tolmetin and Blood Loss, Postoperative studies

Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.

Research Excerpts

Excerpt	Relevance	Reference
"To compare the incidence of vomiting following codeine or ketorolac for tonsillectomy in children."	5.08	Preoperative ketorolac increases bleeding after tonsillectomy in children. ( MacNeill, HB; Reid, CW; Rhine, EJ; Roberts, DW; Splinter, WM, 1996)
"Postoperative pain was assessed by self-report 1."	2.69	Analgesic efficacy and safety of preoperative versus postoperative ketorolac in paediatric tonsillectomy. ( Ostergaard, D; Rømsing, J; Valentin, N; Walther-Larsen, S, 1998)
"The frequency of postoperative hemorrhage was not found to differ significantly between these 2 groups (2."	1.30	Postoperative hemorrhage after tonsillectomy: use of ketorolac tromethamine. ( Agrawal, A; Dsida, RM; Gerson, CR; Seligman, I, 1999)
" A dose-response relationship was evident between average daily ketorolac dose and both gastrointestinal bleeding and operative site bleeding (trend test P < ."	1.29	Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. A postmarketing surveillance study. ( Berlin, JA; Carson, JL; Feldman, H; Hennessy, S; Kimmel, S; Kinman, JL; Spitz, PW; Strom, BL, 1996)
"Ketorolac proved safe for short-term intravenous use in children more than 1 year of age when patients with known contraindications to the use of non-steroidal antiinflammatory drugs were excluded."	1.29	Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. ( Berde, CB; Houck, CS; McDermott, JS; Sethna, NF; Wilder, RT, 1996)

Research

Studies (14)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Average Inpatient Hydromorphone Use

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	14 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Gunter, JB	1
Varughese, AM	1
Harrington, JF	1
Wittkugel, EP	1
Patankar, SS	1
Matar, MM	1
Lowe, EE	1
Myer, CM	1
Willging, JP	1
Etches, RC	1
Warriner, CB	1
Badner, N	1
Buckley, DN	1
Beattie, WS	1
Chan, VW	1
Parsons, D	1
Girard, M	1
Strom, BL	1
Berlin, JA	1
Kinman, JL	1
Spitz, PW	1
Hennessy, S	1
Feldman, H	1
Kimmel, S	1
Carson, JL	1
Hubbell, K	1
Linville, D	1
Dodenhoff, RM	1
Gumprecht, T	1
Houck, CS	1
Wilder, RT	1
McDermott, JS	1
Sethna, NF	1
Berde, CB	1
Hall, SC	1
Splinter, WM	1
Rhine, EJ	1
Roberts, DW	1
Reid, CW	1
MacNeill, HB	1
Judkins, JH	1
Dray, TG	1
Hubbell, RN	1
Rømsing, J	2
Walther-Larsen, S	2
Ostergaard, D	1
Valentin, N	1
Agrawal, A	1
Gerson, CR	1
Seligman, I	1
Dsida, RM	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT02973958]	Phase 1	30 participants (Actual)	Interventional	2017-02-01	Completed
A Randomized Control Trial Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT04646967]	Phase 2	100 participants (Anticipated)	Interventional	2022-11-25	Recruiting
Opioid-Free Versus Transitional Anesthetic With Opioids From Tonsillectomy[NCT04528173]	Phase 4	550 participants (Anticipated)	Interventional	2020-07-22	Recruiting
A Randomized Control Trial Study of the Efficacy of Celecoxib Versus Ketorolac for Perioperative Pain Control[NCT03331315]	Phase 2	170 participants (Actual)	Interventional	2013-09-01	Completed
A Randomized, Double-blinded, Placebo-controlled Study of Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy[NCT03453541]	Phase 4	600 participants (Anticipated)	Interventional	2017-11-21	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Average inpatient hydromorphone use measured in milligrams (NCT03331315)
Timeframe: 48 hrs following surgery

Average Inpatient Ondansetron Use

Intervention	Milligrams (Mean)
Ketorolac	0.7
Celecoxib	0.8

Average inpatient ondansetron use measured in milligrams (NCT03331315)
Timeframe: 48 hrs following surgery

Average Inpatient Postoperative Pain Score

Intervention	Milligrams (Mean)
Ketorolac	1.5
Celecoxib	1.3

Pain measured using the Visual Analog Scale, no pain (0-0.4 cm), mild pain(0.5-4.4 cm), moderate pain (4.5-7.4 cm), and severe pain (7.5-10.0 cm). Subscale scoring was not used in analysis but provided as reference for patient and nursing staff. (NCT03331315)
Timeframe: 48 hrs following surgery

