tolrestat has been researched along with Diabetic Neuropathies in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.00) | 18.7374 |
| 1990's | 20 (80.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kato, N; Oka, M | 1 |
| Acampora, R; Ceriello, A; D'Onofrio, F; De Rosa, N; Di Maro, G; Giugliano, D; Marfella, R; Misso, L; Quatraro, A | 1 |
| Tjon-A-Tsien, AM; van Gerven, JM | 1 |
| Hill, S; Slaney, MA; Wright, M | 1 |
| Luca, S; Terranova, R | 1 |
| Greene, DA; Sima, AA | 1 |
| van Gerven, JM | 1 |
| Brooks, B; Yue, DK | 1 |
| Ceriello, A; Cozzolino, D; De Rosa, N; Giugliano, D; Marfella, R; Quatraro, A; Salvatore, T; Torella, R | 1 |
| Tomlinson, DR | 1 |
| De Vincentis, N; Fabiani, F; Staffilano, A | 1 |
| Coco, MP; Daniele, E | 1 |
| Ziegler, D | 1 |
| Carta, Q; Dani, F; De Mattei, M; Monge, L; Sciarretta, A | 1 |
| Carinci, F; Ferris, F; Graepel, JG; Hohman, TC; Lachin, JM; Nicolucci, A | 1 |
| Ihm, SH; Park, CJ; Park, SW; Yoo, HJ | 1 |
| Chang, K; Ido, Y; LeJeune, W; Monafo, WW; Tilton, RG; Williamson, JR | 1 |
| Gelber, DA; Pfeifer, MA; Schumer, MP | 1 |
| Celotti, F; Colciago, A; Negri-Cesi, P | 1 |
| Hohman, TC; Laver, N; McCaleb, ML; McKean, ML; Robison, WG | 1 |
| Bravenboer, B; Erkelens, DW | 1 |
| Boulton, AJ; Comstock, J; Levin, S | 1 |
| Inserra, JJ; Notvest, RR | 1 |
| Hotta, N; Sakamoto, N | 1 |
| Kador, PF; Kinoshita, JH; Sharpless, NE | 1 |
10 review(s) available for tolrestat and Diabetic Neuropathies
| Article | Year |
|---|---|
Aldose reductase inhibitors.
Topics: Aldehyde Reductase; Binding Sites; Clinical Trials as Topic; Crystallography, X-Ray; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Naphthalenes; Quinazolines | 2001 |
The efficacy of aldose reductase inhibitors in the management of diabetic complications. Comparison with intensive insulin treatment and pancreatic transplantation.
Topics: Adult; Aged; Aldehyde Reductase; Cross-Sectional Studies; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines; Insulin; Islets of Langerhans Transplantation; Middle Aged; Naphthalenes; Pancreas Transplantation; Treatment Outcome | 1995 |
Effects of aldose reductase inhibitors on the progression of nerve damage.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Naphthalenes; Nerve Regeneration; Sural Nerve | 1993 |
Aldose reductase inhibitors and the complications of diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Humans; Kidney; Naphthalenes; Rats | 1993 |
[Tolrestat in the therapy of diabetic peripheral neuropathy: is this drug really useful?].
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Hyperglycemia; Male; Middle Aged; Naphthalenes | 1995 |
Diagnosis and management of diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Electrodiagnosis; Enzyme Inhibitors; Humans; Naphthalenes; Pain; Prevalence | 1996 |
The efficacy of tolrestat in the treatment of diabetic peripheral neuropathy. A meta-analysis of individual patient data.
Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Humans; Male; Median Nerve; Middle Aged; Naphthalenes; Neural Conduction; Peroneal Nerve; Randomized Controlled Trials as Topic; Tibial Nerve; Treatment Outcome; Ulnar Nerve | 1996 |
Aldose reductase inhibitors: the end of an era or the need for different trial designs?
Topics: Aldehyde Reductase; Autonomic Nervous System; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Isoquinolines; Naphthalenes; Phthalazines; Time Factors | 1997 |
[Clinical application of aldose reductase inhibitors--prevention and therapy of diabetic complications].
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Naphthalenes; Phthalazines; Sugar Alcohol Dehydrogenases | 1987 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution | 1985 |
11 trial(s) available for tolrestat and Diabetic Neuropathies
| Article | Year |
|---|---|
Tolrestat in the primary prevention of diabetic neuropathy.
Topics: Administration, Oral; Analysis of Variance; Diabetic Neuropathies; Disease Progression; Double-Blind Method; Drug Tolerance; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Naphthalenes | 1995 |
[Treatment with an aldose reductase inhibitor in peripheral neuropathy in elderly diabetic patients].
