann, G; Römmelt, H; Roth, P	1
Sepúlveda, R	1
Hauth, BA; Karol, MH; Magreni, CM; Riley, EJ	1
Butcher, BT; O'Neil, CE; Reed, MA; Salvaggio, JE; Weill, H	1
Baschieri, L; Cantalupi, R; Filieri, M; Loi, AM; Paggiaro, PL; Parlanti, A; Roselli, MG; Toma, G	1
Karol, MH	2
Karol, MH; Kramarik, JA; Satoh, T; Tollerud, DJ	1
Abe, Y; Irifune, M; Kalubi, B; Matsunaga, T; Ogino, S; Takeda, N	1
Aoyama, K; Huang, J; Ueda, A	1
Blaikie, L; Botham, PA; Hartop, PJ; Hext, P; Morrow, T; Rattray, NJ; Wilson, AP; Woodcock, D	1
Aoyama, K; Huang, J; Matsushita, T; Ueda, A	1
Kitajiri, M; Kubo, N; Kumazawa, T; Maeda, N; Tomoda, K; Yamashita, T	1
Harada, T; Irifune, M; Matsunaga, T; Ogino, S	1
Aoyama, K; Huang, J; Li, Q; Matsushita, T; Ueda, A; Xu, B	1
Buckley, TL; Muis, T; Nijkamp, FP; Scheerens, H; Van Loveren, H	1
Buckley, TL; Dormans, J; Garssen, J; Muis, TL; Nijkamp, FP; Scheerens, H; Van Loveren, H	1
Aul, DJ; Bhaumik, A; Brown, WE; Kennedy, AL; Lesage, J; Malo, JL	1
Halliburton, AT; Shiotsuka, RN; Sturdivant, DW; Warren, DL	1
Butcher, BT; Garg, O; O'Neil, CE; Salvaggio, JE; Weill, H	1
Adams, WG	1
Higgins, RL; Porter, CV; Scheel, LD	1
Hutchcroft, BJ; Pepys, J	1
Butcher, BT; Salvaggio, JE; Weill, H; Ziskind, MM	1
Bernstein, A; Charles, J; Edwards, JH; Jones, B; Jones, DJ; Seal, RM; Seaton, A	1
Reinhardt, CF	1
Alarie, YC; Karol, MH	1
Cirla, AM; Sala, C; Zedda, S	1
Alarie, YC; Ioset, HH; Karol, MH; Riley, EJ	1
Braman, SS; Teplitz, C	1
Hopkins, J	1
Lubach, D	1
Abe, Y; Fukui, H; Imamura, I; Irifune, M; Kalubi, B; Matsunaga, T; Ogino, S; Takeda, N; Wada, H	1
Clark, ED; Sarlo, K	1
Erjefält, I; Persson, CG	1
Fabbri, LM; Mapp, CE; Picotti, G	1
Fabbri, LM	1
Alegre, J; Cobo, E; Morell, F	1
Scypinski, L; Sheppard, D	1
Hori, Y; Kubo, N; Kumazawa, T; Minami, T; Yamashita, T	1
Hori, Y; Kubo, N; Kumazawa, T; Tomoda, K; Yamashita, T	1
Ishibe, T; Kozuki, K; Kubo, N; Kumazawa, T; Tsuji, H; Yamashita, T	1
Liu, JY	1
Banks, DE; Butcher, BT; Salvaggio, JE	1

Reviews

5 review(s) available for toluene 2,4-diisocyanate and Airway Hyper-Responsiveness

Article	Year
Is diacetyl a respiratory sensitizer? A reconsideration using QSAR, QMM, and competition experiments. Chemical research in toxicology, 2013, May-20, Volume: 26, Issue:5 Topics: Allergens; Animals; Binding, Competitive; Diacetyl; Humans; Local Lymph Node Assay; Lymph Nodes; Quantitative Structure-Activity Relationship; Quantum Theory; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate; Toxicity Tests	2013
Which agents cause reactive airways dysfunction syndrome (RADS)? A systematic review. Occupational medicine (Oxford, England), 2008, Volume: 58, Issue:3 Topics: Acetic Acid; Adult; Air Pollutants, Occupational; Chlorine; Environmental Exposure; Female; Humans; Male; Middle Aged; Nitrogen Oxides; Occupational Diseases; Occupational Exposure; Paint; Respiratory Hypersensitivity; Sulfur Dioxide; Toluene 2,4-Diisocyanate	2008
[The problem of isocyanates in industry. From pathology to control of the risk]. La Medicina del lavoro, 1978, Volume: 69 Suppl 3 Topics: Air Pollutants; Air Pollutants, Occupational; Asthma; Bronchitis; Cough; Cyanates; Humans; Industry; Lung Diseases; Occupational Diseases; Polyurethanes; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1978
Late asthmatic reactions, airway inflammation and chronic asthma in TDI sensitized subjects. The European respiratory journal. Supplement, 1991, Volume: 13 Topics: Asthma; Chronic Disease; Humans; Inflammation; Occupational Diseases; Prognosis; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1991
Isocyanate-induced respiratory disease. Annals of allergy, 1986, Volume: 57, Issue:6 Topics: Asthma; Cyanates; Drug Hypersensitivity; Humans; Isocyanates; Occupational Diseases; Respiratory Hypersensitivity; Respiratory System; Toluene 2,4-Diisocyanate	1986

Trials

1 trial(s) available for toluene 2,4-diisocyanate and Airway Hyper-Responsiveness

Article	Year
Effect of antiasthma drugs on asthmatic reactions induced by toluene diisocyanate in sensitized subjects. Lung, 1990, Volume: 168 Suppl Topics: Adrenergic beta-Agonists; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Cyanates; Humans; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1990

