Page last updated: 2024-08-23

tolrestat and Diabetes Mellitus, Type 2

tolrestat has been researched along with Diabetes Mellitus, Type 2 in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tjon-A-Tsien, AM; van Gerven, JM1
Balsano, F; Bravi, C; De Mattia, G; Ghiselli, A; Iuliano, L; Laurenti, O1
van Gerven, JM1
Ceriello, A; Cozzolino, D; De Rosa, N; Giugliano, D; Marfella, R; Quatraro, A; Salvatore, T; Torella, R1
De Vincentis, N; Fabiani, F; Staffilano, A1
Carta, Q; Dani, F; De Mattei, M; Monge, L; Sciarretta, A1
Carinci, F; Ferris, F; Graepel, JG; Hohman, TC; Lachin, JM; Nicolucci, A1
Feman, SS; Leonard-Martin, TC; Redman, JR1
Ihm, SH; Park, CJ; Park, SW; Yoo, HJ1
Basili, S; Bravi, MC; Cassone-Faldetta, M; De Mattia, G; Ferri, C; Laurenti, O; Pietrangeli, P1
Brooks, BA; Fisher, EJ; McAuliffe, AV; Molyneaux, LM; Yue, DK1
Boulton, AJ; Comstock, J; Levin, S1

Reviews

2 review(s) available for tolrestat and Diabetes Mellitus, Type 2

ArticleYear
The efficacy of aldose reductase inhibitors in the management of diabetic complications. Comparison with intensive insulin treatment and pancreatic transplantation.
    Drugs & aging, 1995, Volume: 6, Issue:1

    Topics: Adult; Aged; Aldehyde Reductase; Cross-Sectional Studies; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines; Insulin; Islets of Langerhans Transplantation; Middle Aged; Naphthalenes; Pancreas Transplantation; Treatment Outcome

1995
The efficacy of tolrestat in the treatment of diabetic peripheral neuropathy. A meta-analysis of individual patient data.
    Diabetes care, 1996, Volume: 19, Issue:10

    Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Humans; Male; Median Nerve; Middle Aged; Naphthalenes; Neural Conduction; Peroneal Nerve; Randomized Controlled Trials as Topic; Tibial Nerve; Treatment Outcome; Ulnar Nerve

1996

Trials

9 trial(s) available for tolrestat and Diabetes Mellitus, Type 2

ArticleYear
Further clinical studies with an aldose reductase inhibitor in diabetic neuropathy.
    Diabetic medicine : a journal of the British Diabetic Association, 1993, Volume: 10 Suppl 2

    Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Evoked Potentials, Somatosensory; Female; Humans; Male; Middle Aged; Naphthalenes; Neural Conduction

1993
Tolrestat for mild diabetic neuropathy. A 52-week, randomized, placebo-controlled trial.
    Annals of internal medicine, 1993, Jan-01, Volume: 118, Issue:1

    Topics: Aldehyde Reductase; Autonomic Nervous System Diseases; Blood Pressure; Cardiovascular System; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Female; Follow-Up Studies; Heart Rate; Humans; Male; Middle Aged; Naphthalenes; Peripheral Nerves; Reflex; Sensation; Single-Blind Method

1993
Effect of Tolrestat on oesophageal transit time and cholecystic motility in type 2 diabetic patients with asymptomatic diabetic neuropathy.
    Diabete & metabolisme, 1995, Volume: 21, Issue:5

    Topics: Aged; Aldehyde Reductase; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Esophagus; Female; Follow-Up Studies; Gallbladder; Gastrointestinal Transit; Humans; Male; Middle Aged; Naphthalenes; Statistics as Topic; Time Factors

1995
Effect of treatment with an aldose-reductase inhibitor on symptomatic carpal tunnel syndrome in type 2 diabetes.
    Diabetic medicine : a journal of the British Diabetic Association, 1995, Volume: 12, Issue:12

    Topics: Aldehyde Reductase; Carpal Tunnel Syndrome; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Male; Median Nerve; Middle Aged; Motor Neurons; Naphthalenes; Neural Conduction; Neurons, Afferent; Time Factors; Ulnar Nerve

1995
The Vanderbilt Classification System in the evaluation of diabetic retinopathy patients treated with Alredase.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Double-Blind Method; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naphthalenes; Observer Variation; Prospective Studies; Reproducibility of Results; Tennessee

1996
Effect of tolrestat, an aldose reductase inhibitor, on neutrophil respiratory burst activity in diabetic patients.
    Metabolism: clinical and experimental, 1997, Volume: 46, Issue:6

    Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Naphthalenes; Neutrophils; Reference Values; Regression Analysis; Respiratory Burst; Tetradecanoylphorbol Acetate

1997
Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients.
    Metabolism: clinical and experimental, 1997, Volume: 46, Issue:10

    Topics: Adult; Aged; Aldehyde Reductase; Diabetes Mellitus, Type 2; Double-Blind Method; Enzyme Inhibitors; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Disulfide; Humans; Male; Middle Aged; NADP; Naphthalenes; Oxidation-Reduction; Reference Values

1997
Administration of ascorbic acid and an aldose reductase inhibitor (tolrestat) in diabetes: effect on urinary albumin excretion.
    Nephron, 1998, Volume: 80, Issue:3

    Topics: Administration, Oral; Adult; Aged; Albuminuria; Aldehyde Reductase; Ascorbic Acid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Glycosaminoglycans; Humans; Male; Middle Aged; Naphthalenes; Placebos; Proteoglycans; Time Factors

1998
A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy.
    Diabetologia, 1990, Volume: 33, Issue:7

    Topics: Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Motor Neurons; Multicenter Studies as Topic; Naphthalenes; Neural Conduction; Pain; Random Allocation; Spinal Nerves; Sugar Alcohol Dehydrogenases

1990

Other Studies

1 other study(ies) available for tolrestat and Diabetes Mellitus, Type 2

ArticleYear
Effect of aldose reductase inhibition on glutathione redox status in erythrocytes of diabetic patients.
    Metabolism: clinical and experimental, 1994, Volume: 43, Issue:8

    Topics: Aged; Aldehyde Reductase; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Erythrocytes; Female; Glutathione; Humans; Male; Middle Aged; NADP; Naphthalenes; Oxidation-Reduction

1994