Page last updated: 2024-08-23

tolrestat and Diabetes Mellitus, Type 2

tolrestat has been researched along with Diabetes Mellitus, Type 2 in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Tjon-A-Tsien, AM; van Gerven, JM	1
Balsano, F; Bravi, C; De Mattia, G; Ghiselli, A; Iuliano, L; Laurenti, O	1
van Gerven, JM	1
Ceriello, A; Cozzolino, D; De Rosa, N; Giugliano, D; Marfella, R; Quatraro, A; Salvatore, T; Torella, R	1
De Vincentis, N; Fabiani, F; Staffilano, A	1
Carta, Q; Dani, F; De Mattei, M; Monge, L; Sciarretta, A	1
Carinci, F; Ferris, F; Graepel, JG; Hohman, TC; Lachin, JM; Nicolucci, A	1
Feman, SS; Leonard-Martin, TC; Redman, JR	1
Ihm, SH; Park, CJ; Park, SW; Yoo, HJ	1
Basili, S; Bravi, MC; Cassone-Faldetta, M; De Mattia, G; Ferri, C; Laurenti, O; Pietrangeli, P	1
Brooks, BA; Fisher, EJ; McAuliffe, AV; Molyneaux, LM; Yue, DK	1
Boulton, AJ; Comstock, J; Levin, S	1

Reviews

2 review(s) available for tolrestat and Diabetes Mellitus, Type 2

Article	Year
The efficacy of aldose reductase inhibitors in the management of diabetic complications. Comparison with intensive insulin treatment and pancreatic transplantation. Drugs & aging, 1995, Volume: 6, Issue:1 Topics: Adult; Aged; Aldehyde Reductase; Cross-Sectional Studies; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines; Insulin; Islets of Langerhans Transplantation; Middle Aged; Naphthalenes; Pancreas Transplantation; Treatment Outcome	1995
The efficacy of tolrestat in the treatment of diabetic peripheral neuropathy. A meta-analysis of individual patient data. Diabetes care, 1996, Volume: 19, Issue:10 Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Humans; Male; Median Nerve; Middle Aged; Naphthalenes; Neural Conduction; Peroneal Nerve; Randomized Controlled Trials as Topic; Tibial Nerve; Treatment Outcome; Ulnar Nerve	1996

Article

Year

The efficacy of aldose reductase inhibitors in the management of diabetic complications. Comparison with intensive insulin treatment and pancreatic transplantation.

Drugs & aging, 1995, Volume: 6, Issue:1

Topics: Adult; Aged; Aldehyde Reductase; Cross-Sectional Studies; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines; Insulin; Islets of Langerhans Transplantation; Middle Aged; Naphthalenes; Pancreas Transplantation; Treatment Outcome

1995

The efficacy of tolrestat in the treatment of diabetic peripheral neuropathy. A meta-analysis of individual patient data.

Diabetes care, 1996, Volume: 19, Issue:10

Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Humans; Male; Median Nerve; Middle Aged; Naphthalenes; Neural Conduction; Peroneal Nerve; Randomized Controlled Trials as Topic; Tibial Nerve; Treatment Outcome; Ulnar Nerve

1996

Trials

9 trial(s) available for tolrestat and Diabetes Mellitus, Type 2

Article	Year
Further clinical studies with an aldose reductase inhibitor in diabetic neuropathy. Diabetic medicine : a journal of the British Diabetic Association, 1993, Volume: 10 Suppl 2 Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Evoked Potentials, Somatosensory; Female; Humans; Male; Middle Aged; Naphthalenes; Neural Conduction	1993
Tolrestat for mild diabetic neuropathy. A 52-week, randomized, placebo-controlled trial. Annals of internal medicine, 1993, Jan-01, Volume: 118, Issue:1 Topics: Aldehyde Reductase; Autonomic Nervous System Diseases; Blood Pressure; Cardiovascular System; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Female; Follow-Up Studies; Heart Rate; Humans; Male; Middle Aged; Naphthalenes; Peripheral Nerves; Reflex; Sensation; Single-Blind Method	1993
Effect of Tolrestat on oesophageal transit time and cholecystic motility in type 2 diabetic patients with asymptomatic diabetic neuropathy. Diabete & metabolisme, 1995, Volume: 21, Issue:5 Topics: Aged; Aldehyde Reductase; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Esophagus; Female; Follow-Up Studies; Gallbladder; Gastrointestinal Transit; Humans; Male; Middle Aged; Naphthalenes; Statistics as Topic; Time Factors	1995
Effect of treatment with an aldose-reductase inhibitor on symptomatic carpal tunnel syndrome in type 2 diabetes. Diabetic medicine : a journal of the British Diabetic Association, 1995, Volume: 12, Issue:12 Topics: Aldehyde Reductase; Carpal Tunnel Syndrome; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Male; Median Nerve; Middle Aged; Motor Neurons; Naphthalenes; Neural Conduction; Neurons, Afferent; Time Factors; Ulnar Nerve	1995
The Vanderbilt Classification System in the evaluation of diabetic retinopathy patients treated with Alredase. Transactions of the American Ophthalmological Society, 1996, Volume: 94 Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Double-Blind Method; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naphthalenes; Observer Variation; Prospective Studies; Reproducibility of Results; Tennessee	1996
Effect of tolrestat, an aldose reductase inhibitor, on neutrophil respiratory burst activity in diabetic patients. Metabolism: clinical and experimental, 1997, Volume: 46, Issue:6 Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Naphthalenes; Neutrophils; Reference Values; Regression Analysis; Respiratory Burst; Tetradecanoylphorbol Acetate	1997
Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients. Metabolism: clinical and experimental, 1997, Volume: 46, Issue:10 Topics: Adult; Aged; Aldehyde Reductase; Diabetes Mellitus, Type 2; Double-Blind Method; Enzyme Inhibitors; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Disulfide; Humans; Male; Middle Aged; NADP; Naphthalenes; Oxidation-Reduction; Reference Values	1997
Administration of ascorbic acid and an aldose reductase inhibitor (tolrestat) in diabetes: effect on urinary albumin excretion. Nephron, 1998, Volume: 80, Issue:3 Topics: Administration, Oral; Adult; Aged; Albuminuria; Aldehyde Reductase; Ascorbic Acid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Glycosaminoglycans; Humans; Male; Middle Aged; Naphthalenes; Placebos; Proteoglycans; Time Factors	1998
A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy. Diabetologia, 1990, Volume: 33, Issue:7 Topics: Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Motor Neurons; Multicenter Studies as Topic; Naphthalenes; Neural Conduction; Pain; Random Allocation; Spinal Nerves; Sugar Alcohol Dehydrogenases	1990

Other Studies

1 other study(ies) available for tolrestat and Diabetes Mellitus, Type 2

Article	Year
Effect of aldose reductase inhibition on glutathione redox status in erythrocytes of diabetic patients. Metabolism: clinical and experimental, 1994, Volume: 43, Issue:8 Topics: Aged; Aldehyde Reductase; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Erythrocytes; Female; Glutathione; Humans; Male; Middle Aged; NADP; Naphthalenes; Oxidation-Reduction	1994