tolmetin has been researched along with Acute Disease in 27 studies
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a prospective, double-blind, randomized study, ketorolac 60 mg, meperidine 50 mg plus promethazine 25 mg, and normal saline given by intramuscular injection were compared as treatment for acute headache crises." | 9.08 | The placebo effect in acute headache management: ketorolac, meperidine, and saline in the emergency department. ( Carter, T; Gracely, RH; Harden, RN; Warner, G, 1996) |
| "To determine if a single dose of intramuscular ketorolac given on presentation to the emergency department has a narcotic-sparing effect in adult patients with sickle cell vaso-occlusive crisis pain." | 9.07 | Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992) |
| "In an open trial 15 patients with acute gout attacks were treated with Tolmetin." | 7.66 | [Treatment of acute gout attacks with tolmetin (author's transl)]. ( Gaismayer, K; Petera, P; Tausch, G, 1982) |
| "Postoperative pain was assessed with objective (SAP, DAP, HR) and subjective (VAS, BS 11) methods at 60, 90, 120, 150, and 180 min after the end of surgery." | 6.68 | [Ketorolac for prevention of acute postoperative pain]. ( D'Uva, R; Peduto, VA; Piga, M; Toscano, A, 1995) |
| "Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID), available in several different countries, but not widely used." | 6.47 | Single dose oral fenoprofen for acute postoperative pain in adults. ( Derry, S; Moore, RA; Traa, MX, 2011) |
| "Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID)." | 6.47 | Single dose oral mefenamic acid for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moll, R; Moore, RA, 2011) |
| "Pain was quantified in 6 of the patients using a 10-cm visual analog scale that the patients completed before and 30, 60, and 90 minutes after ketorolac administration." | 5.29 | Treatment of acute gouty arthritis with intramuscular ketorolac tromethamine. ( Chiu, MJ; Cush, JJ; Martin, RL; Shrestha, M; Wainscott, MS, 1994) |
| "In a prospective, double-blind, randomized study, ketorolac 60 mg, meperidine 50 mg plus promethazine 25 mg, and normal saline given by intramuscular injection were compared as treatment for acute headache crises." | 5.08 | The placebo effect in acute headache management: ketorolac, meperidine, and saline in the emergency department. ( Carter, T; Gracely, RH; Harden, RN; Warner, G, 1996) |
| "To determine if a single dose of intramuscular ketorolac given on presentation to the emergency department has a narcotic-sparing effect in adult patients with sickle cell vaso-occlusive crisis pain." | 5.07 | Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992) |
| "To compare the clinical efficacy of single doses of intramuscular ketorolac and oral ibuprofen in the emergency department (ED) treatment of acute pain." | 3.69 | NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac. ( Price, SD; Watson, WA; Wright, JM, 1994) |
| "Twelve patients presenting to an emergency department in headache crisis were treated with Ketorolac tromethamine 60 mg." | 3.68 | Ketorolac in acute headache management. ( Carter, TD; Gilman, CS; Gross, AJ; Harden, RN; Peters, JR, 1991) |
| " A case is described in which allergic acute interstitial nephritis (AIN) was caused by tolmetin." | 3.67 | Tolmetin-induced acute renal failure. A case report. ( Gordon, GD; Pascoe, MD; Temple-Camp, CR, 1986) |
| "In an open trial 15 patients with acute gout attacks were treated with Tolmetin." | 3.66 | [Treatment of acute gout attacks with tolmetin (author's transl)]. ( Gaismayer, K; Petera, P; Tausch, G, 1982) |
| "Ketorolac was significantly (P < ." | 2.69 | Efficacy of ketorolac tromethamine versus meperidine in the ED treatment of acute renal colic. ( Blair, GA; D'Amico, F; Larkin, GL; Peacock, WF; Pearl, SM, 1999) |
