tolmetin has been researched along with Acute Liver Injury, Drug-Induced in 8 studies
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Clearly, longer acyl glucuronide half-lives were observed for safe drugs compared to drugs that can cause IDT." | 1.42 | Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated. ( Aatsinki, SM; Hokkanen, J; Lassila, T; Mattila, S; Tolonen, A; Turpeinen, M, 2015) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "96) or a dose-response relationship (P = ." | 1.30 | Lack of hepatotoxic effects of parenteral ketorolac in the hospital setting. ( Berlin, JA; Carson, JL; Farrar, J; Feldman, HI; Harb, G; Hennessy, S; Kimmel, SE; Kinman, JL; Strom, BL, 1997) |
| " In therapeutic dosage it will adequately control joint symptoms in the majority of patients." | 1.26 | Pharmacotherapy of juvenile rheumatoid arthritis. ( Lindsley, CB, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Lassila, T | 1 |
| Hokkanen, J | 1 |
| Aatsinki, SM | 1 |
| Mattila, S | 1 |
| Turpeinen, M | 1 |
| Tolonen, A | 1 |
| Offerhaus, L | 1 |
| Lindsley, CB | 1 |
| Hennessy, S | 1 |
| Kinman, JL | 1 |
| Berlin, JA | 1 |
| Feldman, HI | 1 |
| Carson, JL | 1 |
| Kimmel, SE | 1 |
| Farrar, J | 1 |
| Harb, G | 1 |
| Strom, BL | 1 |
1 review available for tolmetin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
7 other studies available for tolmetin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated.
Topics: Acetates; Acyl Coenzyme A; Acylation; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Chro | 2015 |
Non-steroidal anti-inflammatory drugs in the treatment of rheumatic disorders: pitfalls and problems with the present plethora.
Topics: Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Humans; Propionates; Rheumatic Dis | 1983 |
Pharmacotherapy of juvenile rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; | 1981 |
Lack of hepatotoxic effects of parenteral ketorolac in the hospital setting.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver I | 1997 |