Other Studies

62 other study(ies) available for toluene 2,4-diisocyanate and Airway Hyper-Responsiveness

Article	Year
Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 125 Topics: Animals; Asthma; Bronchi; Cell Line; Cytokines; Disease Models, Animal; Epithelial Cells; Humans; Inflammasomes; Inflammation; Male; Mice; Mice, Inbred BALB C; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	2020
Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma. Allergology international : official journal of the Japanese Society of Allergology, 2022, Volume: 71, Issue:1 Topics: Animals; Antibodies, Monoclonal, Humanized; Asthma; Disease Models, Animal; Drug Resistance; Humans; Interleukin-6; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Signal Transduction; Toluene 2,4-Diisocyanate	2022
Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice. Toxicological sciences : an official journal of the Society of Toxicology, 2018, 10-01, Volume: 165, Issue:2 Topics: Administration, Oral; Animals; Benzhydryl Compounds; Cell Line; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Disease Progression; Environmental Pollutants; Epithelial Cells; Female; Humans; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Phenols; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	2018
Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory. Environmental health and preventive medicine, 2018, Jun-19, Volume: 23, Issue:1 Topics: Adult; Air Pollutants, Occupational; Environmental Monitoring; Humans; Immunoglobulin G; Japan; Male; Manufacturing and Industrial Facilities; Middle Aged; Occupational Diseases; Occupational Exposure; Phthalic Anhydrides; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate; Workforce	2018
Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction. Pulmonary pharmacology & therapeutics, 2018, Volume: 53 Topics: Animals; Anti-Asthmatic Agents; Asthma, Occupational; Bronchoalveolar Lavage Fluid; Cadherins; Collagen; Disease Models, Animal; Diterpenes; Female; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	2018
Blockade of the NLRP3/Caspase-1 Axis Ameliorates Airway Neutrophilic Inflammation in a Toluene Diisocyanate-Induced Murine Asthma Model. Toxicological sciences : an official journal of the Society of Toxicology, 2019, 08-01, Volume: 170, Issue:2 Topics: Airway Remodeling; Animals; Asthma; Caspase 1; Disease Models, Animal; Furans; Heterocyclic Compounds, 4 or More Rings; Indenes; Interleukin-18; Male; Mice; Mice, Inbred C57BL; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein; Respiratory Hypersensitivity; Serpins; Sulfonamides; Sulfones; Th17 Cells; Th2 Cells; Toluene 2,4-Diisocyanate; Viral Proteins	2019
Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level. Toxicology, 2014, May-07, Volume: 319 Topics: Animals; Dose-Response Relationship, Drug; Haptens; Humans; Irritants; Male; Occupational Exposure; Rats; Rats, Inbred BN; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	2014
Use of long term dermal sensitization followed by intratracheal challenge method to identify low-dose chemical-induced respiratory allergic responses in mice. Toxicology letters, 2008, Oct-01, Volume: 181, Issue:3 Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Disease Models, Animal; Dose-Response Relationship, Immunologic; Environmental Pollutants; Female; Immunoglobulin E; Lung; Mice; Mice, Inbred BALB C; Phthalic Anhydrides; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate; Trachea	2008
Comparative studies of lymph node cell subpopulations and cytokine expression in murine model for testing the potentials of chemicals to induce respiratory sensitization. International journal of occupational medicine and environmental health, 2008, Volume: 21, Issue:3 Topics: Allergens; Animals; Bronchial Provocation Tests; Cytokines; Dinitrochlorobenzene; Disease Models, Animal; Inflammation; Interferon-gamma; Interleukin-4; Irritants; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Phthalic Anhydrides; Respiratory Hypersensitivity; RNA, Messenger; Toluene 2,4-Diisocyanate	2008
Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma. Journal of clinical immunology, 2009, Volume: 29, Issue:6 Topics: Adult; Asthma; Case-Control Studies; Female; GTP-Binding Proteins; Humans; Immunoglobulin E; Immunoglobulin G; Inflammation; Male; Middle Aged; Occupational Diseases; Protein Glutamine gamma Glutamyltransferase 2; Reactive Oxygen Species; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate; Transglutaminases; Young Adult	2009
Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2010, Volume: 105, Issue:1 Topics: Adolescent; Adult; Allergens; Bronchial Provocation Tests; Dust; Female; Humans; Immunization; Immunoglobulin E; Industry; Male; Occupational Exposure; Prospective Studies; Respiratory Hypersensitivity; Spirometry; Toluene 2,4-Diisocyanate; Wood	2010
Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI). Mutation research, 2011, Jul-14, Volume: 723, Issue:1 Topics: Administration, Inhalation; Aerosols; Animals; Hemoglobins; Isocyanates; Male; Mice; Mice, Inbred C57BL; Micronucleus Tests; Mutagens; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	2011
Glutathione-conjugated toluene diisocyanate causes airway inflammation in sensitised mice. Archives of toxicology, 2004, Volume: 78, Issue:9 Topics: Airway Resistance; Animals; Bronchial Provocation Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	2004
Quantitative expression levels of regulated on activation, normal T cell expressed and secreted and eotaxin transcripts in toluene diisocyanate-induced allergic rats. Acta oto-laryngologica, 2005, Volume: 125, Issue:4 Topics: Animals; Asthma; beta 2-Microglobulin; Chemokine CCL11; Chemokine CCL5; Chemokines, CC; Eosinophilia; Gene Expression Regulation; Leukocyte Count; Lymphocyte Activation; Male; Nasal Mucosa; Rats; Rats, Sprague-Dawley; Respiratory Hypersensitivity; Reverse Transcriptase Polymerase Chain Reaction; Rhinitis, Allergic, Perennial; RNA, Messenger; T-Lymphocytes; Toluene 2,4-Diisocyanate; Vascular Cell Adhesion Molecule-1	2005
Prevention of IL-1 signaling attenuates airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma. The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:4 Topics: Animals; Antibody Formation; Antibody Specificity; Asthma; Disease Models, Animal; Female; Inflammation; Interleukin-1; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interleukin-1; Respiratory Hypersensitivity; Signal Transduction; Toluene 2,4-Diisocyanate; Up-Regulation	2005
TDI can induce respiratory allergy with Th2-dominated response in mice. Toxicology, 2006, Jan-20, Volume: 218, Issue:1 Topics: Administration, Topical; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Inhalation Exposure; Injections, Subcutaneous; Lung; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Th2 Cells; Toluene 2,4-Diisocyanate	2006
How long do the systemic and ventilatory responses to toluene diisocyanate persist in dermally sensitized mice? The Journal of allergy and clinical immunology, 2008, Volume: 121, Issue:2 Topics: Administration, Intranasal; Animals; Body Weight; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokine CXCL2; Ear, External; Immunization; Immunoglobulin E; Immunoglobulin G; Interferon-gamma; Interleukin-4; Lymph Nodes; Lymphocyte Subsets; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Respiration; Respiratory Hypersensitivity; Skin; Time Factors; Toluene 2,4-Diisocyanate	2008
Antigens which detect IgE antibodies in workers sensitive to toluene diisocyanate. Clinical allergy, 1980, Volume: 10, Issue:1 Topics: Antigen-Antibody Reactions; Binding Sites, Antibody; Cyanates; Humans; Immunoglobulin E; Radioallergosorbent Test; Respiratory Hypersensitivity; Serum Albumin; Toluene; Toluene 2,4-Diisocyanate	1980
Immunologic sensitization and pulmonary hypersensitivity by repeated inhalation of aromatic isocyanates. Toxicology and applied pharmacology, 1980, Volume: 53, Issue:2 Topics: Animals; Cyanates; Drug Hypersensitivity; Female; Gases; Guinea Pigs; Immunodiffusion; Immunoelectrophoresis; Isocyanates; Passive Cutaneous Anaphylaxis; Respiration; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1980
Approaches to the understanding of mechanisms in occupational asthma. European journal of respiratory diseases. Supplement, 1980, Volume: 107 Topics: Allergens; Asthma; Humans; Lymphocytes; Occupational Diseases; Receptors, Adrenergic, beta; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1980
