tolmetin has been researched along with Adjuvant Arthritis in 9 studies
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The glycine amide of tolmetin sodium (TGA) functions as a prodrug and was demonstrated to be more potent than the parent compound as an inhibitor of developing and established adjuvant arthritis in the female Lewis rat." | 7.67 | Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat. ( Carson, J; Fisher, MC; Persico, FJ; Pritchard, JF; Wong, S; Yorgey, K, 1988) |
| "The glycine amide of tolmetin sodium (TGA) functions as a prodrug and was demonstrated to be more potent than the parent compound as an inhibitor of developing and established adjuvant arthritis in the female Lewis rat." | 3.67 | Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat. ( Carson, J; Fisher, MC; Persico, FJ; Pritchard, JF; Wong, S; Yorgey, K, 1988) |
| "The data obtained from 5-day and long-term evaluations of acetaminophen (APAP) using the adjuvant arthritis rat model, demonstrated the anti-inflammatory and antiarthritic activities of APAP." | 3.66 | Anti-inflammatory and antiarthritic evaluation of acetaminophen and its potentiation of tolmetin. ( Gardocki, JF; Wong, S, 1983) |
| " It was found that compounds with polar substituents at the 2 or 3 position of the ring system are less acutely toxic while maintaining antiinflammatory activity." | 1.26 | Effect of structural change on acute toxicity and antiinflammatory activity in a series of imidazothiazoles and thiazolobenzimidazoles. ( Ariyan, ZS; Fogt, SW; Heilman, RD; Matthews, RJ; Powers, LJ; Rippin, DJ, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maryanoff, BE | 1 |
| Keeley, SL | 1 |
| Persico, FJ | 2 |
| Powers, LJ | 1 |
| Fogt, SW | 1 |
| Ariyan, ZS | 1 |
| Rippin, DJ | 1 |
| Heilman, RD | 1 |
| Matthews, RJ | 1 |
| Wong, S | 2 |
| Gardocki, JF | 1 |
| Rooks, WH | 1 |
| Tomolonis, AJ | 1 |
| Maloney, PJ | 1 |
| Wallach, MB | 1 |
| Schuler, ME | 1 |
| Grindel, JM | 1 |
| Nakamura, H | 1 |
| Yokoyama, Y | 1 |
| Motoyoshi, S | 1 |
| Seto, Y | 1 |
| Kadokawa, T | 1 |
| Shimizu, M | 1 |
| Anderson, NG | 1 |
| Carson, JR | 1 |
| Pritchard, JF | 1 |
| Fisher, MC | 1 |
| Yorgey, K | 1 |
| Carson, J | 1 |
| Ucelay, M | 1 |
| Lasheras, B | 1 |
| Cenarruzabeitia, E | 1 |
1 review available for tolmetin and Adjuvant Arthritis
| Article | Year |
|---|---|
The pharmacokinetic and metabolic profile of the antiinflammatory agent tolmetin in laboratory animals and man.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biological Availability; Guinea Pigs; Human | 1981 |
8 other studies available for tolmetin and Adjuvant Arthritis
| Article | Year |
|---|---|
Replacement of aromatic or heteroaromatic groups in nonsteroidal antiinflammatory agents with the ferrocene group.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Blood Platelets; Female; Ferrous Compoun | 1983 |
Effect of structural change on acute toxicity and antiinflammatory activity in a series of imidazothiazoles and thiazolobenzimidazoles.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1981 |
Anti-inflammatory and antiarthritic evaluation of acetaminophen and its potentiation of tolmetin.
Topics: Acetaminophen; Animals; Arthritis; Arthritis, Experimental; Drug Evaluation, Preclinical; Drug Thera | 1983 |
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, No | 1982 |
[Anti-inflammatory activity of a non-steroidal anti-inflammatory agent, zomepirac sodium, in experimental animals].
Topics: Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Capillary Per | 1982 |
Synthesis and biological activity of 5-(4-chlorobenzoyl)-4-(hydroxymethyl)-1-methyl-1H-pyrrole-2-acetic acid, a major metabolite of zomepirac sodium.
Topics: Analgesics; Animals; Arthritis, Experimental; Humans; In Vitro Techniques; Platelet Aggregation; Pyr | 1980 |
Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat.
Topics: Animals; Arthritis; Arthritis, Experimental; Bone and Bones; Digestive System; Female; Indomethacin; | 1988 |
Pharmacological study of the new nonsteroidal antiinflammatory agent 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Arthritis, Experimental; Carragee | 1988 |