Days of Oral Narcotic Use After Discharge

Intervention	units on a scale (Mean)
Ketorolac	2.7
Celecoxib	2.4

Measured using postoperative questionnaire (NCT03331315)
Timeframe: 2 weeks after discharge

Number of Oral Narcotic Pills Used After Discharge

Intervention	Days (Mean)
Ketorolac	5.7
Celecoxib	3.8

Number of oral narcotic pills used after discharge until 2 week postoperative visit. (NCT03331315)
Timeframe: 2 weeks after discharge

Number of Participants With Perioperative Complications

Intervention	Pills (Mean)
Ketorolac	8.1
Celecoxib	6.0

Perioperative Complications measured intraoperatively and postoperatively by type (NCT03331315)
Timeframe: During and after surgery

Return to Activities of Daily Living

Intervention	Patients (Number)
Ketorolac	5
Celecoxib	6

Average number of days required for complete return to independent activities of daily living (NCT03331315)
Timeframe: 2 weeks after discharge

Total Hospital Stay

Intervention	Days (Mean)
Ketorolac	2.4
Celecoxib	2.2

Total hospital stay from time fo admission to time of discharge measured in hours (NCT03331315)
Timeframe: Following surgery

Article	Year
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine. Anesthesia and analgesia, 1995, Volume: 81, Issue:6 Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B	1995
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine. Anesthesia and analgesia, 1995, Volume: 81, Issue:6 Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B	1995
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine. Anesthesia and analgesia, 1995, Volume: 81, Issue:6 Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B	1995
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine. Anesthesia and analgesia, 1995, Volume: 81, Issue:6 Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B	1995
Continuous intravenous administration of ketorolac reduces pain and morphine consumption after total hip or knee arthroplasty. Anesthesia and analgesia, 1995, Volume: 81, Issue:6 Topics: Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Antiem	1995
Preoperative ketorolac increases bleeding after tonsillectomy in children. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:6 Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anesthesia, Inhalation; Anesthet	1996
Analgesic efficacy and safety of preoperative versus postoperative ketorolac in paediatric tonsillectomy. Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:7 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child;	1998

Article	Year
Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. A postmarketing surveillance study. JAMA, 1996, Feb-07, Volume: 275, Issue:5 Topics: Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies;	1996
Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. A postmarketing surveillance study. JAMA, 1996, Feb-07, Volume: 275, Issue:5 Topics: Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies;	1996
Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. A postmarketing surveillance study. JAMA, 1996, Feb-07, Volume: 275, Issue:5 Topics: Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies;	1996
Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. A postmarketing surveillance study. JAMA, 1996, Feb-07, Volume: 275, Issue:5 Topics: Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies;	1996
Problems and pitfalls in providing acute and short-term pain relief with nonsteroidal anti-inflammatory agents. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1996, Volume: 148, Issue:1 Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Int	1996
Effect of ketorolac tromethamine on bleeding and on requirements for analgesia after total knee arthroplasty. The Journal of bone and joint surgery. American volume, 1996, Volume: 78, Issue:6 Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Cyclooxygenase Inhibitors; Drug	1996
Effect of ketorolac tromethamine on bleeding and on requirements for analgesia after total knee arthroplasty. The Journal of bone and joint surgery. American volume, 1996, Volume: 78, Issue:6 Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Drug Synergism; Hepa	1996
Risk of operative site bleeding with parenteral ketorolac. JAMA, 1996, Aug-07, Volume: 276, Issue:5 Topics: Analgesics, Non-Narcotic; Humans; Ketorolac; Postoperative Hemorrhage; Tolmetin	1996
Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. The Journal of pediatrics, 1996, Volume: 129, Issue:2 Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Prescho	1996
Tonsillectomies, ketorolac, and the march of progress. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:6 Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Child; Contraind	1996
Intraoperative ketorolac and posttonsillectomy bleeding. Archives of otolaryngology--head & neck surgery, 1996, Volume: 122, Issue:9 Topics: Adolescent; Adult; Analgesics; Blood Loss, Surgical; Child; Child, Preschool; Female; Humans; Infant	1996
Postoperative hemorrhage after tonsillectomy: use of ketorolac tromethamine. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1999, Volume: 120, Issue:3 Topics: Adenoidectomy; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female;	1999

tolmetin and Blood Loss, Postoperative