Page last updated: 2024-11-05

tolperisone and Spasm

tolperisone has been researched along with Spasm in 8 studies

Tolperisone: A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)

Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.

Research Excerpts

ExcerptRelevanceReference
"Tolperisone is a nonopioid, centrally acting muscle relaxant in clinical development in the USA for the treatment of symptoms associated with acute, painful muscles spasms of the back."9.51RESUME-1: a Phase III study of tolperisone in the treatment of painful, acute muscle spasms of the back. ( Kaye, R; Torres, K; Vaughan, SA, 2022)
"To generate real world clinical data on efficacy and tolerability of tolperisone 150 mg in painful muscle spasms in Indian population."9.15A phase IV observational multi-centre, open-label study on efficacy and safety of tolperisone 150 mg in patients with painful muscle spasm associated with degenerative or inflammatory diseases of the musculoskeletal system. ( Keny, S; Prabhoo, R; Prabhoo, T; Rana, R; Singh, A, 2011)
"The efficacy and safety of oral tolperisone hydrochloride (Mydocalm) in the treatment of painful reflex muscle spasm was assessed in a prospective, randomized, double-blind, placebo-controlled trial."9.08Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial. ( Alken, RG; Pratzel, HG; Ramm, S, 1996)
"Tolperisone is a nonopioid, centrally acting muscle relaxant in clinical development in the USA for the treatment of symptoms associated with acute, painful muscles spasms of the back."5.51RESUME-1: a Phase III study of tolperisone in the treatment of painful, acute muscle spasms of the back. ( Kaye, R; Torres, K; Vaughan, SA, 2022)
"To generate real world clinical data on efficacy and tolerability of tolperisone 150 mg in painful muscle spasms in Indian population."5.15A phase IV observational multi-centre, open-label study on efficacy and safety of tolperisone 150 mg in patients with painful muscle spasm associated with degenerative or inflammatory diseases of the musculoskeletal system. ( Keny, S; Prabhoo, R; Prabhoo, T; Rana, R; Singh, A, 2011)
"The role of tolperisone hydrochloride, a centrally acting muscle relaxant in relieving painful muscle spasm is recently being discussed."5.10Prophylactic tolperisone for post-exercise muscle soreness causes reduced isometric force--a double-blind randomized crossover control study. ( Arendt-Nielsen, L; Bajaj, P; Madeleine, P; Svensson, P, 2003)
"The efficacy and safety of oral tolperisone hydrochloride (Mydocalm) in the treatment of painful reflex muscle spasm was assessed in a prospective, randomized, double-blind, placebo-controlled trial."5.08Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial. ( Alken, RG; Pratzel, HG; Ramm, S, 1996)
"The high efficacy of mydocalm in the treatment of pain syndromes with the muscle spasm has been demonstrated."2.80[The results of the multicenter pharmaco-epidemiological observational project on the use of mydocalm in the treatment of pain syndromes with the muscle spasm]. ( Baliazin, VA; Barantsevich, ER; Belova, AN; Bogdanov, EI; Danilenko, OA; Gafurov, BG; Galanov, DV; Guekht, AB; Guseinov, SG; Khabirov, FA; Lebedeva, AV; Miakotnykh, VS; Mishchenko, TS; Musaev, SK; Prokopenko, SV; Shprakh, VV; Shyralieva, RK; Skoromets, AA; Spirin, NN; Toktomushev, CT; Volkova, LI, 2015)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Vaughan, SA1
Torres, K1
Kaye, R1
Skoromets, AA1
Guekht, AB1
Galanov, DV1
Danilenko, OA1
Barantsevich, ER1
Lebedeva, AV1
Belova, AN1
Shprakh, VV1
Bogdanov, EI1
Prokopenko, SV1
Khabirov, FA1
Spirin, NN1
Baliazin, VA1
Miakotnykh, VS1
Volkova, LI1
Gafurov, BG1
Mishchenko, TS1
Toktomushev, CT1
Shyralieva, RK1
Musaev, SK1
Guseinov, SG1
Prabhoo, R1
Keny, S1
Prabhoo, T1
Singh, A1
Rana, R1
Glück, J1
Rymarczyk, B1
Rogala, B1
Kocsis, P1
Tarnawa, I1
Kovács, G1
Szombathelyi, Z1
Farkas, S1
Bajaj, P1
Arendt-Nielsen, L1
Madeleine, P1
Svensson, P1
Neverov, VA1
Kurbanov, SKh1
Pratzel, HG1
Alken, RG1
Ramm, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 3, 14-Day, Double-blind, Randomized, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm[NCT04671082]Phase 31,004 participants (Actual)Interventional2020-12-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for tolperisone and Spasm

ArticleYear
RESUME-1: a Phase III study of tolperisone in the treatment of painful, acute muscle spasms of the back.
    Pain management, 2022, Volume: 12, Issue:1

    Topics: Back Pain; Female; Humans; Male; Muscle Relaxants, Central; Spasm; Tolperisone; Treatment Outcome

2022
[The results of the multicenter pharmaco-epidemiological observational project on the use of mydocalm in the treatment of pain syndromes with the muscle spasm].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:12

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Male; Middle Aged; Muscle Relaxants,

2015
A phase IV observational multi-centre, open-label study on efficacy and safety of tolperisone 150 mg in patients with painful muscle spasm associated with degenerative or inflammatory diseases of the musculoskeletal system.
    The Journal of the Association of Physicians of India, 2011, Volume: 59

    Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Female; Humans; India; Male; Middle A

2011
Prophylactic tolperisone for post-exercise muscle soreness causes reduced isometric force--a double-blind randomized crossover control study.
    European journal of pain (London, England), 2003, Volume: 7, Issue:5

    Topics: Adult; Cross-Over Studies; Double-Blind Method; Electromyography; Exercise; Humans; Isometric Contra

2003
Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial.
    Pain, 1996, Volume: 67, Issue:2-3

    Topics: Administration, Oral; Adult; Aged; Double-Blind Method; Humans; Middle Aged; Muscle Relaxants, Centr

1996

Other Studies

3 other studies available for tolperisone and Spasm

ArticleYear
An immediate hypersensitivity reaction caused by tolperisone hydrochloride.
    Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:5

    Topics: Drug Hypersensitivity; Edema; Erythema; Humans; Lidocaine; Male; Middle Aged; Muscle Relaxants, Cent

2011
[Mydeton: a centrally acting muscle relaxant drug from Gedeon Richter LTD].
    Acta pharmaceutica Hungarica, 2002, Volume: 72, Issue:1

    Topics: Animals; Drug Industry; Humans; Hungary; Muscle Relaxants, Central; Sodium Channels; Spasm; Tolperis

2002
[Restorative treatment of degenerative-dystrophic diseases of large joints].
    Vestnik khirurgii imeni I. I. Grekova, 2004, Volume: 163, Issue:2

    Topics: Adult; Female; Humans; Joint Diseases; Male; Middle Aged; Muscle Relaxants, Central; Muscle, Skeleta

2004