Page last updated: 2024-08-23

tolrestat and Galactosemias

tolrestat has been researched along with Galactosemias in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's3 (33.33)18.2507
2000's3 (33.33)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alessi, T; Bagli, J; Ellingboe, J; Guzzo, F; King, A; Millen, J; Prusiewicz, C; Sredy, J; VanEngen, D1
Hohman, TC; Malamas, MS; Millen, J1
Boldrini, E; Da Settimo, A; Da Settimo, F; Greco, G; La Motta, C; Lavecchia, A; Novellino, E; Primofiore, G; Simorini, F; Taliani, S1
Boldrini, E; Da Settimo, A; Da Settimo, F; Greco, G; La Motta, C; Lavecchia, A; Novellino, E; Primofiore, G; Simorini, F1
Da Settimo, F; La Motta, C; Limongelli, V; Marinelli, L; Marini, AM; Novellino, E; Salerno, S; Sartini, S; Simorini, F; Taliani, S1
Behera, P; Sahoo, PK1
Burgan, J; Faller, A; Obrosova, I; Ostrow, E; Williamson, JR1
Dubuc, J; Dvornik, D; Greselin, E; Simard-Duquesne, N1
Dvornik, D; Gonzalez, R; Greselin, E; Simard-Duquesne, N1

Other Studies

9 other study(ies) available for tolrestat and Galactosemias

ArticleYear
(Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:10

    Topics: Acetates; Administration, Oral; Aldehyde Reductase; Alkylation; Animals; Cattle; Chemical Phenomena; Chemistry, Physical; Crystallography; Galactosemias; In Vitro Techniques; Lens, Crystalline; Molecular Structure; Pyrimidines; Rats; Structure-Activity Relationship; X-Ray Diffraction

1990
Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.
    Journal of medicinal chemistry, 1994, Jun-24, Volume: 37, Issue:13

    Topics: Aldehyde Reductase; Animals; Blood Glucose; Cattle; Diabetes Mellitus, Experimental; Dogs; Drug Evaluation, Preclinical; Erythrocytes; Galactitol; Galactosemias; Glyceraldehyde; In Vitro Techniques; Isoquinolines; Lens, Crystalline; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spiro Compounds; Stereoisomerism

1994
[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Acetates; Aldehyde Reductase; Animals; Benzimidazoles; Binding Sites; Cataract; Enzyme Inhibitors; Galactosemias; Humans; Models, Molecular; Ophthalmic Solutions; Protein Binding; Rats; Stereoisomerism; Structure-Activity Relationship; Triazines

2001
Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.
    Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8

    Topics: Acetates; Aldehyde Reductase; Animals; Cataract; Enzyme Inhibitors; Galactosemias; Humans; Indoles; Models, Molecular; Ophthalmic Solutions; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

2003
Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model.
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Acetates; Administration, Topical; Aldehyde Reductase; Animals; Binding Sites; Cataract; Galactosemias; Models, Molecular; Ophthalmic Solutions; Oxadiazoles; Oxazoles; Protein Binding; Protein Conformation; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2008
Synthesis and biological evaluation of [1,2,4]triazino[4,3-a] benzimidazole acetic acid derivatives as selective aldose reductase inhibitors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Acetic Acid; Aldehyde Reductase; Animals; Benzimidazoles; Cataract; Disease Models, Animal; Enzyme Inhibitors; Galactosemias; Inhibitory Concentration 50; Molecular Structure; Naphthalenes; Ophthalmic Solutions; Rats

2010
Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: effect of an aldose reductase inhibitor.
    Current eye research, 1997, Volume: 16, Issue:1

    Topics: Aldehyde Reductase; Animals; Energy Metabolism; Enzyme Inhibitors; Galactitol; Galactose; Galactosemias; Gas Chromatography-Mass Spectrometry; Glycolysis; Inositol; Lens, Crystalline; Male; NADP; Naphthalenes; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley

1997
The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats.
    Metabolism: clinical and experimental, 1985, Volume: 34, Issue:10

    Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Erythrocytes; Galactosemias; Humans; In Vitro Techniques; Lens, Crystalline; Naphthalenes; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases

1985
Prevention of cataract development in severely galactosemic rats by the aldose reductase inhibitor, tolrestat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1985, Volume: 178, Issue:4

    Topics: Animals; Cataract; Dose-Response Relationship, Drug; Galactitol; Galactose; Galactosemias; Humans; Lens, Crystalline; Male; Naphthalenes; Rats

1985