tolperisone has been researched along with Muscle Spasticity in 19 studies
Tolperisone: A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the efficacy and safety of tolperisone--a centrally acting muscle relaxant with membrane stabilizing activity--in the treatment of stroke-related spasticity." | 9.12 | [A randomized, double blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke]. ( Hanasen, C; Horvath, F; Koytchev, R; Kuhn, K; Pongratz, D; Ramm, S; Stamenova, P, 2006) |
| "To study the efficacy and safety of tolperisone - a centrally acting muscle relaxant with membrane stabilizing activity - in the treatment of stroke-related spasticity." | 9.11 | A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke. ( Hansen, C; Horvath, F; Koytchev, R; Kuhn, K; Pongratz, D; Ramm, S; Stamenova, P, 2005) |
| "To study the efficacy and safety of tolperisone--a centrally acting muscle relaxant with membrane stabilizing activity--in the treatment of stroke-related spasticity." | 5.12 | [A randomized, double blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke]. ( Hanasen, C; Horvath, F; Koytchev, R; Kuhn, K; Pongratz, D; Ramm, S; Stamenova, P, 2006) |
| "To study the efficacy and safety of tolperisone - a centrally acting muscle relaxant with membrane stabilizing activity - in the treatment of stroke-related spasticity." | 5.11 | A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke. ( Hansen, C; Horvath, F; Koytchev, R; Kuhn, K; Pongratz, D; Ramm, S; Stamenova, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lipták, J | 2 |
| Lindsay, C | 1 |
| Kouzouna, A | 1 |
| Simcox, C | 1 |
| Pandyan, AD | 1 |
| Agarwal, S | 1 |
| Patel, T | 1 |
| Shah, N | 1 |
| Patel, BM | 1 |
| Benecke, R | 1 |
| Patejdl, R | 1 |
| Kurenkov, AL | 1 |
| Batysheva, TT | 1 |
| Vinogradov, AV | 1 |
| Ziuziaeva, EK | 1 |
| LEHOCZKY, T | 1 |
| DOBI, S | 1 |
| LINKE, H | 1 |
| Stamenova, P | 2 |
| Koytchev, R | 2 |
| Kuhn, K | 2 |
| Hansen, C | 1 |
| Horvath, F | 2 |
| Ramm, S | 2 |
| Pongratz, D | 2 |
| Hanasen, C | 1 |
| Avakian, GN | 1 |
| Chukanova, EI | 1 |
| Nikonov, AA | 1 |
| Shaĭtor, VM | 2 |
| Bogdanov, OV | 2 |
| Huber, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Neuromuscular Electrical Stimulation on Walking Ability and Quality of Life in Individuals With Chronic Stroke[NCT04673045] | 40 participants (Anticipated) | Interventional | 2021-02-02 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for tolperisone and Muscle Spasticity
| Article | Year |
|---|---|
Pharmacological interventions other than botulinum toxin for spasticity after stroke.
Topics: Baclofen; Botulinum Toxins, Type A; Clonidine; Diazepam; Humans; Muscle Relaxants, Central; Muscle S | 2016 |
[New therapies for spastic movement disorders].
Topics: Administration, Oral; Baclofen; Botulinum Toxins, Type A; Cannabinoids; Clonidine; Diazepam; Humans; | 2009 |
5 trials available for tolperisone and Muscle Spasticity
| Article | Year |
|---|---|
[Effectiveness and safety of tolperisone in spasticity following cerebral stroke: randomized, double-blind, placebo-controlled trial].
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Musc | 2013 |
Comparative study of therapeutic response to baclofen vs tolperisone in spasticity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Baclofen; Cerebral Palsy; Child; Child, Preschool; Femal | 2017 |
A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke.
Topics: Aged; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; | 2005 |
[A randomized, double blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke].
Topics: Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Human | 2006 |
[The administration of midocalm in the treatment of vertebrogenic algesic syndromes].
Topics: Adaptation, Psychological; Adult; Electromyography; Female; Humans; Magnetic Resonance Imaging; Male | 2000 |
12 other studies available for tolperisone and Muscle Spasticity
| Article | Year |
|---|---|
[Comparative effectiveness of different muscle relaxants in the rehabilitation of post-stroke patients with spasticity].
Topics: Aged; Baclofen; Clonidine; Comparative Effectiveness Research; Dantrolene; Female; Humans; Male; Mus | 2013 |
[Spasticity in children cerebral palsy: diagnosis and treatment strategies].
Topics: Anti-Dyskinesia Agents; Baclofen; Botulinum Toxins; Cerebral Palsy; Child; Child, Preschool; Humans; | 2012 |
[To make easier everyday life of stroke patients. Muscle relaxants diminish spasms].
Topics: Double-Blind Method; Humans; Muscle Relaxants, Central; Muscle Spasticity; Placebos; Randomized Cont | 2003 |
[Mydocalm, a new drug to relax spastic muscles in neurological diseases].
Topics: Cerebral Arterial Diseases; Cerebral Hemorrhage; Cerebral Palsy; Encephalomyelitis; Humans; Multiple | 1961 |
[Mydocalm and muscle tone].
Topics: Humans; Multiple Sclerosis; Muscle Spasticity; Muscle Tonus; Paralysis; Parasympatholytics; Parkinso | 1961 |
[EXPERIENCE WITH A MYOTONOLYTIC (MYDOCALM) IN THE TREATMENT OF ARTERIAL OCCLUSIVE DISEASE OF THE EXTREMITIES].
Topics: Arteriosclerosis Obliterans; Drug Therapy; Electromyography; Extremities; Hemiplegia; Humans; Interm | 1964 |
[Talperison in spasticity and and muscle rigidity].
Topics: Humans; Muscle Spasticity; Tolperisone | 1996 |
[Tolperisone in spasticity and muscle spasm. Tolperisone in multiple sclerosis].
Topics: Humans; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Tolperisone | 1996 |
[Spastic syndrome. More mobile again after stroke].
Topics: Hemiplegia; Humans; Muscle Relaxants, Central; Muscle Spasticity; Stroke; Tolperisone | 2001 |
[EEG in patients with infantile cerebral palsy before and after the treatment by the method of functional biofeedback].
Topics: Adolescent; Benzoates; Biofeedback, Psychology; Cerebral Cortex; Cerebral Palsy; Child; Child, Presc | 1991 |
[Combined use of pharmacological preparations and a method of functional biocontrol in children with spastic forms of infantile cerebral palsy].
Topics: Adolescent; Biofeedback, Psychology; Cerebral Palsy; Child; Child, Preschool; Combined Modality Ther | 1988 |
Observations with higher Mydocalm doses in outpatients of the surgical department.
Topics: Extremities; Humans; Movement Disorders; Muscle Spasticity; Propiophenones; Regional Blood Flow; Tol | 1986 |