Topics: Aged; Aldehyde Reductase; Diabetic Neuropathies; Female; Humans; Male; Naphthalenes | 1993 |
Effects of aldose reductase inhibitors on the progression of nerve damage.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Naphthalenes; Nerve Regeneration; Sural Nerve | 1993 |
Further clinical studies with an aldose reductase inhibitor in diabetic neuropathy.
Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Evoked Potentials, Somatosensory; Female; Humans; Male; Middle Aged; Naphthalenes; Neural Conduction | 1993 |
Tolrestat for mild diabetic neuropathy. A 52-week, randomized, placebo-controlled trial.
Topics: Aldehyde Reductase; Autonomic Nervous System Diseases; Blood Pressure; Cardiovascular System; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Female; Follow-Up Studies; Heart Rate; Humans; Male; Middle Aged; Naphthalenes; Peripheral Nerves; Reflex; Sensation; Single-Blind Method | 1993 |
Effect of Tolrestat on oesophageal transit time and cholecystic motility in type 2 diabetic patients with asymptomatic diabetic neuropathy.
Topics: Aged; Aldehyde Reductase; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Esophagus; Female; Follow-Up Studies; Gallbladder; Gastrointestinal Transit; Humans; Male; Middle Aged; Naphthalenes; Statistics as Topic; Time Factors | 1995 |
[Tolrestat in the therapy of diabetic peripheral neuropathy: is this drug really useful?].
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Hyperglycemia; Male; Middle Aged; Naphthalenes | 1995 |
Effect of treatment with an aldose-reductase inhibitor on symptomatic carpal tunnel syndrome in type 2 diabetes.
Topics: Aldehyde Reductase; Carpal Tunnel Syndrome; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Male; Median Nerve; Middle Aged; Motor Neurons; Naphthalenes; Neural Conduction; Neurons, Afferent; Time Factors; Ulnar Nerve | 1995 |
Effect of tolrestat, an aldose reductase inhibitor, on neutrophil respiratory burst activity in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Naphthalenes; Neutrophils; Reference Values; Regression Analysis; Respiratory Burst; Tetradecanoylphorbol Acetate | 1997 |
Aldose reductase inhibitors: the end of an era or the need for different trial designs?
Topics: Aldehyde Reductase; Autonomic Nervous System; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Isoquinolines; Naphthalenes; Phthalazines; Time Factors | 1997 |
A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy.
Topics: Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Motor Neurons; Multicenter Studies as Topic; Naphthalenes; Neural Conduction; Pain; Random Allocation; Spinal Nerves; Sugar Alcohol Dehydrogenases | 1990 |
7 other study(ies) available for tolrestat and Diabetic Neuropathies
| Article | Year |
|---|---|
The role of aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Diabetic Neuropathies; Humans; Naphthalenes | 1994 |
The role of aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Naphthalenes; Randomized Controlled Trials as Topic; Rats | 1993 |
Diabetes impairs sciatic nerve hyperemia induced by surgical trauma: implications for diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Desipramine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Gadolinium; Galactose; Hemodynamics; Hyperemia; Inflammation; Laser-Doppler Flowmetry; Male; Microspheres; Naphthalenes; Neurosurgery; Polarography; Radioisotopes; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Time Factors; Tritium; Wounds and Injuries | 1997 |
Pathogenesis of diabetic neuropathy--do hyperglycemia and aldose reductase inhibitors affect neuroactive steroid formation in the rat sciatic nerves?
Topics: 20-alpha-Dihydroprogesterone; 3-Hydroxysteroid Dehydrogenases; Aldehyde Reductase; Animals; Diabetic Neuropathies; Dihydrotestosterone; Enzyme Inhibitors; Hyperglycemia; Imidazoles; Imidazolidines; Male; Naphthalenes; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2002 |
Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats.
Topics: Albuminuria; Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Blood Urea Nitrogen; Capillaries; Creatinine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diabetic Retinopathy; Female; Glycosuria; Muscle, Smooth, Vascular; Naphthalenes; Rats; Rats, Inbred Strains; Retina; Triglycerides | 1991 |
[Aldose reductase inhibitors in diabetic neuropathy].
Topics: Aldehyde Reductase; Diabetic Neuropathies; Humans; Mass Media; Naphthalenes; Publishing; Sugar Alcohol Dehydrogenases | 1990 |
Tolrestat, an aldose reductase inhibitor, prevents nerve dysfunction in conscious diabetic rats.
Topics: Aldehyde Reductase; Animals; Auditory Pathways; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Evoked Potentials, Auditory; Humans; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sugar Alcohol Dehydrogenases | 1987 |