tolrestat has been researched along with Diabetic Retinopathy in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boot, JP; Lemkes, HH; van Best, JA; van Gerven, JM | 1 |
| Tomlinson, DR | 1 |
| Feman, SS; Leonard-Martin, TC; Redman, JR | 1 |
| Ihm, SH; Park, CJ; Park, SW; Yoo, HJ | 1 |
| Azal, O; Baydar, A; Cakir, B; Corakçi, A; Güler, S; Kutlu, M; Yönem, A | 1 |
| Hohman, TC; Laver, N; McCaleb, ML; McKean, ML; Robison, WG | 1 |
| Kinoshita, JH; Laver, N; Robison, WG; Tillis, TN | 1 |
| Frank, RN | 1 |
| Hohman, TC; Kinoshita, JH; Laver, N; Nagata, M; Robison, WG | 1 |
| Kinoshita, JH; Laver, N; Nagata, M; Robison, WG; Tillis, TN | 1 |
| Akagi, Y; Dvornik, D; Gonzalez, R; Kador, PF; Kinoshita, JH; Robison, WG | 1 |
| Kador, PF; Kinoshita, JH; Robison, WG | 1 |
| Kinoshita, JH; Nagata, M; Robison, WG | 1 |
| Hotta, N; Sakamoto, N | 1 |
| Kador, PF; Kinoshita, JH; Sharpless, NE | 1 |
3 review(s) available for tolrestat and Diabetic Retinopathy
| Article | Year |
|---|---|
Aldose reductase inhibitors and the complications of diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Humans; Kidney; Naphthalenes; Rats | 1993 |
[Clinical application of aldose reductase inhibitors--prevention and therapy of diabetic complications].
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Naphthalenes; Phthalazines; Sugar Alcohol Dehydrogenases | 1987 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution | 1985 |
3 trial(s) available for tolrestat and Diabetic Retinopathy
| Article | Year |
|---|---|
Effects of aldose reductase inhibition with tolrestat on diabetic retinopathy in a six months double blind trial.
Topics: Administration, Oral; Aldehyde Reductase; Blood-Retinal Barrier; Capillary Permeability; Diabetic Retinopathy; Double-Blind Method; Female; Fluorescein Angiography; Fluorophotometry; Fundus Oculi; Humans; Male; Middle Aged; Naphthalenes | 1994 |
The Vanderbilt Classification System in the evaluation of diabetic retinopathy patients treated with Alredase.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Double-Blind Method; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naphthalenes; Observer Variation; Prospective Studies; Reproducibility of Results; Tennessee | 1996 |
Effect of tolrestat, an aldose reductase inhibitor, on neutrophil respiratory burst activity in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Naphthalenes; Neutrophils; Reference Values; Regression Analysis; Respiratory Burst; Tetradecanoylphorbol Acetate | 1997 |
9 other study(ies) available for tolrestat and Diabetic Retinopathy
| Article | Year |
|---|---|
Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diabetic Retinopathy; Diuresis; Enzyme Inhibitors; Guanidines; Kidney; Male; Naphthalenes; Nitric Oxide Synthase; Organ Size; Rats; Rats, Sprague-Dawley; Reference Values | 2002 |
Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats.
Topics: Albuminuria; Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Blood Urea Nitrogen; Capillaries; Creatinine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diabetic Retinopathy; Female; Glycosuria; Muscle, Smooth, Vascular; Naphthalenes; Rats; Rats, Inbred Strains; Retina; Triglycerides | 1991 |
Diabetes-related histopathologies of the rat retina prevented with an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Galactose; Microscopy, Electron; Naphthalenes; Rats; Rats, Inbred Strains; Retina; Retinal Vessels; Sugar Alcohol Dehydrogenases | 1990 |
Aldose reductase inhibition. The chemical key to the control of diabetic retinopathy?
Topics: Aldehyde Reductase; Diabetic Retinopathy; Humans; Imidazoles; Imidazolidines; Naphthalenes; Sugar Alcohol Dehydrogenases | 1990 |
Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Diabetic Retinopathy; Disease Models, Animal; Female; Galactose; Naphthalenes; Polymers; Random Allocation; Rats; Rats, Inbred Strains; Retinal Vessels; Sugar Alcohol Dehydrogenases | 1989 |
Aldose reductase and pericyte-endothelial cell contacts in retina and optic nerve.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Capillaries; Diabetic Retinopathy; Disease Models, Animal; Endothelium, Vascular; Female; Galactose; Intercellular Junctions; Naphthalenes; Optic Nerve; Rats; Rats, Inbred Strains; Retina; Retinal Vessels; Sugar Alcohol Dehydrogenases | 1989 |
Prevention of basement membrane thickening in retinal capillaries by a novel inhibitor of aldose reductase, tolrestat.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Capillaries; Cataract; Diabetic Retinopathy; Galactose; Male; Microscopy, Electron; Naphthalenes; Rats; Rats, Inbred Strains; Retinal Vessels; Sugar Alcohol Dehydrogenases | 1986 |
The polyol pathway in retinal microangiopathy.
Topics: Aldehyde Reductase; Animals; Diabetic Retinopathy; Galactose; Imidazoles; Imidazolidines; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sugar Alcohol Dehydrogenases; Sugar Alcohols | 1986 |
Aldose reductase and retinal capillary basement membrane thickening.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Capillaries; Diabetic Retinopathy; Dietary Carbohydrates; Galactose; Male; Naphthalenes; Rats; Rats, Inbred Strains; Retinal Vessels; Sugar Alcohol Dehydrogenases | 1988 |