tolmetin has been researched along with Disease Models, Animal in 11 studies
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study used a rabbit model of hearing loss in experimental pneumococcal meningitis to evaluate the therapeutic effect of two anti-inflammatory agents, dexamethasone and ketorolac, coadministered with ampicillin." | 7.70 | Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. ( Bhatt, SM; Burkard, RF; Merchant, SN; Nadol, JB; Rappaport, JM, 1999) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 7.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| "To determine in rabbits whether periocular injection of ketorolac tromethamine effectively delivers the drug to the eye and, if so, whether this is efficacious in the treatment of experimental uveitis." | 7.69 | Intraocular penetration of periocular ketorolac and efficacy in experimental uveitis. ( Fiscella, RG; Rabiah, PK; Tessler, HH, 1996) |
| " This study used a rabbit model of hearing loss in experimental pneumococcal meningitis to evaluate the therapeutic effect of two anti-inflammatory agents, dexamethasone and ketorolac, coadministered with ampicillin." | 3.70 | Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. ( Bhatt, SM; Burkard, RF; Merchant, SN; Nadol, JB; Rappaport, JM, 1999) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 3.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| "The therapeutic utility of cyclooxygenase (CO) inhibitors, such as ketorolac, in reducing the inflammatory events associated with allergic conjunctivitis is not unexpected since prostanoids (PG) elicit conjunctival redness (PGD2, PGE2, PGF2 alpha), edema (PGD2, TxA2), eosinophil infiltration (PGD2, PGJ2) and mucous cell discharge (PGD2, PGJ2, TxA2)." | 3.69 | The pruritogenic and inflammatory effects of prostanoids in the conjunctiva. ( Hawley, SB; Joseph, R; Merlino, GF; Nieves, AL; Spada, CS; Woodward, DF, 1995) |
| "To determine in rabbits whether periocular injection of ketorolac tromethamine effectively delivers the drug to the eye and, if so, whether this is efficacious in the treatment of experimental uveitis." | 3.69 | Intraocular penetration of periocular ketorolac and efficacy in experimental uveitis. ( Fiscella, RG; Rabiah, PK; Tessler, HH, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buckley, RC | 1 |
| Davidson, SF | 1 |
| Das, SK | 1 |
| Montz, FJ | 1 |
| Monk, BJ | 1 |
| Lacy, SM | 1 |
| Fowler, JM | 1 |
| Woodward, DF | 1 |
| Nieves, AL | 1 |
| Hawley, SB | 1 |
| Joseph, R | 1 |
| Merlino, GF | 1 |
| Spada, CS | 1 |
| Rabiah, PK | 1 |
| Fiscella, RG | 1 |
| Tessler, HH | 1 |
| Chávez, E | 1 |
| Téllez, F | 1 |
| Pichardo, J | 1 |
| Milán, R | 1 |
| Cuéllar, A | 1 |
| Carbajal, K | 1 |
| Cruz, D | 1 |
| Brook, JW | 1 |
| Boike, A | 1 |
| Zema, RL | 1 |
| Weaver, M | 1 |
| Postak, P | 1 |
| De Winter, BY | 1 |
| Boeckxstaens, GE | 1 |
| De Man, JG | 1 |
| Moreels, TG | 1 |
| Herman, AG | 1 |
| Pelckmans, PA | 1 |
| Swift, JQ | 1 |
| Roszkowski, MT | 1 |
| Alton, T | 1 |
| Hargreaves, KM | 1 |
| Rappaport, JM | 1 |
| Bhatt, SM | 1 |
| Burkard, RF | 1 |
| Merchant, SN | 1 |
| Nadol, JB | 1 |
| López-Muñoz, FJ | 1 |
| Ventura, R | 1 |
| Díaz, I | 1 |
| Fernández-Guasti, A | 1 |
| Tost, D | 1 |
| Cabré, F | 1 |
| Mauleón, D | 1 |
| Jett, MF | 1 |
| Ramesha, CS | 1 |
| Brown, CD | 1 |
| Chiu, S | 1 |
| Emmett, C | 1 |
| Voronin, T | 1 |
| Sun, T | 1 |
| O'Yang, C | 1 |
| Hunter, JC | 1 |
| Eglen, RM | 1 |
| Johnson, RM | 1 |
11 other studies available for tolmetin and Disease Models, Animal
| Article | Year |
|---|---|
Effects of ketorolac tromethamine (Toradol) on a functional model of microvascular thrombosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Combinations; Femoral | 1993 |
Ketorolac tromethamine, a nonsteroidal anti-inflammatory drug: ability to inhibit post-radical pelvic surgery adhesions in a porcine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Combinations; Female; | 1993 |
The pruritogenic and inflammatory effects of prostanoids in the conjunctiva.
Topics: Animals; Capillary Permeability; Conjunctiva; Conjunctivitis, Allergic; Cyclooxygenase Inhibitors; D | 1995 |
Intraocular penetration of periocular ketorolac and efficacy in experimental uveitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Conjunctiva; Disease Models, Animal | 1996 |
On the protection by ketorolac of reperfusion-induced heart damage.
Topics: Analysis of Variance; Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium; Creatine Kinase; Cyclo | 1996 |
1997 William J. Stickel Silver Award. The anti-inflammatory action of locally injected ketorolac.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Awards and Prizes; Disease Models | 1997 |
Differential effect of indomethacin and ketorolac on postoperative ileus in rats.
Topics: Animals; Disease Models, Animal; Indomethacin; Intestinal Obstruction; Ketorolac; Nitric Oxide; Nitr | 1998 |
Effect of intra-articular versus systemic anti-inflammatory drugs in a rabbit model of temporomandibular joint inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bradykinin; D | 1998 |
Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac.
Topics: Acoustic Stimulation; Ampicillin; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-S | 1999 |
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Dise | 1998 |
Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Carrageenan; Cyclo | 1999 |