Page last updated: 2024-11-05

tolperisone and Stroke

tolperisone has been researched along with Stroke in 9 studies

Tolperisone: A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
"To study the efficacy and safety of tolperisone--a centrally acting muscle relaxant with membrane stabilizing activity--in the treatment of stroke-related spasticity."9.12[A randomized, double blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke]. ( Hanasen, C; Horvath, F; Koytchev, R; Kuhn, K; Pongratz, D; Ramm, S; Stamenova, P, 2006)
"To study the efficacy and safety of tolperisone - a centrally acting muscle relaxant with membrane stabilizing activity - in the treatment of stroke-related spasticity."9.11A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke. ( Hansen, C; Horvath, F; Koytchev, R; Kuhn, K; Pongratz, D; Ramm, S; Stamenova, P, 2005)
"To study the efficacy and safety of tolperisone--a centrally acting muscle relaxant with membrane stabilizing activity--in the treatment of stroke-related spasticity."5.12[A randomized, double blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke]. ( Hanasen, C; Horvath, F; Koytchev, R; Kuhn, K; Pongratz, D; Ramm, S; Stamenova, P, 2006)
"To study the efficacy and safety of tolperisone - a centrally acting muscle relaxant with membrane stabilizing activity - in the treatment of stroke-related spasticity."5.11A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke. ( Hansen, C; Horvath, F; Koytchev, R; Kuhn, K; Pongratz, D; Ramm, S; Stamenova, P, 2005)
" Adverse events in the mydocalm group have been identified more rarely than in the control group."2.78[Evaluation of efficacy and safety of mydocalm in the early rehabilitation of stroke]. ( Kovalchuk, VV, 2013)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kovalchuk, VV1
Lipták, J2
Lindsay, C1
Kouzouna, A1
Simcox, C1
Pandyan, AD1
Agarwal, S1
Patel, T1
Shah, N1
Patel, BM1
Stamenova, P2
Koytchev, R2
Kuhn, K2
Hansen, C1
Horvath, F2
Ramm, S2
Pongratz, D2
Hanasen, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Neuromuscular Electrical Stimulation on Walking Ability and Quality of Life in Individuals With Chronic Stroke[NCT04673045]40 participants (Anticipated)Interventional2021-02-02Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for tolperisone and Stroke

ArticleYear
Pharmacological interventions other than botulinum toxin for spasticity after stroke.
    The Cochrane database of systematic reviews, 2016, Oct-06, Volume: 10

    Topics: Baclofen; Botulinum Toxins, Type A; Clonidine; Diazepam; Humans; Muscle Relaxants, Central; Muscle S

2016

Trials

5 trials available for tolperisone and Stroke

ArticleYear
[Evaluation of efficacy and safety of mydocalm in the early rehabilitation of stroke].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2013, Volume: 113, Issue:4

    Topics: Adult; Case-Control Studies; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle To

2013
[Effectiveness and safety of tolperisone in spasticity following cerebral stroke: randomized, double-blind, placebo-controlled trial].
    Ideggyogyaszati szemle, 2013, Jul-30, Volume: 66, Issue:7-8

    Topics: Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Musc

2013
Comparative study of therapeutic response to baclofen vs tolperisone in spasticity.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 87

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Baclofen; Cerebral Palsy; Child; Child, Preschool; Femal

2017
A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke.
    European journal of neurology, 2005, Volume: 12, Issue:6

    Topics: Aged; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans;

2005
[A randomized, double blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2006, Volume: 106, Issue:1

    Topics: Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Human

2006

Other Studies

3 other studies available for tolperisone and Stroke

ArticleYear
[Comparative effectiveness of different muscle relaxants in the rehabilitation of post-stroke patients with spasticity].
    Ideggyogyaszati szemle, 2013, Nov-30, Volume: 66, Issue:11-12

    Topics: Aged; Baclofen; Clonidine; Comparative Effectiveness Research; Dantrolene; Female; Humans; Male; Mus

2013
[To make easier everyday life of stroke patients. Muscle relaxants diminish spasms].
    MMW Fortschritte der Medizin, 2003, Feb-27, Volume: 145, Issue:9

    Topics: Double-Blind Method; Humans; Muscle Relaxants, Central; Muscle Spasticity; Placebos; Randomized Cont

2003
[Spastic syndrome. More mobile again after stroke].
    MMW Fortschritte der Medizin, 2001, Mar-08, Volume: 143, Issue:10

    Topics: Hemiplegia; Humans; Muscle Relaxants, Central; Muscle Spasticity; Stroke; Tolperisone

2001