tolrestat has been researched along with Alloxan Diabetes in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (21.95) | 18.7374 |
| 1990's | 24 (58.54) | 18.2507 |
| 2000's | 7 (17.07) | 29.6817 |
| 2010's | 1 (2.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dietrich, A; Harrison, MC; Hohman, TC; McCaleb, M; Millen, J; Sredy, J; Sullivan, D; Woolson, SA; Wrobel, J | 1 |
| Beyer, TA; Mylari, BL; Siegel, TW | 1 |
| Bauman, JG; Dietrich, A; Gorham, BJ; Harrison, MC; Jones, LR; Kelly, JM; Malamas, M; Millen, J; Sredy, J; Wrobel, J | 1 |
| Abraham, N; Bellini, F; Dvornik, D; Fung, S; Humber, L; Sestanj, K; Simard-Duquesne, N; Treasurywala, A | 1 |
| Hohman, TC; Malamas, MS; Millen, J | 1 |
| Fujitani, B; Komiya, M; Kuromiya, A; Matsumoto, J; Murata, M; Negoro, T; Ono, Y; Suzuki, K; Ueda, S | 1 |
| Dicioccio, AT; Geraci, LS; Gunn, DE; Jacot, JL; Jones, JH; Jones, ML; Mitschler, A; Petrova, T; Podjarny, AD; Sawicki, DR; Sredy, J; Van Zandt, MC | 1 |
| Barski, OA; Bhatnagar, A; Chung, SS; Dawn, B; Hunt, G; Kaiserova, K; Petrash, JM; Spite, M; Srivastava, S; Vladykovskaya, E | 1 |
| Blessing, K; Kador, PF; Marx, DB; O'Meara, JD; Reinhardt, RA | 1 |
| Bhatnagar, A; Chandra, D; Jackson, EB; Kelley, R; Ramana, KV; Srivastava, SK | 1 |
| Bhatnagar, A; Ramana, KV; Srivastava, S; Srivastava, SK; Tammali, R | 1 |
| Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG | 1 |
| Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T | 1 |
| Calcutt, NA; Kalichman, MW; Mizisin, AP | 1 |
| Brooks, B; Yue, DK | 1 |
| Tomlinson, DR | 1 |
| Calcutt, NA; Li, L; Malmberg, AB; Yaksh, TL | 1 |
| Becker, C; Fortes, ZB; Oliveira, MA; Scivoletto, R | 1 |
| Kikkawa, R; Shigeta, Y; Terada, M; Yasuda, H | 1 |
| Epstein, M; Forster, HG; Hohman, TC; ter Wee, PM | 1 |
| Donnelly, SM; Huang, JT; Whiteside, CI; Zhou, XP | 1 |
| Chang, K; Ido, Y; LeJeune, W; Monafo, WW; Tilton, RG; Williamson, JR | 1 |
| Chang, K; Ido, Y; LeJeune, W; Tilton, RG; Williamson, JR | 1 |
| Flores, LE; Gagliardino, JJ; Malaisse, WJ; Sener, A | 1 |
| Haneda, M; Kashiwagi, A; Kikkawa, R; Maeda, K; Sasaki, T; Taniguchi, Y; Terada, M; Yasuda, H | 1 |
| Banditelli, S; Boldrini, E; Cappiello, M; Cecconi, I; Dal Monte, M; Del Corso, A; Marini, I; Mura, U; Vilardo, PG | 1 |
| Cruz, JW; Fortes, ZB; Hohman, TC; Oliveira, MA | 1 |
| Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF | 1 |
| Cameron, NE; Cotter, MA; Hohman, TC | 1 |
| Azal, O; Baydar, A; Cakir, B; Corakçi, A; Güler, S; Kutlu, M; Yönem, A | 1 |
| Flam, BR; Sawicki, DR; Sredy, J | 1 |
| Hohman, TC; Laver, N; McCaleb, ML; McKean, ML; Robison, WG | 1 |
| Kinoshita, JH; Laver, N; Robison, WG; Tillis, TN | 1 |
| Capogreco, C; Fisher, E; Heffernan, S; McLennan, S; Ross, GR; Turtle, JR; Yue, DK | 2 |
| Chang, K; Eades, DM; Kilo, C; Province, MA; Pugliese, G; Sherman, WR; Tilton, RG; Williamson, JR | 1 |
| Dvornik, D; Kemper, C | 1 |
| Inserra, JJ; Notvest, RR | 1 |
| Akagi, Y; Kador, PF; Kinoshita, JH; Terubayashi, H | 2 |
| Dubuc, J; Dvornik, D; Greselin, E; Simard-Duquesne, N | 1 |
1 review(s) available for tolrestat and Alloxan Diabetes
| Article | Year |
|---|---|
Aldose reductase inhibitors and the complications of diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Humans; Kidney; Naphthalenes; Rats | 1993 |
40 other study(ies) available for tolrestat and Alloxan Diabetes
| Article | Year |
|---|---|
Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cattle; Diabetes Mellitus, Experimental; Glyceraldehyde; Hypoglycemic Agents; Indoles; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Rats; Structure-Activity Relationship; Succinimides; Thiazoles; Thiazolidinediones | 1992 |
A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.
Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Female; Humans; Kidney; Lens, Crystalline; Molecular Structure; Placenta; Pyrrolidonecarboxylic Acid; Sciatic Nerve; Sorbitol; Structure-Activity Relationship; Swine | 1991 |
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Cattle; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Diaphragm; Galactitol; Galactose; Glycine; Lens, Crystalline; Male; Molecular Structure; Naphthalenes; Prodrugs; Rats; Rats, Inbred Strains; Sciatic Nerve | 1991 |
N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Galactitol; Isoquinolines; Lens, Crystalline; Naphthalenes; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cattle; Diabetes Mellitus, Experimental; Dogs; Drug Evaluation, Preclinical; Erythrocytes; Galactitol; Galactosemias; Glyceraldehyde; In Vitro Techniques; Isoquinolines; Lens, Crystalline; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spiro Compounds; Stereoisomerism | 1994 |
Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners.
Topics: Aldehyde Reductase; Animals; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Enzyme Inhibitors; In Vitro Techniques; Lens, Crystalline; Male; Molecular Conformation; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Swine | 1998 |
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complications; Diabetes Mellitus, Experimental; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Structure-Activity Relationship; Thiazoles; Tissue Distribution | 2005 |
Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice.
Topics: Aldehyde Reductase; Aldehydes; Animals; Apolipoproteins E; Atherosclerosis; Diabetes Mellitus, Experimental; Dietary Fats; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Imidazolidines; Macrophages; Male; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Naphthalenes; Oxidation-Reduction; Phospholipids; Up-Regulation | 2009 |
Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats.
Topics: Aldehyde Reductase; Alveolar Bone Loss; Animals; Antioxidants; Citric Acid Cycle; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluorenes; Glycolysis; Hydantoins; Lipopolysaccharides; Male; Naphthalenes; Periodontitis; Quercetin; Rats; Rats, Sprague-Dawley; Sorbitol | 2011 |
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Glucose; Imidazoles; Imidazolidines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley; Sorbitol | 2002 |
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells.
Topics: Aldehyde Reductase; Animals; Aorta; Cell Cycle; Cell Division; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose; Hyperplasia; Imidazolidines; Male; Muscle, Smooth, Vascular; Naphthalenes; Rats; Rats, Sprague-Dawley; Reference Values; Tunica Intima | 2006 |
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.
Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; Body Weight; Capillary Permeability; Citrulline; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Imidazoles; Imidazolidines; Inositol; Iodine Radioisotopes; Male; Methylguanidine; Naphthalenes; Nitric Oxide Synthase; omega-N-Methylarginine; Phthalazines; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Serum Albumin, Bovine; Sorbitol; Thiazoles; Uvea | 1993 |
Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats.
