tolterodine-tartrate has been researched along with Cystitis--Interstitial* in 4 studies
1 review(s) available for tolterodine-tartrate and Cystitis--Interstitial
Article | Year |
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Pharmacotherapy of the overactive bladder and advances in drug delivery.
Topics: Administration, Intravesical; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Botulinum Toxins; Capsaicin; Cholinergic Antagonists; Cresols; Cystitis, Interstitial; Diterpenes; Humans; Mandelic Acids; Neurotoxins; Phenylpropanolamine; Tolterodine Tartrate; Urinary Bladder; Urinary Bladder Diseases; Urination Disorders | 2002 |
1 trial(s) available for tolterodine-tartrate and Cystitis--Interstitial
Article | Year |
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A rational combination of intravesical and systemic agents for the treatment of interstitial cystitis.
Interstitial cystitis is a condition with a poorly understood etiology and, consequently, various treatment options have been described in the literature, with a less than optimal outcome. The aim of this study was to examine the role of a combination of intravesical hydrocortisone and heparin, together with oral bladder sedatives and systemic triamcinolone, for the treatment of interstitial cystitis.. A total of 26 patients who were diagnosed as having interstitial cystitis were treated with weekly intravesical hydrocortisone (200 mg) and heparin (25,000 IU) in physiological saline for 6 weeks. In addition, they were given oral bladder sedatives such as oxybutynin or tolterodine. Ulcerative, refractory and recurrent cases were treated with intramuscular triamcinolone (40 mg) weekly for 6 weeks.. All patients experienced an improvement in symptoms within 48 h of their first intravesical instillation. While 19 patients (73%) experienced almost complete pain relief, five of the remaining seven patients improved with intramuscular triamcinolone. Frequency reduced from a mean of 23.2 to 10.9 voids per day and was acceptable in 21 patients (80%). Six patients (23%) had a relapse of symptoms in the form of pain and were treated satisfactorily by means of intramuscular triamcinolone. The mean duration of follow-up was 18.3 months.. A combination of intravesical hydrocortisone and heparin, along with oral bladder sedatives and systemic steroids, has been used with encouraging results in a small group of patients with interstitial cystitis. Topics: Administration, Intravesical; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Anticoagulants; Benzhydryl Compounds; Cresols; Cystitis, Interstitial; Drug Therapy, Combination; Female; Heparin; Humans; Hydrocortisone; Injections, Intramuscular; Male; Mandelic Acids; Middle Aged; Muscarinic Antagonists; Phenylpropanolamine; Tolterodine Tartrate; Treatment Outcome; Triamcinolone | 2007 |
2 other study(ies) available for tolterodine-tartrate and Cystitis--Interstitial
Article | Year |
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Mast cell activation and response to tolterodine in the rat urinary bladder in a chronic model of intravesical protamine sulfate and bacterial endotoxin-induced cystitis.
The aim of the present study was to use an animal model of interstitial cystitis (IC) in order to investigate the histology and function of the bladder, with a particular focus on mast cell degranulation and response to detrusor overactivity (DO) to tolterodine. A total of 18 female Sprague‑Dawley rats were used. In 12 rats, lipopolysaccharide (LPS) was intravesically instilled following the induction of IC by protamine sulfate (PS) and six rats were subjected to sham instillations. Following 1 month, cystometry was performed. The effects of tolterodine were tested in half of the animals with IC. All rats in the IC group demonstrated DO during the filling phase and no significant changes in the frequency or pressure compared with that following tolterodine injection were identified. Histological examination revealed a significant increase in the total number of infiltrated mast cells in IC rats compared with that in the sham rats (P<0.05). Degranulated mast cells were evident in 80% of rats with IC; however, they were not apparent in the sham rats. Urinary bladder inflammation, similar to that in human IC in terms of degranulated mast cells and bladder function, was induced in rats. The animal model used in the present study provided insight into the pathophysiological mechanisms underlying the ineffectiveness of anticholinergics in patients with overlapping IC and overactive bladder (OAB). Topics: Animals; Benzhydryl Compounds; Chronic Disease; Cresols; Cystitis, Interstitial; Disease Models, Animal; Female; Lipopolysaccharides; Mast Cells; Phenylpropanolamine; Protamines; Rats; Rats, Sprague-Dawley; Tolterodine Tartrate; Urinary Bladder; Urodynamics; Urological Agents | 2014 |
Lower urinary tract symptoms revisited.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Aged; Benzhydryl Compounds; Cresols; Cystitis, Interstitial; Doxazosin; Drug Therapy, Combination; Humans; Lower Urinary Tract Symptoms; Male; Mandelic Acids; Middle Aged; Muscarinic Antagonists; Phenylpropanolamine; Tolterodine Tartrate | 2012 |