[Clinical symptoms and results of RAST and inhalation provocation tests]. Zentralblatt fur Arbeitsmedizin, Arbeitsschutz, Prophylaxe und Ergonomie, 1980, Volume: 30, Issue:4 Topics: Adult; Cyanates; Humans; Middle Aged; Occupational Diseases; Radioallergosorbent Test; Radioimmunoassay; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1980
[Occupational asthma (author's transl)]. Revista medica de Chile, 1980, Volume: 108, Issue:2 Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Cyanates; Humans; Occupational Diseases; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1980
Dermal contact with toluene diisocyanate (TDI) produces respiratory tract hypersensitivity in guinea pigs. Toxicology and applied pharmacology, 1981, Volume: 58, Issue:2 Topics: Administration, Topical; Animals; Antibody Formation; Cyanates; Dermatitis, Contact; Female; Guinea Pigs; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1981
Development and loss of toluene diisocyanate reactivity: immunologic, pharmacologic, and provocative challenge studies. The Journal of allergy and clinical immunology, 1982, Volume: 70, Issue:4 Topics: Adult; Bronchial Provocation Tests; Cyanates; Humans; Isocyanates; Lymphocyte Activation; Male; Methacholine Compounds; Plants, Edible; Radioallergosorbent Test; Respiratory Function Tests; Respiratory Hypersensitivity; Serum Albumin; Skin Tests; Toluene 2,4-Diisocyanate	1982
Absence of IgG antibodies to TDI-HSA in a radioimmunological study. Clinical allergy, 1983, Volume: 13, Issue:1 Topics: Animals; Asthma; Cyanates; Humans; Immunoglobulin G; Occupational Diseases; Rabbits; Radioimmunoassay; Respiratory Hypersensitivity; Serum Albumin; Toluene 2,4-Diisocyanate	1983
Concentration-dependent immunologic response to toluene diisocyanate (TDI) following inhalation exposure. Toxicology and applied pharmacology, 1983, Volume: 68, Issue:2 Topics: Animals; Antibody Formation; Atmosphere Exposure Chambers; Bronchial Provocation Tests; Cyanates; Dose-Response Relationship, Drug; Female; Guinea Pigs; Immunization; Intradermal Tests; Lung; Passive Cutaneous Anaphylaxis; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1983
A murine model for assessing the respiratory hypersensitivity potential of chemical allergens. Toxicology letters, 1995, Volume: 78, Issue:1 Topics: Administration, Intranasal; Administration, Topical; Allergens; Analysis of Variance; Animals; Cytokines; Dinitrochlorobenzene; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Haptens; Immunoglobulin E; Immunoglobulin G; Luminescent Measurements; Lung; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Skin; Toluene 2,4-Diisocyanate	1995
Neurogenic inflammation in nasal allergy: histochemical and pharmacological studies in guinea pigs. A review. Acta oto-laryngologica. Supplementum, 1993, Volume: 501 Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Desensitization, Immunologic; Fluorescent Antibody Technique; Guinea Pigs; Male; Nerve Endings; Nerve Fibers; Neural Pathways; Neurons, Afferent; Nose Diseases; Nucleic Acid Hybridization; Respiratory Hypersensitivity; Substance P; Toluene 2,4-Diisocyanate; Trigeminal Ganglion	1993
Experimental study on respiratory sensitivity to inhaled toluene diisocyanate. Archives of toxicology, 1993, Volume: 67, Issue:6 Topics: Administration, Inhalation; Animals; Antibody Specificity; Disease Models, Animal; Female; Guinea Pigs; Histamine Release; Immunoglobulin G; Lung; Mast Cells; Prostaglandins E; Respiratory Hypersensitivity; Serum Albumin; Toluene 2,4-Diisocyanate	1993
A two-centre study for the evaluation and validation of an animal model for the assessment of the potential of small molecular weight chemicals to cause respiratory allergy. Toxicology, 1995, Jan-19, Volume: 96, Issue:1 Topics: Administration, Inhalation; Allergens; Animals; Antibody Specificity; Antigen-Antibody Complex; Dinitrochlorobenzene; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Guinea Pigs; Haptens; Injections, Intradermal; Isocyanates; Male; Molecular Weight; Phthalic Anhydrides; Respiration; Respiratory Hypersensitivity; Serum Albumin; Toluene 2,4-Diisocyanate	1995
Provocation of respiratory allergy in guinea pigs following inhalation of free toluene diisocyanate. Archives of environmental contamination and toxicology, 1994, Volume: 26, Issue:3 Topics: Air Pollutants, Occupational; Animals; Female; Guinea Pigs; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1994
Sympathetic nerve disturbance and fine structure of adrenergic nerve terminals in nasal mucosa after experimentally-induced nasal hypersensitivity. Acta oto-laryngologica. Supplementum, 1993, Volume: 506 Topics: Adrenergic Fibers; Animals; Female; Guinea Pigs; Microscopy, Electron; Nasal Mucosa; Nerve Endings; Norepinephrine; Respiratory Hypersensitivity; Synaptic Transmission; Toluene 2,4-Diisocyanate	1993
Acute and chronic effects of unilateral cervical sympathectomy on nasal allergy-like symptoms induced by toluene diisocyanate in guinea pigs. Acta oto-laryngologica. Supplementum, 1993, Volume: 501 Topics: Animals; Ganglia, Sympathetic; Ganglionectomy; Guinea Pigs; Immunization; Male; Nose Diseases; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1993
An experimental study to evaluate inhalative allergenicity of industrial chemicals: a preliminary study. Sangyo igaku. Japanese journal of industrial health, 1993, Volume: 35, Issue:3 Topics: Administration, Inhalation; Animals; Atmosphere Exposure Chambers; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypersensitivity, Immediate; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1993
The involvement of sensory neuropeptides in toluene diisocyanate-induced tracheal hyperreactivity in the mouse airways. British journal of pharmacology, 1996, Volume: 119, Issue:8 Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Indoles; Isoindoles; Isometric Contraction; Male; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Neuropeptides; Respiratory Hypersensitivity; Skin; Substance P; Tachykinins; Toluene 2,4-Diisocyanate; Tracheal Diseases	1996
Assessment of respiratory hypersensitivity in guinea pigs sensitized to toluene diisocyanate: improvements on analysis of respiratory response. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1997, Volume: 40, Issue:2 Topics: Administration, Inhalation; Allergens; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypersensitivity, Delayed; Injections, Intradermal; Mathematics; Reproducibility of Results; Respiration; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1997
Long-term topical exposure to toluene diisocyanate in mice leads to antibody production and in vivo airway hyperresponsiveness three hours after intranasal challenge. American journal of respiratory and critical care medicine, 1999, Volume: 159, Issue:4 Pt 1 Topics: Administration, Intranasal; Administration, Topical; Airway Resistance; Animals; Antibody Formation; Bronchial Hyperreactivity; Immunization; Immunoglobulin E; Immunoglobulin G; In Vitro Techniques; Lung; Male; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Skin Tests; Time Factors; Toluene 2,4-Diisocyanate; Trachea	1999
Specific IgG response to monomeric and polymeric diphenylmethane diisocyanate conjugates in subjects with respiratory reactions to isocyanates. The Journal of allergy and clinical immunology, 1999, Volume: 103, Issue:5 Pt 1 Topics: Adult; Allergens; Antibody Specificity; Asthma; Cross Reactions; Female; Forced Expiratory Volume; Humans; Immunoglobulin G; Isocyanates; Male; Middle Aged; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1999
A comparative respiratory sensitization study of 2,4- and 2,6-toluene diisocyanate using guinea pigs. Inhalation toxicology, 2000, Volume: 12, Issue:7 Topics: Administration, Inhalation; Aerosols; Air Pollutants, Occupational; Anaphylaxis; Animals; Body Weight; Drug Hypersensitivity; Guinea Pigs; Haptens; Inhalation Exposure; Male; Plethysmography, Whole Body; Respiration; Respiratory Hypersensitivity; Serum Albumin; Toluene 2,4-Diisocyanate	2000
