tolrestat has been researched along with Galactosemias in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alessi, T; Bagli, J; Ellingboe, J; Guzzo, F; King, A; Millen, J; Prusiewicz, C; Sredy, J; VanEngen, D | 1 |
| Hohman, TC; Malamas, MS; Millen, J | 1 |
| Boldrini, E; Da Settimo, A; Da Settimo, F; Greco, G; La Motta, C; Lavecchia, A; Novellino, E; Primofiore, G; Simorini, F; Taliani, S | 1 |
| Boldrini, E; Da Settimo, A; Da Settimo, F; Greco, G; La Motta, C; Lavecchia, A; Novellino, E; Primofiore, G; Simorini, F | 1 |
| Da Settimo, F; La Motta, C; Limongelli, V; Marinelli, L; Marini, AM; Novellino, E; Salerno, S; Sartini, S; Simorini, F; Taliani, S | 1 |
| Behera, P; Sahoo, PK | 1 |
| Burgan, J; Faller, A; Obrosova, I; Ostrow, E; Williamson, JR | 1 |
| Dubuc, J; Dvornik, D; Greselin, E; Simard-Duquesne, N | 1 |
| Dvornik, D; Gonzalez, R; Greselin, E; Simard-Duquesne, N | 1 |
9 other study(ies) available for tolrestat and Galactosemias
| Article | Year |
|---|---|
(Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors.
Topics: Acetates; Administration, Oral; Aldehyde Reductase; Alkylation; Animals; Cattle; Chemical Phenomena; Chemistry, Physical; Crystallography; Galactosemias; In Vitro Techniques; Lens, Crystalline; Molecular Structure; Pyrimidines; Rats; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cattle; Diabetes Mellitus, Experimental; Dogs; Drug Evaluation, Preclinical; Erythrocytes; Galactitol; Galactosemias; Glyceraldehyde; In Vitro Techniques; Isoquinolines; Lens, Crystalline; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spiro Compounds; Stereoisomerism | 1994 |
[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.
Topics: Acetates; Aldehyde Reductase; Animals; Benzimidazoles; Binding Sites; Cataract; Enzyme Inhibitors; Galactosemias; Humans; Models, Molecular; Ophthalmic Solutions; Protein Binding; Rats; Stereoisomerism; Structure-Activity Relationship; Triazines | 2001 |
Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.
Topics: Acetates; Aldehyde Reductase; Animals; Cataract; Enzyme Inhibitors; Galactosemias; Humans; Indoles; Models, Molecular; Ophthalmic Solutions; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship | 2003 |
Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model.
Topics: Acetates; Administration, Topical; Aldehyde Reductase; Animals; Binding Sites; Cataract; Galactosemias; Models, Molecular; Ophthalmic Solutions; Oxadiazoles; Oxazoles; Protein Binding; Protein Conformation; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2008 |
Synthesis and biological evaluation of [1,2,4]triazino[4,3-a] benzimidazole acetic acid derivatives as selective aldose reductase inhibitors.
Topics: Acetic Acid; Aldehyde Reductase; Animals; Benzimidazoles; Cataract; Disease Models, Animal; Enzyme Inhibitors; Galactosemias; Inhibitory Concentration 50; Molecular Structure; Naphthalenes; Ophthalmic Solutions; Rats | 2010 |
Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: effect of an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Energy Metabolism; Enzyme Inhibitors; Galactitol; Galactose; Galactosemias; Gas Chromatography-Mass Spectrometry; Glycolysis; Inositol; Lens, Crystalline; Male; NADP; Naphthalenes; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1997 |
The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats.
Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Erythrocytes; Galactosemias; Humans; In Vitro Techniques; Lens, Crystalline; Naphthalenes; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Prevention of cataract development in severely galactosemic rats by the aldose reductase inhibitor, tolrestat.
Topics: Animals; Cataract; Dose-Response Relationship, Drug; Galactitol; Galactose; Galactosemias; Humans; Lens, Crystalline; Male; Naphthalenes; Rats | 1985 |