Topics: Aldehyde Reductase; Animals; Behavior, Animal; Body Weight; Diabetes Mellitus, Experimental; Female; Formaldehyde; Galactose; Hyperalgesia; Hyperglycemia; Naphthalenes; Neural Pathways; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sorbitol | 1994 |
Aldose reductase inhibition, Doppler flux and conduction in diabetic rat nerve.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Laser-Doppler Flowmetry; Motor Neurons; Naphthalenes; Neural Conduction; Phthalazines; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 1994 |
The role of aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Naphthalenes; Randomized Controlled Trials as Topic; Rats | 1993 |
Different effects of two aldose reductase inhibitors on nociception and prostaglandin E.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; Formaldehyde; Hyperalgesia; Injections, Spinal; Naphthalenes; Nitroparaffins; Nociceptors; Pain Measurement; Prostaglandins E; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Sulfones | 1995 |
Influence of aldose reductase inhibition on the microvascular reactivity in experimental diabetes.
Topics: Acetylcholine; Aldehyde Reductase; Animals; Arterioles; Blood Glucose; Bradykinin; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Histamine; Male; Microcirculation; Naphthalenes; Nitroprusside; Rats; Rats, Wistar; Splanchnic Circulation; Venules | 1996 |
Tolrestat improves nerve regeneration after crush injury in streptozocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Male; Naphthalenes; Nerve Crush; Nerve Regeneration; Neural Conduction; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Wounds, Nonpenetrating | 1996 |
Impairment of afferent arteriolar myogenic responsiveness in the galactose-fed rat is prevented by tolrestat.
Topics: Aldehyde Reductase; Angiotensin II; Animals; Arterioles; Blood Pressure; Cohort Studies; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet; Disease Models, Animal; Enzyme Inhibitors; Galactitol; Galactose; Image Processing, Computer-Assisted; In Vitro Techniques; Kidney; Male; Muscle, Smooth, Vascular; Naphthalenes; Perfusion; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents | 1996 |
Prevention of early glomerulopathy with tolrestat in the streptozotocin-induced diabetic rat.
Topics: Ampholyte Mixtures; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney Glomerulus; Male; Naphthalenes; Polymers; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 1996 |
Diabetes impairs sciatic nerve hyperemia induced by surgical trauma: implications for diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Desipramine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Gadolinium; Galactose; Hemodynamics; Hyperemia; Inflammation; Laser-Doppler Flowmetry; Male; Microspheres; Naphthalenes; Neurosurgery; Polarography; Radioisotopes; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Time Factors; Tritium; Wounds and Injuries | 1997 |
Increased sciatic nerve blood flow in diabetic rats: assessment by "molecular" vs. particulate microspheres.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Blood Pressure; Desipramine; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gadolinium; Heart Rate; Hematocrit; Hemodynamics; Laser-Doppler Flowmetry; Male; Microspheres; Naphthalenes; Polarography; Radioisotopes; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Tritium; Ultrasonography | 1997 |
Effects of two aldose reductase inhibitors upon sorbitol output, D-glucose metabolism and insulin release in islets from normal and hereditarily diabetic rats.