| "Postoperative pain was assessed with objective (SAP, DAP, HR) and subjective (VAS, BS 11) methods at 60, 90, 120, 150, and 180 min after the end of surgery." | 2.68 | [Ketorolac for prevention of acute postoperative pain]. ( D'Uva, R; Peduto, VA; Piga, M; Toscano, A, 1995) |
| "Forty-seven adult patients with migraines enrolled on 50 visits." | 2.67 | Ketorolac versus meperidine and hydroxyzine in the treatment of acute migraine headache: a randomized, prospective, double-blind trial. ( Aldag, J; Duarte, C; Dunaway, F; Frederick, R; Turner, L, 1992) |
| "Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID), available in several different countries, but not widely used." | 2.47 | Single dose oral fenoprofen for acute postoperative pain in adults. ( Derry, S; Moore, RA; Traa, MX, 2011) |
| "Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID)." | 2.47 | Single dose oral mefenamic acid for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moll, R; Moore, RA, 2011) |
| "Pain was quantified in 6 of the patients using a 10-cm visual analog scale that the patients completed before and 30, 60, and 90 minutes after ketorolac administration." | 1.29 | Treatment of acute gouty arthritis with intramuscular ketorolac tromethamine. ( Chiu, MJ; Cush, JJ; Martin, RL; Shrestha, M; Wainscott, MS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (22.22) | 18.7374 |
| 1990's | 19 (70.37) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Traa, MX | 1 |
| Derry, S | 2 |
| Moore, RA | 2 |
| Moll, R | 1 |
| McQuay, HJ | 1 |
| Ahmad, S | 1 |
| Forrest, WH | 1 |
| Petera, P | 1 |
| Gaismayer, K | 1 |
| Tausch, G | 1 |
| Stefanini, M | 1 |
| Nassif, RI | 1 |
| Katz, SM | 1 |
| Capaldo, R | 1 |
| Everts, EA | 1 |
| DiGregorio, JG | 1 |
| Shrestha, M | 1 |
| Chiu, MJ | 1 |
| Martin, RL | 1 |
| Cush, JJ | 1 |
| Wainscott, MS | 1 |
| Shapiro, N | 1 |
| Wright, JM | 1 |
| Price, SD | 1 |
| Watson, WA | 1 |
| Davis, CP | 1 |
| Torre, PR | 1 |
| Schafer, NC | 1 |
| Dave, B | 1 |
| Bass, B | 1 |
| Martín Carrasco, C | 1 |
| Rodríguez Vázquez, M | 1 |
| Palacios Garciá, R | 1 |
| Arunasalam, S | 1 |
| Siegel, RJ | 1 |
| Hubbell, K | 1 |
| Harden, RN | 2 |
| Gracely, RH | 1 |
| Carter, T | 1 |
| Warner, G | 1 |
| Peduto, VA | 1 |
| Toscano, A | 1 |
| D'Uva, R | 1 |
| Piga, M | 1 |
| Goyal, SB | 1 |
| Goyal, RS | 1 |
| Tauber, J | 1 |
| Raizman, MB | 1 |
| Ostrov, CS | 1 |
| Laibovitz, RA | 1 |
| Abelson, MB | 1 |
| Betts, JG | 1 |
| Koester, JM | 1 |
| Gill, D | 1 |
| Schaich, L | 1 |
| Larkin, GL | 2 |
| Peacock, WF | 1 |
| Pearl, SM | 1 |
| Blair, GA | 1 |
| D'Amico, F | 1 |
| Sadeghein, A | 1 |
| Shahidi, N | 1 |
| Dehpour, AR | 1 |
| Prescott, JE | 1 |
| Wright, SW | 1 |
| Norris, RL | 1 |
| Mitchell, TR | 1 |
| Yealy, DM | 1 |
| Duarte, C | 1 |
| Dunaway, F | 1 |
| Turner, L | 1 |
| Aldag, J | 1 |
| Frederick, R | 1 |
| Carter, TD | 1 |
| Gilman, CS | 1 |
| Gross, AJ | 1 |
| Peters, JR | 1 |
| Pascoe, MD | 1 |
| Gordon, GD | 1 |
| Temple-Camp, CR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial Comparing the Combination of Intravenous Lidocaine and Ketorolac to Either Analgesics Alone for ED Patients With Acute Renal Colic[NCT02902770] | Phase 4 | 150 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| IM Ketorolac vs Diclofenac Potassium Powder for Oral Solution (Cambia) for the Acute Treatment of Severe Migraine[NCT02664116] | Phase 4 | 40 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The trial will compare the patient's pain score on a 11 point Likert scale, ranging from 0 to 10 with 0 being no pain, 5 moderate pain and 10 very severe pain, at 30 minutes (NCT02902770)
Timeframe: 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Lidocaine and Normal Saline Push | 5.52 |
| Ketorolac and Normal Saline Drip | 3.88 |
| Lidocaine and Ketorolac | 3.14 |
2 reviews available for tolmetin and Acute Disease
| Article | Year |
|---|---|
Single dose oral fenoprofen for acute postoperative pain in adults.
Topics: Acute Disease; Administration, Oral; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroi | 2011 |
Single dose oral mefenamic acid for acute postoperative pain in adults.
Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans | 2011 |
11 trials available for tolmetin and Acute Disease
| Article | Year |
|---|---|
Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain.
Topics: Acute Disease; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Female; Humans; Injections, I | 1980 |
Ketorolac as a rapid and effective treatment of migraine headache: evaluations by patients.
Topics: Acute Disease; Adult; Analgesics; Body Weight; Emergency Service, Hospital; Female; Humans; Injectio | 1993 |
[A double-blind study of the analgesic efficacy in kidney colic of the combination of dipyrone and spasmolytic with ketorolac trometamol].
Topics: Acute Disease; Adolescent; Adult; Aged; Analgesics; Butylscopolammonium Bromide; Colic; Dipyrone; Do | 1993 |
The placebo effect in acute headache management: ketorolac, meperidine, and saline in the emergency department.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 1996 |
[Ketorolac for prevention of acute postoperative pain].
Topics: Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Female; Humans; Ketorolac; Male; Pain Me | 1995 |
A multicenter comparison of the ocular efficacy and safety of diclofenac 0.1% solution with that of ketorolac 0.5% solution in patients with acute seasonal allergic conjunctivitis.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Allergic; Diclofenac; | 1998 |
Efficacy of ketorolac tromethamine versus meperidine in the ED treatment of acute renal colic.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Colic; | 1999 |
A comparison of ketorolac tromethamine and acetaminophen codeine in the management of acute apical periodontitis.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti- | 1999 |
A randomized, double-blind, comparative study of the efficacy of ketorolac tromethamine versus meperidine in the treatment of severe migraine.
Topics: Acute Disease; Adolescent; Adult; Analgesics; Double-Blind Method; Drug Combinations; Emergencies; F | 1992 |
Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect.
Topics: Acute Disease; Adult; Analgesics; Anemia, Sickle Cell; Double-Blind Method; Emergencies; Female; Hum | 1992 |
Ketorolac versus meperidine and hydroxyzine in the treatment of acute migraine headache: a randomized, prospective, double-blind trial.
Topics: Acute Disease; Adolescent; Adult; Analgesics; Double-Blind Method; Drug Combinations; Female; Humans | 1992 |
14 other studies available for tolmetin and Acute Disease
| Article | Year |
|---|---|
Severe coronary spasm during zomepirac-induced allergic reaction.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Coronary Vasospasm; Drug Hypersensitivity; F | 1984 |
[Treatment of acute gout attacks with tolmetin (author's transl)].
Topics: Acute Disease; Adult; Aged; Analgesia; Gout; Humans; Male; Middle Aged; Pyrroles; Tolmetin; Uric Aci | 1982 |
Acute thrombocytopenic purpura traced to tolmetin-related antibody.
Topics: Acute Disease; Antibody Formation; Blood Platelets; Female; Humans; Middle Aged; Platelet Count; Pur | 1982 |
Tolmetin. Association with reversible renal failure and acute interstitial nephritis.
Topics: Acute Disease; Acute Kidney Injury; Aged; Biopsy; Female; Humans; Kidney; Nephritis, Interstitial; O | 1981 |
Treatment of acute gouty arthritis with intramuscular ketorolac tromethamine.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Drug Evaluation; Emergency | 1994 |
Acute angioedema after ketorolac ingestion: report of case.
Topics: Acute Disease; Administration, Oral; Aged; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Drug | 1994 |
NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-St | 1994 |
Rapid resolution of symptomatic acute pericarditis with ketorolac tromethamine: a parenteral nonsteroidal antiinflammatory agent.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chest Pain; Drug Combinations; | 1993 |
Problems and pitfalls in providing acute and short-term pain relief with nonsteroidal anti-inflammatory agents.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Int | 1996 |
Ketorolac tromethamine-induced acute pancreatitis.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Chest Pain; Female; Humans; Ketorolac Tromethamine; | 1998 |
Ketorolac in the treatment of acute pain: the pendulum swings.
Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
[Introductory Press Conference: Toratex--the new mono-analgesics in acute, intense pain. Frankfurt, 21 February 1992].
Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
Ketorolac in acute headache management.
Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Headache; Humans; Ketorolac Trom | 1991 |
Tolmetin-induced acute renal failure. A case report.
Topics: Acute Disease; Acute Kidney Injury; Humans; Male; Middle Aged; Nephritis, Interstitial; Peritoneal D | 1986 |