tolmetin has been researched along with Anesthesia in 9 studies
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-four ASA I and II children 1 to 10 yr of age undergoing strabismus surgery were randomized to receive in a double-blind fashion intravenous ketorolac (0." | 9.08 | The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery. ( Guarnieri, KM; Mendel, HG; Sundt, LM; Torjman, MC, 1995) |
| "The efficacy of intraoperatively administered ketorolac for the prophylactic treatment of pain in the postanesthesia care unit (PACU) was examined in a prospective, double-blinded study." | 9.07 | Effect of intraoperative ketorolac on postanesthesia care unit comfort. ( Behrman, KH; Disbrow, EA; Hanowell, LH; Loeb, RG; Valdrighi, JB, 1994) |
| "Two cases of bradycardia following the intra-operative use of ketorolac given intravenously (i." | 7.69 | Bradycardia following intravenous ketorolac in children. ( Foster, PN; Williams, JG, 1997) |
| "Fifty-four ASA I and II children 1 to 10 yr of age undergoing strabismus surgery were randomized to receive in a double-blind fashion intravenous ketorolac (0." | 5.08 | The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery. ( Guarnieri, KM; Mendel, HG; Sundt, LM; Torjman, MC, 1995) |
| "The efficacy of intraoperatively administered ketorolac for the prophylactic treatment of pain in the postanesthesia care unit (PACU) was examined in a prospective, double-blinded study." | 5.07 | Effect of intraoperative ketorolac on postanesthesia care unit comfort. ( Behrman, KH; Disbrow, EA; Hanowell, LH; Loeb, RG; Valdrighi, JB, 1994) |
| "Two cases of bradycardia following the intra-operative use of ketorolac given intravenously (i." | 3.69 | Bradycardia following intravenous ketorolac in children. ( Foster, PN; Williams, JG, 1997) |
| "Ketorolac tromethamine (0." | 1.28 | The pharmacokinetics of postoperative intravenous ketorolac tromethamine in children. ( Maunuksela, EL; Olkkola, KT, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 8 (88.89) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moore, GK | 1 |
| Noordewier, B | 1 |
| Hook, JB | 1 |
| Yorgey, KA | 1 |
| O'Neill, PJ | 1 |
| Blackburn, A | 1 |
| Stevens, JD | 1 |
| Wheatley, RG | 1 |
| Madej, TH | 1 |
| Hunter, D | 1 |
| Mendel, HG | 1 |
| Guarnieri, KM | 1 |
| Sundt, LM | 1 |
| Torjman, MC | 1 |
| Valdrighi, JB | 1 |
| Hanowell, LH | 1 |
| Loeb, RG | 1 |
| Behrman, KH | 1 |
| Disbrow, EA | 1 |
| Monagle, J | 1 |
| Wongprasartsuk, P | 1 |
| Shearer, W | 1 |
| Foster, PN | 1 |
| Williams, JG | 1 |
| Hall, SR | 1 |
| Milne, B | 1 |
| Loomis, C | 1 |
| Olkkola, KT | 1 |
| Maunuksela, EL | 1 |
| Smith, PC | 1 |
| McDonagh, AF | 1 |
| Benet, LZ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Evaluation of the Effects of IV Ketorolac on Platelet Function Post-Cesarean Delivery[NCT03805607] | Phase 4 | 40 participants (Actual) | Interventional | 2021-01-18 | Active, not recruiting | ||
| A Prospective, Randomized, Control Trial of Ketorolac Versus Placebo on Opioid Analgesic Use, Estimated Blood Loss and Complications Following Cesarean Delivery With Epidural Morphine[NCT02509312] | Phase 4 | 70 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total doses of medications to treat pruritus (opioid side-effect) including ondansetron and promethazine. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | doses (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Corrected change in Hct on POD1. Performed by subtracting POD1 Hct from POD0 Hct. Correction for transfusion by further subtracting 3 per unit of pRBC transfused to account for the typical change seen per unit transfused. (NCT02509312)
Timeframe: POD1
| Intervention | mg/dl (Mean) |
|---|---|
| Ketorolac | -5.1 |
| Placebo | -3.5 |
Estimation of blood loss during surgery (NCT02509312)
Timeframe: Immediately post-op
| Intervention | ml (Median) |
|---|---|
| Ketorolac | 900 |
| Placebo | 800 |
Rate of Post-Partum Hemorrhage between groups during the first 24 hours pst-partum. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketorolac | 7 |
| Placebo | 4 |
Total doses of medications to treat pruritus (opioid side-effect) including diphenhydramine, nalbuphine and naloxone. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | doses (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Total hydromorphone doses in mg in the first 24 hours post-partum. (NCT02509312)
Timeframe: 0 - 24 hours post-partum.
| Intervention | mg (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0.2 |
Total number of Units of Packed Reb Blood Cell Transfused in intra-op until 24 hours post-partum. (NCT02509312)
Timeframe: Intra-op until 24 hours post-partum.
| Intervention | units of pRBCs (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Total number of uterotonic doses including methylergonovine, carboprost and misoprostol. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | doses (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Pain score post-Cesarean Delivery using 11-point numerical rating scale (NRS): 0-10 where 0 is no pain and 10 is the worst pain imaginable (NCT02509312)
Timeframe: Up to 24 hours post-cesarean delivery
| Intervention | units on NRS (Median) | |||||
|---|---|---|---|---|---|---|
| Baseline | 15 mins | 1 hour | 6 hours | 12 hours | 24 hours | |
| Ketorolac | 0 | 0 | 0 | 1 | 2 | 4.5 |
| Placebo | 0 | 0 | 0 | 3 | 3.5 | 5.5 |
Percentile change in diastolic Blood Pressure at 6,12, and 24 hours for each patient's baseline defined by immediate post-op PACU vitals. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | Percent change (Mean) | ||
|---|---|---|---|
| 6 hours | 12 hours | 24 hours | |
| Ketorolac | 12.30 | 8.8 | 12.0 |
| Placebo | 7.6 | 8.8 | 11.1 |
Percentile change in Systolic Blood Pressure at 6,12, and 24 hours for each patient's baseline defined by immediate post-op PACU vitals. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | Percent change (Mean) | ||
|---|---|---|---|
| 6 hours | 12 hours | 24 hours | |
| Ketorolac | -2.0 | -9.10 | -5.9 |
| Placebo | -0.6 | -2.85 | -3.5 |
4 trials available for tolmetin and Anesthesia
| Article | Year |
|---|---|
Balanced analgesia with intravenous ketorolac and patient-controlled morphine following lower abdominal surgery.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anesthesia; Double | 1995 |
Balanced analgesia with intravenous ketorolac and patient-controlled morphine following lower abdominal surgery.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anesthesia; Double | 1995 |
Balanced analgesia with intravenous ketorolac and patient-controlled morphine following lower abdominal surgery.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anesthesia; Double | 1995 |
Balanced analgesia with intravenous ketorolac and patient-controlled morphine following lower abdominal surgery.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anesthesia; Double | 1995 |
The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthesia; Child; Child, P | 1995 |
Effect of intraoperative ketorolac on postanesthesia care unit comfort.
Topics: Adult; Analgesics; Anesthesia; Double-Blind Method; Female; Humans; Intraoperative Care; Ketorolac; | 1994 |
Ketorolac versus fentanyl for gynaecological day-case surgery.
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Female; Fentanyl; Genital Diseases, Female; Human | 1993 |
5 other studies available for tolmetin and Anesthesia
| Article | Year |
|---|---|
Effects of zomepirac and indomethacin on renal blood flow and electrolyte excretion in anesthetized monkeys.
Topics: Anesthesia; Animals; Electrolytes; Glomerular Filtration Rate; Indomethacin; Macaca mulatta; Male; P | 1981 |
Bradycardia following intravenous ketorolac in children.
Topics: Analgesics, Non-Narcotic; Anesthesia; Bradycardia; Child; Female; Humans; Injections, Intravenous; I | 1997 |
Spinal action of ketorolac, S(+)- and R(-)-ibuprofen on non-noxious activation of the catechol oxidation in the rat locus coeruleus: evidence for a central role of prostaglandins in the strychnine model of allodynia.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Catechols; Electrophys | 1999 |
The pharmacokinetics of postoperative intravenous ketorolac tromethamine in children.
Topics: Anesthesia; Child; Child, Preschool; Drug Combinations; Female; Half-Life; Humans; Injections, Intra | 1991 |
Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig.
Topics: Anesthesia; Animals; Blood Proteins; Clofibric Acid; Esterases; Guinea Pigs; Hydrolysis; Male; Metab | 1990 |