Topics: Aldehyde Reductase; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Naphthalenes; Rats; Rats, Wistar; Sorbitol | 1998 |
Impaired regeneration and no amelioration with aldose reductase inhibitor in crushed unmyelinated nerve fibers of diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Male; Naphthalenes; Nerve Crush; Nerve Fibers; Nerve Regeneration; Rats; Rats, Sprague-Dawley | 1999 |
A new approach against sugar cataract through aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Enzyme Inhibitors; Galactitol; Galactose; Lens, Crystalline; Naphthalenes; Rats; Rats, Sprague-Dawley | 1999 |
Influence of tolrestat on the defective leukocyte-endothelial interaction in experimental diabetes.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Carrageenan; Cell Migration Inhibition; Cell Movement; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Hemodynamics; Interleukin-16; Leukocyte Count; Leukocytes; Male; Naphthalenes; Rats; Rats, Wistar; Receptors, Leukocyte-Adhesion; Spermatic Cord | 2000 |
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorenes; Glutathione; Glycation End Products, Advanced; Glycosylation; Hydantoins; Lens, Crystalline; Naphthalenes; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol; Spectrometry, Fluorescence | 2000 |
Correction of nerve conduction and endoneurial blood flow deficits by the aldose reductase inhibitor, tolrestat, in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Male; Naphthalenes; Neural Conduction; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve | 1998 |
Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diabetic Retinopathy; Diuresis; Enzyme Inhibitors; Guanidines; Kidney; Male; Naphthalenes; Nitric Oxide Synthase; Organ Size; Rats; Rats, Sprague-Dawley; Reference Values | 2002 |
Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effect of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sucrose | 1991 |
Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats.
Topics: Albuminuria; Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Blood Urea Nitrogen; Capillaries; Creatinine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diabetic Retinopathy; Female; Glycosuria; Muscle, Smooth, Vascular; Naphthalenes; Rats; Rats, Inbred Strains; Retina; Triglycerides | 1991 |
Diabetes-related histopathologies of the rat retina prevented with an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Galactose; Microscopy, Electron; Naphthalenes; Rats; Rats, Inbred Strains; Retina; Retinal Vessels; Sugar Alcohol Dehydrogenases | 1990 |
Ascorbic acid metabolism and polyol pathway in diabetes.
Topics: Aldehyde Reductase; Animals; Ascorbic Acid; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Female; Galactose; Inositol; Kidney Cortex; Kidney Medulla; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Sorbitol | 1989 |
Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors.
Topics: Albuminuria; Aldehyde Reductase; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Fluorenes; Glomerular Filtration Rate; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Iodine Radioisotopes; Male; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow; Serum Albumin, Bovine; Sorbitol; Strontium; Sugar Alcohol Dehydrogenases; Vascular Resistance | 1989 |
Deficiency of ascorbic acid in experimental diabetes. Relationship with collagen and polyol pathway abnormalities.
Topics: Aldehyde Reductase; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Collagen; Diabetes Mellitus, Experimental; Female; Granulation Tissue; Naphthalenes; Procollagen-Proline Dioxygenase; Rats; Rats, Inbred Strains; Sugar Alcohol Dehydrogenases | 1988 |
Prevention of neural myoinositol depletion in diabetic rats by aldose reductase inhibition with tolrestat.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose; Inositol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Tolrestat, an aldose reductase inhibitor, prevents nerve dysfunction in conscious diabetic rats.
Topics: Aldehyde Reductase; Animals; Auditory Pathways; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Evoked Potentials, Auditory; Humans; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sugar Alcohol Dehydrogenases | 1987 |
[Diabetic changes in pupillary reaction and iridal pathology. No. 1. The role of aldose reductase to the delayed pupillary reaction in galactose-fed rats].
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Male; Naphthalenes; Phenylephrine; Pupil; Rats; Rats, Inbred Strains; Sugar Alcohol Dehydrogenases | 1988 |
[Diabetic changes in pupillary reactions and iris histology. No. 3. The role of aldose reductase inhibitor to iridal vessel hyperpermeability of galactose-fed rats].
Topics: Aldehyde Reductase; Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Galactose; Horseradish Peroxidase; Imidazoles; Imidazolidines; Iris; Male; Naphthalenes; Rats; Rats, Inbred Strains; Reflex, Pupillary; Sugar Alcohol Dehydrogenases | 1988 |
The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats.
Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Erythrocytes; Galactosemias; Humans; In Vitro Techniques; Lens, Crystalline; Naphthalenes; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |