tolmetin and Acute Kidney Injury studies

Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.

Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Research Excerpts

Excerpt	Relevance	Reference
"Three patients who were treated with ketorolac tromethamine (Toradol), an injectable nonsteroidal anti-inflammatory drug for pain management, developed acute renal failure or hyperkalemia or both."	7.68	Renal failure and hyperkalemia associated with ketorolac tromethamine. ( Gonzalez, FM; Pearce, CJ; Wallin, JD, 1993)
"Zomepirac (ZP) was withdrawn from the market because of adverse effects such as renal toxicity."	5.43	Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice. ( Akai, S; Iwamura, A; Kume, T; Nishinosono, T; Oda, S; Tsuneyama, K; Watanabe, K; Yokoi, T, 2016)
"Three patients who were treated with ketorolac tromethamine (Toradol), an injectable nonsteroidal anti-inflammatory drug for pain management, developed acute renal failure or hyperkalemia or both."	3.68	Renal failure and hyperkalemia associated with ketorolac tromethamine. ( Gonzalez, FM; Pearce, CJ; Wallin, JD, 1993)
" A case is described in which allergic acute interstitial nephritis (AIN) was caused by tolmetin."	3.67	Tolmetin-induced acute renal failure. A case report. ( Gordon, GD; Pascoe, MD; Temple-Camp, CR, 1986)
"Zomepirac sodium is a new nonsteroidal anti-inflammatory agent for management of mild to moderate pain."	3.66	Zomepirac-induced renal failure. ( Lacher, JW; Miller, FC; Schorr, WJ, 1983)
"Zomepirac (ZP) was withdrawn from the market because of adverse effects such as renal toxicity."	1.43	Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice. ( Akai, S; Iwamura, A; Kume, T; Nishinosono, T; Oda, S; Tsuneyama, K; Watanabe, K; Yokoi, T, 2016)
"To compare the risk for acute renal failure associated with ketorolac with that associated with opioids."	1.30	Parenteral ketorolac: the risk for acute renal failure. ( Berlin, JA; Carson, JL; Farrar, J; Feldman, HI; Hennessy, S; Kimmel, SE; Kinman, JL; Strom, BL, 1997)
"We present three new cases of acute renal failure and hyperkalemia secondary to ketorolac."	1.29	Ketorolac-induced acute renal failure and hyperkalemia: report of three cases. ( Bagga, H; Bastani, B; Dalal, R; Haragsim, L, 1994)
"We describe a case of rapidly appearing acute renal failure following a single intramuscular dose of ketorolac."	1.29	Ketorolac induced acute renal failure following a single dose. ( Kayser, SR; Quan, DJ, 1994)
" Finally, since ketorolac is excreted almost entirely by the kidney, either elderly patients or patients with underlying renal insufficiency must have an adjustment of the dosing interval, or this medication should be avoided in such patients altogether."	1.29	NSAID nephrotoxicity revisited: acute renal failure due to parenteral ketorolac. ( Buller, GK; Perazella, MA, 1993)
"A case of acute renal failure in a chronic acetaminophen abuser receiving concurrent zomepirac therapy is reported."	1.27	Zomepirac-related acute renal failure. ( Boike, SC; Rybak, MJ; Tintinalli, JE; Veneri, R, 1983)
"We report here a case of nonoliguric acute renal failure associated with zomepirac sodium therapy."	1.26	Reversible nonoliguric acute renal failure associated with zomepirac therapy. ( Blair, TJ; McCarthy, JT; Pierides, AM; Schwartz, GL; Van den Berg, CJ, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (31.58)	18.7374
1990's	24 (63.16)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (5.26)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Yamashita, S	1
Oda, S	2
Endo, H	1
Tsuneyama, K	2
Yokoi, T	2
Iwamura, A	1
Watanabe, K	1
Akai, S	1
Nishinosono, T	1
Kume, T	1
Miller, FC	1
Schorr, WJ	1
Lacher, JW	1
Boike, SC	1
Rybak, MJ	1
Tintinalli, JE	1
Veneri, R	1
Lisker, WH	1
Ratner, SJ	1
Smith, VT	1
McCarthy, JT	1
Schwartz, GL	1
Blair, TJ	1
Pierides, AM	1
Van den Berg, CJ	1
Mease, PJ	1
Ellsworth, AJ	1
Killen, PD	1
Willkens, RF	1
Blackshear, JL	1
Katz, SM	1
Capaldo, R	1
Everts, EA	1
DiGregorio, JG	1
Fellner, SK	1
Affarah, HB	1
Wolfe, C	1
Patel, NY	1
Landercasper, J	1
Waters, JH	1
Jones, SF	1
Ulyatt, D	1
Haragsim, L	1
Dalal, R	1
Bagga, H	1
Bastani, B	2
Quan, DJ	1
Kayser, SR	1
Epelde Gonzalo, FD	1
Llibre Bombardó, J	1
Tomás Vecina, S	1
Murray, RP	1
Watson, RC	1
Phillips, G	1
Perazella, MA	2
Buller, GK	2
Smith, K	1
Halliwell, RM	1
Lawrence, S	1
Klineberg, PL	1
O'Connell, P	1
Fong, J	1
Gora, ML	1
Pearce, CJ	1
Gonzalez, FM	1
Wallin, JD	1
Kelley, M	1
Buck, ML	1
Norwood, VF	1
Revell, S	1
Mofenson, HC	2
Caraccio, TR	2
Feldman, HI	1
Kinman, JL	1
Berlin, JA	1
Hennessy, S	1
Kimmel, SE	1
Farrar, J	1
Carson, JL	1
Strom, BL	1
Murrell, GC	1
Leake, T	1
Hughes, PJ	1
Myles, PS	1
Power, I	1
Licker, A	1
Höhn, L	1
Schweizer, A	1
Boras-Uber, LA	1
Brackett, NC	1
Pascoe, MD	1
Gordon, GD	1
Temple-Camp, CR	1
Bander, SJ	1

Article	Year
Neutrophil depletion protects against zomepirac-induced acute kidney injury in mice. Chemico-biological interactions, 2018, Jan-05, Volume: 279 Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antigens, Ly; Che	2018
Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice. Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:7 Topics: Acute Kidney Injury; Animals; Antioxidants; Biomarkers; Biotransformation; Blood Urea Nitrogen; Buth	2016
Zomepirac-induced renal failure. Archives of internal medicine, 1983, Volume: 143, Issue:6 Topics: Acute Kidney Injury; Adult; Aged; Arthritis; Back Pain; Body Weight; Coronary Artery Bypass; Creatin	1983
Zomepirac-related acute renal failure. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:1 Topics: Acute Kidney Injury; Anti-Inflammatory Agents; Female; Humans; Middle Aged; Pyrroles; Tolmetin	1983
Nonoliguric renal failure associated with zomepirac. JAMA, 1983, Apr-01, Volume: 249, Issue:13 Topics: Acute Kidney Injury; Analgesics; Humans; Male; Middle Aged; Oliguria; Pain; Pyrroles; Tolmetin	1983
Zomepirac and renal failure. Annals of internal medicine, 1982, Volume: 96, Issue:6 Pt 1 Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Humans; Male; Pyrroles; Tolmeti	1982
Anaphylactic shock, acute renal failure, and disseminated intravascular coagulation. Suspected complications of zomepirac. JAMA, 1982, Feb-26, Volume: 247, Issue:8 Topics: Acute Kidney Injury; Aged; Anaphylaxis; Disseminated Intravascular Coagulation; Humans; Male; Pain;	1982
Reversible nonoliguric acute renal failure associated with zomepirac therapy. Mayo Clinic proceedings, 1982, Volume: 57, Issue:6 Topics: Acute Kidney Injury; Aged; Analgesics; Creatinine; Female; Humans; Kidney Glomerulus; Pyrroles; Tolm	1982
Zomepirac, interstitial nephritis, and renal failure. Annals of internal medicine, 1982, Volume: 97, Issue:3 Topics: Acute Kidney Injury; Female; Humans; Male; Middle Aged; Nephritis, Interstitial; Pyrroles; Tolmetin	1982
Drug-induced failure. Mayo Clinic proceedings, 1982, Volume: 57, Issue:10 Topics: Acute Kidney Injury; Humans; Pyrroles; Tolmetin	1982
Tolmetin. Association with reversible renal failure and acute interstitial nephritis. JAMA, 1981, Jul-17, Volume: 246, Issue:3 Topics: Acute Disease; Acute Kidney Injury; Aged; Biopsy; Female; Humans; Kidney; Nephritis, Interstitial; O	1981
Acute renal failure and zomepirac. Archives of internal medicine, 1981, Volume: 141, Issue:13 Topics: Acute Kidney Injury; Adult; Analgesics; Female; Humans; Pyrroles; Tolmetin	1981
Ketorolac-induced postoperative acute renal failure: a case report. Wisconsin medical journal, 1995, Volume: 94, Issue:8 Topics: Acute Kidney Injury; Analgesics, Non-Narcotic; Fundoplication; Gastroesophageal Reflux; Humans; Inje	1995
Keterolac-induced hyperkalemia. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1995, Volume: 26, Issue:1 Topics: Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors;	1995
Ketorolac and renal impairment. Anaesthesia and intensive care, 1994, Volume: 22, Issue:1 Topics: Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Injections, Intram	1994
Ketorolac-induced acute renal failure and hyperkalemia: report of three cases. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1994, Volume: 24, Issue:4 Topics: Acute Kidney Injury; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhib	1994
Ketorolac induced acute renal failure following a single dose. Journal of toxicology. Clinical toxicology, 1994, Volume: 32, Issue:3 Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Defibrillators, Imp	1994
Acute renal failure and gastrointestinal bleed associated with postoperative toradol and vancomycin. Orthopedics, 1993, Volume: 16, Issue:12 Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Gastrointest	1993
Intramuscular ketorolac. Anaesthesia and intensive care, 1994, Volume: 22, Issue:1 Topics: Acute Kidney Injury; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Injections,	1994
NSAID nephrotoxicity revisited: acute renal failure due to parenteral ketorolac. Southern medical journal, 1993, Volume: 86, Issue:12 Topics: Acute Kidney Injury; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Injection	1993
Acute renal failure associated with intramuscular ketorolac. Anaesthesia and intensive care, 1993, Volume: 21, Issue:5 Topics: Acute Kidney Injury; Adult; Analgesics; Female; Humans; Injections, Intramuscular; Ketorolac; Male;	1993
Ketorolac and renal failure. Adverse Drug Reactions Advisory Committee. The Medical journal of Australia, 1993, Oct-04, Volume: 159, Issue:7 Topics: Acute Kidney Injury; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; H	1993
Reversible renal insufficiency following ketorolac therapy. The Annals of pharmacotherapy, 1993, Volume: 27, Issue:4 Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Male; Risk Fa	1993
Renal failure and hyperkalemia associated with ketorolac tromethamine. Archives of internal medicine, 1993, Apr-26, Volume: 153, Issue:8 Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Female; Humans; Hyp	1993
Ketorolac-induced acute renal failure and hyperkalemia. Clinical nephrology, 1995, Volume: 44, Issue:4 Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Humans; Hyperkalemia; Ketorolac; Male;	1995
Ketorolac-induced acute renal failure in a previously healthy adolescent. Pediatrics, 1996, Volume: 98, Issue:2 Pt 1 Topics: Acute Kidney Injury; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory A	1996
Ketorolac-induced renal failure. Wisconsin medical journal, 1996, Volume: 95, Issue:3 Topics: Acute Kidney Injury; Humans; Ketorolac; Tolmetin	1996
Analgesia in renal colic. Annals of emergency medicine, 1997, Volume: 29, Issue:2 Topics: Acute Kidney Injury; Analgesics, Non-Narcotic; Colic; Humans; Ketorolac; Kidney Calculi; Tolmetin	1997
Parenteral ketorolac: the risk for acute renal failure. Annals of internal medicine, 1997, Feb-01, Volume: 126, Issue:3 Topics: Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Creatinine; Drug Administration Schedule; Fema	1997
Safety of intravenous ketorolac therapy. The Journal of pediatrics, 1997, Volume: 130, Issue:5 Topics: Acute Kidney Injury; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship	1997
Acute renal failure and ketorolac. Annals of internal medicine, 1997, Sep-15, Volume: 127, Issue:6 Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Tolmetin	1997
Does ketorolac cause postoperative renal failure: how do we assess the evidence? British journal of anaesthesia, 1998, Volume: 80, Issue:4 Topics: Acute Kidney Injury; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Evidence-Bas	1998
Ketorolac does not increase the risk of renal dysfunction after lung surgery. British journal of anaesthesia, 1998, Volume: 81, Issue:3 Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Middle Aged;	1998
Ketorolac-induced acute renal failure. The American journal of medicine, 1992, Volume: 92, Issue:4 Topics: Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Anuria; Drug Combinations;	1992
Tolmetin-induced acute renal failure. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Aug-16, Volume: 70, Issue:4 Topics: Acute Disease; Acute Kidney Injury; Humans; Male; Middle Aged; Nephritis, Interstitial; Peritoneal D	1986
Reversible renal failure and nephrotic syndrome without interstitial nephritis from zomepirac. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1985, Volume: 6, Issue:4 Topics: Acute Kidney Injury; Aged; Biopsy; Creatinine; Female; Fluorescent Antibody Technique; Humans; Kidne	1985

tolmetin and Acute Kidney Injury

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