tolmetin has been researched along with Chemical Dependence in 8 studies
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacokinetic parameters were derived from plasma samples collected after the first and last active doses." | 2.67 | Tolerability, central effects and pharmacokinetics of intravenous ketorolac tromethamine in volunteers. ( Bullingham, R; Hooftman, L; Lloyd, J; Lucker, P; Mroszczak, E, 1994) |
| "Zomepirac is a new nonsteroidal anti-inflammatory agent (NSAIA) approved for the treatment of mild to moderately severe pain." | 2.36 | Evaluation of zomepirac sodium. ( McEvoy, GK, 1981) |
| "Zomepirac is an analgesic which is closely related chemically to the nonsteroidal anti-inflammatory agent, tolmetin." | 2.36 | Zomepirac: a review of its pharmacological properties and analgesic efficacy. ( Avery, GS; Brogden, RN; Carmine, AA; Heel, RC; Morley, PA; Speight, TM, 1982) |
| "Zomepirac was inactive in some analgesic assays in mice: tail-flick (1-30 mg/kg s." | 1.27 | Zomepirac: preclinical narcotic abuse liability evaluation. ( Aceto, MD; Harris, LS; Jacobson, AE; Medzihradsky, F; Smith, CB; Woods, JH; Young, AM, 1983) |
| "Zomepirac was inactive in a number of tests that detect narcotic agents, suggesting that the drug will not induce physical dependence." | 1.26 | Evaluation of the analgesic properties of zomepirac. ( Gardocki, JF; Muschek, LD; Pruss, TP; Taylor, RJ, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Woods, JH | 1 |
| Young, AM | 1 |
| Medzihradsky, F | 1 |
| Smith, CB | 1 |
| Aceto, MD | 1 |
| Harris, LS | 1 |
| Jacobson, AE | 1 |
| Pruss, TP | 1 |
| Gardocki, JF | 1 |
| Taylor, RJ | 1 |
| Muschek, LD | 1 |
| Jasinski, DR | 2 |
| Haertzen, CA | 1 |
| Henningfield, JE | 1 |
| Johnson, RE | 2 |
| Makhzoumi, HM | 1 |
| Miyasato, K | 1 |
| Kocher, TR | 1 |
| McEvoy, GK | 1 |
| Morley, PA | 1 |
| Brogden, RN | 1 |
| Carmine, AA | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Lucker, P | 1 |
| Bullingham, R | 1 |
| Hooftman, L | 1 |
| Lloyd, J | 1 |
| Mroszczak, E | 1 |
| Capasso, A | 1 |
| Sorrentino, L | 1 |
2 reviews available for tolmetin and Chemical Dependence
| Article | Year |
|---|---|
Evaluation of zomepirac sodium.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Costs a | 1981 |
Zomepirac: a review of its pharmacological properties and analgesic efficacy.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Humans; Kinetics; P | 1982 |
2 trials available for tolmetin and Chemical Dependence
| Article | Year |
|---|---|
Abuse potential of zomepirac.
Topics: Blood Pressure; Drug Evaluation; Euphoria; Humans; Morphine; Pupil; Pyrroles; Substance-Related Diso | 1983 |
Tolerability, central effects and pharmacokinetics of intravenous ketorolac tromethamine in volunteers.
Topics: Adult; Analgesics; Anxiety; Brain; Chromatography, High Pressure Liquid; Data Interpretation, Statis | 1994 |
4 other studies available for tolmetin and Chemical Dependence
| Article | Year |
|---|---|
Zomepirac: preclinical narcotic abuse liability evaluation.
Topics: Analgesics, Opioid; Animals; Discrimination, Psychological; Female; Humans; In Vitro Techniques; Mac | 1983 |
Evaluation of the analgesic properties of zomepirac.
Topics: Analgesics; Animals; Cattle; Cyclooxygenase Inhibitors; Drug Interactions; Hindlimb; Humans; In Vitr | 1980 |
Progress report of the NIDA Addiction Research Center.
Topics: Analgesics; Buprenorphine; Chlordiazepoxide; Clonidine; Diazepam; Humans; Morphine; National Institu | 1982 |
Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase Inhibitors; Guine | 1997 |