Toluene diisocyanate pulmonary disease: immunopharmacologic and mecholyl challenge studies. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:3 Topics: Administration, Intranasal; Aerosols; Cyanates; Cyclic AMP; Histamine Release; Isoproterenol; Lymphocytes; Methacholine Compounds; Occupational Diseases; Receptors, Adrenergic, beta; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1977
Long-term effects on the health of men engaged in the manufacture of tolylene di-isocyanate. British journal of industrial medicine, 1975, Volume: 32, Issue:1 Topics: Age Factors; Body Height; Chemical Industry; Cyanates; Humans; Male; Occupational Diseases; Prospective Studies; Respiratory Hypersensitivity; Smoking; Spirometry; Toluene; Toluene 2,4-Diisocyanate; Vital Capacity	1975
A retrospective study of clinical, physiologic and immunologic changes in workers exposed to toluene diisocyanate. American Industrial Hygiene Association journal, 1975, Volume: 36, Issue:3 Topics: Adult; Agglutination Tests; Air Pollution; Chemical Industry; Cyanates; Environmental Exposure; Humans; Hypersensitivity, Delayed; Immunization, Passive; Middle Aged; Occupational Diseases; Pollen; Respiratory Function Tests; Respiratory Hypersensitivity; Retrospective Studies; Time Factors; Toluene 2,4-Diisocyanate	1975
Bronchial provocation tests in etiologic diagnosis and analysis of asthma. The American review of respiratory disease, 1975, Volume: 112, Issue:6 Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Aspergillus fumigatus; Asthma; Bronchi; Bronchodilator Agents; Cromolyn Sodium; Dust; Environmental Exposure; Flour; Foreign-Body Reaction; Granuloma; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Occupational Diseases; Piperazines; Platinum; Pulmonary Alveoli; Resins, Plant; Resins, Synthetic; Respiratory Function Tests; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate; Wood	1975
Toluene diisocyanate (TDI) pulmonary disease: immunologic and inhalation challenge studies. The Journal of allergy and clinical immunology, 1976, Volume: 58, Issue:1 PT 1 Topics: Airway Obstruction; Allergens; Antibodies; Cyanates; Eosinophils; Humans; Immunoglobulin E; Immunoglobulin G; Intradermal Tests; Leukocyte Count; Lymphocyte Activation; Passive Cutaneous Anaphylaxis; Radioimmunoassay; Respiratory Hypersensitivity; Serum Albumin; Skin Tests; Toluene 2,4-Diisocyanate	1976
Hypersensitivity pneumonitis after exposure to isocyanates. Thorax, 1976, Volume: 31, Issue:2 Topics: Animals; Cyanates; Dyspnea; Humans; Lung; Male; Middle Aged; Pneumonia; Prednisone; Rabbits; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1976
Chemical hypersusceptibility. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1978, Volume: 20, Issue:5 Topics: Adult; alpha 1-Antitrypsin Deficiency; Anemia, Sickle Cell; Antibodies; Carbon Disulfide; Dermatitis, Occupational; Environmental Exposure; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Male; Occupational Diseases; Respiratory Hypersensitivity; Smoking; Toluene 2,4-Diisocyanate	1978
Serologic test for toluene diisocyanate (TDI) antibodies. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1978, Volume: 20, Issue:6 Topics: Antibodies; Cyanates; Dermatitis, Occupational; Humans; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1978
Hapten-specific respiratory hypersensitivity in guinea pigs. American Industrial Hygiene Association journal, 1978, Volume: 39, Issue:7 Topics: Animals; Antibodies; Arsanilic Acid; Environmental Exposure; Female; Guinea Pigs; Haptens; Ovalbumin; p-Azobenzenearsonate; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1978
Occupational lung disease. Primary care, 1978, Volume: 5, Issue:3 Topics: Asthma; Berylliosis; Bronchitis; Byssinosis; Carcinoma, Bronchogenic; Environmental Exposure; Humans; Lung Diseases; Lung Neoplasms; Occupational Diseases; Pneumoconiosis; Pulmonary Alveoli; Respiratory Hypersensitivity; Silicosis; Toluene 2,4-Diisocyanate	1978
Evidence of a safe level of TDI. Food and cosmetics toxicology, 1979, Volume: 17, Issue:1 Topics: Cyanates; Forced Expiratory Volume; Humans; Lung Diseases; Occupational Diseases; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1979
[Diseases caused by diisocyanates. 1. Irritation of the respiratory system and skin]. Dermatosen in Beruf und Umwelt. Occupation and environment, 1978, Volume: 26, Issue:6 Topics: Cyanates; Dermatitis, Contact; Dermatitis, Occupational; Environmental Exposure; Fever; Humans; Lung Diseases; Maximum Allowable Concentration; Occupational Diseases; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1978
Effects of capsaicin desensitization on nasal allergy-like symptoms and histamine release in the nose induced by toluene diisocyanate in guinea pigs. Acta oto-laryngologica, 1992, Volume: 112, Issue:4 Topics: Animals; Capsaicin; Desensitization, Immunologic; Guinea Pigs; Histamine Release; Male; Nasal Mucosa; Neurons, Afferent; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1992
A tier approach for evaluating the respiratory allergenicity of low molecular weight chemicals. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1992, Volume: 18, Issue:1 Topics: Administration, Inhalation; Aerosols; Allergens; Anaphylaxis; Animals; Antibody Formation; Enzyme-Linked Immunosorbent Assay; Female; Guinea Pigs; Injections, Subcutaneous; Intubation, Intratracheal; Passive Cutaneous Anaphylaxis; Phthalic Anhydrides; Proteins; Respiratory Hypersensitivity; Serum Albumin; Skin Tests; Structure-Activity Relationship; Toluene 2,4-Diisocyanate	1992
Increased sensitivity to toluene diisocyanate (TDI) in airways previously exposed to low doses of TDI. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1992, Volume: 22, Issue:9 Topics: Administration, Cutaneous; Administration, Topical; Animals; Budesonide; Guinea Pigs; Inflammation; Intubation, Intratracheal; Male; Pregnenediones; Respiratory Hypersensitivity; Theophylline; Toluene 2,4-Diisocyanate; Xanthines	1992
Comparison of clinical and experimental data from an animal model of pulmonary immunologic sensitivity. Annals of allergy, 1991, Volume: 66, Issue:6 Topics: Allergens; Animals; Antigen-Antibody Reactions; Atmosphere Exposure Chambers; Cyanates; Disease Models, Animal; Equipment Design; Guinea Pigs; Lung Diseases; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1991
Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia. Scandinavian journal of work, environment & health, 1990, Volume: 16, Issue:3 Topics: Adult; Alveolitis, Extrinsic Allergic; Chronic Disease; Confounding Factors, Epidemiologic; Cross-Sectional Studies; Cyanates; Environmental Exposure; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Respiratory Function Tests; Respiratory Hypersensitivity; Risk Factors; Spain; Spores, Fungal; Toluene 2,4-Diisocyanate; Trees	1990
A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. The American review of respiratory disease, 1988, Volume: 138, Issue:3 Topics: Acetylcholine; Animals; Cyanates; Depression, Chemical; Drug Synergism; Glycopeptides; Guinea Pigs; Male; Receptors, Neurotransmitter; Receptors, Tachykinin; Respiratory Hypersensitivity; Substance P; Tachykinins; Toluene 2,4-Diisocyanate	1988
Enhanced parasympathetic nerve activities in experimentally-induced nasal hypersensitivity. Acta oto-laryngologica. Supplementum, 1989, Volume: 463 Topics: Animals; Choline O-Acetyltransferase; Female; Guinea Pigs; Nasal Mucosa; Receptors, Muscarinic; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1989
Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity. Acta oto-laryngologica. Supplementum, 1989, Volume: 463 Topics: Animals; Chromatography, High Pressure Liquid; Female; Guinea Pigs; Histamine; Nasal Mucosa; Receptors, Histamine H1; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1989
Functional disturbances of the sympathetic nerve in experimentally-induced nasal hypersensitivity. Acta oto-laryngologica. Supplementum, 1989, Volume: 463 Topics: Animals; Female; Guinea Pigs; Nasal Mucosa; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1989
[Toluene diisocyanate induced asthma]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 1985, Volume: 19, Issue:4 Topics: Adult; Asthma; Cyanates; Female; Humans; Immunoglobulin E; Male; Middle Aged; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1985
Bathtub refinishers' lung. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1987, Volume: 29, Issue:5 Topics: Cyanates; Humans; Occupational Diseases; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1987